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Q8K5E0

- LPAR3_RAT

UniProt

Q8K5E0 - LPAR3_RAT

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Protein

Lysophosphatidic acid receptor 3

Gene

Lpar3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins (By similarity).By similarity

GO - Molecular functioni

  1. G-protein alpha-subunit binding Source: RGD
  2. lysophosphatidic acid receptor activity Source: InterPro
  3. phospholipid binding Source: RGD

GO - Biological processi

  1. activation of MAPK activity Source: Ensembl
  2. bleb assembly Source: Ensembl
  3. G-protein coupled receptor signaling pathway Source: RGD
  4. positive regulation of calcium ion transport Source: RGD
  5. positive regulation of collateral sprouting Source: Ensembl
  6. positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway Source: RGD
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_233455. G alpha (i) signalling events.
REACT_239650. Lysosphingolipid and LPA receptors.
REACT_263374. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Lysophosphatidic acid receptor 3
Short name:
LPA receptor 3
Short name:
LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
snGPCR32
Gene namesi
Name:Lpar3
Synonyms:Edg7, Lpa3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 2

Organism-specific databases

RGDi620565. Lpar3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 3131ExtracellularSequence AnalysisAdd
BLAST
Transmembranei32 – 5221Helical; Name=1Sequence AnalysisAdd
BLAST
Topological domaini53 – 6715CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei68 – 8821Helical; Name=2Sequence AnalysisAdd
BLAST
Topological domaini89 – 10113ExtracellularSequence AnalysisAdd
BLAST
Transmembranei102 – 12423Helical; Name=3Sequence AnalysisAdd
BLAST
Topological domaini125 – 14622CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei147 – 16721Helical; Name=4Sequence AnalysisAdd
BLAST
Topological domaini168 – 18619ExtracellularSequence AnalysisAdd
BLAST
Transmembranei187 – 20721Helical; Name=5Sequence AnalysisAdd
BLAST
Topological domaini208 – 24033CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei241 – 26121Helical; Name=6Sequence AnalysisAdd
BLAST
Topological domaini262 – 27615ExtracellularSequence AnalysisAdd
BLAST
Transmembranei277 – 29519Helical; Name=7Sequence AnalysisAdd
BLAST
Topological domaini296 – 35459CytoplasmicSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. axon Source: Ensembl
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 354354Lysophosphatidic acid receptor 3PRO_0000069435Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi15 – 151N-linked (GlcNAc...)Sequence Analysis
Glycosylationi172 – 1721N-linked (GlcNAc...)Sequence Analysis
Lipidationi309 – 3091S-palmitoyl cysteineBy similarity

Keywords - PTMi

Glycoprotein, Lipoprotein, Palmitate

Proteomic databases

PRIDEiQ8K5E0.

PTM databases

PhosphoSiteiQ8K5E0.

Expressioni

Gene expression databases

GenevestigatoriQ8K5E0.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000020656.

Structurei

3D structure databases

ProteinModelPortaliQ8K5E0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the G-protein coupled receptor 1 family.PROSITE-ProRule annotation

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG288678.
GeneTreeiENSGT00760000118804.
HOGENOMiHOG000233501.
HOVERGENiHBG103071.
InParanoidiQ8K5E0.
KOiK04294.
OMAiDISACSS.
OrthoDBiEOG7HTHH1.
PhylomeDBiQ8K5E0.
TreeFamiTF330052.

Family and domain databases

Gene3Di1.20.1070.10. 1 hit.
InterProiIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view]
PfamiPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSiPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEiPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K5E0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL
60 70 80 90 100
VIAAVITNRK FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN
110 120 130 140 150
RWLLRQGLLD TSLTASLANL LVIAVERHMS IMRMRIHSNL TKKRVTLLIL
160 170 180 190 200
LVWAIAIFMG AVPTLGWNCL CNISACSSLA PIYSRSYLIF WTVSNLLAFF
210 220 230 240 250
IMVVVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT VMTVLGAFVV
260 270 280 290 300
CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM
310 320 330 340 350
YNTMRKMICC APHDSNAERH PSRIPSTIHS RSDTGSQYLE DSISQGQVCN

KSSS
Length:354
Mass (Da):40,287
Last modified:October 1, 2002 - v1
Checksum:i3536C8FA6EC59286
GO

Sequence cautioni

The sequence AAG24262.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti74 – 741A → V in AAG24262. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051164 mRNA. Translation: BAB91247.1.
AF097733 mRNA. Translation: AAG24262.1. Different initiation.
RefSeqiNP_076459.1. NM_023969.1.
XP_006233531.1. XM_006233469.2.
XP_006233532.1. XM_006233470.2.
XP_006233533.1. XM_006233471.2.
XP_008759744.1. XM_008761522.1.
XP_008759745.1. XM_008761523.1.
UniGeneiRn.64507.

Genome annotation databases

EnsembliENSRNOT00000020656; ENSRNOP00000020656; ENSRNOG00000015260.
GeneIDi66025.
KEGGirno:66025.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051164 mRNA. Translation: BAB91247.1 .
AF097733 mRNA. Translation: AAG24262.1 . Different initiation.
RefSeqi NP_076459.1. NM_023969.1.
XP_006233531.1. XM_006233469.2.
XP_006233532.1. XM_006233470.2.
XP_006233533.1. XM_006233471.2.
XP_008759744.1. XM_008761522.1.
XP_008759745.1. XM_008761523.1.
UniGenei Rn.64507.

3D structure databases

ProteinModelPortali Q8K5E0.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000020656.

Chemistry

BindingDBi Q8K5E0.
ChEMBLi CHEMBL4424.
GuidetoPHARMACOLOGYi 274.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8K5E0.

Proteomic databases

PRIDEi Q8K5E0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000020656 ; ENSRNOP00000020656 ; ENSRNOG00000015260 .
GeneIDi 66025.
KEGGi rno:66025.

Organism-specific databases

CTDi 23566.
RGDi 620565. Lpar3.

Phylogenomic databases

eggNOGi NOG288678.
GeneTreei ENSGT00760000118804.
HOGENOMi HOG000233501.
HOVERGENi HBG103071.
InParanoidi Q8K5E0.
KOi K04294.
OMAi DISACSS.
OrthoDBi EOG7HTHH1.
PhylomeDBi Q8K5E0.
TreeFami TF330052.

Enzyme and pathway databases

Reactomei REACT_233455. G alpha (i) signalling events.
REACT_239650. Lysosphingolipid and LPA receptors.
REACT_263374. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 614330.
PROi Q8K5E0.

Gene expression databases

Genevestigatori Q8K5E0.

Family and domain databases

Gene3Di 1.20.1070.10. 1 hit.
InterProi IPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view ]
Pfami PF00001. 7tm_1. 1 hit.
[Graphical view ]
PRINTSi PR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEi PS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Molecular cloning of the rat EDG7 protein and its identification as a functional cellular receptor for lysophosphatidic acid."
    Higashioka M., Mori K.
    Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Testis.
  2. "Identification and characterization of novel G-protein coupled receptors expressed in regenerating peripheral nerve."
    Carroll S.L., Miller M.L., Benedict-Hamilton H.M.
    Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-354.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiLPAR3_RAT
AccessioniPrimary (citable) accession number: Q8K5E0
Secondary accession number(s): Q9ESJ6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: November 26, 2014
This is version 100 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3