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Protein

Interleukin-31 receptor subunit alpha

Gene

Il31ra

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Associates with OSMR to form the interleukin-31 receptor which activates STAT3 and to a lower extent STAT1 and STAT5. May function in skin immunity (PubMed:15184896). Mediates IL31-induced itch, probably in a manner dependent on cation channels TRPA1 and TRPV1 (PubMed:24373353). Positively regulates numbers and cycling status of immature subsets of myeloid progenitor cells in bone marrow in vivo and enhances myeloid progenitor cell survival in vitro (PubMed:17379091).3 Publications

GO - Molecular functioni

  • cytokine binding Source: MGI
  • cytokine receptor activity Source: MGI

GO - Biological processi

  • acute inflammatory response to antigenic stimulus Source: MGI
  • defense response to other organism Source: MGI
  • glandular epithelial cell differentiation Source: MGI
  • JAK-STAT cascade Source: UniProtKB
  • monocyte differentiation Source: UniProtKB
  • positive regulation of cell proliferation Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of Stat3 protein Source: UniProtKB
  • positive regulation of tyrosine phosphorylation of Stat5 protein Source: UniProtKB
  • T-helper 2 cell cytokine production Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Immunity

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Names & Taxonomyi

Protein namesi
Recommended name:
Interleukin-31 receptor subunit alpha
Short name:
IL-31 receptor subunit alpha
Short name:
IL-31R subunit alpha
Short name:
IL-31R-alpha
Short name:
IL-31RA
Alternative name(s):
GLM-R
Short name:
mGLM-R
Gp130-like monocyte receptor
Short name:
Gp130-like receptor
Novel cytokine receptor 10
Short name:
NR10
ZcytoR17
Gene namesi
Name:Il31ra
Synonyms:Glmr
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2180511. Il31ra.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 499481ExtracellularSequence analysisAdd
BLAST
Transmembranei500 – 52021HelicalSequence analysisAdd
BLAST
Topological domaini521 – 716196CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Cell projection, Membrane, Synapse

Pathology & Biotechi

Disruption phenotypei

Mice do not develop dermatitis upon Il31 overexpression (PubMed:15184896). Decreased levels of immature myeloid progenitor cells in bone marrow and spleen but normal numbers of circulating blood cells (PubMed:17379091).2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818By similarityAdd
BLAST
Chaini19 – 716698Interleukin-31 receptor subunit alphaPRO_0000274573Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi36 – 361N-linked (GlcNAc...)Sequence analysis
Glycosylationi48 – 481N-linked (GlcNAc...)Sequence analysis
Glycosylationi64 – 641N-linked (GlcNAc...)Sequence analysis
Glycosylationi382 – 3821N-linked (GlcNAc...)Sequence analysis

Post-translational modificationi

N-glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K5B1.
PRIDEiQ8K5B1.

PTM databases

iPTMnetiQ8K5B1.
PhosphoSiteiQ8K5B1.

Expressioni

Tissue specificityi

Expressed in a subset of dorsal root ganglia neurons (PubMed:16926070, PubMed:24373353, PubMed:25381841). Expressed in spinal cord and trigeminal ganglion (at protein level) (PubMed:25381841). Expressed in skin, testis, bone marrow and thymus (PubMed:15184896).4 Publications

Developmental stagei

Primarily expressed at postnatal day 10 in the dorsal root ganglia where expression gradually increases as the development proceed.1 Publication

Inductioni

Up-regulated in the diseased tissues of a mouse models of allergic asthma and airway hypersensitivity (PubMed:15184896, PubMed:25847241). Up-regulated by IL31 in dorsal root ganglia (PubMed:25381841). Up-regulated by Th2 cytokines IL4 and IL13 in macrophages (PubMed:25847241).3 Publications

Gene expression databases

BgeeiENSMUSG00000050377.
CleanExiMM_IL31RA.
GenevisibleiQ8K5B1. MM.

Interactioni

Subunit structurei

Heterodimer with OSMR. Interacts with JAK1 and STAT3.By similarity

GO - Molecular functioni

  • cytokine binding Source: MGI

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058045.

Structurei

3D structure databases

ProteinModelPortaliQ8K5B1.
SMRiQ8K5B1. Positions 21-213, 218-499.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini23 – 11593Fibronectin type-III 1PROSITE-ProRule annotationAdd
BLAST
Domaini117 – 21195Fibronectin type-III 2PROSITE-ProRule annotationAdd
BLAST
Domaini213 – 30492Fibronectin type-III 3PROSITE-ProRule annotationAdd
BLAST
Domaini305 – 40399Fibronectin type-III 4PROSITE-ProRule annotationAdd
BLAST
Domaini408 – 50295Fibronectin type-III 5PROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 5 fibronectin type-III domains.PROSITE-ProRule annotation

