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Protein

Trem-like transcript 1 protein

Gene

Treml1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Cell surface receptor that may play a role in the innate and adaptive immune response.1 Publication

GO - Molecular functioni

  • receptor activity Source: MGI

GO - Biological processi

  • calcium-mediated signaling Source: MGI
  • negative regulation of signal transduction Source: MGI
  • platelet activation Source: UniProtKB
  • wound healing Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
Trem-like transcript 1 protein
Short name:
TLT-1
Alternative name(s):
Triggering receptor expressed on myeloid cells-like protein 1
Gene namesi
Name:Treml1
Synonyms:Tlt1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 17

Organism-specific databases

MGIiMGI:1918576. Treml1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 175155ExtracellularSequence analysisAdd
BLAST
Transmembranei176 – 19621HelicalSequence analysisAdd
BLAST
Topological domaini197 – 317121CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • cell surface Source: UniProtKB
  • integral component of membrane Source: UniProtKB-KW
  • plasma membrane Source: UniProtKB-SubCell
  • platelet alpha granule Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020Sequence analysisAdd
BLAST
Chaini21 – 317297Trem-like transcript 1 proteinPRO_0000253856Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi39 ↔ 105By similarity
Disulfide bondi53 ↔ 60By similarity
Lipidationi208 – 2081S-palmitoyl cysteineBy similarity
Modified residuei283 – 2831PhosphoserineCombined sources

Post-translational modificationi

Phosphorylated on tyrosine residues.1 Publication

Keywords - PTMi

Disulfide bond, Lipoprotein, Palmitate, Phosphoprotein

Proteomic databases

MaxQBiQ8K558.
PaxDbiQ8K558.
PeptideAtlasiQ8K558.
PRIDEiQ8K558.

PTM databases

iPTMnetiQ8K558.
PhosphoSiteiQ8K558.

Expressioni

Tissue specificityi

Highly expressed in bone marrow leukocytes, splenic megakaryocytes and platelets. Detected in brain, liver and in peritoneal monocytes.2 Publications

Gene expression databases

BgeeiQ8K558.
GenevisibleiQ8K558. MM.

Interactioni

Subunit structurei

When phosphorylated, interacts with PTPN11 (By similarity). When phosphorylated, interacts with PTPN6.By similarity1 Publication

Protein-protein interaction databases

IntActiQ8K558. 1 interaction.
MINTiMINT-8013457.
STRINGi10090.ENSMUSP00000024792.

Structurei

3D structure databases

ProteinModelPortaliQ8K558.
SMRiQ8K558. Positions 22-126.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini21 – 122102Ig-like V-typeAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi284 – 2907ITIM

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi245 – 27531Pro-richAdd
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IKSQ. Eukaryota.
ENOG411182M. LUCA.
GeneTreeiENSGT00470000042300.
HOGENOMiHOG000154685.
HOVERGENiHBG094092.
InParanoidiQ8K558.
KOiK14363.
OMAiCHYRLQD.
OrthoDBiEOG7ZD1W6.
PhylomeDBiQ8K558.
TreeFamiTF337145.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.

Sequences (2)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 2 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K558-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MDCYLLLLLL LLGLAGQGSA DSHPEVLQAP VGSSILVQCH YRLQDVRALK
60 70 80 90 100
VWCQFLQEGC HPLVTSAVDR RAPGNGRIFL TDLGGGLLQV EMVTLQEEDT
110 120 130 140 150
GEYGCVVEGA AGPQTLHRVS LLVLPPVPGP REGEEAEDEK ETYRIGTGSL
160 170 180 190 200
LEDPSLDPSA SAGPHEFRRR ENSIPLIWGA VLLLALVVVA VVIFAVMARK
210 220 230 240 250
KGNRLVVCGP SQSTGVPGMD PPSAAHRSSD SGLPSDIPHV RLDSPPSFDS
260 270 280 290 300
IYTGSSLDPP SSEPPAPPSQ PPLPPKVLMS SKSVTYATVV FPGGDKGKIA
310
SCEPVQDPPN SQTPPSK
Length:317
Mass (Da):33,522
Last modified:October 17, 2006 - v2
Checksum:i097E16B34D03E87B
GO
Isoform 2 (identifier: Q8K558-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     173-173: S → RCQKQC

