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Q8K595

- MCLN2_MOUSE

UniProt

Q8K595 - MCLN2_MOUSE

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Protein
Mucolipin-2
Gene
Mcoln2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. ion transport Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Ion channel

Keywords - Biological processi

Ion transport, Transport

Enzyme and pathway databases

ReactomeiREACT_227861. TRP channels.

Names & Taxonomyi

Protein namesi
Recommended name:
Mucolipin-2
Gene namesi
Name:Mcoln2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 3

Organism-specific databases

MGIiMGI:1915529. Mcoln2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei289 – 30921Helical; Reviewed prediction
Add
BLAST
Transmembranei342 – 36221Helical; Reviewed prediction
Add
BLAST
Transmembranei380 – 40021Helical; Reviewed prediction
Add
BLAST
Transmembranei420 – 44021Helical; Reviewed prediction
Add
BLAST
Transmembranei486 – 50621Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 566566Mucolipin-2
PRO_0000215366Add
BLAST

Proteomic databases

PRIDEiQ8K595.

Expressioni

Gene expression databases

ArrayExpressiQ8K595.
BgeeiQ8K595.
CleanExiMM_MCOLN2.
GenevestigatoriQ8K595.

Structurei

3D structure databases

ProteinModelPortaliQ8K595.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG149591.
GeneTreeiENSGT00390000017126.
HOGENOMiHOG000232158.
HOVERGENiHBG052430.
InParanoidiQ8K595.
KOiK04993.
OMAiRRQIPWK.
OrthoDBiEOG7V1FQ9.
PhylomeDBiQ8K595.
TreeFamiTF317783.

Family and domain databases

InterProiIPR013122. PKD1_2_channel.
[Graphical view]
PfamiPF08016. PKD_channel. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K595-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MPGDEETLDL PAWNRVPDLT WGPHHRSAMA SLDSEVREEC LREDLKFYFM    50
SPCEKYRARR QIPWKLGLQI LKIVMVTTQL VRFGLSNQLV VAFKEDNTVA 100
FKHLFLKGFS GVDEDDYSCS IYTQENTYES IFFAIKQYRH LKNISLATLG 150
YGESEDNRTG LKVCKQHYKT GAMFSSNETL NIDSDIETDC IHLDLQVLTT 200
EPEDWAQTSF FRLDFYRLVQ VDISFALKGI DLQAVHSREI PDCYLFQNTI 250
TFDNTAHSGK IKIYLNSEAN IEECKNMNIS GSTQRSTHYL LVFDVFVIMI 300
CLASLILCTR SIVLALRLRK RFLNFFLEKY KQRVCGADQW EFVNGWYVLV 350
TISDLMTIIG SILKMEIKAK KLTNYDVCSI LLGTSTLFVW VGVIRYLGYF 400
QTYNVLILTM QASLPKVLRF CACAGMIYLG YTFCGWIVLG PYHEKFENLN 450
IVAECLFSLV NGDDMFATFA QIQQKSILVW LFSRLYLYSF ISLFIYMVLS 500
LFIALITDSY HTIKKYQQHG FPETDLQKFL KESGSKDGYQ KQPSALLSCL 550
CCLRRRRSND HLILID 566
Length:566
Mass (Da):65,450
Last modified:October 1, 2002 - v1
Checksum:i314CEC662B3BDC07
GO
Isoform 2 (identifier: Q8K595-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-28: Missing.

