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Q8K595

- MCLN2_MOUSE

UniProt

Q8K595 - MCLN2_MOUSE

Protein

Mucolipin-2

Gene

Mcoln2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. ion transport Source: UniProtKB-KW

    Keywords - Molecular functioni

    Ion channel

    Keywords - Biological processi

    Ion transport, Transport

    Enzyme and pathway databases

    ReactomeiREACT_227861. TRP channels.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Mucolipin-2
    Gene namesi
    Name:Mcoln2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 3

    Organism-specific databases

    MGIiMGI:1915529. Mcoln2.

    Subcellular locationi

    GO - Cellular componenti

    1. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 566566Mucolipin-2PRO_0000215366Add
    BLAST

    Proteomic databases

    PRIDEiQ8K595.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K595.
    BgeeiQ8K595.
    CleanExiMM_MCOLN2.
    GenevestigatoriQ8K595.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K595.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei289 – 30921HelicalSequence AnalysisAdd
    BLAST
    Transmembranei342 – 36221HelicalSequence AnalysisAdd
    BLAST
    Transmembranei380 – 40021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei420 – 44021HelicalSequence AnalysisAdd
    BLAST
    Transmembranei486 – 50621HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG149591.
    GeneTreeiENSGT00390000017126.
    HOGENOMiHOG000232158.
    HOVERGENiHBG052430.
    InParanoidiQ8K595.
    KOiK04993.
    OMAiRRQIPWK.
    OrthoDBiEOG7V1FQ9.
    PhylomeDBiQ8K595.
    TreeFamiTF317783.

    Family and domain databases

    InterProiIPR013122. PKD1_2_channel.
    [Graphical view]
    PfamiPF08016. PKD_channel. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K595-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MPGDEETLDL PAWNRVPDLT WGPHHRSAMA SLDSEVREEC LREDLKFYFM    50
    SPCEKYRARR QIPWKLGLQI LKIVMVTTQL VRFGLSNQLV VAFKEDNTVA 100
    FKHLFLKGFS GVDEDDYSCS IYTQENTYES IFFAIKQYRH LKNISLATLG 150
    YGESEDNRTG LKVCKQHYKT GAMFSSNETL NIDSDIETDC IHLDLQVLTT 200
    EPEDWAQTSF FRLDFYRLVQ VDISFALKGI DLQAVHSREI PDCYLFQNTI 250
    TFDNTAHSGK IKIYLNSEAN IEECKNMNIS GSTQRSTHYL LVFDVFVIMI 300
    CLASLILCTR SIVLALRLRK RFLNFFLEKY KQRVCGADQW EFVNGWYVLV 350
    TISDLMTIIG SILKMEIKAK KLTNYDVCSI LLGTSTLFVW VGVIRYLGYF 400
    QTYNVLILTM QASLPKVLRF CACAGMIYLG YTFCGWIVLG PYHEKFENLN 450
    IVAECLFSLV NGDDMFATFA QIQQKSILVW LFSRLYLYSF ISLFIYMVLS 500
    LFIALITDSY HTIKKYQQHG FPETDLQKFL KESGSKDGYQ KQPSALLSCL 550
    CCLRRRRSND HLILID 566
    Length:566
    Mass (Da):65,450
    Last modified:October 1, 2002 - v1
    Checksum:i314CEC662B3BDC07
    GO
    Isoform 2 (identifier: Q8K595-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-28: Missing.

    Show »
    Length:538
    Mass (Da):62,269
    Checksum:i9C35081FE96A628B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti558 – 5581S → N in AAH29847. (PubMed:15489334)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 2828Missing in isoform 2. 3 PublicationsVSP_010822Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY083532 mRNA. Translation: AAM08925.1.
    AF503575 mRNA. Translation: AAM28596.1.
    AK014467 mRNA. Translation: BAB29372.1.
    AK019454 mRNA. Translation: BAB31730.1.
    AK150446 mRNA. Translation: BAE29568.1.
    AK150547 mRNA. Translation: BAE29649.1.
    AK152067 mRNA. Translation: BAE30921.1.
    AK152943 mRNA. Translation: BAE31614.1.
    AK159172 mRNA. Translation: BAE34872.1.
    BC029847 mRNA. Translation: AAH29847.1.
    CCDSiCCDS38663.1. [Q8K595-1]
    CCDS38664.1. [Q8K595-2]
    RefSeqiNP_001005846.1. NM_001005846.2. [Q8K595-2]
    NP_080932.2. NM_026656.4. [Q8K595-1]
    UniGeneiMm.116862.