Show »
Length:322
Mass (Da):34,182
Checksum:i64E06AA0F2AAF34F
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei173 – 1731S → RCQKQC in isoform 2. 1 PublicationVSP_021127

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078502 mRNA. Translation: AAL85488.1.
AY286071 mRNA. Translation: AAP33393.1.
AK017256 mRNA. Translation: BAB30655.1.
BC138399 mRNA. Translation: AAI38400.1.
CCDSiCCDS28866.1. [Q8K558-2]
RefSeqiNP_001276380.1. NM_001289451.1.
NP_001276386.1. NM_001289457.1. [Q8K558-1]
NP_082039.1. NM_027763.2. [Q8K558-2]
UniGeneiMm.90177.

Genome annotation databases

EnsembliENSMUST00000024792; ENSMUSP00000024792; ENSMUSG00000023993. [Q8K558-2]
GeneIDi71326.
KEGGimmu:71326.
UCSCiuc008cxm.2. mouse. [Q8K558-2]
uc008cxn.2. mouse. [Q8K558-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY078502 mRNA. Translation: AAL85488.1.
AY286071 mRNA. Translation: AAP33393.1.
AK017256 mRNA. Translation: BAB30655.1.
BC138399 mRNA. Translation: AAI38400.1.
CCDSiCCDS28866.1. [Q8K558-2]
RefSeqiNP_001276380.1. NM_001289451.1.
NP_001276386.1. NM_001289457.1. [Q8K558-1]
NP_082039.1. NM_027763.2. [Q8K558-2]
UniGeneiMm.90177.

3D structure databases

ProteinModelPortaliQ8K558.
SMRiQ8K558. Positions 22-126.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K558. 1 interaction.
MINTiMINT-8013457.
STRINGi10090.ENSMUSP00000024792.

PTM databases

iPTMnetiQ8K558.
PhosphoSiteiQ8K558.

Proteomic databases

MaxQBiQ8K558.
PaxDbiQ8K558.
PeptideAtlasiQ8K558.
PRIDEiQ8K558.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000024792; ENSMUSP00000024792; ENSMUSG00000023993. [Q8K558-2]
GeneIDi71326.
KEGGimmu:71326.
UCSCiuc008cxm.2. mouse. [Q8K558-2]
uc008cxn.2. mouse. [Q8K558-1]

Organism-specific databases

CTDi340205.
MGIiMGI:1918576. Treml1.

Phylogenomic databases

eggNOGiENOG410IKSQ. Eukaryota.
ENOG411182M. LUCA.
GeneTreeiENSGT00470000042300.
HOGENOMiHOG000154685.
HOVERGENiHBG094092.
InParanoidiQ8K558.
KOiK14363.
OMAiCHYRLQD.
OrthoDBiEOG7ZD1W6.
PhylomeDBiQ8K558.
TreeFamiTF337145.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

PROiQ8K558.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K558.
GenevisibleiQ8K558. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
[Graphical view]
SMARTiSM00409. IG. 1 hit.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 1 hit.
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Initial characterization of TREM-like transcript (TLT)-1: a putative inhibitory receptor within the TREM cluster."
    Washington A.V., Quigley L., McVicar D.W.
    Blood 100:3822-3824(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, PHOSPHORYLATION, INTERACTION WITH PTPN6, TISSUE SPECIFICITY.
    Strain: C57BL/6J.
    Tissue: Bone marrow.
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: C57BL/6J.
    Tissue: Head.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Tissue: Brain.
  4. "A TREM family member, TLT-1, is found exclusively in the alpha-granules of megakaryocytes and platelets."
    Washington A.V., Schubert R.L., Quigley L., Disipio T., Feltz R., Cho E.H., McVicar D.W.
    Blood 104:1042-1047(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION, TISSUE SPECIFICITY.
  5. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  6. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-283, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Lung and Spleen.

Entry informationi

Entry nameiTRML1_MOUSE
AccessioniPrimary (citable) accession number: Q8K558
Secondary accession number(s): B2RRH0, Q9D3N6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: October 17, 2006
Last modified: July 6, 2016
This is version 89 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.