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Protein

One cut domain family member 3

Gene

Onecut3

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

Transcriptional activator. Binds the consensus DNA sequence 5'-DHWATTGAYTWWD-3' on a variety of gene promoters such as those of HNF3B and TTR.1 Publication

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
DNA bindingi309 – 39587CUTPROSITE-ProRule annotationAdd
BLAST
DNA bindingi411 – 47060HomeoboxPROSITE-ProRule annotationAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding

Enzyme and pathway databases

ReactomeiR-MMU-210744. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
R-MMU-210747. Regulation of gene expression in early pancreatic precursor cells.

Names & Taxonomyi

Protein namesi
Recommended name:
One cut domain family member 3
Alternative name(s):
One cut homeobox 3
Transcription factor ONECUT-3
Short name:
OC-3
Gene namesi
Name:Onecut3
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 10

Organism-specific databases

MGIiMGI:1891409. Onecut3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: Reactome
  • nucleus Source: GO_Central
  • transcription factor complex Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 490490One cut domain family member 3PRO_0000271219Add
BLAST

Proteomic databases

PaxDbiQ8K557.
PRIDEiQ8K557.

PTM databases

PhosphoSiteiQ8K557.

Expressioni

Tissue specificityi

Specifically expressed in brain, stomach and gut. Within the gut, expressed only in duodenum and jejunum.1 Publication

Developmental stagei

Expressed in the endoderm from the 14-somite stage. Aroound E9.5, present in the ventral prepancreatic and prehepatic regions (at protein level). At E14.5, expressed in brain, stomach and gut.2 Publications

Inductioni

Transcriptionally regulated by ONECUT1 in the developing endoderm.1 Publication

Gene expression databases

BgeeiENSMUSG00000045518.
CleanExiMM_ONECUT3.
GenevisibleiQ8K557. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053288.

Structurei

3D structure databases

ProteinModelPortaliQ8K557.
SMRiQ8K557. Positions 317-463.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi42 – 10261Gly-richAdd
BLAST
Compositional biasi136 – 238103Pro-richAdd
BLAST
Compositional biasi253 – 31260Gly-richAdd
BLAST

Sequence similaritiesi

Belongs to the CUT homeobox family.Curated
Contains 1 CUT DNA-binding domain.PROSITE-ProRule annotation
Contains 1 homeobox DNA-binding domain.PROSITE-ProRule annotation

Keywords - Domaini

Homeobox

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiQ8K557.
OMAiAHGPHGG.
OrthoDBiEOG091G0E7H.
PhylomeDBiQ8K557.
TreeFamiTF318206.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K557-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MELSLESLGG LHGVTHAQAG ELLSPGHARS AAAQHRSLVA SGRPGLVAGM
60 70 80 90 100
ASLLDGGGAG GGGAGGAGAA GAAGGGPDFR GELAGPLHPA MGMACEAPGL
110 120 130 140 150
GGTYTTLTPL QHLPPLAAVA DKFHQHAVAG AHGGHPHAHP HPATAPPPPP
160 170 180 190 200
PQRLAASVSG SFTLMRDERA ALASVGHLYG PYGKELPTMG SPLSPLPSAL
210 220 230 240 250
PPALHSAPQP PPPPPLAAYG APGHLAGDKL LPPAAFEPHA ALLGRAEDAL
260 270 280 290 300
ARGLPGGGGG AGGGGAAGGA AAGLLAPLGG LAAAGAHGPH SGGGGPGGGG
310 320 330 340 350
GAGGGSGGPG AGAAAEEINT KEVAQRITAE LKRYSIPQAI FAQRILCRSQ
360 370 380 390 400
GTLSDLLRNP KPWSKLKSGR ETFRRMWKWL QEPEFQRMSA LRLAACKRKE
410 420 430 440 450
QDQQKERALQ PKKQRLVFTD LQRRTLIAIF KENKRPSKEM QATISQQLGL
460 470 480 490
ELNTVSNFFM NARRRCMNRW AEEPGATPGT GTATATFSKA
Length:490
Mass (Da):49,571
Last modified:January 9, 2007 - v2
Checksum:iD9030944CED1BA06
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti64 – 641A → R in AAL86921 (PubMed:11944891).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY080897 mRNA. Translation: AAL86921.1.
BC058700 mRNA. Translation: AAH58700.1.
CCDSiCCDS24023.1.
RefSeqiNP_631972.2. NM_139226.3.
UniGeneiMm.250572.

Genome annotation databases

EnsembliENSMUST00000051773; ENSMUSP00000053288; ENSMUSG00000045518.
GeneIDi246086.
KEGGimmu:246086.
UCSCiuc007gdn.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AY080897 mRNA. Translation: AAL86921.1.
BC058700 mRNA. Translation: AAH58700.1.
CCDSiCCDS24023.1.
RefSeqiNP_631972.2. NM_139226.3.
UniGeneiMm.250572.

3D structure databases

ProteinModelPortaliQ8K557.
SMRiQ8K557. Positions 317-463.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000053288.

PTM databases

PhosphoSiteiQ8K557.

Proteomic databases

PaxDbiQ8K557.
PRIDEiQ8K557.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000051773; ENSMUSP00000053288; ENSMUSG00000045518.
GeneIDi246086.
KEGGimmu:246086.
UCSCiuc007gdn.1. mouse.

Organism-specific databases

CTDi390874.
MGIiMGI:1891409. Onecut3.

Phylogenomic databases

eggNOGiKOG2252. Eukaryota.
ENOG410YWY4. LUCA.
GeneTreeiENSGT00530000063019.
HOGENOMiHOG000232114.
HOVERGENiHBG005981.
InParanoidiQ8K557.
OMAiAHGPHGG.
OrthoDBiEOG091G0E7H.
PhylomeDBiQ8K557.
TreeFamiTF318206.

Enzyme and pathway databases

ReactomeiR-MMU-210744. Regulation of gene expression in late stage (branching morphogenesis) pancreatic bud precursor cells.
R-MMU-210747. Regulation of gene expression in early pancreatic precursor cells.

Miscellaneous databases

ChiTaRSiOnecut3. mouse.
PROiQ8K557.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045518.
CleanExiMM_ONECUT3.
GenevisibleiQ8K557. MM.

Family and domain databases

Gene3Di1.10.10.60. 1 hit.
1.10.260.40. 1 hit.
InterProiIPR003350. CUT_dom.
IPR001356. Homeobox_dom.
IPR009057. Homeodomain-like.
IPR010982. Lambda_DNA-bd_dom.
[Graphical view]
PfamiPF02376. CUT. 1 hit.
PF00046. Homeobox. 1 hit.
[Graphical view]
SMARTiSM01109. CUT. 1 hit.
SM00389. HOX. 1 hit.
[Graphical view]
SUPFAMiSSF46689. SSF46689. 1 hit.
SSF47413. SSF47413. 1 hit.
PROSITEiPS51042. CUT. 1 hit.
PS50071. HOMEOBOX_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiONEC3_MOUSE
AccessioniPrimary (citable) accession number: Q8K557
Secondary accession number(s): Q6PDH9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 9, 2007
Last sequence update: January 9, 2007
Last modified: September 7, 2016
This is version 107 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.