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Q8K4Z6

- GPC6A_MOUSE

UniProt

Q8K4Z6 - GPC6A_MOUSE

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Protein

G-protein coupled receptor family C group 6 member A

Gene
Gprc6a
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at protein leveli

Functioni

Receptor activated by amino acids with a preference for basic amino acids such as L-Lys, L-Arg and L-ornithine but also by small and polar amino acids. The L-alpha amino acids respond is augmented by divalent cations Ca2+ and Mg2+. Activated by extracellular calcium and osteocalin. Seems to act through a G(q)/G(11) and G(i)-coupled pathway. Mediates the non-genomic effects of androgens in multiple tissue. May coordinates nutritional and hormonal anabolic signals through the sensing of extracellular amino acids, osteocalcin, divalents ions and its responsiveness to anabolic steroids.4 Publications

GO - Molecular functioni

  1. G-protein coupled receptor activity Source: MGI

GO - Biological processi

  1. calcium-mediated signaling Source: MGI
  2. G-protein coupled receptor signaling pathway Source: MGI
  3. response to amino acid Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

G-protein coupled receptor, Receptor, Transducer

Enzyme and pathway databases

ReactomeiREACT_207651. G alpha (q) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
G-protein coupled receptor family C group 6 member A
Gene namesi
Name:Gprc6a
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 10

Organism-specific databases

MGIiMGI:2429498. Gprc6a.

Subcellular locationi

Cell membrane; Multi-pass membrane protein 1 Publication

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini21 – 594574Extracellular Reviewed predictionAdd
BLAST
Transmembranei595 – 61521Helical; Reviewed predictionAdd
BLAST
Topological domaini616 – 63015Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei631 – 65121Helical; Reviewed predictionAdd
BLAST
Topological domaini652 – 66918Extracellular Reviewed predictionAdd
BLAST
Transmembranei670 – 69021Helical; Reviewed predictionAdd
BLAST
Topological domaini691 – 70616Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei707 – 72721Helical; Reviewed predictionAdd
BLAST
Topological domaini728 – 75023Extracellular Reviewed predictionAdd
BLAST
Transmembranei751 – 77121Helical; Reviewed predictionAdd
BLAST
Topological domaini772 – 78413Cytoplasmic Reviewed predictionAdd
BLAST
Transmembranei785 – 80521Helical; Reviewed predictionAdd
BLAST
Topological domaini806 – 8127Extracellular Reviewed prediction
Transmembranei813 – 83321Helical; Reviewed predictionAdd
BLAST
Topological domaini834 – 92895Cytoplasmic Reviewed predictionAdd
BLAST

GO - Cellular componenti

  1. cell surface Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
  3. plasma membrane Source: UniProtKB
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

Pathology & Biotechi

Disruption phenotypei

Deficient mice shown normal body weight, an increased fat mass, decreased lean body, hyperglycemia and insulin resistance, proteinuria, renal calcium, phosphate wasting, impaired bone mineral density and defective testicular function.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2020 Reviewed predictionAdd
BLAST
Chaini21 – 928908G-protein coupled receptor family C group 6 member APRO_0000043197Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Glycosylationi332 – 3321N-linked (GlcNAc...) Reviewed prediction
Glycosylationi555 – 5551N-linked (GlcNAc...) Reviewed prediction
Glycosylationi567 – 5671N-linked (GlcNAc...) Reviewed prediction

Post-translational modificationi

N-glycosylated.1 Publication

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PRIDEiQ8K4Z6.

PTM databases

PhosphoSiteiQ8K4Z6.

Expressioni

Tissue specificityi

Expressed at high level in liver, lung, spleen and heart. Expressed at lower level in kidney, skeletal muscle and brain. Expressed in E7, E11, E15 and E17 embryos.2 Publications

Gene expression databases

BgeeiQ8K4Z6.
GenevestigatoriQ8K4Z6.

Interactioni

Subunit structurei

Homodimer; disulfide-linked.1 Publication

Protein-protein interaction databases

MINTiMINT-4997775.

