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Protein

Homeobox protein Hox-C12

Gene

Hoxc12

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi212 – 27160HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Homeobox protein Hox-C12
Alternative name(s):
Homeobox protein Hox-3.8
Gene namesi
Name:Hoxc12
Synonyms:Hox-3.8, Hoxc-12
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 15

Organism-specific databases

MGIiMGI:96194. Hoxc12.

Subcellular locationi

  • Nucleus PROSITE-ProRule annotation

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 280280Homeobox protein Hox-C12PRO_0000248840Add
BLAST

Proteomic databases

MaxQBiQ8K5B8.
PaxDbiQ8K5B8.
PRIDEiQ8K5B8.

Expressioni

Gene expression databases

BgeeiQ8K5B8.
CleanExiMM_HOXC12.

Interactioni

Protein-protein interaction databases

BioGridi200384. 8 interactions.
STRINGi10090.ENSMUSP00000051003.

Structurei

3D structure databases

ProteinModelPortaliQ8K5B8.
SMRiQ8K5B8. Positions 212-270.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Abd-B homeobox family.Curated
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiNOG239684.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiQ8K5B8.
KOiK09297.
OMAiVSINPSF.
OrthoDBiEOG7FV3R4.
PhylomeDBiQ8K5B8.
TreeFamiTF351604.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K5B8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV
60 70 80 90 100
CSLPWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED SKGYYREPCA
110 120 130 140 150
EGGGGGLKRE ERGREPGAGP GAALLQLEPS GPPALGFKYD YTASGGGGDG
160 170 180 190 200
STGPPHDPPS CQSLESDSSS SLLNEGNKSA SAGDPGSLVS PLNPGGGLSA
210 220 230 240 250
SGAPWYPIHS RSRKKRKPYS KLQLAELEGE FLVNEFITRQ RRRELSDRLN
260 270 280
LSDQQVKIWF QNRRMKKKRL LLREQALSFF
Length:280
Mass (Da):30,345
Last modified:October 1, 2002 - v1
Checksum:iF42405EFC51AE60B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448482 mRNA. Translation: AAM28679.1.
BC120845 mRNA. Translation: AAI20846.1.
BC120847 mRNA. Translation: AAI20848.1.
CCDSiCCDS27891.1.
RefSeqiNP_034593.1. NM_010463.1.
UniGeneiMm.221179.

Genome annotation databases

EnsembliENSMUST00000055562; ENSMUSP00000051003; ENSMUSG00000050328.
GeneIDi15421.
KEGGimmu:15421.
UCSCiuc007xww.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF448482 mRNA. Translation: AAM28679.1.
BC120845 mRNA. Translation: AAI20846.1.
BC120847 mRNA. Translation: AAI20848.1.
CCDSiCCDS27891.1.
RefSeqiNP_034593.1. NM_010463.1.
UniGeneiMm.221179.

3D structure databases

ProteinModelPortaliQ8K5B8.
SMRiQ8K5B8. Positions 212-270.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi200384. 8 interactions.
STRINGi10090.ENSMUSP00000051003.

Proteomic databases

MaxQBiQ8K5B8.
PaxDbiQ8K5B8.
PRIDEiQ8K5B8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000055562; ENSMUSP00000051003; ENSMUSG00000050328.
GeneIDi15421.
KEGGimmu:15421.
UCSCiuc007xww.1. mouse.

Organism-specific databases

CTDi3228.
MGIiMGI:96194. Hoxc12.

Phylogenomic databases

eggNOGiNOG239684.
GeneTreeiENSGT00760000118834.
HOGENOMiHOG000231177.
HOVERGENiHBG052050.
InParanoidiQ8K5B8.
KOiK09297.
OMAiVSINPSF.
OrthoDBiEOG7FV3R4.
PhylomeDBiQ8K5B8.
TreeFamiTF351604.

Miscellaneous databases

NextBioi288158.
PROiQ8K5B8.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K5B8.
CleanExiMM_HOXC12.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
InterProiIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamiPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSiPR00024. HOMEOBOX.
SMARTiSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
PROSITEiPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Hoxc12 expression pattern in developing and cycling murine hair follicles."
    Shang L., Pruett N.D., Awgulewitsch A.
    Mech. Dev. 113:207-210(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: CD-1.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiHXC12_MOUSE
AccessioniPrimary (citable) accession number: Q8K5B8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. Vertebrate homeotic Hox proteins
    Nomenclature of vertebrate homeotic Hox proteins and list of entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.