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Q8K5E0 (LPAR3_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 97. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Lysophosphatidic acid receptor 3

Short name=LPA receptor 3
Short name=LPA-3
Alternative name(s):
Lysophosphatidic acid receptor Edg-7
snGPCR32
Gene names
Name:Lpar3
Synonyms:Edg7, Lpa3
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length354 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor for lysophosphatidic acid (LPA), a mediator of diverse cellular activities. Seems to be coupled to the G(i)/G(o) and G(q) families of heteromeric G proteins By similarity.

Subcellular location

Cell membrane; Multi-pass membrane protein Probable.

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Sequence caution

The sequence AAG24262.1 differs from that shown. Reason: Erroneous initiation.

Ontologies

Keywords
   Cellular componentCell membrane
Membrane
   DomainTransmembrane
Transmembrane helix
   Molecular functionG-protein coupled receptor
Receptor
Transducer
   PTMGlycoprotein
Lipoprotein
Palmitate
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processG-protein coupled receptor signaling pathway

Inferred from mutant phenotype PubMed 16504475. Source: RGD

activation of MAPK activity

Inferred from electronic annotation. Source: Ensembl

bleb assembly

Inferred from electronic annotation. Source: Ensembl

positive regulation of calcium ion transport

Inferred from mutant phenotype PubMed 11340076. Source: RGD

positive regulation of collateral sprouting

Inferred from electronic annotation. Source: Ensembl

positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G-protein coupled signaling pathway

Inferred from direct assay PubMed 16242672. Source: RGD

   Cellular_componentaxon

Inferred from electronic annotation. Source: Ensembl

integral component of membrane

Inferred from electronic annotation. Source: UniProtKB-KW

intracellular membrane-bounded organelle

Inferred from electronic annotation. Source: Ensembl

plasma membrane

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionG-protein alpha-subunit binding

Inferred from mutant phenotype PubMed 16504475. Source: RGD

lysophosphatidic acid receptor activity

Inferred from electronic annotation. Source: InterPro

phospholipid binding

Inferred from direct assay PubMed 16242672. Source: RGD

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 354354Lysophosphatidic acid receptor 3
PRO_0000069435

Regions

Topological domain1 – 3131Extracellular Potential
Transmembrane32 – 5221Helical; Name=1; Potential
Topological domain53 – 6715Cytoplasmic Potential
Transmembrane68 – 8821Helical; Name=2; Potential
Topological domain89 – 10113Extracellular Potential
Transmembrane102 – 12423Helical; Name=3; Potential
Topological domain125 – 14622Cytoplasmic Potential
Transmembrane147 – 16721Helical; Name=4; Potential
Topological domain168 – 18619Extracellular Potential
Transmembrane187 – 20721Helical; Name=5; Potential
Topological domain208 – 24033Cytoplasmic Potential
Transmembrane241 – 26121Helical; Name=6; Potential
Topological domain262 – 27615Extracellular Potential
Transmembrane277 – 29519Helical; Name=7; Potential
Topological domain296 – 35459Cytoplasmic Potential

Amino acid modifications

Lipidation3091S-palmitoyl cysteine By similarity
Glycosylation151N-linked (GlcNAc...) Potential
Glycosylation1721N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict741A → V in AAG24262. Ref.2

Sequences

Sequence LengthMass (Da)Tools
Q8K5E0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 3536C8FA6EC59286

FASTA35440,287
        10         20         30         40         50         60 
MNECHYDKRM DFFYNRSNTD TADEWTGTKL VIVLCVGTFF CLFIFFSNSL VIAAVITNRK 

        70         80         90        100        110        120 
FHFPFYYLLA NLAAADFFAG IAYVFLMFNT GPVSKTLTVN RWLLRQGLLD TSLTASLANL 

       130        140        150        160        170        180 
LVIAVERHMS IMRMRIHSNL TKKRVTLLIL LVWAIAIFMG AVPTLGWNCL CNISACSSLA 

       190        200        210        220        230        240 
PIYSRSYLIF WTVSNLLAFF IMVVVYVRIY MYVKRKTNVL SPHTSGSISR RRAPMKLMKT 

       250        260        270        280        290        300 
VMTVLGAFVV CWTPGLVVLL LDGLNCKQCN VQHVKRWFLL LALLNSVMNP IIYSYKDEDM 

       310        320        330        340        350 
YNTMRKMICC APHDSNAERH PSRIPSTIHS RSDTGSQYLE DSISQGQVCN KSSS 

« Hide

References

[1]"Molecular cloning of the rat EDG7 protein and its identification as a functional cellular receptor for lysophosphatidic acid."
Higashioka M., Mori K.
Submitted (NOV-2000) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Testis.
[2]"Identification and characterization of novel G-protein coupled receptors expressed in regenerating peripheral nerve."
Carroll S.L., Miller M.L., Benedict-Hamilton H.M.
Submitted (OCT-1998) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 8-354.
Strain: Sprague-Dawley.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051164 mRNA. Translation: BAB91247.1.
AF097733 mRNA. Translation: AAG24262.1. Different initiation.
RefSeqNP_076459.1. NM_023969.1.
XP_006233531.1. XM_006233469.1.
XP_006233532.1. XM_006233470.1.
XP_006233533.1. XM_006233471.1.
UniGeneRn.64507.

3D structure databases

ProteinModelPortalQ8K5E0.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000020656.

Chemistry

BindingDBQ8K5E0.
ChEMBLCHEMBL4424.
GuidetoPHARMACOLOGY274.

Protein family/group databases

GPCRDBSearch...

PTM databases

PhosphoSiteQ8K5E0.

Proteomic databases

PRIDEQ8K5E0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000020656; ENSRNOP00000020656; ENSRNOG00000015260.
GeneID66025.
KEGGrno:66025.

Organism-specific databases

CTD23566.
RGD620565. Lpar3.

Phylogenomic databases

eggNOGNOG288678.
GeneTreeENSGT00740000115422.
HOGENOMHOG000233501.
HOVERGENHBG103071.
InParanoidQ8K5E0.
KOK04294.
OMADISACSS.
OrthoDBEOG7HTHH1.
PhylomeDBQ8K5E0.
TreeFamTF330052.

Gene expression databases

GenevestigatorQ8K5E0.

Family and domain databases

Gene3D1.20.1070.10. 1 hit.
InterProIPR000276. GPCR_Rhodpsn.
IPR017452. GPCR_Rhodpsn_7TM.
IPR004065. LPA_rcpt.
IPR005385. LPA_rcpt_EDG7.
[Graphical view]
PfamPF00001. 7tm_1. 1 hit.
[Graphical view]
PRINTSPR01560. EDG7RECEPTOR.
PR00237. GPCRRHODOPSN.
PR01527. LPARECEPTOR.
PROSITEPS00237. G_PROTEIN_RECEP_F1_1. 1 hit.
PS50262. G_PROTEIN_RECEP_F1_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio614330.
PROQ8K5E0.

Entry information

Entry nameLPAR3_RAT
AccessionPrimary (citable) accession number: Q8K5E0
Secondary accession number(s): Q9ESJ6
Entry history
Integrated into UniProtKB/Swiss-Prot: December 6, 2002
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 97 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

7-transmembrane G-linked receptors

List of 7-transmembrane G-linked receptor entries