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Q8K595 (MCLN2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 29, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order
to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Mucolipin-2
Gene names
Name:Mcoln2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length566 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subcellular location

Membrane; Multi-pass membrane protein Potential.

Sequence similarities

Belongs to the transient receptor (TC 1.A.4) family. Polycystin subfamily. MCOLN2 sub-subfamily. [View classification]

Ontologies

Keywords
   Biological processIon transport
Transport
   Cellular componentMembrane
   Coding sequence diversityAlternative splicing
   DomainTransmembrane
Transmembrane helix
   Molecular functionIon channel
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_procession transport

Inferred from electronic annotation. Source: UniProtKB-KW

   Cellular_componentintegral to membrane

Inferred from electronic annotation. Source: UniProtKB-KW

Complete GO annotation...

Alternative products

This entry describes 2 isoforms produced by alternative splicing. [Align] [Select]
Isoform 1 (identifier: Q8K595-1)

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
Isoform 2 (identifier: Q8K595-2)

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 566566Mucolipin-2
PRO_0000215366

Regions

Transmembrane289 – 30921Helical; Potential
Transmembrane342 – 36221Helical; Potential
Transmembrane380 – 40021Helical; Potential
Transmembrane420 – 44021Helical; Potential
Transmembrane486 – 50621Helical; Potential

Natural variations

Alternative sequence1 – 2828Missing in isoform 2.
VSP_010822

Experimental info

Sequence conflict5581S → N in AAH29847. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Isoform 1 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 314CEC662B3BDC07

FASTA56665,450
        10         20         30         40         50         60 
MPGDEETLDL PAWNRVPDLT WGPHHRSAMA SLDSEVREEC LREDLKFYFM SPCEKYRARR 

        70         80         90        100        110        120 
QIPWKLGLQI LKIVMVTTQL VRFGLSNQLV VAFKEDNTVA FKHLFLKGFS GVDEDDYSCS 

       130        140        150        160        170        180 
IYTQENTYES IFFAIKQYRH LKNISLATLG YGESEDNRTG LKVCKQHYKT GAMFSSNETL 

       190        200        210        220        230        240 
NIDSDIETDC IHLDLQVLTT EPEDWAQTSF FRLDFYRLVQ VDISFALKGI DLQAVHSREI 

       250        260        270        280        290        300 
PDCYLFQNTI TFDNTAHSGK IKIYLNSEAN IEECKNMNIS GSTQRSTHYL LVFDVFVIMI 

       310        320        330        340        350        360 
CLASLILCTR SIVLALRLRK RFLNFFLEKY KQRVCGADQW EFVNGWYVLV TISDLMTIIG 

       370        380        390        400        410        420 
SILKMEIKAK KLTNYDVCSI LLGTSTLFVW VGVIRYLGYF QTYNVLILTM QASLPKVLRF 

       430        440        450        460        470        480 
CACAGMIYLG YTFCGWIVLG PYHEKFENLN IVAECLFSLV NGDDMFATFA QIQQKSILVW 

       490        500        510        520        530        540 
LFSRLYLYSF ISLFIYMVLS LFIALITDSY HTIKKYQQHG FPETDLQKFL KESGSKDGYQ 

       550        560 
KQPSALLSCL CCLRRRRSND HLILID

« Hide

Isoform 2 [UniParc].

Checksum: 9C35081FE96A628B
Show »

FASTA53862,269

References

« Hide 'large scale' references
[1]"Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice."
Di Palma F., Belyantseva I.A., Kim H.J., Vogt T.F., Kachar B., Noben-Trauth K.
Proc. Natl. Acad. Sci. U.S.A. 99:14994-14999(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
Strain: C57BL/6J.
[2]Kennedy J.C., Falardeau J.L., Acierno J.S. Jr., Slaugenhaupt S.A.
Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
Strain: C57BL/6J.
[3]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
Strain: C57BL/6J.
Tissue: Bone marrow and Embryo.
[4]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
Tissue: Mammary tumor.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AY083532 mRNA. Translation: AAM08925.1.
AF503575 mRNA. Translation: AAM28596.1.
AK014467 mRNA. Translation: BAB29372.1.
AK019454 mRNA. Translation: BAB31730.1.
AK150446 mRNA. Translation: BAE29568.1.
AK150547 mRNA. Translation: BAE29649.1.
AK152067 mRNA. Translation: BAE30921.1.
AK152943 mRNA. Translation: BAE31614.1.
AK159172 mRNA. Translation: BAE34872.1.
BC029847 mRNA. Translation: AAH29847.1.
IPIIPI00322835.
IPI00454189.
RefSeqNP_001005846.1. NM_001005846.2.
NP_080932.2. NM_026656.4.
UniGeneMm.116862.

3D structure databases

ProteinModelPortalQ8K595.
ModBaseSearch...

Proteomic databases

PRIDEQ8K595.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000011152; ENSMUSP00000011152; ENSMUSG00000011008.
ENSMUST00000098524; ENSMUSP00000096125; ENSMUSG00000011008.
GeneID68279.
KEGGmmu:68279.
UCSCuc008rqy.1. mouse.

Organism-specific databases

CTD255231.
MGIMGI:1915529. Mcoln2.

Phylogenomic databases

eggNOGNOG149591.
GeneTreeENSGT00390000017126.
HOGENOMHOG000232158.
HOVERGENHBG052430.
InParanoidQ8K595.
KOK04993.
OMARRQIPWK.
OrthoDBEOG4229JK.

Gene expression databases

ArrayExpressQ8K595.
BgeeQ8K595.
CleanExMM_MCOLN2.
GenevestigatorQ8K595.
GermOnlineENSMUSG00000011008. Mus musculus.

Family and domain databases

InterProIPR013122. PKD1_2_channel.
[Graphical view]
PfamPF08016. PKD_channel. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio326914.
SOURCESearch...

Entry information

Entry nameMCLN2_MOUSE
AccessionPrimary (citable) accession number: Q8K595
Secondary accession number(s): Q3UCG4, Q8K2T6, Q9CQD3
Entry history
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: May 29, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

to top of pageNames·Attributes·General annotation·Ontologies·Alt products·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents