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Protein

Phospholipid phosphatase 2

Gene

Plpp2

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P) (By similarity).By similarity

Catalytic activityi

A 1,2-diacylglycerol 3-phosphate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.

GO - Molecular functioni

  • lipid phosphatase activity Source: GO_Central
  • phosphatidate phosphatase activity Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Hydrolase

Enzyme and pathway databases

ReactomeiR-RNO-1660661. Sphingolipid de novo biosynthesis.

Names & Taxonomyi

Protein namesi
Recommended name:
Phospholipid phosphatase 2Imported (EC:3.1.3.4)
Alternative name(s):
Lipid phosphate phosphohydrolase 2
PAP2-gamma
Short name:
PAP2-G
Phosphatidate phosphohydrolase type 2c
Phosphatidic acid phosphatase 2c
Short name:
PAP-2c
Short name:
PAP2c
Gene namesi
Name:Plpp2Imported
Synonyms:Lpp2, Ppap2c
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 7

Organism-specific databases

RGDi628893. Plpp2.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei5 – 2521HelicalSequence analysisAdd
BLAST
Transmembranei52 – 7221HelicalSequence analysisAdd
BLAST
Transmembranei88 – 10821HelicalSequence analysisAdd
BLAST
Transmembranei162 – 18221HelicalSequence analysisAdd
BLAST
Transmembranei190 – 21021HelicalSequence analysisAdd
BLAST
Transmembranei226 – 24621HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Phospholipid phosphatase 2PRO_0000220911Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi139 – 1391N-linked (GlcNAc...)Sequence analysis
Glycosylationi155 – 1551N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K593.

Expressioni

Tissue specificityi

Expressed in the brain.1 Publication

Gene expression databases

GenevisibleiQ8K593. RN.

Interactioni

Subunit structurei

Homodimer.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000193.

Structurei

3D structure databases

ProteinModelPortaliQ8K593.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000041307.
HOVERGENiHBG002048.
InParanoidiQ8K593.
KOiK01080.
OMAiVACLTVR.
OrthoDBiEOG7C5M9Q.
PhylomeDBiQ8K593.
TreeFamiTF316040.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028674. LPP2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF25. PTHR10165:SF25. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K593-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MERRWVFVLL DVLCVLVASL PFIILTLVNA PYKRGFYCGD DSIRYPYRPD
60 70 80 90 100
TITHGLMAGV IITATVVLVS SGEAYLVYTD RLYSRSDFNN YVAAIYKVLG
110 120 130 140 150
TFLFGAAVSQ SLTDLAKYMI GRLRPSFLAV CDPDWSRVNC SGYVQVEVCR
160 170 180 190 200
GSPANVTEAR LSFYSGHSSF GMYCMLFLAL YVQARLCWKW ARLLRPTVQF
210 220 230 240 250
FLVAFAIYVG YTRVSDNKHH WSDVLVGLLQ GALVACLTVC YVSDFFKSRP
260 270
PQSCQENEES ERKPSLSLTL TLGDRP
Length:276
Mass (Da):31,101
Last modified:October 1, 2002 - v1
Checksum:i41A0E1243458E24C
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503611 mRNA. Translation: AAM28632.1.
BC062088 mRNA. Translation: AAH62088.1.
RefSeqiNP_640345.1. NM_139252.1.
UniGeneiRn.3301.

Genome annotation databases

EnsembliENSRNOT00000000193; ENSRNOP00000000193; ENSRNOG00000000177.
GeneIDi246115.
KEGGirno:246115.
UCSCiRGD:628893. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF503611 mRNA. Translation: AAM28632.1.
BC062088 mRNA. Translation: AAH62088.1.
RefSeqiNP_640345.1. NM_139252.1.
UniGeneiRn.3301.

3D structure databases

ProteinModelPortaliQ8K593.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000000193.

Proteomic databases

PaxDbiQ8K593.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000000193; ENSRNOP00000000193; ENSRNOG00000000177.
GeneIDi246115.
KEGGirno:246115.
UCSCiRGD:628893. rat.

Organism-specific databases

CTDi8612.
RGDi628893. Plpp2.

Phylogenomic databases

eggNOGiKOG3030. Eukaryota.
COG0671. LUCA.
GeneTreeiENSGT00620000087654.
HOGENOMiHOG000041307.
HOVERGENiHBG002048.
InParanoidiQ8K593.
KOiK01080.
OMAiVACLTVR.
OrthoDBiEOG7C5M9Q.
PhylomeDBiQ8K593.
TreeFamiTF316040.

Enzyme and pathway databases

ReactomeiR-RNO-1660661. Sphingolipid de novo biosynthesis.

Miscellaneous databases

PROiQ8K593.

Gene expression databases

GenevisibleiQ8K593. RN.

Family and domain databases

Gene3Di1.20.144.10. 1 hit.
InterProiIPR028674. LPP2.
IPR000326. P_Acid_Pase_2/haloperoxidase.
[Graphical view]
PANTHERiPTHR10165:SF25. PTHR10165:SF25. 1 hit.
PfamiPF01569. PAP2. 1 hit.
[Graphical view]
SMARTiSM00014. acidPPc. 1 hit.
[Graphical view]
SUPFAMiSSF48317. SSF48317. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Expression of lipid phosphate phosphohydrolase isoforms in rat lung development."
    Zhao L., Nanjundan M., Possmayer F.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.
    Tissue: Lung.
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Prostate.
  3. "Molecular cloning and expression of pulmonary lipid phosphate phosphohydrolases."
    Nanjundan M., Possmayer F.
    Am. J. Physiol. 281:L1484-L1493(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiPLPP2_RAT
AccessioniPrimary (citable) accession number: Q8K593
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 15, 2004
Last sequence update: October 1, 2002
Last modified: July 6, 2016
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.