Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Basket 0
(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Q8K592

- AMHR2_MOUSE

UniProt

Q8K592 - AMHR2_MOUSE

Protein

Anti-Muellerian hormone type-2 receptor

Gene

Amhr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
    • BLAST
    • Align
    • Format
    • Add to basket
    • History
      Entry version 104 (01 Oct 2014)
      Sequence version 2 (28 Nov 2006)
      Previous versions | rss
    • Help video
    • Feedback
    • Comment

    Functioni

    On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

    Catalytic activityi

    ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

    Cofactori

    Magnesium or manganese.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Binding sitei226 – 2261ATPPROSITE-ProRule annotation
    Active sitei329 – 3291Proton acceptorPROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi205 – 2139ATPPROSITE-ProRule annotation

    GO - Molecular functioni

    1. anti-Mullerian hormone receptor activity Source: MGI
    2. ATP binding Source: UniProtKB-KW
    3. hormone binding Source: UniProtKB
    4. metal ion binding Source: UniProtKB-KW
    5. receptor activity Source: UniProtKB
    6. receptor signaling protein serine/threonine kinase activity Source: InterPro
    7. transforming growth factor beta-activated receptor activity Source: MGI
    8. transforming growth factor beta receptor activity, type II Source: Ensembl

    GO - Biological processi

    1. anti-Mullerian hormone signaling pathway Source: MGI
    2. negative regulation of anti-Mullerian hormone signaling pathway Source: MGI
    3. sex differentiation Source: MGI
    4. signal transduction Source: UniProtKB
    5. transforming growth factor beta receptor signaling pathway Source: MGI

    Keywords - Molecular functioni

    Kinase, Receptor, Serine/threonine-protein kinase, Transferase

    Keywords - Ligandi

    ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
    Alternative name(s):
    Anti-Muellerian hormone type II receptor
    Short name:
    AMH type II receptor
    MIS type II receptor
    Short name:
    MISRII
    Short name:
    MRII
    Gene namesi
    Name:Amhr2
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:105062. Amhr2.

    Subcellular locationi

    Membrane By similarity; Single-pass type I membrane protein By similarity

    GO - Cellular componenti

    1. integral component of plasma membrane Source: MGI

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1515Sequence AnalysisAdd
    BLAST
    Chaini16 – 568553Anti-Muellerian hormone type-2 receptorPRO_0000260265Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

    Keywords - PTMi

    Glycoprotein

    Proteomic databases

    PaxDbiQ8K592.
    PRIDEiQ8K592.

    PTM databases

    PhosphoSiteiQ8K592.

    Expressioni

    Gene expression databases

    BgeeiQ8K592.
    CleanExiMM_AMHR2.
    GenevestigatoriQ8K592.

    Interactioni

    Protein-protein interaction databases

    IntActiQ8K592. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K592.
    SMRiQ8K592. Positions 195-504.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini16 – 147132ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini169 – 568400CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei148 – 16821HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini199 – 504306Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG243040.
    GeneTreeiENSGT00560000076906.
    HOGENOMiHOG000033920.
    HOVERGENiHBG097461.
    InParanoidiQ8K592.
    KOiK04672.
    OMAiCNANYSH.
    OrthoDBiEOG7WHH97.
    PhylomeDBiQ8K592.
    TreeFamiTF314724.

    Family and domain databases

    InterProiIPR000472. Activin_rcpt.
    IPR015771. Anti-muellerian_hrmn_rcpt_II.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR000333. TGFB_receptor.
    [Graphical view]
    PANTHERiPTHR23255. PTHR23255. 1 hit.
    PfamiPF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view]
    PIRSFiPIRSF037392. AMHRII. 1 hit.
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K592-1 [UniParc]FASTAAdd to Basket

