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Protein

Multiple coagulation factor deficiency protein 2 homolog

Gene

Mcfd2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Calcium bindingi80 – 91121PROSITE-ProRule annotationAdd
BLAST
Calcium bindingi128 – 139122PROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

  • carboxylic acid metabolic process Source: MGI
  • protein transport Source: UniProtKB-KW
  • vesicle-mediated transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple coagulation factor deficiency protein 2 homolog
Alternative name(s):
Neural stem cell-derived neuronal survival protein
Gene namesi
Name:Mcfd2
Synonyms:Sdnsf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628690. Mcfd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2626Sequence analysisAdd
BLAST
Chaini27 – 145119Multiple coagulation factor deficiency protein 2 homologPRO_0000004161Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei105 – 1051PhosphoserineCombined sources

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K5B3.
PRIDEiQ8K5B3.

PTM databases

iPTMnetiQ8K5B3.

Interactioni

Subunit structurei

Interacts in a calcium-dependent manner with LMAN1.By similarity

Protein-protein interaction databases

MINTiMINT-4576246.
STRINGi10116.ENSRNOP00000020328.

Structurei

3D structure databases

ProteinModelPortaliQ8K5B3.
SMRiQ8K5B3. Positions 66-145.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini67 – 10236EF-hand 1PROSITE-ProRule annotationAdd
BLAST
Domaini115 – 14531EF-hand 2PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4065. Eukaryota.
ENOG41124J6. LUCA.
HOGENOMiHOG000113497.
HOVERGENiHBG060762.
InParanoidiQ8K5B3.
PhylomeDBiQ8K5B3.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K5B3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MASLQLLRGP FLCVLLWAFC VPGARAQEHG AGVHHGSVGL DKSTVHDQEH
60 70 80 90 100
IMEHLEGVIN QPEAEMSPQE LQLHYFKMHD YDGNSLLDGL ELSTAITHVH
110 120 130 140
KEEGSEQVPP MSEDELISII DGVLRDDDKN NDGYIDYAEF AKSLQ
Length:145
Mass (Da):16,148
Last modified:October 1, 2002 - v1
Checksum:i3B3670BB12C89AFF
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF475282 mRNA. Translation: AAM28463.1.
RefSeqiNP_640346.1. NM_139253.1.
UniGeneiRn.7871.

Genome annotation databases

GeneIDi246117.
KEGGirno:246117.
UCSCiRGD:628690. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF475282 mRNA. Translation: AAM28463.1.
RefSeqiNP_640346.1. NM_139253.1.
UniGeneiRn.7871.

3D structure databases

ProteinModelPortaliQ8K5B3.
SMRiQ8K5B3. Positions 66-145.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

MINTiMINT-4576246.
STRINGi10116.ENSRNOP00000020328.

PTM databases

iPTMnetiQ8K5B3.

Proteomic databases

PaxDbiQ8K5B3.
PRIDEiQ8K5B3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246117.
KEGGirno:246117.
UCSCiRGD:628690. rat.

Organism-specific databases

CTDi90411.
RGDi628690. Mcfd2.

Phylogenomic databases

eggNOGiKOG4065. Eukaryota.
ENOG41124J6. LUCA.
HOGENOMiHOG000113497.
HOVERGENiHBG060762.
InParanoidiQ8K5B3.
PhylomeDBiQ8K5B3.

Miscellaneous databases

PROiQ8K5B3.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Isolation and characterization of SDNSF, a novel secretory molecule with neuronal survival effect, from adult rat hippocampal stem cells."
    Toda H., Tashiro K., Takahashi J., Hashimoto N., Nakano I., Kobuke K., Tsuji M., Honjo T.
    Submitted (JAN-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Fischer 344.
  2. "Quantitative maps of protein phosphorylation sites across 14 different rat organs and tissues."
    Lundby A., Secher A., Lage K., Nordsborg N.B., Dmytriyev A., Lundby C., Olsen J.V.
    Nat. Commun. 3:876-876(2012) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-105, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].

Entry informationi

Entry nameiMCFD2_RAT
AccessioniPrimary (citable) accession number: Q8K5B3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.