    Genome annotation databases

    EnsembliENSMUST00000011152; ENSMUSP00000011152; ENSMUSG00000011008. [Q8K595-1]
    ENSMUST00000098524; ENSMUSP00000096125; ENSMUSG00000011008. [Q8K595-2]
    GeneIDi68279.
    KEGGimmu:68279.
    UCSCiuc008rqy.1. mouse. [Q8K595-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AY083532 mRNA. Translation: AAM08925.1 .
    AF503575 mRNA. Translation: AAM28596.1 .
    AK014467 mRNA. Translation: BAB29372.1 .
    AK019454 mRNA. Translation: BAB31730.1 .
    AK150446 mRNA. Translation: BAE29568.1 .
    AK150547 mRNA. Translation: BAE29649.1 .
    AK152067 mRNA. Translation: BAE30921.1 .
    AK152943 mRNA. Translation: BAE31614.1 .
    AK159172 mRNA. Translation: BAE34872.1 .
    BC029847 mRNA. Translation: AAH29847.1 .
    CCDSi CCDS38663.1. [Q8K595-1 ]
    CCDS38664.1. [Q8K595-2 ]
    RefSeqi NP_001005846.1. NM_001005846.2. [Q8K595-2 ]
    NP_080932.2. NM_026656.4. [Q8K595-1 ]
    UniGenei Mm.116862.

    3D structure databases

    ProteinModelPortali Q8K595.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PRIDEi Q8K595.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000011152 ; ENSMUSP00000011152 ; ENSMUSG00000011008 . [Q8K595-1 ]
    ENSMUST00000098524 ; ENSMUSP00000096125 ; ENSMUSG00000011008 . [Q8K595-2 ]
    GeneIDi 68279.
    KEGGi mmu:68279.
    UCSCi uc008rqy.1. mouse. [Q8K595-1 ]

    Organism-specific databases

    CTDi 255231.
    MGIi MGI:1915529. Mcoln2.

    Phylogenomic databases

    eggNOGi NOG149591.
    GeneTreei ENSGT00390000017126.
    HOGENOMi HOG000232158.
    HOVERGENi HBG052430.
    InParanoidi Q8K595.
    KOi K04993.
    OMAi RRQIPWK.
    OrthoDBi EOG7V1FQ9.
    PhylomeDBi Q8K595.
    TreeFami TF317783.

    Enzyme and pathway databases

    Reactomei REACT_227861. TRP channels.

    Miscellaneous databases

    NextBioi 326914.
    PROi Q8K595.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K595.
    Bgeei Q8K595.
    CleanExi MM_MCOLN2.
    Genevestigatori Q8K595.

    Family and domain databases

    InterProi IPR013122. PKD1_2_channel.
    [Graphical view ]
    Pfami PF08016. PKD_channel. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mutations in Mcoln3 associated with deafness and pigmentation defects in varitint-waddler (Va) mice."
      Di Palma F., Belyantseva I.A., Kim H.J., Vogt T.F., Kachar B., Noben-Trauth K.
      Proc. Natl. Acad. Sci. U.S.A. 99:14994-14999(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
    2. Kennedy J.C., Falardeau J.L., Acierno J.S. Jr., Slaugenhaupt S.A.
      Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Strain: C57BL/6J.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6J.
      Tissue: Bone marrow and Embryo.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Tissue: Mammary tumor.

    Entry informationi

    Entry nameiMCLN2_MOUSE
    AccessioniPrimary (citable) accession number: Q8K595
    Secondary accession number(s): Q3UCG4, Q8K2T6, Q9CQD3
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 19, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3