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Q8K5E0

- LPAR3_RAT

UniProt

Q8K5E0 - LPAR3_RAT

Protein

Lysophosphatidic acid receptor 3

Gene

Lpar3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 98 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins By similarity.By similarity

    GO - Molecular functioni

    1. G-protein alpha-subunit binding Source: RGD
    2. lysophosphatidic acid receptor activity Source: InterPro
    3. phospholipid binding Source: RGD

    GO - Biological processi

    1. activation of MAPK activity Source: Ensembl
    2. bleb assembly Source: Ensembl
    3. G-protein coupled receptor signaling pathway Source: RGD
    4. positive regulation of calcium ion transport Source: RGD
    5. positive regulation of collateral sprouting Source: Ensembl
    6. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD

    Keywords - Molecular functioni

    G-protein coupled receptor, Receptor, Transducer

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Lysophosphatidic acid receptor 3
    Short name:
    LPA receptor 3
    Short name:
    LPA-3
    Alternative name(s):
    Lysophosphatidic acid receptor Edg-7
    snGPCR32
    Gene namesi
    Name:Lpar3
    Synonyms:Edg7, Lpa3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 2

    Organism-specific databases

    RGDi620565. Lpar3.

    Subcellular locationi

    GO - Cellular componenti

    1. axon Source: Ensembl
    2. integral component of membrane Source: UniProtKB-KW
    3. intracellular membrane-bounded organelle Source: Ensembl
    4. plasma membrane Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 354354Lysophosphatidic acid receptor 3PRO_0000069435Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
    Lipidationi309 – 3091S-palmitoyl cysteineBy similarity

    Keywords - PTMi

    Glycoprotein, Lipoprotein, Palmitate

    Proteomic databases

    PRIDEiQ8K5E0.

    PTM databases

    PhosphoSiteiQ8K5E0.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8K5E0.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000020656.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K5E0.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini53 – 6715CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini89 – 10113ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini125 – 14622CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini168 – 18619ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini208 – 24033CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini296 – 35459CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
    BLAST
    Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
    BLAST
    Transmembranei102 – 12423Helical; Name=3Sequence AnalysisAdd
    BLAST
    Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
    BLAST
    Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
    BLAST
    Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
    BLAST
    Transmembranei277 – 29519Helical; Name=7Sequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG288678.
    GeneTreeiENSGT00740000115422.
    HOGENOMiHOG000233501.
    HOVERGENiHBG103071.
    InParanoidiQ8K5E0.
    KOiK04294.
    OMAiDISACSS.
    OrthoDBiEOG7HTHH1.
    PhylomeDBiQ8K5E0.
    TreeFamiTF330052.

    Family and domain databases

    Gene3Di1.20.1070.10. 1 hit.
    InterProiIPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004065. LPA_rcpt.
    IPR005385. LPA_rcpt_EDG7.
    [Graphical view]
    PfamiPF00001. 7tm_1. 1 hit.
    [Graphical view]
    PRINTSiPR01560. EDG7RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01527. LPARECEPTOR.
    PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K5E0-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL    50
    VIAAVITNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN 100
    RWLLRQGLLD TSLTASLANL LVIAVERHMS IMRMRIHSNL TKKRVTLLIL 150
    LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLIF WTVSNLLAFF 200
    IMVVVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT VMTVLGAFVV 250
    CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM 300
    YNTMRKMICC APHDSNAERH PSRIPSTIHS RSDTGSQYLE DSISQGQVCN 350
    KSSS 354
    Length:354
    Mass (Da):40,287
    Last modified:October 1, 2002 - v1
    Checksum:i3536C8FA6EC59286
    GO

    Sequence cautioni

    The sequence AAG24262.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti74 – 741A → V in AAG24262. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051164 mRNA. Translation: BAB91247.1.
    AF097733 mRNA. Translation: AAG24262.1. Different initiation.
    RefSeqiNP_076459.1. NM_023969.1.
    XP_006233531.1. XM_006233469.1.
    XP_006233532.1. XM_006233470.1.
    XP_006233533.1. XM_006233471.1.
    UniGeneiRn.64507.

    Genome annotation databases

    EnsembliENSRNOT00000020656; ENSRNOP00000020656; ENSRNOG00000015260.
    GeneIDi66025.
    KEGGirno:66025.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051164 mRNA. Translation: BAB91247.1 .
    AF097733 mRNA. Translation: AAG24262.1 . Different initiation.
    RefSeqi NP_076459.1. NM_023969.1.
    XP_006233531.1. XM_006233469.1.
    XP_006233532.1. XM_006233470.1.
    XP_006233533.1. XM_006233471.1.
    UniGenei Rn.64507.

    3D structure databases

    ProteinModelPortali Q8K5E0.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000020656.

    Chemistry

    BindingDBi Q8K5E0.
    ChEMBLi CHEMBL4424.
    GuidetoPHARMACOLOGYi 274.

    Protein family/group databases

    GPCRDBi Search...

    PTM databases

    PhosphoSitei Q8K5E0.

    Proteomic databases

    PRIDEi Q8K5E0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000020656 ; ENSRNOP00000020656 ; ENSRNOG00000015260 .
    GeneIDi 66025.
    KEGGi rno:66025.

    Organism-specific databases

    CTDi 23566.
    RGDi 620565. Lpar3.

    Phylogenomic databases

    eggNOGi NOG288678.
    GeneTreei ENSGT00740000115422.
    HOGENOMi HOG000233501.
    HOVERGENi HBG103071.
    InParanoidi Q8K5E0.
    KOi K04294.
    OMAi DISACSS.
    OrthoDBi EOG7HTHH1.
    PhylomeDBi Q8K5E0.
    TreeFami TF330052.

    Miscellaneous databases

    NextBioi 614330.
    PROi Q8K5E0.

    Gene expression databases

    Genevestigatori Q8K5E0.

    Family and domain databases

    Gene3Di 1.20.1070.10. 1 hit.
    InterProi IPR000276. GPCR_Rhodpsn.
    IPR017452. GPCR_Rhodpsn_7TM.
    IPR004065. LPA_rcpt.
    IPR005385. LPA_rcpt_EDG7.
    [Graphical view ]
    Pfami PF00001. 7tm_1. 1 hit.
    [Graphical view ]
    PRINTSi PR01560. EDG7RECEPTOR.
    PR00237. GPCRRHODOPSN.
    PR01527. LPARECEPTOR.
    PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
    PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Molecular cloning of the rat EDG7 protein and its identification as a functional cellular receptor for lysophosphatidic acid."
      Higashioka M., Mori K.
      Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Testis.
    2. "Identification and characterization of novel G-protein coupled receptors expressed in regenerating peripheral nerve."
      Carroll S.L., Miller M.L., Benedict-Hamilton H.M.
      Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-354.
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiLPAR3_RAT
    AccessioniPrimary (citable) accession number: Q8K5E0
    Secondary accession number(s): Q9ESJ6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 98 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. 7-transmembrane G-linked receptors
      List of 7-transmembrane G-linked receptor entries
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3