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Protein

Cystatin-11

Gene

Cst11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-11
Gene namesi
Name:Cst11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620589. Cst11.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000666029 – 139Cystatin-11Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 102By similarity
Disulfide bondi115 ↔ 135By similarity
Glycosylationi134N-linked (GlcNAc...) asparagineSequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K5A3.
PRIDEiQ8K5A3.

Expressioni

Gene expression databases

GenevisibleiQ8K5A3. RN.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000006427.

Structurei

3D structure databases

ProteinModelPortaliQ8K5A3.
SMRiQ8K5A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 80Secondary area of contactSequence analysis5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ0B. Eukaryota.
ENOG4111EFC. LUCA.
GeneTreeiENSGT00900000141055.
HOGENOMiHOG000231754.
HOVERGENiHBG096361.
InParanoidiQ8K5A3.
KOiK13906.
OMAiEMRRTTC.
OrthoDBiEOG091G0TP1.
PhylomeDBiQ8K5A3.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
SMARTiView protein in SMART
SM00043. CY. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K5A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMARLWKTTW FLLAILVALV AFSYQVKRKT FIRVEEVNAL ESSVKETLEY
60 70 80 90 100
VTEEYNKKSE DLYNFRILRI LKIEKQMTNH MEFHITVEMQ RTTCLKTEKN
110 120 130
LCNVQEGELH KQIQCYFSVY VIPWLEVFKM LKKNCTNSS
Length:139
Mass (Da):16,686
Last modified:October 1, 2002 - v1
Checksum:iE1E36DB786B4D08C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF501290 mRNA. Translation: AAM21709.1.
RefSeqiNP_620785.1. NM_139085.1.
UniGeneiRn.83602.

Genome annotation databases

EnsembliENSRNOT00000006427; ENSRNOP00000006427; ENSRNOG00000004808.
GeneIDi245916.
KEGGirno:245916.
UCSCiRGD:620589. rat.

Similar proteinsi

Entry informationi

Entry nameiCST11_RAT
AccessioniPrimary (citable) accession number: Q8K5A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 95 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families