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Protein

tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

Gene

Dus1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79FMNBy similarity1
Active sitei108Proton donorBy similarity1
Binding sitei147FMNBy similarity1
Binding sitei175FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 25FMNBy similarity3
Nucleotide bindingi208 – 210FMNBy similarity3
Nucleotide bindingi232 – 233FMNBy similarity2

GO - Molecular functioni

Keywordsi

Molecular functionOxidoreductase
Biological processtRNA processing
LigandFlavoprotein, FMN

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC:1.3.1.-)
Alternative name(s):
Liver regeneration-related protein LRRG08/LRRG09
tRNA-dihydrouridine synthase 1-like
Gene namesi
Name:Dus1l
Synonyms:Pp3111
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708389 Dus1l

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472281 – 438tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-likeAdd BLAST438

Proteomic databases

PaxDbiQ8K582

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067257

Structurei

3D structure databases

ProteinModelPortaliQ8K582
SMRiQ8K582
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family. Dus1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2335 Eukaryota
COG0042 LUCA
HOVERGENiHBG061241
InParanoidiQ8K582
KOiK05542
PhylomeDBiQ8K582

Family and domain databases

CDDicd02801 DUS_like_FMN, 1 hit
Gene3Di3.20.20.70, 1 hit
InterProiView protein in InterPro
IPR013785 Aldolase_TIM
IPR035587 DUS-like_FMN-bd
IPR001269 tRNA_hU_synthase
IPR018517 tRNA_hU_synthase_CS
PANTHERiPTHR11082 PTHR11082, 1 hit
PfamiView protein in Pfam
PF01207 Dus, 1 hit
PROSITEiView protein in PROSITE
PS01136 UPF0034, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLQGFEFW SRALGGARHV VAPMVDQSEL AWRLLSRRHG AQLCYTPMLH
60 70 80 90 100
AQVFVRDANY RKENLYCDVC PEDRPLIVQF CANDPEVFVQ AALLAQDYCD
110 120 130 140 150
AIDLNLGCPQ MIAKRGRYGA FLQEEWDLLQ RMILLAHERL SVPVTCKIRV
160 170 180 190 200
FPEIDKTVRY AQMLEKAGCQ LLTVHGRTKE QKGPMAGTAS WEHIKAVRKA
210 220 230 240 250
VGIPVFANGN IRCLQDVERC IQDTGVQGVM SAEGNLHNPA LFEGRSPAVW
260 270 280 290 300
ELADEYLDIV RQHPCPLSYV RAHLFKLWHH TLQVHQQLRE ELAKVKTLEG
310 320 330 340 350
VAAVSQALKL RCQEDMARQQ EGVRPADNLP AFHWICQPYI RPGPKEGSKE
360 370 380 390 400
NSSGRSKRAL EEEEGSMEGL SKNKLKKQLR NPHKTFDPSL KPKYAKCDQC
410 420 430
GNPKGNRCVF NLCRGCCKKR AFRETADCPG HDCFLRPN
Length:438
Mass (Da):49,709
Last modified:October 1, 2002 - v1
Checksum:i9C13F8681D3BD194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508021 mRNA Translation: AAM34683.1
AY327509 mRNA Translation: AAP97740.1
AY327510 mRNA Translation: AAP97741.1
RefSeqiNP_742015.1, NM_172018.1
UniGeneiRn.179335

Genome annotation databases

GeneIDi246185
KEGGirno:246185

Similar proteinsi

Entry informationi

Entry nameiDUS1L_RAT
AccessioniPrimary (citable) accession number: Q8K582
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 76 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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