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Protein

Cystatin-11

Gene

Cst11

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionProtease inhibitor, Thiol protease inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Cystatin-11
Gene namesi
Name:Cst11
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi620589. Cst11.

Subcellular locationi

GO - Cellular componenti

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 28Sequence analysisAdd BLAST28
ChainiPRO_000000666029 – 139Cystatin-11Add BLAST111

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi94 ↔ 102By similarity
Disulfide bondi115 ↔ 135By similarity
Glycosylationi134N-linked (GlcNAc...)Sequence analysis1

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K5A3.
PRIDEiQ8K5A3.

Expressioni

Gene expression databases

GenevisibleiQ8K5A3. RN.

Interactioni

GO - Molecular functioni

Structurei

3D structure databases

ProteinModelPortaliQ8K5A3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi76 – 80Secondary area of contactSequence analysis5

Sequence similaritiesi

Belongs to the cystatin family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410IZ0B. Eukaryota.
ENOG4111EFC. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG096361.
InParanoidiQ8K5A3.
KOiK13906.
OMAiEMRRTTC.
OrthoDBiEOG09040MFK.
PhylomeDBiQ8K5A3.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
SMARTiView protein in SMART
SM00043. CY. 1 hit.

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K5A3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MMARLWKTTW FLLAILVALV AFSYQVKRKT FIRVEEVNAL ESSVKETLEY
60 70 80 90 100
VTEEYNKKSE DLYNFRILRI LKIEKQMTNH MEFHITVEMQ RTTCLKTEKN
110 120 130
LCNVQEGELH KQIQCYFSVY VIPWLEVFKM LKKNCTNSS
Length:139
Mass (Da):16,686
Last modified:October 1, 2002 - v1
Checksum:iE1E36DB786B4D08C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF501290 mRNA. Translation: AAM21709.1.
RefSeqiNP_620785.1. NM_139085.1.
UniGeneiRn.83602.

Genome annotation databases

EnsembliENSRNOT00000006427; ENSRNOP00000006427; ENSRNOG00000004808.
GeneIDi245916.
KEGGirno:245916.
UCSCiRGD:620589. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF501290 mRNA. Translation: AAM21709.1.
RefSeqiNP_620785.1. NM_139085.1.
UniGeneiRn.83602.

3D structure databases

ProteinModelPortaliQ8K5A3.
ModBaseiSearch...
MobiDBiSearch...

Proteomic databases

PaxDbiQ8K5A3.
PRIDEiQ8K5A3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000006427; ENSRNOP00000006427; ENSRNOG00000004808.
GeneIDi245916.
KEGGirno:245916.
UCSCiRGD:620589. rat.

Organism-specific databases

CTDi140880.
RGDi620589. Cst11.

Phylogenomic databases

eggNOGiENOG410IZ0B. Eukaryota.
ENOG4111EFC. LUCA.
GeneTreeiENSGT00860000133739.
HOGENOMiHOG000231754.
HOVERGENiHBG096361.
InParanoidiQ8K5A3.
KOiK13906.
OMAiEMRRTTC.
OrthoDBiEOG09040MFK.
PhylomeDBiQ8K5A3.

Miscellaneous databases

PROiQ8K5A3.

Gene expression databases

GenevisibleiQ8K5A3. RN.

Family and domain databases

CDDicd00042. CY. 1 hit.
InterProiView protein in InterPro
IPR027214. Cystatin.
IPR000010. Cystatin_dom.
PANTHERiPTHR11413. PTHR11413. 1 hit.
PfamiView protein in Pfam
PF00031. Cystatin. 1 hit.
SMARTiView protein in SMART
SM00043. CY. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiCST11_RAT
AccessioniPrimary (citable) accession number: Q8K5A3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 4, 2005
Last sequence update: October 1, 2002
Last modified: February 15, 2017
This is version 88 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.