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Q8K595

- MCLN2_MOUSE

UniProt

Q8K595 - MCLN2_MOUSE

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Protein

Mucolipin-2

Gene

Mcoln2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucolipin-2
Gene namesi
Name:Mcoln2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1915529. Mcoln2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei289 – 30921HelicalSequence AnalysisAdd
BLAST
Transmembranei342 – 36221HelicalSequence AnalysisAdd
BLAST
Transmembranei380 – 40021HelicalSequence AnalysisAdd
BLAST
Transmembranei420 – 44021HelicalSequence AnalysisAdd
BLAST
Transmembranei486 – 50621HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Mucolipin-2PRO_0000215366Add
BLAST

Proteomic databases

MaxQBiQ8K595.
PRIDEiQ8K595.

Expressioni

Gene expression databases

BgeeiQ8K595.
CleanExiMM_MCOLN2.
ExpressionAtlasiQ8K595. baseline and differential.
GenevestigatoriQ8K595.

Structurei

3D structure databases

ProteinModelPortaliQ8K595.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149591.
GeneTreeiENSGT00390000017126.
HOGENOMiHOG000232158.
HOVERGENiHBG052430.
InParanoidiQ8K595.
KOiK04993.
OMAiRRQIPWK.
OrthoDBiEOG7V1FQ9.
PhylomeDBiQ8K595.
TreeFamiTF317783.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K595-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPGDEETLDL PAWNRVPDLT WGPHHRSAMA SLDSEVREEC LREDLKFYFM
60 70 80 90 100
SPCEKYRARR QIPWKLGLQI LKIVMVTTQL VRFGLSNQLV VAFKEDNTVA
110 120 130 140 150
FKHLFLKGFS GVDEDDYSCS IYTQENTYES IFFAIKQYRH LKNISLATLG
160 170 180 190 200
YGESEDNRTG LKVCKQHYKT GAMFSSNETL NIDSDIETDC IHLDLQVLTT
210 220 230 240 250
EPEDWAQTSF FRLDFYRLVQ VDISFALKGI DLQAVHSREI PDCYLFQNTI
260 270 280 290 300
TFDNTAHSGK IKIYLNSEAN IEECKNMNIS GSTQRSTHYL LVFDVFVIMI
310 320 330 340 350
CLASLILCTR SIVLALRLRK RFLNFFLEKY KQRVCGADQW EFVNGWYVLV
360 370 380 390 400
TISDLMTIIG SILKMEIKAK KLTNYDVCSI LLGTSTLFVW VGVIRYLGYF
410 420 430 440 450
QTYNVLILTM QASLPKVLRF CACAGMIYLG YTFCGWIVLG PYHEKFENLN
460 470 480 490 500
IVAECLFSLV NGDDMFATFA QIQQKSILVW LFSRLYLYSF ISLFIYMVLS
510 520 530 540 550
LFIALITDSY HTIKKYQQHG FPETDLQKFL KESGSKDGYQ KQPSALLSCL
560
CCLRRRRSND HLILID
Length:566
Mass (Da):65,450
Last modified:October 1, 2002 - v1
Checksum:i314CEC662B3BDC07
GO
Isoform 2 (identifier: Q8K595-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:538
Mass (Da):62,269
Checksum:i9C35081FE96A628B
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti558 – 5581S → N in AAH29847. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828Missing in isoform 2. 3 PublicationsVSP_010822Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083532 mRNA. Translation: AAM08925.1.
AF503575 mRNA. Translation: AAM28596.1.
AK014467 mRNA. Translation: BAB29372.1.
AK019454 mRNA. Translation: BAB31730.1.
AK150446 mRNA. Translation: BAE29568.1.
AK150547 mRNA. Translation: BAE29649.1.
AK152067 mRNA. Translation: BAE30921.1.
AK152943 mRNA. Translation: BAE31614.1.
AK159172 mRNA. Translation: BAE34872.1.
BC029847 mRNA. Translation: AAH29847.1.
CCDSiCCDS38663.1. [Q8K595-1]
CCDS38664.1. [Q8K595-2]
RefSeqiNP_001005846.1. NM_001005846.2. [Q8K595-2]
NP_080932.2. NM_026656.4. [Q8K595-1]
UniGeneiMm.116862.

Genome annotation databases

EnsembliENSMUST00000011152; ENSMUSP00000011152; ENSMUSG00000011008. [Q8K595-1]
ENSMUST00000098524; ENSMUSP00000096125; ENSMUSG00000011008. [Q8K595-2]
GeneIDi68279.
KEGGimmu:68279.
UCSCiuc008rqy.1. mouse. [Q8K595-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY083532 mRNA. Translation: AAM08925.1 .
AF503575 mRNA. Translation: AAM28596.1 .
AK014467 mRNA. Translation: BAB29372.1 .
AK019454 mRNA. Translation: BAB31730.1 .
AK150446 mRNA. Translation: BAE29568.1 .
AK150547 mRNA. Translation: BAE29649.1 .
AK152067 mRNA. Translation: BAE30921.1 .
AK152943 mRNA. Translation: BAE31614.1 .
AK159172 mRNA. Translation: BAE34872.1 .
BC029847 mRNA. Translation: AAH29847.1 .
CCDSi CCDS38663.1. [Q8K595-1 ]
CCDS38664.1. [Q8K595-2 ]
RefSeqi NP_001005846.1. NM_001005846.2. [Q8K595-2 ]
NP_080932.2. NM_026656.4. [Q8K595-1 ]
UniGenei Mm.116862.

3D structure databases

ProteinModelPortali Q8K595.
ModBasei Search...
MobiDBi Search...

Proteomic databases

MaxQBi Q8K595.
PRIDEi Q8K595.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000011152 ; ENSMUSP00000011152 ; ENSMUSG00000011008 . [Q8K595-1 ]
ENSMUST00000098524 ; ENSMUSP00000096125 ; ENSMUSG00000011008 . [Q8K595-2 ]
GeneIDi 68279.
KEGGi mmu:68279.
UCSCi uc008rqy.1. mouse. [Q8K595-1 ]

Organism-specific databases

CTDi 255231.
MGIi MGI:1915529. Mcoln2.

Phylogenomic databases

eggNOGi NOG149591.
GeneTreei ENSGT00390000017126.
HOGENOMi HOG000232158.
HOVERGENi HBG052430.
InParanoidi Q8K595.
KOi K04993.
OMAi RRQIPWK.
OrthoDBi EOG7V1FQ9.
PhylomeDBi Q8K595.
TreeFami TF317783.

Enzyme and pathway databases

Reactomei REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 326914.
PROi Q8K595.
SOURCEi Search...

Gene expression databases

Bgeei Q8K595.
CleanExi MM_MCOLN2.
ExpressionAtlasi Q8K595. baseline and differential.
Genevestigatori Q8K595.

Family and domain databases

InterProi IPR013122. PKD1_2_channel.
[Graphical view ]
Pfami PF08016. PKD_channel. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice."
    Di Palma F., Belyantseva I.A., Kim H.J., Vogt T.F., Kachar B., Noben-Trauth K.
    Proc. Natl. Acad. Sci. U.S.A. 99:14994-14999(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  2. Kennedy J.C., Falardeau J.L., Acierno J.S. Jr., Slaugenhaupt S.A.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow and Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Mammary tumor.

Entry informationi

Entry nameiMCLN2_MOUSE
AccessioniPrimary (citable) accession number: Q8K595
Secondary accession number(s): Q3UCG4, Q8K2T6, Q9CQD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3