Reviewed, UniProtKB/Swiss-Prot Q8K7F0 (CITX_STRP3)

Names and origin

Protein names

Recommended name:
    Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase
    EC=2.7.7.61
Alternative name(s):
    Holo-ACP synthase
    Holo-citrate lyase synthase
    Apo-ACP nucleodityltransferase

Gene names

Name:	citX
Ordered Locus Names:	SpyM3_0835, SPs1035

Organism

Streptococcus pyogenes serotype M3 [Complete proteome] [HAMAP]

Taxonomic identifier

301448 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	192 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is not processed.
Protein existence	Inferred from homology.

General annotation (Comments)

Function	Transfers 2-(5''-triphosphoribosyl)-3'-dephosphocoenzyme-A on a serine residue to the apo-acyl carrier protein (gamma chain) of the citrate lyase to yield holo-acyl carrier protein By similarity.
Catalytic activity	2'-(5-triphosphoribosyl)-3'-dephospho-CoA + citrate lyase apo-[acyl-carrier-protein] = citrate lyase holo-[acyl-carrier-protein] + diphosphate. HAMAP MF_00398
Sequence similarities	Belongs to the citX family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Molecular function	holo-citrate lyase synthase activity Inferred from electronic annotation. Source: HAMAP
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 192	192	Probable apo-citrate lyase phosphoribosyl-dephospho-CoA transferase HAMAP MF_00398		PRO_0000214689

Sequences

	Sequence		Length	Mass (Da)
	Q8K7F0-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5F314CC12808D0F4	FASTA	192	21,646
	10 20 30 40 50 60 MCKDTYFSGE AIQLSDMLRA REERALRQLH LLKEYPEGSL LSVTMNIPGP IKTSPKLLEV 70 80 90 100 110 120 FDIVIKAIQT ALADDKICYQ LRLLPTTGYE YYLITSLPSR DLKLKMIALE TELPIGRLMD 130 140 150 160 170 180 LDVLVLQNDL PHSISRTVLG GSPRQCFICS KEAKVCGRLR KHSVEEMQTA ISKLLHSFFN 190 KDNQSSSSDK TG

References

[1]

"Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence." Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed: 12122206] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-595 / MGAS315 / Serotype M3.

[2]

"Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution." Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S. Genome Res. 13:1042-1055(2003) [PubMed: 12799345] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SSI-1 / Serotype M3.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AE014074 Genomic DNA. Translation: AAM79442.1. BA000034 Genomic DNA. Translation: BAC64130.1. Different initiation.
RefSeq	NP_664639.1. NP_802297.1.
3D structure databases
ModBase	Search...
Genome annotation databases
GeneID	1009149. 1065052.
GenomeReviews	Gene locus SpyM3_0835 in contig AE014074_GR. Gene locus SPs1035 in contig BA000034_GR.
KEGG	spg:SpyM3_0835. sps:SPs1035.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	Q8K7F0.
OMA	Q8K7F0. TGYEYYL.
Enzyme and pathway databases
BioCyc	SPYO193567:SPS1035-MON. SPYO198466:SPYM3_0835-MON.
Family and domain databases
HAMAP	MF_00398. [Tree]
InterPro	IPR005551. CitX. [Graphical view]
Pfam	PF03802. CitX. 1 hit. [Graphical view]
TIGRFAMs	TIGR03124. ctirate_citX. 1 hit.
ProtoNet	Search...

Entry information

Entry name

CITX_STRP3

Accession

Primary (citable) accession number: Q8K7F0

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 15, 2002
Last sequence update:	October 1, 2002
Last modified:	June 16, 2009
This is version 40 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)