Reviewed,
UniProtKB/Swiss-Prot Q8K592 (AMHR2_MOUSE)
Last modified
July 22, 2008.
Version 49.
History...
Clusters with 100%,
90%,
50% identity |
Documents (4) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Anti-Muellerian hormone type-2 receptor EC=2.7.11.30 Alternative name(s): Anti-Muellerian hormone type II receptor Short name=AMH type II receptor MIS type II receptor MISRII Short name=MRII | ||
| Gene names |
| ||
| Organism | Mus musculus (Mouse) | ||
| Taxonomic identifier | 10090 [NCBI] | ||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 568 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone. |
| Catalytic activity | ATP + [receptor-protein] = ADP + [receptor-protein] phosphate. |
| Cofactor | Magnesium or manganese By similarity. |
| Subcellular location | Membrane; Single-pass type I membrane proteinBy similarity. |
| Sequence similarities | Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain. |
Ontologies
Keywords | |
|---|---|
| Cellular component | Membrane |
| Domain | Signal Transmembrane |
| Ligand | ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding |
| Molecular function | Kinase Receptor Serine/threonine-protein kinase Transferase |
| PTM | Glycoprotein |
Gene Ontology (GO) | |
| Biological process | sex differentiation Inferred from mutant phenotype. Source: MGI transforming growth factor beta receptor signaling pathwayTraceable author statement. Source: MGI |
| Cellular component | integral to plasma membrane Traceable author statement. Source: MGI |
| Molecular function | hormone binding Inferred from sequence or structural similarity. Source: UniProtKB transforming growth factor beta receptor activityTraceable author statement. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | ||||
Molecule processing | ||||||||
|---|---|---|---|---|---|---|---|---|
| Signal peptide | 1 – 15 | 15 | Potential | |||||
| Chain | 16 – 568 | 553 | Anti-Muellerian hormone type-2 receptor | |||||
Regions | ||||||||
| Topological domain | 16 – 147 | 132 | Extracellular Potential | |||||
| Transmembrane | 148 – 168 | 21 | Potential | |||||
| Topological domain | 169 – 568 | 400 | Cytoplasmic Potential | |||||
| Domain | 199 – 504 | 306 | Protein kinase | |||||
| Nucleotide binding | 205 – 213 | 9 | ATP By similarity | |||||
Sites | ||||||||
| Active site | 329 | 1 | Proton acceptor By similarity | |||||
| Binding site | 226 | 1 | ATP By similarity | |||||
Amino acid modifications | ||||||||
| Glycosylation | 66 | 1 | N-linked (GlcNAc...) Potential | |||||
| Glycosylation | 119 | 1 | N-linked (GlcNAc...) Potential | |||||
Experimental info | ||||||||
| Sequence conflict | 240 | 1 | R → G in AAM28608. Ref.1 | |||||
Sequences
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References
| « Hide 'large scale' references | |
| [1] | "Sequence, genomic organization, and chromosomal location of the mouse Muellerian-inhibiting substance type II receptor gene." Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G., Jenkins N.A., Cate R.L., Behringer R.R. Biochem. Biophys. Res. Commun. 237:741-746(1997) [PubMed: 9299437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| [2] | "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| AF503863 mRNA. Translation: AAM28608.1. BC119571 mRNA. Translation: AAI19572.1. | |
| PIR | JC5629. |
| RefSeq | NP_653130.1. |
| UniGene | Mm.60331 |
3D structure databases | |
| HSSP | HSSP built from PDB template 1IAS based on UniProtKB P36897. |
| ModBase | Search... |
Genome annotation databases | |
| Ensembl | ENSMUSG00000023047. Mus musculus. [Contig view] |
| GeneID | 110542. |
| KEGG | mmu:110542. |
| NMPDR | fig|10090.3.peg.30707. |
Organism-specific databases | |
| MGI | MGI:105062. Amhr2. |
Phylogenomic databases | |
| HOVERGEN | Q8K592. |
Gene expression databases | |
| ArrayExpress | Q8K592. |
| CleanEx | MM_AMHR2. |
| GermOnline | ENSMUSG00000023047. Mus musculus. |
Family and domain databases | |
| InterPro | IPR017193. Anti-muellerian_hrmn_rcpt_II. IPR015771. Anti-muellerian_hrmn_rcpt_II_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view] |
| PANTHER | PTHR23255:SF4. MIS_II_R. 1 hit. |
| Pfam | PF00069. Pkinase. 1 hit. [Graphical view] |
| PIRSF | PIRSF037392. AMHRII. 1 hit. |
| ProDom | PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain] |
| PROSITE | PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view] |
| BLOCKS | Search... |
Other Resources | |
| SOURCE | Search... |
| ProtoNet | Search... |
Entry information
| Entry name | AMHR2_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K592 Secondary accession number(s): Q0VDQ4 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| Human and mouse protein kinases Human and mouse protein kinases: classification and index |
| UniProtKB secondary accession numbers Index of UniProtKB secondary accession numbers |
| SIMILARITY comments Index of protein domains and families |

Clusters with


