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Q8K5B8

- HXC12_MOUSE

UniProt

Q8K5B8 - HXC12_MOUSE

Protein

Homeobox protein Hox-C12

Gene

Hoxc12

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 83 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis.By similarity

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    DNA bindingi212 – 27160HomeoboxPROSITE-ProRule annotationAdd
    BLAST

    GO - Molecular functioni

    1. sequence-specific DNA binding Source: InterPro
    2. sequence-specific DNA binding transcription factor activity Source: InterPro

    GO - Biological processi

    1. multicellular organismal development Source: UniProtKB-KW
    2. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental protein

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    DNA-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Homeobox protein Hox-C12
    Alternative name(s):
    Homeobox protein Hox-3.8
    Gene namesi
    Name:Hoxc12
    Synonyms:Hox-3.8, Hoxc-12
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:96194. Hoxc12.

    Subcellular locationi

    Nucleus PROSITE-ProRule annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell

    Keywords - Cellular componenti

    Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 280280Homeobox protein Hox-C12PRO_0000248840Add
    BLAST

    Proteomic databases

    PaxDbiQ8K5B8.
    PRIDEiQ8K5B8.

    Expressioni

    Gene expression databases

    BgeeiQ8K5B8.
    CleanExiMM_HOXC12.
    GenevestigatoriQ8K5B8.

    Interactioni

    Protein-protein interaction databases

    BioGridi200384. 8 interactions.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K5B8.
    SMRiQ8K5B8. Positions 212-270.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the Abd-B homeobox family.Curated
    Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Homeobox

    Phylogenomic databases

    eggNOGiNOG239684.
    GeneTreeiENSGT00750000117432.
    HOGENOMiHOG000231177.
    HOVERGENiHBG052050.
    InParanoidiQ8K5B8.
    KOiK09297.
    OMAiQDPPSCQ.
    OrthoDBiEOG7FV3R4.
    PhylomeDBiQ8K5B8.
    TreeFamiTF351604.

    Family and domain databases

    Gene3Di1.10.10.60. 1 hit.
    InterProiIPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view]
    PfamiPF00046. Homeobox. 1 hit.
    [Graphical view]
    PRINTSiPR00024. HOMEOBOX.
    SMARTiSM00389. HOX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K5B8-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGEHNLLNPG FVGPLVNIHT GDTFYFPNFR ASGAQLPGLP SLSYPRRDNV    50
    CSLPWPSAEP CNGYPQPYLG SPVSLNPPFG RTCELARVED SKGYYREPCA 100
    EGGGGGLKRE ERGREPGAGP GAALLQLEPS GPPALGFKYD YTASGGGGDG 150
    STGPPHDPPS CQSLESDSSS SLLNEGNKSA SAGDPGSLVS PLNPGGGLSA 200
    SGAPWYPIHS RSRKKRKPYS KLQLAELEGE FLVNEFITRQ RRRELSDRLN 250
    LSDQQVKIWF QNRRMKKKRL LLREQALSFF 280
    Length:280
    Mass (Da):30,345
    Last modified:October 1, 2002 - v1
    Checksum:iF42405EFC51AE60B
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF448482 mRNA. Translation: AAM28679.1.
    BC120845 mRNA. Translation: AAI20846.1.
    BC120847 mRNA. Translation: AAI20848.1.
    CCDSiCCDS27891.1.
    RefSeqiNP_034593.1. NM_010463.1.
    UniGeneiMm.221179.

    Genome annotation databases

    EnsembliENSMUST00000055562; ENSMUSP00000051003; ENSMUSG00000050328.
    GeneIDi15421.
    KEGGimmu:15421.
    UCSCiuc007xww.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF448482 mRNA. Translation: AAM28679.1 .
    BC120845 mRNA. Translation: AAI20846.1 .
    BC120847 mRNA. Translation: AAI20848.1 .
    CCDSi CCDS27891.1.
    RefSeqi NP_034593.1. NM_010463.1.
    UniGenei Mm.221179.

    3D structure databases

    ProteinModelPortali Q8K5B8.
    SMRi Q8K5B8. Positions 212-270.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 200384. 8 interactions.

    Proteomic databases

    PaxDbi Q8K5B8.
    PRIDEi Q8K5B8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000055562 ; ENSMUSP00000051003 ; ENSMUSG00000050328 .
    GeneIDi 15421.
    KEGGi mmu:15421.
    UCSCi uc007xww.1. mouse.

    Organism-specific databases

    CTDi 3228.
    MGIi MGI:96194. Hoxc12.

    Phylogenomic databases

    eggNOGi NOG239684.
    GeneTreei ENSGT00750000117432.
    HOGENOMi HOG000231177.
    HOVERGENi HBG052050.
    InParanoidi Q8K5B8.
    KOi K09297.
    OMAi QDPPSCQ.
    OrthoDBi EOG7FV3R4.
    PhylomeDBi Q8K5B8.
    TreeFami TF351604.

    Miscellaneous databases

    NextBioi 288158.
    PROi Q8K5B8.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K5B8.
    CleanExi MM_HOXC12.
    Genevestigatori Q8K5B8.

    Family and domain databases

    Gene3Di 1.10.10.60. 1 hit.
    InterProi IPR017970. Homeobox_CS.
    IPR001356. Homeobox_dom.
    IPR020479. Homeobox_metazoa.
    IPR009057. Homeodomain-like.
    [Graphical view ]
    Pfami PF00046. Homeobox. 1 hit.
    [Graphical view ]
    PRINTSi PR00024. HOMEOBOX.
    SMARTi SM00389. HOX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00027. HOMEOBOX_1. 1 hit.
    PS50071. HOMEOBOX_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Hoxc12 expression pattern in developing and cycling murine hair follicles."
      Shang L., Pruett N.D., Awgulewitsch A.
      Mech. Dev. 113:207-210(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: CD-1.
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiHXC12_MOUSE
    AccessioniPrimary (citable) accession number: Q8K5B8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 5, 2006
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 83 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. Vertebrate homeotic Hox proteins
      Nomenclature of vertebrate homeotic Hox proteins and list of entries
    2. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3