Anti-Muellerian hormone type-2 receptor precursor

Contribute

Send feedback

Read comments (?) or add your own

Q8K592 (AMHR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 91. History...

Clusters with 100%, 90%, 50% identity |

Documents (3) |

Third-party data

text xml rdf/xml gff fasta

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents Customize order

Names and origin

Protein names

Recommended name:
Anti-Muellerian hormone type-2 receptor
EC=2.7.11.30

Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name=AMH type II receptor
MIS type II receptor
Short name=MISRII
Short name=MRII

Gene names

Name:

Amhr2

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane protein By similarity.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane Transmembrane helix
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	sex differentiation Inferred from mutant phenotype PubMed 8895659. Source: MGI transforming growth factor beta receptor signaling pathway Traceable author statement PubMed 8895659. Source: MGI
Cellular_component	integral to plasma membrane Inferred from sequence orthology PubMed 11960012. Source: MGI
Molecular_function	ATP binding Inferred from electronic annotation. Source: UniProtKB-KW hormone binding Inferred from sequence or structural similarity. Source: UniProtKB metal ion binding Inferred from electronic annotation. Source: UniProtKB-KW transforming growth factor beta receptor activity, type II Inferred from electronic annotation. Source: Compara transforming growth factor beta-activated receptor activity Traceable author statement PubMed 8895659. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

Feature key

Position(s)

Length

Description

Graphical view

Feature identifier

Molecule processing

Signal peptide

1 – 15

Potential

Chain

16 – 568

553

Anti-Muellerian hormone type-2 receptor

PRO_0000260265

Regions

Topological domain

16 – 147

132

Extracellular Potential

Transmembrane

148 – 168

Helical; Potential

Topological domain

169 – 568

400

Cytoplasmic Potential

Domain

199 – 504

306

Protein kinase

Nucleotide binding

205 – 213

ATP By similarity

Sites

Active site

329

Proton acceptor By similarity

Binding site

226

ATP By similarity

Amino acid modifications

Glycosylation

N-linked (GlcNAc...) Potential

Glycosylation

119

N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict

240

R → G in AAM28608. Ref.1

Sequences

Sequence

Length

Mass (Da)

Tools

Q8K592 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: AE89AA1727600E5E
Show »

FASTA

568

61,195

        10         20         30         40         50         60 
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP KGIRCLYSHC 

        70         80         90        100        110        120 
CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP NPSSTLFTCS CGTDFCNANY 

       130        140        150        160        170        180 
SHLPPSGNQG APGPQEPQAT PGGPVWMALL LLGMFLVLLL SSIILALLQR KACRVQGGSD 

       190        200        210        220        230        240 
PEPGSGGDCS EELPELAELR FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER 

       250        260        270        280        290        300 
AVYQLLGLQH DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM 

       310        320        330        340        350        360 
ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL ALVLPGLAQP 

       370        380        390        400        410        420 
PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA LQRADVYSLA LLLWEILSRC 

       430        440        450        460        470        480 
SDLRPDHRPP PFQLAYEAEL GSNPSACELW ALAVEERKRP NIPSTWSCSA TDPRGLRELL 

       490        500        510        520        530        540 
EDCWDADPEA RLTAECVQQR LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS 

       550        560 
SCLLSVQQGP GSRSPDPVGD TVQVYVNE

« Hide

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, genomic organization, and chromosomal location of the mouse Muellerian-inhibiting substance type II receptor gene." Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G., Jenkins N.A., Cate R.L., Behringer R.R. Biochem. Biophys. Res. Commun. 237:741-746(1997) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF503863 mRNA. Translation: AAM28608.1. BC119571 mRNA. Translation: AAI19572.1.
IPI	IPI00170306.
PIR	JC5629.
RefSeq	NP_653130.2. NM_144547.2.
UniGene	Mm.60331.
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
ProteinModelPortal	Q8K592.
SMR	Q8K592. Positions 195-504.
ModBase	Search...
Protein-protein interaction databases
IntAct	Q8K592. 1 interaction.
PTM databases
PhosphoSite	Q8K592.
Proteomic databases
PaxDb	Q8K592.
PRIDE	Q8K592.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000023809; ENSMUSP00000023809; ENSMUSG00000023047.
GeneID	110542.
KEGG	mmu:110542.
UCSC	uc007xvq.2. mouse.
Organism-specific databases
CTD	269.
MGI	MGI:105062. Amhr2.
Phylogenomic databases
eggNOG	NOG243040.
GeneTree	ENSGT00560000076906.
HOGENOM	HOG000033920.
HOVERGEN	HBG097461.
InParanoid	Q8K592.
KO	K04672.
OMA	LTAECVQ.
OrthoDB	EOG4SQWWM.
Gene expression databases
Bgee	Q8K592.
CleanEx	MM_AMHR2.
Genevestigator	Q8K592.
GermOnline	ENSMUSG00000023047. Mus musculus.
Family and domain databases
InterPro	IPR000472. Activin_rcpt. IPR015771. Anti-muellerian_hrmn_rcpt_II. IPR011009. Kinase-like_dom. IPR000719. Prot_kinase_cat_dom. [Graphical view]
PANTHER	PTHR23255:SF4. PTHR23255:SF4. 1 hit.
Pfam	PF01064. Activin_recp. 1 hit. PF00069. Pkinase. 1 hit. [Graphical view]
PIRSF	PIRSF037392. AMHRII. 1 hit.
SUPFAM	SSF56112. Kinase_like. 1 hit.
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
ProtoNet	Search...
Other
NextBio	364193.
SOURCE	Search...

Entry information

Entry name

AMHR2_MOUSE

Accession

Primary (citable) accession number: Q8K592
Secondary accession number(s): Q0VDQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	May 1, 2013
This is version 91 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program

Relevant documents

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

Names·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·Documents

Preferred order of sections

Names and origin

Protein attributes

General annotation (Comments)

Ontologies

Sequence annotation (Features)

Molecule processing

Regions

Sites

Amino acid modifications

Experimental info

Sequences

References

Cross-references

Sequence databases

3D structure databases

Protein-protein interaction databases

PTM databases

Proteomic databases

Protocols and materials databases

Genome annotation databases

Organism-specific databases

Phylogenomic databases

Gene expression databases

Family and domain databases

Other

Entry information

Relevant documents