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Protein

One cut domain family member 3

Gene

Onecut3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR.1 Publication

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
DNA bindingi309 – 395CUTPROSITE-ProRule annotationAdd BLAST87
DNA bindingi411 – 470HomeoboxPROSITE-ProRule annotationAdd BLAST60

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionActivator, DNA-binding
Biological processTranscription, Transcription regulation

Enzyme and pathway databases

ReactomeiR-MMU-210744. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
R-MMU-210747. Regulation of gene expression in early pancreatic precursor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 3
Alternative name(s):
One cut homeobox 3
Transcription factor ONECUT-3
Short name:
OC-3
Gene namesi
Name:Onecut3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1891409. Onecut3.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002712191 – 490One cut domain family member 3Add BLAST490

Proteomic databases

MaxQBiQ8K557.
PaxDbiQ8K557.
PRIDEiQ8K557.

PTM databases

PhosphoSitePlusiQ8K557.

Expressioni

Tissue specificityi

Specifically expressed in brain, stomach and gut. Within the gut, expressed only in duodenum and jejunum.1 Publication

Developmental stagei

Expressed in the endoderm from the 14-somite stage. Aroound E9.5, present in the ventral prepancreatic and prehepatic regions (at protein level). At E14.5, expressed in brain, stomach and gut.2 Publications

Inductioni

Transcriptionally regulated by ONECUT1 in the developing endoderm.1 Publication

Gene expression databases

BgeeiENSMUSG00000045518.
CleanExiMM_ONECUT3.
GenevisibleiQ8K557. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053288.

Structurei

3D structure databases

ProteinModelPortaliQ8K557.
SMRiQ8K557.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Compositional biasi42 – 102Gly-richAdd BLAST61
Compositional biasi136 – 238Pro-richAdd BLAST103
Compositional biasi253 – 312Gly-richAdd BLAST60

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiQ8K557.
OMAiAMTMSCD.
OrthoDBiEOG091G0E7H.
PhylomeDBiQ8K557.
TreeFamiTF318206.

Family and domain databases

CDDicd00086. homeodomain. 1 hit.
InterProiView protein in InterPro
IPR003350. CUT_dom.
IPR009057. Homeobox-like.
IPR001356. Homeobox_dom.
IPR010982. Lambda_DNA-bd_dom.
PfamiView protein in Pfam
PF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
SMARTiView protein in SMART
SM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiView protein in PROSITE
PS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSLESLGG LHGVTHAQAG ELLSPGHARS AAAQHRSLVA SGRPGLVAGM
60 70 80 90 100
ASLLDGGGAG GGGAGGAGAA GAAGGGPDFR GELAGPLHPA MGMACEAPGL
110 120 130 140 150
GGTYTTLTPL QHLPPLAAVA DKFHQHAVAG AHGGHPHAHP HPATAPPPPP
160 170 180 190 200
PQRLAASVSG SFTLMRDERA ALASVGHLYG PYGKELPTMG SPLSPLPSAL
210 220 230 240 250
PPALHSAPQP PPPPPLAAYG APGHLAGDKL LPPAAFEPHA ALLGRAEDAL
260 270 280 290 300
ARGLPGGGGG AGGGGAAGGA AAGLLAPLGG LAAAGAHGPH SGGGGPGGGG
310 320 330 340 350
GAGGGSGGPG AGAAAEEINT KEVAQRITAE LKRYSIPQAI FAQRILCRSQ
360 370 380 390 400
GTLSDLLRNP KPWSKLKSGR ETFRRMWKWL QEPEFQRMSA LRLAACKRKE
410 420 430 440 450
QDQQKERALQ PKKQRLVFTD LQRRTLIAIF KENKRPSKEM QATISQQLGL
460 470 480 490
ELNTVSNFFM NARRRCMNRW AEEPGATPGT GTATATFSKA
Length:490
Mass (Da):49,571
Last modified:January 9, 2007 - v2
Checksum:iD9030944CED1BA06
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti64A → R in AAL86921 (PubMed:11944891).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY080897 mRNA. Translation: AAL86921.1.
BC058700 mRNA. Translation: AAH58700.1.
CCDSiCCDS24023.1.
RefSeqiNP_631972.2. NM_139226.3.
UniGeneiMm.250572.

Genome annotation databases

EnsembliENSMUST00000051773; ENSMUSP00000053288; ENSMUSG00000045518.
GeneIDi246086.
KEGGimmu:246086.
UCSCiuc007gdn.1. mouse.

Similar proteinsi

Entry informationi

Entry nameiONEC3_MOUSE
AccessioniPrimary (citable) accession number: Q8K557
Secondary accession number(s): Q6PDH9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: September 27, 2017
This is version 115 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families