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Protein

Checkpoint protein HUS1B

Gene

Hus1b

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Checkpoint protein HUS1B
Short name:
mHUS1B
Gene namesi
Name:Hus1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 13

Organism-specific databases

MGIiMGI:2671003. Hus1b.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 276276Checkpoint protein HUS1BPRO_0000226246Add
BLAST

Proteomic databases

PaxDbiQ8K572.
PRIDEiQ8K572.

PTM databases

PhosphoSiteiQ8K572.

Expressioni

Gene expression databases

BgeeiENSMUSG00000076430.
CleanExiMM_HUS1B.
ExpressionAtlasiQ8K572. baseline and differential.

Interactioni

Subunit structurei

Interacts with RAD1 and RAD9B.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100007.

Structurei

3D structure databases

ProteinModelPortaliQ8K572.
SMRiQ8K572. Positions 1-275.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the HUS1 family.Curated

Phylogenomic databases

eggNOGiKOG3999. Eukaryota.
ENOG410ZQ9J. LUCA.
GeneTreeiENSGT00390000000706.
HOGENOMiHOG000253011.
HOVERGENiHBG053069.
InParanoidiQ8K572.
KOiK10996.
OMAiQVRVDNR.
OrthoDBiEOG091G0H06.
PhylomeDBiQ8K572.
TreeFamiTF314491.

Family and domain databases

InterProiIPR016580. Cell_cycle_HUS1.
IPR007150. Hus1/Mec3.
[Graphical view]
PfamiPF04005. Hus1. 1 hit.
[Graphical view]
PIRSFiPIRSF011312. Cell_cycle_HUS1. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K572-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MRFRARITSK RFIELFIQVS STVAKLAKVC VLRVCPDRLY FCPMGLLGEA
60 70 80 90 100
QLWGEMRRDV FHHFCMEGAS QEFNEICLEL MSEHLARAVK NAGNASSLKL
110 120 130 140 150
QLTNKQRPCL TLVVELASCP GHTRAVVHDL PVRVLPRRRW KDCTEPHVRG
160 170 180 190 200
SDVSVYLPAL KTLKNMVERM ANVGSHVLVE ANLNGRMNLT VETDRVTIKS
210 220 230 240 250
YFKNLGNPPN AVLCMSQGRD PETMVQVRVD NRKLLQCFDG HQINPTMALC
260 270
NILSNTLLHL VLVHEDISLQ YFIPAS
Length:276
Mass (Da):31,251
Last modified:October 1, 2002 - v1
Checksum:i4C4A0E326DE4A963
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508546 mRNA. Translation: AAM28903.1.
AL606764 Genomic DNA. Translation: CAI25613.1.
CCDSiCCDS26421.1.
RefSeqiNP_694712.1. NM_153072.2.
UniGeneiMm.450571.

Genome annotation databases

EnsembliENSMUST00000102943; ENSMUSP00000100007; ENSMUSG00000076430.
GeneIDi210554.
KEGGimmu:210554.
UCSCiuc007pzf.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF508546 mRNA. Translation: AAM28903.1.
AL606764 Genomic DNA. Translation: CAI25613.1.
CCDSiCCDS26421.1.
RefSeqiNP_694712.1. NM_153072.2.
UniGeneiMm.450571.

3D structure databases

ProteinModelPortaliQ8K572.
SMRiQ8K572. Positions 1-275.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000100007.

PTM databases

PhosphoSiteiQ8K572.

Proteomic databases

PaxDbiQ8K572.
PRIDEiQ8K572.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102943; ENSMUSP00000100007; ENSMUSG00000076430.
GeneIDi210554.
KEGGimmu:210554.
UCSCiuc007pzf.2. mouse.

Organism-specific databases

CTDi135458.
MGIiMGI:2671003. Hus1b.

Phylogenomic databases

eggNOGiKOG3999. Eukaryota.
ENOG410ZQ9J. LUCA.
GeneTreeiENSGT00390000000706.
HOGENOMiHOG000253011.
HOVERGENiHBG053069.
InParanoidiQ8K572.
KOiK10996.
OMAiQVRVDNR.
OrthoDBiEOG091G0H06.
PhylomeDBiQ8K572.
TreeFamiTF314491.

Miscellaneous databases

PROiQ8K572.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000076430.
CleanExiMM_HUS1B.
ExpressionAtlasiQ8K572. baseline and differential.

Family and domain databases

InterProiIPR016580. Cell_cycle_HUS1.
IPR007150. Hus1/Mec3.
[Graphical view]
PfamiPF04005. Hus1. 1 hit.
[Graphical view]
PIRSFiPIRSF011312. Cell_cycle_HUS1. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiHUS1B_MOUSE
AccessioniPrimary (citable) accession number: Q8K572
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 7, 2006
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.