Keywords - Domaini

Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IJG6. Eukaryota.
ENOG410YAI2. LUCA.
GeneTreeiENSGT00550000074436.
HOVERGENiHBG081788.
InParanoidiQ8K5B1.
OMAiIWYFPEN.
OrthoDBiEOG091G01XM.
TreeFamiTF338122.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K5B1-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MWTLALWAFS FLCKFSLAVL PTKPENISCV FYFDRNLTCT WRPEKETNDT
60 70 80 90 100
SYIVTLTYSY GKSNYSDNAT EASYSFPRSC AMPPDICSVE VQAQNGDGKV
110 120 130 140 150
KSDITYWHLI SIAKTEPPII LSVNPICNRM FQIQWKPREK TRGFPLVCML
160 170 180 190 200
RFRTVNSSHW TEVNFENCKQ VCNLTGLQAF TEYVLALRFR FNDSRYWSKW
210 220 230 240 250
SKEETRVTME EVPHVLDLWR ILEPADMNGD RKVRLLWKKA RGAPVLEKTF
260 270 280 290 300
GYHIQYFAEN STNLTEINNI TTQQYELLLM SQAHSVSVTS FNSLGKSQEA
310 320 330 340 350
ILRIPDVHEK TFQYIKSMKA YIAEPLLVVN WQSSIPAVDT WIVEWLPEAA
360 370 380 390 400
MSKFPALSWE SVSQVTNWTI EQDKLKPFTC YNISVYPVLG HRVGEPYSIQ
410 420 430 440 450
AYAKEGTPLK GPETRVENIG LRTATITWKE IPKSARNGFI NNYTVFYQAE
460 470 480 490 500
GGKELSKTVN SHALQCDLES LTRRTSYTVW VMASTRAGGT NGVRINFKTL
510 520 530 540 550
SISVFEIVLL TSLVGGGLLL LSIKTVTFGL RKPNRLTPLC CPDVPNPAES
560 570 580 590 600
SLATWLGDGF KKSNMKETGN SGDTEDVVLK PCPVPADLID KLVVNFENFL
610 620 630 640 650
EVVLTEEAGK GQASILGGEA NEYVTSPSRP DGPPGKSFKE PSVLTEVASE
660 670 680 690 700
DSHSTCSRMA DEAYSELARQ PSSSCQSPGL SPPREDQAQN PYLKNSVTTR
710
EFLVHENIPE HSKGEV
Length:716
Mass (Da):80,580
Last modified:July 27, 2011 - v3
Checksum:i21A539EDCCD1FEFD
GO
Isoform 2 (identifier: Q8K5B1-2) [UniParc]FASTAAdd to basket
Also known as: muZcytoR17x1

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSSQKGSCSQEPGAAHVQPLGVNAGIM
     624-635: VTSPSRPDGPPG → ILSQEPSCPGHC
     636-716: Missing.

Show »
Length:662
Mass (Da):74,387
Checksum:iA81ED670713D349E
GO
Isoform 3 (identifier: Q8K5B1-3) [UniParc]FASTAAdd to basket
Also known as: muZcytoR17x2

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MLSSQKGSCSQEPGAAHVQPLGVNAGIM
     504-520: VFEIVLLTSLVGGGLLL → EYWLQASFWSLLRVGNV
     521-716: Missing.

Show »
Length:547
Mass (Da):62,427
Checksum:i88E1B06BC1F737AD
GO
Isoform 4 (identifier: Q8K5B1-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-1: M → MNPLGVNAGIM
     463-482: ALQCDLESLTRRTSYTVWVM → SPQVYYALTAAKSRNSRNLQ
     483-716: Missing.

Show »
Length:492
Mass (Da):56,458
Checksum:i8AA4C0C8E2ED1FA8
GO
Isoform 5 (identifier: Q8K5B1-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-481: Missing.

