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Q8K5B8 (HXC12_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 82. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Homeobox protein Hox-C12
Alternative name(s):
Homeobox protein Hox-3.8
Gene names
Name:Hoxc12
Synonyms:Hox-3.8, Hoxc-12
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length280 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis By similarity.

Subcellular location

Nucleus By similarity.

Sequence similarities

Belongs to the Abd-B homeobox family.

Contains 1 homeobox DNA-binding domain.

Ontologies

Keywords
   Biological processTranscription
Transcription regulation
   Cellular componentNucleus
   DomainHomeobox
   LigandDNA-binding
   Molecular functionDevelopmental protein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processmulticellular organismal development

Inferred from electronic annotation. Source: UniProtKB-KW

transcription, DNA-templated

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentnucleus

Inferred from electronic annotation. Source: UniProtKB-SubCell

   Molecular_functionsequence-specific DNA binding

Inferred from electronic annotation. Source: InterPro

sequence-specific DNA binding transcription factor activity

Inferred from electronic annotation. Source: InterPro

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 280280Homeobox protein Hox-C12
PRO_0000248840

Regions

DNA binding212 – 27160Homeobox

Sequences

Sequence LengthMass (Da)Tools
Q8K5B8 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: F42405EFC51AE60B

FASTA28030,345
        10         20         30         40         50         60 
MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV CSLPWPSAEP 

        70         80         90        100        110        120 
CNGYPQPYLG SPVSLNPPFG RTCELARVED SKGYYREPCA EGGGGGLKRE ERGREPGAGP 

       130        140        150        160        170        180 
GAALLQLEPS GPPALGFKYD YTASGGGGDG STGPPHDPPS CQSLESDSSS SLLNEGNKSA 

       190        200        210        220        230        240 
SAGDPGSLVS PLNPGGGLSA SGAPWYPIHS RSRKKRKPYS KLQLAELEGE FLVNEFITRQ 

       250        260        270        280 
RRRELSDRLN LSDQQVKIWF QNRRMKKKRL LLREQALSFF 

« Hide

References

« Hide 'large scale' references
[1]"Hoxc12 expression pattern in developing and cycling murine hair follicles."
Shang L., Pruett N.D., Awgulewitsch A.
Mech. Dev. 113:207-210(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: CD-1.
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF448482 mRNA. Translation: AAM28679.1.
BC120845 mRNA. Translation: AAI20846.1.
BC120847 mRNA. Translation: AAI20848.1.
CCDSCCDS27891.1.
RefSeqNP_034593.1. NM_010463.1.
UniGeneMm.221179.

3D structure databases

ProteinModelPortalQ8K5B8.
SMRQ8K5B8. Positions 212-270.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

BioGrid200384. 8 interactions.

Proteomic databases

PaxDbQ8K5B8.
PRIDEQ8K5B8.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000055562; ENSMUSP00000051003; ENSMUSG00000050328.
GeneID15421.
KEGGmmu:15421.
UCSCuc007xww.1. mouse.

Organism-specific databases

CTD3228.
MGIMGI:96194. Hoxc12.

Phylogenomic databases

eggNOGNOG239684.
GeneTreeENSGT00750000117432.
HOGENOMHOG000231177.
HOVERGENHBG052050.
InParanoidQ8K5B8.
KOK09297.
OMAQDPPSCQ.
OrthoDBEOG7FV3R4.
PhylomeDBQ8K5B8.
TreeFamTF351604.

Gene expression databases

BgeeQ8K5B8.
CleanExMM_HOXC12.
GenevestigatorQ8K5B8.

Family and domain databases

Gene3D1.10.10.60. 1 hit.
InterProIPR017970. Homeobox_CS.
IPR001356. Homeobox_dom.
IPR020479. Homeobox_metazoa.
IPR009057. Homeodomain-like.
[Graphical view]
PfamPF00046. Homeobox. 1 hit.
[Graphical view]
PRINTSPR00024. HOMEOBOX.
SMARTSM00389. HOX. 1 hit.
[Graphical view]
SUPFAMSSF46689. SSF46689. 1 hit.
PROSITEPS00027. HOMEOBOX_1. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio288158.
PROQ8K5B8.
SOURCESearch...

Entry information

Entry nameHXC12_MOUSE
AccessionPrimary (citable) accession number: Q8K5B8
Entry history
Integrated into UniProtKB/Swiss-Prot: September 5, 2006
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 82 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

Vertebrate homeotic Hox proteins

Nomenclature of vertebrate homeotic Hox proteins and list of entries