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Protein

Multiple coagulation factor deficiency protein 2 homolog

Gene

Mcfd2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

The MCFD2-LMAN1 complex forms a specific cargo receptor for the ER-to-Golgi transport of selected proteins.By similarity

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Calcium bindingi80 – 911PROSITE-ProRule annotationAdd BLAST12
Calcium bindingi128 – 1392PROSITE-ProRule annotationAdd BLAST12

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

ER-Golgi transport, Protein transport, Transport

Keywords - Ligandi

Calcium, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-948021. Transport to the Golgi and subsequent modification.

Names & Taxonomyi

Protein namesi
Recommended name:
Multiple coagulation factor deficiency protein 2 homolog
Alternative name(s):
Neural stem cell-derived neuronal survival protein
Gene namesi
Name:Mcfd2
Synonyms:Sdnsf
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:2183439. Mcfd2.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Golgi apparatus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 26Sequence analysisAdd BLAST26
ChainiPRO_000000416027 – 145Multiple coagulation factor deficiency protein 2 homologAdd BLAST119

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei105PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K5B2.
MaxQBiQ8K5B2.
PaxDbiQ8K5B2.
PeptideAtlasiQ8K5B2.
PRIDEiQ8K5B2.

PTM databases

iPTMnetiQ8K5B2.
PhosphoSitePlusiQ8K5B2.

Expressioni

Gene expression databases

BgeeiENSMUSG00000024150.
CleanExiMM_MCFD2.
ExpressionAtlasiQ8K5B2. baseline and differential.
GenevisibleiQ8K5B2. MM.

Interactioni

Subunit structurei

Interacts in a calcium-dependent manner with LMAN1.By similarity

Protein-protein interaction databases

IntActiQ8K5B2. 4 interactors.
MINTiMINT-1863633.
STRINGi10090.ENSMUSP00000024963.

Structurei

3D structure databases

ProteinModelPortaliQ8K5B2.
SMRiQ8K5B2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini67 – 102EF-hand 1PROSITE-ProRule annotationAdd BLAST36
Domaini115 – 145EF-hand 2PROSITE-ProRule annotationAdd BLAST31

Sequence similaritiesi

Contains 2 EF-hand domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal

Phylogenomic databases

eggNOGiKOG4065. Eukaryota.
ENOG41124J6. LUCA.
GeneTreeiENSGT00390000003130.
HOGENOMiHOG000113497.
HOVERGENiHBG060762.
InParanoidiQ8K5B2.
KOiK20364.
OMAiISHVHKE.
OrthoDBiEOG091G0ZJA.
PhylomeDBiQ8K5B2.
TreeFamiTF315801.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K5B2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATLQLLRAP LLCVLLWVFC APGARAHDHG ADVHHGSVGL DKSTVHDQEH
60 70 80 90 100
IMEHLEGVID QPEAEMSPQE LQLHYFKMHD YDGNSLLDGL ELSIAITHVH
110 120 130 140
KEEGSEQAPV MSEDELVSII DGVLRDDDKN NDGYIDYAEF AKSLQ
Length:145
Mass (Da):16,168
Last modified:October 1, 2002 - v1
Checksum:iEB654BA9B76E0269
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF475283 mRNA. Translation: AAM28464.1.
AK033139 mRNA. Translation: BAC28169.1.
AK075781 mRNA. Translation: BAC35955.1.
AK077139 mRNA. Translation: BAC36638.1.
AK077631 mRNA. Translation: BAC36914.1.
AK141599 mRNA. Translation: BAE24757.1.
AK151803 mRNA. Translation: BAE30702.1.
CCDSiCCDS29015.1.
RefSeqiNP_647456.1. NM_139295.3.
NP_789778.1. NM_176808.5.
XP_006523964.1. XM_006523901.3.
UniGeneiMm.30251.

Genome annotation databases

EnsembliENSMUST00000024963; ENSMUSP00000024963; ENSMUSG00000024150.
ENSMUST00000129616; ENSMUSP00000123352; ENSMUSG00000024150.
ENSMUST00000144236; ENSMUSP00000121820; ENSMUSG00000024150.
GeneIDi193813.
KEGGimmu:193813.
UCSCiuc008dur.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF475283 mRNA. Translation: AAM28464.1.
AK033139 mRNA. Translation: BAC28169.1.
AK075781 mRNA. Translation: BAC35955.1.
AK077139 mRNA. Translation: BAC36638.1.
AK077631 mRNA. Translation: BAC36914.1.
AK141599 mRNA. Translation: BAE24757.1.
AK151803 mRNA. Translation: BAE30702.1.
CCDSiCCDS29015.1.
RefSeqiNP_647456.1. NM_139295.3.
NP_789778.1. NM_176808.5.
XP_006523964.1. XM_006523901.3.
UniGeneiMm.30251.

3D structure databases

ProteinModelPortaliQ8K5B2.
SMRiQ8K5B2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K5B2. 4 interactors.
MINTiMINT-1863633.
STRINGi10090.ENSMUSP00000024963.

PTM databases

iPTMnetiQ8K5B2.
PhosphoSitePlusiQ8K5B2.

Proteomic databases

EPDiQ8K5B2.
MaxQBiQ8K5B2.
PaxDbiQ8K5B2.
PeptideAtlasiQ8K5B2.
PRIDEiQ8K5B2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024963; ENSMUSP00000024963; ENSMUSG00000024150.
ENSMUST00000129616; ENSMUSP00000123352; ENSMUSG00000024150.
ENSMUST00000144236; ENSMUSP00000121820; ENSMUSG00000024150.
GeneIDi193813.
KEGGimmu:193813.
UCSCiuc008dur.2. mouse.

Organism-specific databases

CTDi90411.
MGIiMGI:2183439. Mcfd2.

Phylogenomic databases

eggNOGiKOG4065. Eukaryota.
ENOG41124J6. LUCA.
GeneTreeiENSGT00390000003130.
HOGENOMiHOG000113497.
HOVERGENiHBG060762.
InParanoidiQ8K5B2.
KOiK20364.
OMAiISHVHKE.
OrthoDBiEOG091G0ZJA.
PhylomeDBiQ8K5B2.
TreeFamiTF315801.

Enzyme and pathway databases

ReactomeiR-MMU-204005. COPII (Coat Protein 2) Mediated Vesicle Transport.
R-MMU-5694530. Cargo concentration in the ER.
R-MMU-948021. Transport to the Golgi and subsequent modification.

Miscellaneous databases

ChiTaRSiMcfd2. mouse.
PROiQ8K5B2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000024150.
CleanExiMM_MCFD2.
ExpressionAtlasiQ8K5B2. baseline and differential.
GenevisibleiQ8K5B2. MM.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
InterProiIPR011992. EF-hand-dom_pair.
IPR018247. EF_Hand_1_Ca_BS.
IPR002048. EF_hand_dom.
[Graphical view]
PfamiPF13499. EF-hand_7. 1 hit.
[Graphical view]
SUPFAMiSSF47473. SSF47473. 1 hit.
PROSITEiPS00018. EF_HAND_1. 1 hit.
PS50222. EF_HAND_2. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiMCFD2_MOUSE
AccessioniPrimary (citable) accession number: Q8K5B2
Secondary accession number(s): Q3U9G5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 21, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 111 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.