Reviewed, UniProtKB/Swiss-Prot Q8K593 (LPP2_RAT)

Names and origin

Protein names

Recommended name:
    Lipid phosphate phosphohydrolase 2
    EC=3.1.3.4
Alternative name(s):
    Phosphatidic acid phosphatase 2c
      Short name=PAP-2c
      Short name=PAP2c
    Phosphatidate phosphohydrolase type 2c
    PAP2-gamma
      Short name=PAP2-G

Gene names

Name:	Ppap2c
Synonyms:	Lpp2

Organism

Rattus norvegicus (Rat)

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	276 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Catalyzes the conversion of phosphatidic acid (PA) to diacylglycerol (DG). In addition it hydrolyzes lysophosphatidic acid (LPA), ceramide-1-phosphate (C-1-P) and sphingosine-1-phosphate (S-1-P) By similarity.
Catalytic activity	A 3-sn-phosphatidate + H2O = a 1,2-diacyl-sn-glycerol + phosphate.
Subunit structure	Homodimer By similarity.
Subcellular location	Membrane; Multi-pass membrane protein.
Tissue specificity	Expressed in the brain. Ref.3
Sequence similarities	Belongs to the PA-phosphatase related phosphoesterase family.

Ontologies

Keywords
Cellular component	Membrane
Domain	Transmembrane
Molecular function	Hydrolase
PTM	Glycoprotein
Gene Ontology (GO)
Cellular component	integral to membrane Inferred from electronic annotation. Source: UniProtKB-SubCell
Molecular function	phosphatidate phosphatase activity Non-traceable author statement. Source: RGD
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 276	276	Lipid phosphate phosphohydrolase 2		PRO_0000220911
Regions
	Transmembrane	5 – 25	21	Potential
	Transmembrane	52 – 72	21	Potential
	Transmembrane	88 – 108	21	Potential
	Transmembrane	162 – 182	21	Potential
	Transmembrane	190 – 210	21	Potential
	Transmembrane	226 – 246	21	Potential
Amino acid modifications
	Glycosylation	139	1	N-linked (GlcNAc...) Potential
	Glycosylation	155	1	N-linked (GlcNAc...) Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8K593-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 41A0E1243458E24C	FASTA	276	31,101
	10 20 30 40 50 60 MERRWVFVLL DVLCVLVASL PFIILTLVNA PYKRGFYCGD DSIRYPYRPD TITHGLMAGV 70 80 90 100 110 120 IITATVVLVS SGEAYLVYTD RLYSRSDFNN YVAAIYKVLG TFLFGAAVSQ SLTDLAKYMI 130 140 150 160 170 180 GRLRPSFLAV CDPDWSRVNC SGYVQVEVCR GSPANVTEAR LSFYSGHSSF GMYCMLFLAL 190 200 210 220 230 240 YVQARLCWKW ARLLRPTVQF FLVAFAIYVG YTRVSDNKHH WSDVLVGLLQ GALVACLTVC 250 260 270 YVSDFFKSRP PQSCQENEES ERKPSLSLTL TLGDRP

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Expression of lipid phosphate phosphohydrolase isoforms in rat lung development." Zhao L., Nanjundan M., Possmayer F. Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. Tissue: Lung.
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. Tissue: Prostate.
[3]	"Molecular cloning and expression of pulmonary lipid phosphate phosphohydrolases." Nanjundan M., Possmayer F. Am. J. Physiol. 281:L1484-L1493(2001) [PubMed: 11704545] [Abstract] Cited for: TISSUE SPECIFICITY. Strain: Sprague-Dawley.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF503611 mRNA. Translation: AAM28632.1. BC062088 mRNA. Translation: AAH62088.1.
IPI	IPI00203761.
RefSeq	NP_640345.1.
UniGene	Rn.3301
3D structure databases
SMR	Q8K593. Positions 94-249.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8K593.
Genome annotation databases
Ensembl	ENSRNOT00000000193; ENSRNOP00000000193; ENSRNOG00000000177; Rattus norvegicus. [Genome view]
GeneID	246115.
KEGG	rno:246115.
UCSC	NM_139252. rat.
Organism-specific databases
CTD	246115.
RGD	628893. Ppap2c.
Phylogenomic databases
eggNOG	maNOG09199.
HOVERGEN	Q8K593.
InParanoid	Q8K593.
OMA	WKWARLL.
OrthoDB	EOG93R66R.
PhylomeDB	Q8K593.
Enzyme and pathway databases
BRENDA	3.1.3.4. 248.
Gene expression databases
ArrayExpress	Q8K593.
Genevestigator	Q8K593.
GermOnline	ENSRNOG00000000177. Rattus norvegicus.
Family and domain databases
InterPro	IPR016118. P_Acid_Pase/Cl_peroxidase_N. IPR000326. P_Acid_Pase_2/haloperoxidase. [Graphical view]
Gene3D	G3DSA:1.20.144.10. P_Acid_Pase/Cl_peroxidase_N. 1 hit.
Pfam	PF01569. PAP2. 1 hit. [Graphical view]
SMART	SM00014. acidPPc. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
NextBio	623369.

Entry information

Entry name

LPP2_RAT

Accession

Primary (citable) accession number: Q8K593

Entry history

Integrated into UniProtKB/Swiss-Prot:	March 15, 2004
Last sequence update:	October 1, 2002
Last modified:	January 19, 2010
This is version 51 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)