ID   HASC1_STRP3             Reviewed;         304 AA.
AC   Q8K5G4; Q79VY2;
DT   30-AUG-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 37.
DE   RecName: Full=UTP--glucose-1-phosphate uridylyltransferase 1;
DE            EC=2.7.7.9;
DE   AltName: Full=UDP-glucose pyrophosphorylase 1;
DE            Short=UDPGP 1;
DE   AltName: Full=Alpha-D-glucosyl-1-phosphate uridylyltransferase 1;
DE   AltName: Full=Uridine diphosphoglucose pyrophosphorylase 1;
GN   Name=hasC1; Synonyms=hasC; OrderedLocusNames=SpyM3_1853, SPs1849;
OS   Streptococcus pyogenes serotype M3.
OC   Bacteria; Firmicutes; Lactobacillales; Streptococcaceae;
OC   Streptococcus.
OX   NCBI_TaxID=301448;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=ATCC BAA-595 / MGAS315 / Serotype M3;
RX   MEDLINE=22133808; PubMed=12122206; DOI=10.1073/pnas.152298499;
RA   Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S.,
RA   Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D.,
RA   Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M.,
RA   Schlievert P.M., Musser J.M.;
RT   "Genome sequence of a serotype M3 strain of group A Streptococcus:
RT   phage-encoded toxins, the high-virulence phenotype, and clone
RT   emergence.";
RL   Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=SSI-1 / Serotype M3;
RX   MEDLINE=22683278; PubMed=12799345; DOI=10.1101/gr.1096703;
RA   Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y.,
RA   Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T.,
RA   Hayashi H., Hattori M., Hamada S.;
RT   "Genome sequence of an M3 strain of Streptococcus pyogenes reveals a
RT   large-scale genomic rearrangement in invasive strains and new insights
RT   into phage evolution.";
RL   Genome Res. 13:1042-1055(2003).
CC   -!- CATALYTIC ACTIVITY: UTP + alpha-D-glucose 1-phosphate =
CC       diphosphate + UDP-glucose.
CC   -!- PATHWAY: Carbohydrate metabolism; nucleotide-sugar metabolism.
CC   -!- SIMILARITY: Belongs to the UDPGP type 2 family.
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DR   EMBL; AE014074; AAM80460.1; -; Genomic_DNA.
DR   EMBL; BA000034; BAC64944.1; -; Genomic_DNA.
DR   RefSeq; NP_665657.1; -.
DR   RefSeq; NP_803111.1; -.
DR   GeneID; 1010168; -.
DR   GeneID; 1066096; -.
DR   GenomeReviews; AE014074_GR; SpyM3_1853.
DR   GenomeReviews; BA000034_GR; SPs1849.
DR   KEGG; spg:SpyM3_1853; -.
DR   KEGG; sps:SPs1849; -.
DR   HOGENOM; Q8K5G4; -.
DR   OMA; Q8K5G4; GFIETTL.
DR   BioCyc; SPYO193567:SPS1849-MON; -.
DR   BioCyc; SPYO198466:SPYM3_1853-MON; -.
DR   GO; GO:0003983; F:UTP:glucose-1-phosphate uridylyltransferase...; IEA:EC.
DR   GO; GO:0009058; P:biosynthetic process; IEA:InterPro.
DR   GO; GO:0006011; P:UDP-glucose metabolic process; IEA:InterPro.
DR   InterPro; IPR005771; GalU_trans_bac.
DR   InterPro; IPR005835; NTP_transferase.
DR   Pfam; PF00483; NTP_transferase; 1.
DR   TIGRFAMs; TIGR01099; galU; 1.
PE   3: Inferred from homology;
KW   Complete proteome; Nucleotidyltransferase; Transferase.
FT   CHAIN         1    304       UTP--glucose-1-phosphate
FT                                uridylyltransferase 1.
FT                                /FTId=PRO_0000201369.
SQ   SEQUENCE   304 AA;  33706 MW;  5D717DF01DBC4411 CRC64;
     MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILVVTGKA
     KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF IRQSHPRGLG DAVLQAKAFV
     GNEPFVVMLG DDLMDITNAS AKPLTKQLME DYDKTHASTI AVMKVPHEDV SSYGVIAPQG
     KAVKGLYSVD TFVEKPQPED APSDLAIIGR YLLTPEIFDI LERQVPGAGN EVQLTDAIDT
     LNKTQRVFAR EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP
     THSK
//