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Q8K592

- AMHR2_MOUSE

UniProt

Q8K592 - AMHR2_MOUSE

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Protein

Anti-Muellerian hormone type-2 receptor

Gene

Amhr2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli

Functioni

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activityi

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactori

Magnesium or manganese.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Binding sitei226 – 2261ATPPROSITE-ProRule annotation
Active sitei329 – 3291Proton acceptorPROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi205 – 2139ATPPROSITE-ProRule annotation

GO - Molecular functioni

  1. anti-Mullerian hormone receptor activity Source: MGI
  2. ATP binding Source: UniProtKB-KW
  3. hormone binding Source: UniProtKB
  4. metal ion binding Source: UniProtKB-KW
  5. receptor activity Source: UniProtKB
  6. receptor signaling protein serine/threonine kinase activity Source: InterPro
  7. transforming growth factor beta-activated receptor activity Source: MGI
  8. transforming growth factor beta receptor activity, type II Source: Ensembl

GO - Biological processi

  1. anti-Mullerian hormone signaling pathway Source: MGI
  2. negative regulation of anti-Mullerian hormone signaling pathway Source: MGI
  3. sex differentiation Source: MGI
  4. signal transduction Source: UniProtKB
  5. transforming growth factor beta receptor signaling pathway Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Kinase, Receptor, Serine/threonine-protein kinase, Transferase

Keywords - Ligandi

ATP-binding, Magnesium, Manganese, Metal-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Anti-Muellerian hormone type-2 receptor (EC:2.7.11.30)
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name:
AMH type II receptor
MIS type II receptor
Short name:
MISRII
Short name:
MRII
Gene namesi
Name:Amhr2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:105062. Amhr2.

Subcellular locationi

Membrane By similarity; Single-pass type I membrane protein By similarity

GO - Cellular componenti

  1. integral component of plasma membrane Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1515Sequence AnalysisAdd
BLAST
Chaini16 – 568553Anti-Muellerian hormone type-2 receptorPRO_0000260265Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi66 – 661N-linked (GlcNAc...)Sequence Analysis
Glycosylationi119 – 1191N-linked (GlcNAc...)Sequence Analysis

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K592.
PRIDEiQ8K592.

PTM databases

PhosphoSiteiQ8K592.

Expressioni

Gene expression databases

BgeeiQ8K592.
CleanExiMM_AMHR2.
ExpressionAtlasiQ8K592. baseline and differential.
GenevestigatoriQ8K592.

Interactioni

Protein-protein interaction databases

IntActiQ8K592. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K592.
SMRiQ8K592. Positions 195-504.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini16 – 147132ExtracellularSequence AnalysisAdd
BLAST
Topological domaini169 – 568400CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei148 – 16821HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini199 – 504306Protein kinasePROSITE-ProRule annotationAdd
BLAST

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG243040.
GeneTreeiENSGT00760000118876.
HOGENOMiHOG000033920.
HOVERGENiHBG097461.
InParanoidiQ8K592.
KOiK04672.
OMAiCNANYSH.
OrthoDBiEOG7WHH97.
PhylomeDBiQ8K592.
TreeFamiTF314724.

Family and domain databases

InterProiIPR000472. Activin_rcpt.
IPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERiPTHR23255. PTHR23255. 1 hit.
PfamiPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFiPIRSF037392. AMHRII. 1 hit.
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K592-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP
60 70 80 90 100
KGIRCLYSHC CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP
110 120 130 140 150
NPSSTLFTCS CGTDFCNANY SHLPPSGNQG APGPQEPQAT PGGPVWMALL
160 170 180 190 200
LLGMFLVLLL SSIILALLQR KACRVQGGSD PEPGSGGDCS EELPELAELR
210 220 230 240 250
FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER AVYQLLGLQH
260 270 280 290 300
DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM
310 320 330 340 350
ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL
360 370 380 390 400
ALVLPGLAQP PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA
410 420 430 440 450
LQRADVYSLA LLLWEILSRC SDLRPDHRPP PFQLAYEAEL GSNPSACELW
460 470 480 490 500
ALAVEERKRP NIPSTWSCSA TDPRGLRELL EDCWDADPEA RLTAECVQQR
510 520 530 540 550
LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS SCLLSVQQGP
560
GSRSPDPVGD TVQVYVNE
Length:568
Mass (Da):61,195
Last modified:November 28, 2006 - v2
Checksum:iAE89AA1727600E5E
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti240 – 2401R → G in AAM28608. (PubMed:9299437)Curated

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503863 mRNA. Translation: AAM28608.1.
BC119571 mRNA. Translation: AAI19572.1.
CCDSiCCDS27882.1.
PIRiJC5629.
RefSeqiNP_653130.2. NM_144547.2.
XP_006520356.1. XM_006520293.1.
UniGeneiMm.60331.

Genome annotation databases

EnsembliENSMUST00000023809; ENSMUSP00000023809; ENSMUSG00000023047.
GeneIDi110542.
KEGGimmu:110542.
UCSCiuc007xvq.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF503863 mRNA. Translation: AAM28608.1 .
BC119571 mRNA. Translation: AAI19572.1 .
CCDSi CCDS27882.1.
PIRi JC5629.
RefSeqi NP_653130.2. NM_144547.2.
XP_006520356.1. XM_006520293.1.
UniGenei Mm.60331.

3D structure databases

ProteinModelPortali Q8K592.
SMRi Q8K592. Positions 195-504.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

IntActi Q8K592. 1 interaction.

PTM databases

PhosphoSitei Q8K592.

Proteomic databases

PaxDbi Q8K592.
PRIDEi Q8K592.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000023809 ; ENSMUSP00000023809 ; ENSMUSG00000023047 .
GeneIDi 110542.
KEGGi mmu:110542.
UCSCi uc007xvq.2. mouse.

Organism-specific databases

CTDi 269.
MGIi MGI:105062. Amhr2.

Phylogenomic databases

eggNOGi NOG243040.
GeneTreei ENSGT00760000118876.
HOGENOMi HOG000033920.
HOVERGENi HBG097461.
InParanoidi Q8K592.
KOi K04672.
OMAi CNANYSH.
OrthoDBi EOG7WHH97.
PhylomeDBi Q8K592.
TreeFami TF314724.

Miscellaneous databases

NextBioi 364193.
PROi Q8K592.
SOURCEi Search...

Gene expression databases

Bgeei Q8K592.
CleanExi MM_AMHR2.
ExpressionAtlasi Q8K592. baseline and differential.
Genevestigatori Q8K592.

Family and domain databases

InterProi IPR000472. Activin_rcpt.
IPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view ]
PANTHERi PTHR23255. PTHR23255. 1 hit.
Pfami PF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view ]
PIRSFi PIRSF037392. AMHRII. 1 hit.
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Sequence, genomic organization, and chromosomal location of the mouse Muellerian-inhibiting substance type II receptor gene."
    Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G., Jenkins N.A., Cate R.L., Behringer R.R.
    Biochem. Biophys. Res. Commun. 237:741-746(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].

Entry informationi

Entry nameiAMHR2_MOUSE
AccessioniPrimary (citable) accession number: Q8K592
Secondary accession number(s): Q0VDQ4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: October 29, 2014
This is version 105 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3