Note: No experimental confirmation available.
Show »
Length:235
Mass (Da):25,133
Checksum:i50928397A1AD126F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti159 – 1591H → R in AAM27959 (PubMed:11877449).Curated
Sequence conflicti159 – 1591H → R in AAS82847 (PubMed:15184896).Curated
Sequence conflicti159 – 1591H → R in AAS82848 (PubMed:15184896).Curated
Sequence conflicti159 – 1591H → R in BAB88745 (Ref. 3) Curated
Sequence conflicti300 – 3001A → T in AAM27959 (PubMed:11877449).Curated
Sequence conflicti300 – 3001A → T in AAS82847 (PubMed:15184896).Curated
Sequence conflicti300 – 3001A → T in AAS82848 (PubMed:15184896).Curated
Sequence conflicti319 – 3191K → Q in AAM27959 (PubMed:11877449).Curated
Sequence conflicti319 – 3191K → Q in AAS82847 (PubMed:15184896).Curated
Sequence conflicti319 – 3191K → Q in AAS82848 (PubMed:15184896).Curated
Sequence conflicti573 – 5731D → N in AAM27959 (PubMed:11877449).Curated
Sequence conflicti573 – 5731D → N in AAS82847 (PubMed:15184896).Curated
Sequence conflicti643 – 6431V → I in AAM27959 (PubMed:11877449).Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 481481Missing in isoform 5. 1 PublicationVSP_022814Add
BLAST
Alternative sequencei1 – 11M → MLSSQKGSCSQEPGAAHVQP LGVNAGIM in isoform 2 and isoform 3. 1 PublicationVSP_022815
Alternative sequencei1 – 11M → MNPLGVNAGIM in isoform 4. 1 PublicationVSP_022816
Alternative sequencei463 – 48220ALQCD…TVWVM → SPQVYYALTAAKSRNSRNLQ in isoform 4. 1 PublicationVSP_022817Add
BLAST
Alternative sequencei483 – 716234Missing in isoform 4. 1 PublicationVSP_022818Add
BLAST
Alternative sequencei504 – 52017VFEIV…GGLLL → EYWLQASFWSLLRVGNV in isoform 3. 1 PublicationVSP_022819Add
BLAST
Alternative sequencei521 – 716196Missing in isoform 3. 1 PublicationVSP_022820Add
BLAST
Alternative sequencei624 – 63512VTSPS…DGPPG → ILSQEPSCPGHC in isoform 2. 1 PublicationVSP_022821Add
BLAST
Alternative sequencei636 – 71681Missing in isoform 2. 1 PublicationVSP_022822Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486621 mRNA. Translation: AAM27959.1.
AY509150 mRNA. Translation: AAS82847.1.
AY509151 mRNA. Translation: AAS82848.1.
AB083111 mRNA. Translation: BAB88745.1.
AK030512 mRNA. Translation: BAC26998.1.
AC154767 Genomic DNA. No translation available.
AC159196 Genomic DNA. No translation available.
BC066164 mRNA. Translation: AAH66164.1.
CCDSiCCDS36781.1. [Q8K5B1-1]
RefSeqiNP_647460.2. NM_139299.2. [Q8K5B1-1]
XP_006517684.1. XM_006517621.2. [Q8K5B1-1]
XP_006517685.1. XM_006517622.2. [Q8K5B1-1]
UniGeneiMm.380801.

Genome annotation databases

EnsembliENSMUST00000051756; ENSMUSP00000058045; ENSMUSG00000050377. [Q8K5B1-1]
GeneIDi218624.
KEGGimmu:218624.
UCSCiuc007rwi.2. mouse. [Q8K5B1-1]
uc007rwj.1. mouse. [Q8K5B1-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF486621 mRNA. Translation: AAM27959.1.
AY509150 mRNA. Translation: AAS82847.1.
AY509151 mRNA. Translation: AAS82848.1.
AB083111 mRNA. Translation: BAB88745.1.
AK030512 mRNA. Translation: BAC26998.1.
AC154767 Genomic DNA. No translation available.
AC159196 Genomic DNA. No translation available.
BC066164 mRNA. Translation: AAH66164.1.
CCDSiCCDS36781.1. [Q8K5B1-1]
RefSeqiNP_647460.2. NM_139299.2. [Q8K5B1-1]
XP_006517684.1. XM_006517621.2. [Q8K5B1-1]
XP_006517685.1. XM_006517622.2. [Q8K5B1-1]
UniGeneiMm.380801.

3D structure databases

ProteinModelPortaliQ8K5B1.
SMRiQ8K5B1. Positions 21-213, 218-499.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058045.

PTM databases

iPTMnetiQ8K5B1.
PhosphoSiteiQ8K5B1.

Proteomic databases

PaxDbiQ8K5B1.
PRIDEiQ8K5B1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051756; ENSMUSP00000058045; ENSMUSG00000050377. [Q8K5B1-1]
GeneIDi218624.
KEGGimmu:218624.
UCSCiuc007rwi.2. mouse. [Q8K5B1-1]
uc007rwj.1. mouse. [Q8K5B1-3]

Organism-specific databases

CTDi133396.
MGIiMGI:2180511. Il31ra.

Phylogenomic databases

eggNOGiENOG410IJG6. Eukaryota.
ENOG410YAI2. LUCA.
GeneTreeiENSGT00550000074436.
HOVERGENiHBG081788.
InParanoidiQ8K5B1.
OMAiIWYFPEN.
OrthoDBiEOG091G01XM.
TreeFamiTF338122.

Enzyme and pathway databases

ReactomeiR-MMU-449147. Signaling by Interleukins.

Miscellaneous databases

ChiTaRSiIl31ra. mouse.
PROiQ8K5B1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000050377.
CleanExiMM_IL31RA.
GenevisibleiQ8K5B1. MM.

Family and domain databases

Gene3Di2.60.40.10. 5 hits.
InterProiIPR003961. FN3_dom.
IPR013783. Ig-like_fold.
[Graphical view]
PfamiPF00041. fn3. 1 hit.
[Graphical view]
SMARTiSM00060. FN3. 4 hits.
[Graphical view]
SUPFAMiSSF49265. SSF49265. 3 hits.
PROSITEiPS50853. FN3. 3 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiIL31R_MOUSE
AccessioniPrimary (citable) accession number: Q8K5B1
Secondary accession number(s): E9QQ31
, Q6EAL6, Q6EAL7, Q6NZF0, Q8BSU3, Q8R501
Entry historyi
Integrated into UniProtKB/Swiss-Prot: February 6, 2007
Last sequence update: July 27, 2011
Last modified: September 7, 2016
This is version 102 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.