Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8K592 (AMHR2_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 102. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (3) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Anti-Muellerian hormone type-2 receptor

EC=2.7.11.30
Alternative name(s):
Anti-Muellerian hormone type II receptor
Short name=AMH type II receptor
MIS type II receptor
Short name=MISRII
Short name=MRII
Gene names
Name:Amhr2
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length568 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.

Catalytic activity

ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.

Cofactor

Magnesium or manganese By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein By similarity.

Sequence similarities

Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.

Contains 1 protein kinase domain.

Ontologies

Keywords
   Cellular componentMembrane
   DomainSignal
Transmembrane
Transmembrane helix
   LigandATP-binding
Magnesium
Manganese
Metal-binding
Nucleotide-binding
   Molecular functionKinase
Receptor
Serine/threonine-protein kinase
Transferase
   PTMGlycoprotein
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processanti-Mullerian hormone signaling pathway

Inferred from direct assay PubMed 23624077. Source: MGI

negative regulation of anti-Mullerian hormone signaling pathway

Inferred from direct assay PubMed 23624077. Source: MGI

sex differentiation

Inferred from mutant phenotype PubMed 8895659. Source: MGI

signal transduction

Inferred from sequence or structural similarity. Source: UniProtKB

transforming growth factor beta receptor signaling pathway

Traceable author statement PubMed 8895659. Source: MGI

   Cellular_componentintegral component of plasma membrane

Inferred from sequence orthology PubMed 11960012. Source: MGI

   Molecular_functionATP binding

Inferred from electronic annotation. Source: UniProtKB-KW

anti-Mullerian hormone receptor activity

Inferred from direct assay PubMed 23624077. Source: MGI

hormone binding

Inferred from sequence or structural similarity. Source: UniProtKB

metal ion binding

Inferred from electronic annotation. Source: UniProtKB-KW

receptor activity

Inferred from sequence or structural similarity. Source: UniProtKB

transforming growth factor beta receptor activity, type II

Inferred from electronic annotation. Source: Ensembl

transforming growth factor beta-activated receptor activity

Traceable author statement PubMed 8895659. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1515 Potential
Chain16 – 568553Anti-Muellerian hormone type-2 receptor
PRO_0000260265

Regions

Topological domain16 – 147132Extracellular Potential
Transmembrane148 – 16821Helical; Potential
Topological domain169 – 568400Cytoplasmic Potential
Domain199 – 504306Protein kinase
Nucleotide binding205 – 2139ATP By similarity

Sites

Active site3291Proton acceptor By similarity
Binding site2261ATP By similarity

Amino acid modifications

Glycosylation661N-linked (GlcNAc...) Potential
Glycosylation1191N-linked (GlcNAc...) Potential

Experimental info

Sequence conflict2401R → G in AAM28608. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K592 [UniParc].

Last modified November 28, 2006. Version 2.
Checksum: AE89AA1727600E5E

FASTA56861,195
        10         20         30         40         50         60 
MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP KGIRCLYSHC 

        70         80         90        100        110        120 
CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP NPSSTLFTCS CGTDFCNANY 

       130        140        150        160        170        180 
SHLPPSGNQG APGPQEPQAT PGGPVWMALL LLGMFLVLLL SSIILALLQR KACRVQGGSD 

       190        200        210        220        230        240 
PEPGSGGDCS EELPELAELR FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER 

       250        260        270        280        290        300 
AVYQLLGLQH DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM 

       310        320        330        340        350        360 
ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL ALVLPGLAQP 

       370        380        390        400        410        420 
PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA LQRADVYSLA LLLWEILSRC 

       430        440        450        460        470        480 
SDLRPDHRPP PFQLAYEAEL GSNPSACELW ALAVEERKRP NIPSTWSCSA TDPRGLRELL 

       490        500        510        520        530        540 
EDCWDADPEA RLTAECVQQR LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS 

       550        560 
SCLLSVQQGP GSRSPDPVGD TVQVYVNE 

« Hide

References

« Hide 'large scale' references
[1]"Sequence, genomic organization, and chromosomal location of the mouse Muellerian-inhibiting substance type II receptor gene."
Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G., Jenkins N.A., Cate R.L., Behringer R.R.
Biochem. Biophys. Res. Commun. 237:741-746(1997) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
The MGC Project Team
Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF503863 mRNA. Translation: AAM28608.1.
BC119571 mRNA. Translation: AAI19572.1.
CCDSCCDS27882.1.
PIRJC5629.
RefSeqNP_653130.2. NM_144547.2.
XP_006520356.1. XM_006520293.1.
UniGeneMm.60331.

3D structure databases

ProteinModelPortalQ8K592.
SMRQ8K592. Positions 195-504.
ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

IntActQ8K592. 1 interaction.

PTM databases

PhosphoSiteQ8K592.

Proteomic databases

PaxDbQ8K592.
PRIDEQ8K592.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000023809; ENSMUSP00000023809; ENSMUSG00000023047.
GeneID110542.
KEGGmmu:110542.
UCSCuc007xvq.2. mouse.

Organism-specific databases

CTD269.
MGIMGI:105062. Amhr2.

Phylogenomic databases

eggNOGNOG243040.
GeneTreeENSGT00560000076906.
HOGENOMHOG000033920.
HOVERGENHBG097461.
InParanoidQ8K592.
KOK04672.
OMACNANYSH.
OrthoDBEOG7WHH97.
PhylomeDBQ8K592.
TreeFamTF314724.

Gene expression databases

BgeeQ8K592.
CleanExMM_AMHR2.
GenevestigatorQ8K592.

Family and domain databases

InterProIPR000472. Activin_rcpt.
IPR015771. Anti-muellerian_hrmn_rcpt_II.
IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR000333. TGFB_receptor.
[Graphical view]
PANTHERPTHR23255. PTHR23255. 1 hit.
PfamPF01064. Activin_recp. 1 hit.
PF00069. Pkinase. 1 hit.
[Graphical view]
PIRSFPIRSF037392. AMHRII. 1 hit.
SUPFAMSSF56112. SSF56112. 1 hit.
PROSITEPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio364193.
PROQ8K592.
SOURCESearch...

Entry information

Entry nameAMHR2_MOUSE
AccessionPrimary (citable) accession number: Q8K592
Secondary accession number(s): Q0VDQ4
Entry history
Integrated into UniProtKB/Swiss-Prot: November 28, 2006
Last sequence update: November 28, 2006
Last modified: July 9, 2014
This is version 102 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

Human and mouse protein kinases

Human and mouse protein kinases: classification and index

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot