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Protein

tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like

Gene

Dus1l

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs.By similarity

Cofactori

FMNBy similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Binding sitei79FMNBy similarity1
Active sitei108Proton donorBy similarity1
Binding sitei147FMNBy similarity1
Binding sitei175FMNBy similarity1

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi23 – 25FMNBy similarity3
Nucleotide bindingi208 – 210FMNBy similarity3
Nucleotide bindingi232 – 233FMNBy similarity2

GO - Molecular functioni

Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Biological processi

tRNA processing

Keywords - Ligandi

Flavoprotein, FMN

Names & Taxonomyi

Protein namesi
Recommended name:
tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-like (EC:1.3.1.-)
Alternative name(s):
Liver regeneration-related protein LRRG08/LRRG09
tRNA-dihydrouridine synthase 1-like
Gene namesi
Name:Dus1l
Synonyms:Pp3111
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708389. Dus1l.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002472281 – 438tRNA-dihydrouridine(16/17) synthase [NAD(P)(+)]-likeAdd BLAST438

Proteomic databases

PaxDbiQ8K582.
PRIDEiQ8K582.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067257.

Structurei

3D structure databases

ProteinModelPortaliQ8K582.
SMRiQ8K582.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the Dus family. Dus1 subfamily.Curated

Phylogenomic databases

eggNOGiKOG2335. Eukaryota.
COG0042. LUCA.
HOVERGENiHBG061241.
InParanoidiQ8K582.
KOiK05542.
PhylomeDBiQ8K582.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K582-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPKLQGFEFW SRALGGARHV VAPMVDQSEL AWRLLSRRHG AQLCYTPMLH
60 70 80 90 100
AQVFVRDANY RKENLYCDVC PEDRPLIVQF CANDPEVFVQ AALLAQDYCD
110 120 130 140 150
AIDLNLGCPQ MIAKRGRYGA FLQEEWDLLQ RMILLAHERL SVPVTCKIRV
160 170 180 190 200
FPEIDKTVRY AQMLEKAGCQ LLTVHGRTKE QKGPMAGTAS WEHIKAVRKA
210 220 230 240 250
VGIPVFANGN IRCLQDVERC IQDTGVQGVM SAEGNLHNPA LFEGRSPAVW
260 270 280 290 300
ELADEYLDIV RQHPCPLSYV RAHLFKLWHH TLQVHQQLRE ELAKVKTLEG
310 320 330 340 350
VAAVSQALKL RCQEDMARQQ EGVRPADNLP AFHWICQPYI RPGPKEGSKE
360 370 380 390 400
NSSGRSKRAL EEEEGSMEGL SKNKLKKQLR NPHKTFDPSL KPKYAKCDQC
410 420 430
GNPKGNRCVF NLCRGCCKKR AFRETADCPG HDCFLRPN
Length:438
Mass (Da):49,709
Last modified:October 1, 2002 - v1
Checksum:i9C13F8681D3BD194
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508021 mRNA. Translation: AAM34683.1.
AY327509 mRNA. Translation: AAP97740.1.
AY327510 mRNA. Translation: AAP97741.1.
RefSeqiNP_742015.1. NM_172018.1.
UniGeneiRn.179335.

Genome annotation databases

GeneIDi246185.
KEGGirno:246185.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508021 mRNA. Translation: AAM34683.1.
AY327509 mRNA. Translation: AAP97740.1.
AY327510 mRNA. Translation: AAP97741.1.
RefSeqiNP_742015.1. NM_172018.1.
UniGeneiRn.179335.

3D structure databases

ProteinModelPortaliQ8K582.
SMRiQ8K582.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000067257.

Proteomic databases

PaxDbiQ8K582.
PRIDEiQ8K582.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246185.
KEGGirno:246185.

Organism-specific databases

CTDi64118.
RGDi708389. Dus1l.

Phylogenomic databases

eggNOGiKOG2335. Eukaryota.
COG0042. LUCA.
HOVERGENiHBG061241.
InParanoidiQ8K582.
KOiK05542.
PhylomeDBiQ8K582.

Miscellaneous databases

PROiQ8K582.

Family and domain databases

Gene3Di3.20.20.70. 1 hit.
InterProiIPR013785. Aldolase_TIM.
IPR001269. tRNA_hU_synthase.
IPR018517. tRNA_hU_synthase_CS.
[Graphical view]
PfamiPF01207. Dus. 1 hit.
[Graphical view]
PROSITEiPS01136. UPF0034. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDUS1L_RAT
AccessioniPrimary (citable) accession number: Q8K582
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2006
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 70 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.