Reviewed, UniProtKB/Swiss-Prot Q8K592 (AMHR2_MOUSE)

Names and origin

Protein names

Recommended name:
    Anti-Muellerian hormone type-2 receptor
    EC=2.7.11.30
Alternative name(s):
    Anti-Muellerian hormone type II receptor
      Short name=AMH type II receptor
    MIS type II receptor
    MISRII
      Short name=MRII

Gene names

Name:

Amhr2

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	568 AA.
Sequence status	Complete.
Sequence processing	The displayed sequence is further processed into a mature form.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	On ligand binding, forms a receptor complex consisting of two type II and two type I transmembrane serine/threonine kinases. Type II receptors phosphorylate and activate type I receptors which autophosphorylate, then bind and activate SMAD transcriptional regulators. Receptor for anti-Muellerian hormone.
Catalytic activity	ATP + [receptor-protein] = ADP + [receptor-protein] phosphate.
Cofactor	Magnesium or manganese By similarity.
Subcellular location	Membrane; Single-pass type I membrane proteinBy similarity.
Sequence similarities	Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. Contains 1 protein kinase domain.

Ontologies

Keywords
Cellular component	Membrane
Domain	Signal Transmembrane
Ligand	ATP-binding Magnesium Manganese Metal-binding Nucleotide-binding
Molecular function	Kinase Receptor Serine/threonine-protein kinase Transferase
PTM	Glycoprotein
Gene Ontology (GO)
Biological process	sex differentiation Inferred from mutant phenotype. Source: MGI transforming growth factor beta receptor signaling pathway Traceable author statement. Source: MGI
Cellular component	integral to plasma membrane Traceable author statement. Source: MGI
Molecular function	hormone binding Inferred from sequence or structural similarity. Source: UniProtKB transforming growth factor beta receptor activity Traceable author statement. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view
Molecule processing
	Signal peptide	1 – 15	15	Potential
	Chain	16 – 568	553	Anti-Muellerian hormone type-2 receptor
Regions
	Topological domain	16 – 147	132	Extracellular Potential
	Transmembrane	148 – 168	21	Potential
	Topological domain	169 – 568	400	Cytoplasmic Potential
	Domain	199 – 504	306	Protein kinase
	Nucleotide binding	205 – 213	9	ATP By similarity
Sites
	Active site	329	1	Proton acceptor By similarity
	Binding site	226	1	ATP By similarity
Amino acid modifications
	Glycosylation	66	1	N-linked (GlcNAc...) Potential
	Glycosylation	119	1	N-linked (GlcNAc...) Potential
Experimental info
	Sequence conflict	240	1	R → G in AAM28608. Ref.1

Sequences

	Sequence		Length	Mass (Da)
	Q8K592-1 [UniParc]. Last modified November 28, 2006. Version 2. Checksum: AE89AA1727600E5E	FASTA	568	61,195
	10 20 30 40 50 60 MLGTLGLWTL LPAAAQVSPN RRTCVFFEAP GVRGSTKTLG EMVDAGPGPP KGIRCLYSHC 70 80 90 100 110 120 CFGIWNLTHG RAQVEMQGCR DSDEPGCESL HCDPVPRAHP NPSSTLFTCS CGTDFCNANY 130 140 150 160 170 180 SHLPPSGNQG APGPQEPQAT PGGPVWMALL LLGMFLVLLL SSIILALLQR KACRVQGGSD 190 200 210 220 230 240 PEPGSGGDCS EELPELAELR FSQVIQEGGH AVVWAGRLQG EMVAIKAFPP RAVAQFRAER 250 260 270 280 290 300 AVYQLLGLQH DHIVRFITAG QGGPGPLPSG PLLVLELYPK GSLCHYLTQY TSDWGSSLRM 310 320 330 340 350 360 ALSLAEGLAF LHEERWQDGQ YKPGIAHRDL SSQNVLIRED RSCAIGDLGL ALVLPGLAQP 370 380 390 400 410 420 PALAPTQPRG PAAILEAGTQ RYMAPELLDK TLDLQDWGTA LQRADVYSLA LLLWEILSRC 430 440 450 460 470 480 SDLRPDHRPP PFQLAYEAEL GSNPSACELW ALAVEERKRP NIPSTWSCSA TDPRGLRELL 490 500 510 520 530 540 EDCWDADPEA RLTAECVQQR LAALAYPHGA SSFPESPQGC PENCLSAPAS AVFPCRPQQS 550 560 SCLLSVQQGP GSRSPDPVGD TVQVYVNE

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Sequence, genomic organization, and chromosomal location of the mouse Muellerian-inhibiting substance type II receptor gene." Mishina Y., Tizard R., Deng J.M., Pathak B.G., Copeland N.G., Jenkins N.A., Cate R.L., Behringer R.R. Biochem. Biophys. Res. Commun. 237:741-746(1997) [PubMed: 9299437] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
[2]	"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)." The MGC Project Team Genome Res. 14:2121-2127(2004) [PubMed: 15489334] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBLGenBankDDBJ	AF503863 mRNA. Translation: AAM28608.1. BC119571 mRNA. Translation: AAI19572.1.
PIR	JC5629.
RefSeq	NP_653130.1.
UniGene	Mm.60331
3D structure databases
HSSP	HSSP built from PDB template 1IAS based on UniProtKB P36897.
ModBase	Search...
Genome annotation databases
Ensembl	ENSMUSG00000023047. Mus musculus. [Contig view]
GeneID	110542.
KEGG	mmu:110542.
NMPDR	fig|10090.3.peg.30707.
Organism-specific databases
MGI	MGI:105062. Amhr2.
Phylogenomic databases
HOVERGEN	Q8K592.
Gene expression databases
ArrayExpress	Q8K592.
CleanEx	MM_AMHR2.
GermOnline	ENSMUSG00000023047. Mus musculus.
Family and domain databases
InterPro	IPR017193. Anti-muellerian_hrmn_rcpt_II. IPR015771. Anti-muellerian_hrmn_rcpt_II_C. IPR000719. Prot_kinase_core. IPR017441. Protein_kinase_ATP_bd_CS. IPR017442. Se/Thr_pkinase-rel. IPR008271. Ser_thr_pkin_AS. [Graphical view]
PANTHER	PTHR23255:SF4. MIS_II_R. 1 hit.
Pfam	PF00069. Pkinase. 1 hit. [Graphical view]
PIRSF	PIRSF037392. AMHRII. 1 hit.
ProDom	PD000001. Prot_kinase. 1 hit. [Graphical view] [Entries sharing at least one domain]
PROSITE	PS00107. PROTEIN_KINASE_ATP. False negative. PS50011. PROTEIN_KINASE_DOM. 1 hit. PS00108. PROTEIN_KINASE_ST. False negative. [Graphical view]
BLOCKS	Search...
Other Resources
SOURCE	Search...
ProtoNet	Search...

Entry information

Entry name

AMHR2_MOUSE

Accession

Primary (citable) accession number: Q8K592
Secondary accession number(s): Q0VDQ4

Entry history

Integrated into UniProtKB/Swiss-Prot:	November 28, 2006
Last sequence update:	November 28, 2006
Last modified:	July 22, 2008
This is version 49 of the entry and version 2 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)