    « Hide

    MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP    50
    KGIRCLYSHC CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP 100
    NPSSTLFTCS CGTDFCNANY SHLPPSGNQG APGPQEPQAT PGGPVWMALL 150
    LLGMFLVLLL SSIILALLQR KACRVQGGSD PEPGSGGDCS EELPELAELR 200
    FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER AVYQLLGLQH 250
    DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM 300
    ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL 350
    ALVLPGLAQP PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA 400
    LQRADVYSLA LLLWEILSRC SDLRPDHRPP PFQLAYEAEL GSNPSACELW 450
    ALAVEERKRP NIPSTWSCSA TDPRGLRELL EDCWDADPEA RLTAECVQQR 500
    LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS SCLLSVQQGP 550
    GSRSPDPVGD TVQVYVNE 568
    Length:568
    Mass (Da):61,195
    Last modified:November 28, 2006 - v2
    Checksum:iAE89AA1727600E5E
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti240 – 2401R → G in AAM28608. (PubMed:9299437)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503863 mRNA. Translation: AAM28608.1.
    BC119571 mRNA. Translation: AAI19572.1.
    CCDSiCCDS27882.1.
    PIRiJC5629.
    RefSeqiNP_653130.2. NM_144547.2.
    XP_006520356.1. XM_006520293.1.
    UniGeneiMm.60331.

    Genome annotation databases

    EnsembliENSMUST00000023809; ENSMUSP00000023809; ENSMUSG00000023047.
    GeneIDi110542.
    KEGGimmu:110542.
    UCSCiuc007xvq.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF503863 mRNA. Translation: AAM28608.1 .
    BC119571 mRNA. Translation: AAI19572.1 .
    CCDSi CCDS27882.1.
    PIRi JC5629.
    RefSeqi NP_653130.2. NM_144547.2.
    XP_006520356.1. XM_006520293.1.
    UniGenei Mm.60331.

    3D structure databases

    ProteinModelPortali Q8K592.
    SMRi Q8K592. Positions 195-504.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    IntActi Q8K592. 1 interaction.

    PTM databases

    PhosphoSitei Q8K592.

    Proteomic databases

    PaxDbi Q8K592.
    PRIDEi Q8K592.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000023809 ; ENSMUSP00000023809 ; ENSMUSG00000023047 .
    GeneIDi 110542.
    KEGGi mmu:110542.
    UCSCi uc007xvq.2. mouse.

    Organism-specific databases

    CTDi 269.
    MGIi MGI:105062. Amhr2.

    Phylogenomic databases

    eggNOGi NOG243040.
    GeneTreei ENSGT00560000076906.
    HOGENOMi HOG000033920.
    HOVERGENi HBG097461.
    InParanoidi Q8K592.
    KOi K04672.
    OMAi CNANYSH.
    OrthoDBi EOG7WHH97.
    PhylomeDBi Q8K592.
    TreeFami TF314724.

    Miscellaneous databases

    NextBioi 364193.
    PROi Q8K592.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K592.
    CleanExi MM_AMHR2.
    Genevestigatori Q8K592.

    Family and domain databases

    InterProi IPR000472. Activin_rcpt.
    IPR015771. Anti-muellerian_hrmn_rcpt_II.
    IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR000333. TGFB_receptor.
    [Graphical view ]
    PANTHERi PTHR23255. PTHR23255. 1 hit.
    Pfami PF01064. Activin_recp. 1 hit.
    PF00069. Pkinase. 1 hit.
    [Graphical view ]
    PIRSFi PIRSF037392. AMHRII. 1 hit.
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Sequence, genomic organization, and chromosomal location of the mouse Muellerian-inhibiting substance type II receptor gene."
      Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G., Jenkins N.A., Cate R.L., Behringer R.R.
      Biochem. Biophys. Res. Commun. 237:741-746(1997) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

    Entry informationi

    Entry nameiAMHR2_MOUSE
    AccessioniPrimary (citable) accession number: Q8K592
    Secondary accession number(s): Q0VDQ4
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: November 28, 2006
    Last sequence update: November 28, 2006
    Last modified: October 1, 2014
    This is version 104 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3