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Protein

Bcl-2-modifying factor

Gene

Bmf

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May play a role in apoptosis.

GO - Biological processi

Complete GO annotation...

Keywords - Biological processi

Apoptosis

Enzyme and pathway databases

ReactomeiR-RNO-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-RNO-139910. Activation of BMF and translocation to mitochondria.

Names & Taxonomyi

Protein namesi
Recommended name:
Bcl-2-modifying factor
Gene namesi
Name:Bmf
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 3

Organism-specific databases

RGDi628658. Bmf.

Subcellular locationi

GO - Cellular componenti

  • acrosomal vesicle Source: RGD
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 185185Bcl-2-modifying factorPRO_0000143113Add
BLAST

Proteomic databases

PaxDbiQ8K589.

Expressioni

Gene expression databases

GenevisibleiQ8K589. RN.

Interactioni

Subunit structurei

Interacts with MCL1, BCL2, BCL2L1/BCL-Xl, BCL2A1 and BCL2L2/BCL-w. Interacts with the myosin V actin motor complex through its binding to DLC2 (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010381.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni67 – 759Interaction with DLC2

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi134 – 14815BH3Add
BLAST

Sequence similaritiesi

Belongs to the Bcl-2 family.Curated

Phylogenomic databases

eggNOGiENOG410IHFT. Eukaryota.
ENOG410YIXY. LUCA.
GeneTreeiENSGT00390000017896.
HOGENOMiHOG000231996.
HOVERGENiHBG050697.
InParanoidiQ8K589.
KOiK17460.
OMAiFHRLHMQ.
OrthoDBiEOG7QRQW6.
PhylomeDBiQ8K589.

Family and domain databases

InterProiIPR028192. BMF.
[Graphical view]
PANTHERiPTHR32014. PTHR32014. 1 hit.
PfamiPF15185. BMF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K589-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEPPQCVEEL EDDVFQPEDG EPGTQPGSLL SADLFAQSQL DCPLSRLQLF
60 70 80 90 100
PLTHCCGPGL RPVSQEDKAT QTLSPASPSQ GVMLPCGVTE EPQRLFYGNA
110 120 130 140 150
GYRLPLPASF PAGSALGEQP PEGQFLQHRA EVQIARKLQC IADQFHRLHM
160 170 180
QQHQQNRDRA WRQVFLFLQN LALNRRENRE GVGPW
Length:185
Mass (Da):20,710
Last modified:October 1, 2002 - v1
Checksum:iA8F8D9FF10AD15B4
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506761 mRNA. Translation: AAM28890.1.
RefSeqiNP_640351.1. NM_139258.1.
UniGeneiRn.213264.

Genome annotation databases

EnsembliENSRNOT00000010381; ENSRNOP00000010381; ENSRNOG00000007529.
GeneIDi246142.
KEGGirno:246142.
UCSCiRGD:628658. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF506761 mRNA. Translation: AAM28890.1.
RefSeqiNP_640351.1. NM_139258.1.
UniGeneiRn.213264.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000010381.

Proteomic databases

PaxDbiQ8K589.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000010381; ENSRNOP00000010381; ENSRNOG00000007529.
GeneIDi246142.
KEGGirno:246142.
UCSCiRGD:628658. rat.

Organism-specific databases

CTDi90427.
RGDi628658. Bmf.

Phylogenomic databases

eggNOGiENOG410IHFT. Eukaryota.
ENOG410YIXY. LUCA.
GeneTreeiENSGT00390000017896.
HOGENOMiHOG000231996.
HOVERGENiHBG050697.
InParanoidiQ8K589.
KOiK17460.
OMAiFHRLHMQ.
OrthoDBiEOG7QRQW6.
PhylomeDBiQ8K589.

Enzyme and pathway databases

ReactomeiR-RNO-111453. BH3-only proteins associate with and inactivate anti-apoptotic BCL-2 members.
R-RNO-139910. Activation of BMF and translocation to mitochondria.

Miscellaneous databases

NextBioi623401.
PROiQ8K589.

Gene expression databases

GenevisibleiQ8K589. RN.

Family and domain databases

InterProiIPR028192. BMF.
[Graphical view]
PANTHERiPTHR32014. PTHR32014. 1 hit.
PfamiPF15185. BMF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Bcl-2-related protein family gene expression during oligodendroglial differentiation."
    Itoh T., Itoh A., Pleasure D.
    J. Neurochem. 85:1500-1512(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiBMF_RAT
AccessioniPrimary (citable) accession number: Q8K589
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 21, 2004
Last sequence update: October 1, 2002
Last modified: May 11, 2016
This is version 71 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.