Q8K5B8 (HXC12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Homeobox protein Hox-C12

Alternative name(s):
Homeobox protein Hox-3.8

Gene names

Name:	Hoxc12
Synonyms:	Hox-3.8, Hoxc-12

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	280 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.
Subcellular location	Nucleus By similarity.
Sequence similarities	Belongs to the Abd-B homeobox family. Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
Biological process	Transcription Transcription regulation
Cellular component	Nucleus
Domain	Homeobox
Ligand	DNA-binding
Molecular function	Developmental protein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	multicellular organismal development Inferred from electronic annotation. Source: UniProtKB-KW transcription, DNA-dependent Inferred from electronic annotation. Source: UniProtKB-KW
Cellular_component	nucleus Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular_function	sequence-specific DNA binding Inferred from electronic annotation. Source: InterPro sequence-specific DNA binding transcription factor activity Inferred from electronic annotation. Source: InterPro
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 280	280	Homeobox protein Hox-C12		PRO_0000248840
Regions
	DNA binding	212 – 271	60	Homeobox

Sequences

	Sequence		Length	Mass (Da)
	Q8K5B8 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: F42405EFC51AE60B	FASTA	280	30,345
	10 20 30 40 50 60 MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLPWPSAEP 70 80 90 100 110 120 CNGYPQPYLG SPVSLNPPFG RTCELARVED SKGYYREPCA EGGGGGLKRE ERGREPGAGP 130 140 150 160 170 180 GAALLQLEPS GPPALGFKYD YTASGGGGDG STGPPHDPPS CQSLESDSSS SLLNEGNKSA 190 200 210 220 230 240 SAGDPGSLVS PLNPGGGLSA SGAPWYPIHS RSRKKRKPYS KLQLAELEGE FLVNEFITRQ 250 260 270 280 RRRELSDRLN LSDQQVKIWF QNRRMKKKRL LLREQALSFF

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Hoxc12 expression pattern in developing and cycling murine hair follicles." Shang L., Pruett N.D., Awgulewitsch A. Mech. Dev. 113:207-210(2002) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: CD-1.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF448482 mRNA. Translation: AAM28679.1. BC120845 mRNA. Translation: AAI20846.1. BC120847 mRNA. Translation: AAI20848.1.
IPI	IPI00170318.
RefSeq	NP_034593.1. NM_010463.1.
UniGene	Mm.221179.
3D structure databases
HSSP	HSSP built from PDB template 2CRA based on UniProtKB Q92826.
ProteinModelPortal	Q8K5B8.
SMR	Q8K5B8. Positions 212-270.
ModBase	Search...
Proteomic databases
PaxDb	Q8K5B8.
PRIDE	Q8K5B8.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000055562; ENSMUSP00000051003; ENSMUSG00000050328.
GeneID	15421.
KEGG	mmu:15421.
UCSC	uc007xww.1. mouse.
Organism-specific databases
CTD	3228.
MGI	MGI:96194. Hoxc12.
Phylogenomic databases
eggNOG	NOG239684.
GeneTree	ENSGT00700000104263.
HOGENOM	HOG000231177.
HOVERGEN	HBG052050.
InParanoid	Q8K5B8.
KO	K09297.
OMA	EPCNGYS.
OrthoDB	EOG4BP1CK.
Gene expression databases
ArrayExpress	Q8K5B8.
Bgee	Q8K5B8.
CleanEx	MM_HOXC12.
Genevestigator	Q8K5B8.
Family and domain databases
Gene3D	1.10.10.60. 1 hit.
InterPro	IPR017970. Homeobox_CS. IPR020479. Homeobox_metazoa. IPR001356. Homeodomain. IPR009057. Homeodomain-like. [Graphical view]
Pfam	PF00046. Homeobox. 1 hit. [Graphical view]
PRINTS	PR00024. HOMEOBOX.
SMART	SM00389. HOX. 1 hit. [Graphical view]
SUPFAM	SSF46689. Homeodomain_like. 1 hit.
PROSITE	PS00027. HOMEOBOX_1. 1 hit. PS50071. HOMEOBOX_2. 1 hit. [Graphical view]
ProtoNet	Search...
Other
NextBio	288158.
SOURCE	Search...

Entry information

Entry name

HXC12_MOUSE

Accession

Primary (citable) accession number: Q8K5B8

Entry history

Integrated into UniProtKB/Swiss-Prot:	September 5, 2006
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 73 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program