Reviewed, UniProtKB/Swiss-Prot Q8K5G4 (HASC1_STRP3)

Names and origin

Protein names

Recommended name:
    UTP--glucose-1-phosphate uridylyltransferase 1
    EC=2.7.7.9
Alternative name(s):
    UDP-glucose pyrophosphorylase 1
      Short name=UDPGP 1
    Alpha-D-glucosyl-1-phosphate uridylyltransferase 1
    Uridine diphosphoglucose pyrophosphorylase 1

Gene names

Name:	hasC1
Synonyms:	hasC
Ordered Locus Names:	SpyM3_1853, SPs1849

Organism

Streptococcus pyogenes serotype M3 [Complete proteome] [HAMAP]

Taxonomic identifier

301448 [NCBI]

Taxonomic lineage

Bacteria › Firmicutes › Lactobacillales › Streptococcaceae › Streptococcus

Protein attributes

Sequence length	304 AA.
Sequence status	Complete.
Protein existence	Inferred from homology.

General annotation (Comments)

Catalytic activity	UTP + alpha-D-glucose 1-phosphate = diphosphate + UDP-glucose.
Pathway	Carbohydrate metabolism; nucleotide-sugar metabolism.
Sequence similarities	Belongs to the UDPGP type 2 family.

Ontologies

Keywords
Molecular function	Nucleotidyltransferase Transferase
Technical term	Complete proteome
Gene Ontology (GO)
Biological process	UDP-glucose metabolic process Inferred from electronic annotation. Source: InterPro biosynthetic process Inferred from electronic annotation. Source: InterPro
Molecular function	UTP:glucose-1-phosphate uridylyltransferase activity Inferred from electronic annotation. Source: EC
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 304	304	UTP--glucose-1-phosphate uridylyltransferase 1		PRO_0000201369

Sequences

	Sequence		Length	Mass (Da)
	Q8K5G4-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5D717DF01DBC4411	FASTA	304	33,706
	10 20 30 40 50 60 MTKVRKAIIP AAGLGTRFLP ATKALAKEML PIVDKPTIQF IVEEALKSGI EEILVVTGKA 70 80 90 100 110 120 KRSIEDHFDS NFELEYNLQA KGKNELLKLV DETTAINLHF IRQSHPRGLG DAVLQAKAFV 130 140 150 160 170 180 GNEPFVVMLG DDLMDITNAS AKPLTKQLME DYDKTHASTI AVMKVPHEDV SSYGVIAPQG 190 200 210 220 230 240 KAVKGLYSVD TFVEKPQPED APSDLAIIGR YLLTPEIFDI LERQVPGAGN EVQLTDAIDT 250 260 270 280 290 300 LNKTQRVFAR EFKGNRYDVG DKFGFMKTSI DYALEHPQVK EDLKNYIIKL GKALEKSKVP THSK

References

[1]

"Genome sequence of a serotype M3 strain of group A Streptococcus: phage-encoded toxins, the high-virulence phenotype, and clone emergence." Beres S.B., Sylva G.L., Barbian K.D., Lei B., Hoff J.S., Mammarella N.D., Liu M.-Y., Smoot J.C., Porcella S.F., Parkins L.D., Campbell D.S., Smith T.M., McCormick J.K., Leung D.Y.M., Schlievert P.M., Musser J.M. Proc. Natl. Acad. Sci. U.S.A. 99:10078-10083(2002) [PubMed: 12122206] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: ATCC BAA-595 / MGAS315 / Serotype M3.

[2]

"Genome sequence of an M3 strain of Streptococcus pyogenes reveals a large-scale genomic rearrangement in invasive strains and new insights into phage evolution." Nakagawa I., Kurokawa K., Yamashita A., Nakata M., Tomiyasu Y., Okahashi N., Kawabata S., Yamazaki K., Shiba T., Yasunaga T., Hayashi H., Hattori M., Hamada S. Genome Res. 13:1042-1055(2003) [PubMed: 12799345] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: SSI-1 / Serotype M3.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AE014074 Genomic DNA. Translation: AAM80460.1. BA000034 Genomic DNA. Translation: BAC64944.1.
RefSeq	NP_665657.1. NP_803111.1.
3D structure databases
SMR	Q8K5G4. Positions 2-287.
ModBase	Search...
Genome annotation databases
GeneID	1010168. 1066096.
GenomeReviews	Gene locus SpyM3_1853 in contig AE014074_GR. Gene locus SPs1849 in contig BA000034_GR.
KEGG	spg:SpyM3_1853. sps:SPs1849.
Organism-specific databases
CMR	Search...
Phylogenomic databases
HOGENOM	HBG688195.
OMA	VVDGREW.
Enzyme and pathway databases
BioCyc	SPYO193567:SPS1849-MONOMER. SPYO198466:SPYM3_1853-MONOMER.
Family and domain databases
InterPro	IPR005771. GalU_uridylyltTrfase_bac/arc. IPR005835. NTP_transferase. [Graphical view]
Pfam	PF00483. NTP_transferase. 1 hit. [Graphical view]
TIGRFAMs	TIGR01099. galU. 1 hit.
ProtoNet	Search...

Entry information

Entry name

HASC1_STRP3

Accession

Primary (citable) accession number: Q8K5G4
Secondary accession number(s): Q79VY2

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 30, 2005
Last sequence update:	October 1, 2002
Last modified:	February 9, 2010
This is version 43 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HAMAP (High-quality Automated and Manual Annotation of microbial Proteomes)