Show »
Length:538
Mass (Da):62,269
Checksum:i9C35081FE96A628B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 2828Missing in isoform 2.
VSP_010822Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti558 – 5581S → N in AAH29847. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY083532 mRNA. Translation: AAM08925.1.
AF503575 mRNA. Translation: AAM28596.1.
AK014467 mRNA. Translation: BAB29372.1.
AK019454 mRNA. Translation: BAB31730.1.
AK150446 mRNA. Translation: BAE29568.1.
AK150547 mRNA. Translation: BAE29649.1.
AK152067 mRNA. Translation: BAE30921.1.
AK152943 mRNA. Translation: BAE31614.1.
AK159172 mRNA. Translation: BAE34872.1.
BC029847 mRNA. Translation: AAH29847.1.
CCDSiCCDS38663.1. [Q8K595-1]
CCDS38664.1. [Q8K595-2]
RefSeqiNP_001005846.1. NM_001005846.2. [Q8K595-2]
NP_080932.2. NM_026656.4. [Q8K595-1]
UniGeneiMm.116862.

Genome annotation databases

EnsembliENSMUST00000011152; ENSMUSP00000011152; ENSMUSG00000011008. [Q8K595-1]
ENSMUST00000098524; ENSMUSP00000096125; ENSMUSG00000011008. [Q8K595-2]
GeneIDi68279.
KEGGimmu:68279.
UCSCiuc008rqy.1. mouse. [Q8K595-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY083532 mRNA. Translation: AAM08925.1 .
AF503575 mRNA. Translation: AAM28596.1 .
AK014467 mRNA. Translation: BAB29372.1 .
AK019454 mRNA. Translation: BAB31730.1 .
AK150446 mRNA. Translation: BAE29568.1 .
AK150547 mRNA. Translation: BAE29649.1 .
AK152067 mRNA. Translation: BAE30921.1 .
AK152943 mRNA. Translation: BAE31614.1 .
AK159172 mRNA. Translation: BAE34872.1 .
BC029847 mRNA. Translation: AAH29847.1 .
CCDSi CCDS38663.1. [Q8K595-1 ]
CCDS38664.1. [Q8K595-2 ]
RefSeqi NP_001005846.1. NM_001005846.2. [Q8K595-2 ]
NP_080932.2. NM_026656.4. [Q8K595-1 ]
UniGenei Mm.116862.

3D structure databases

ProteinModelPortali Q8K595.
ModBasei Search...

Proteomic databases

PRIDEi Q8K595.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000011152 ; ENSMUSP00000011152 ; ENSMUSG00000011008 . [Q8K595-1 ]
ENSMUST00000098524 ; ENSMUSP00000096125 ; ENSMUSG00000011008 . [Q8K595-2 ]
GeneIDi 68279.
KEGGi mmu:68279.
UCSCi uc008rqy.1. mouse. [Q8K595-1 ]

Organism-specific databases

CTDi 255231.
MGIi MGI:1915529. Mcoln2.

Phylogenomic databases

eggNOGi NOG149591.
GeneTreei ENSGT00390000017126.
HOGENOMi HOG000232158.
HOVERGENi HBG052430.
InParanoidi Q8K595.
KOi K04993.
OMAi RRQIPWK.
OrthoDBi EOG7V1FQ9.
PhylomeDBi Q8K595.
TreeFami TF317783.

Enzyme and pathway databases

Reactomei REACT_227861. TRP channels.

Miscellaneous databases

NextBioi 326914.
PROi Q8K595.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K595.
Bgeei Q8K595.
CleanExi MM_MCOLN2.
Genevestigatori Q8K595.

Family and domain databases

InterProi IPR013122. PKD1_2_channel.
[Graphical view ]
Pfami PF08016. PKD_channel. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice."
    Di Palma F., Belyantseva I.A., Kim H.J., Vogt T.F., Kachar B., Noben-Trauth K.
    Proc. Natl. Acad. Sci. U.S.A. 99:14994-14999(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
    Strain: C57BL/6J.
  2. Kennedy J.C., Falardeau J.L., Acierno J.S. Jr., Slaugenhaupt S.A.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Bone marrow and Embryo.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Mammary tumor.

Entry informationi

Entry nameiMCLN2_MOUSE
AccessioniPrimary (citable) accession number: Q8K595
Secondary accession number(s): Q3UCG4, Q8K2T6, Q9CQD3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 19, 2004
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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