Structurei

3D structure databases

ProteinModelPortaliQ8K4Z6.
SMRiQ8K4Z6. Positions 34-580, 584-846.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG295353.
GeneTreeiENSGT00750000117484.
HOGENOMiHOG000063697.
HOVERGENiHBG096042.
InParanoidiQ8K4Z6.
KOiK04622.
OMAiETHWAPV.
OrthoDBiEOG7DZ8J8.
PhylomeDBiQ8K4Z6.
TreeFamiTF331269.

Family and domain databases

InterProiIPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view]
PfamiPF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view]
PRINTSiPR00248. GPCRMGR.
SUPFAMiSSF53822. SSF53822. 1 hit.
PROSITEiPS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

This entry describes 3 isoformsi produced by alternative splicing. Align

Isoform 1 (identifier: Q8K4Z6-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MALLITVVTC FMIILDTSQS CHTPDDFVAI TSPGHIMIGG LFAIHEKMLS    50
SDDHPRRPQI QKCAGFEISV FLQTLAMIHS IEMINNSTLL SGVKLGYEIY 100
DTCTEVTAAM AATLRFLSKF NCSRETVVFQ CDYSSYMPRV KAVIGAGYSE 150
TSIAVSRMLN LQLMPQVSYE STAEILSDKI RFPSFLRTVP SDFYQTKAMA 200
HLIRQSGWNW IGAITTDDDY GRLALNTFAI QAAENNVCIA FKEVLPAFLS 250
DNTIEVRINQ TLEKIIAEAQ VNVIVVFLRK FHVFNLFTKA IERKISKIWI 300
ASDNWSTATK IITIPNVKKL GKVVGFAFRR GNTSSFHSFL QTLHMYPNDN 350
NKPLHEFAML VSACKYIKDG DLSQCISNYS QATLTYDTTK TIENHLFKRN 400
DFLWHYTEPG LIYSIQLAVF ALGHAIRDLC QARDCKKPNA FQPWELLAVL 450
KNVTFTDGRN SFHFDAHGDL NTGYDVVLWK ETNGLMTVTK MAEYDLQRDV 500
FITTNQETKH EFRKLKQILS KCSKECSPGQ MKKATGSQHS CCYECVSCPE 550
NHYSNETDMD HCLLCNNETH WAPVRSTTCF EKEVEYLDWD DSLALLLIAL 600
SLLGIAFVLA IGIIFTRNLK TPVVKSSGGL VVCYVMLICH ALNFASTGFF 650
IGEPQDFACK TRQTLFGVSF TLCVSCILTK SLKILLAFSF DPKLTMFLKC 700
LYRPVPIVLT CTGIQVVICT LWLVLAAPSV EENISLPRVI ILECEEGSAL 750
AFGTMLGYIT VLAFICFVFA FKGRKLPENY NEAKFLTFGM LIYFIAWITF 800
IPVYTTTFGK YLPAVEIIVI LISNYGILCC IFFPKCYIIL CKQKTNTKSA 850
FLQMVYNYSA HSVDSLALSH VSLDSTSYDT ATTNQSPGNK MTACQNDNHL 900
PAQVLPHTGT AKTIKASKTL RQKRSSSI 928
Length:928
Mass (Da):104,213
Last modified:October 1, 2002 - v1
Checksum:iD670E3FEC700BD9B
GO
Isoform 2 (identifier: Q8K4Z6-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     271-445: Missing.

Show »
Length:753
Mass (Da):83,999
Checksum:iB9ADC85A644F2CD1
GO
Isoform 3 (identifier: Q8K4Z6-3) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     446-516: Missing.

Show »
Length:857
Mass (Da):95,968
Checksum:iAF97BC4E8F20E7F7
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei271 – 445175Missing in isoform 2. VSP_016456Add
BLAST
Alternative sequencei446 – 51671Missing in isoform 3. VSP_016457Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY735399 mRNA. Translation: AAW68012.1.
AY735400 mRNA. Translation: AAW68013.1.
AY735401 mRNA. Translation: AAW68014.1.
AY101365 mRNA. Translation: AAM22280.1.
BC108998 mRNA. Translation: AAI08999.1.
CCDSiCCDS23834.1. [Q8K4Z6-1]
RefSeqiNP_694711.1. NM_153071.1. [Q8K4Z6-1]
UniGeneiMm.221031.

Genome annotation databases

EnsembliENSMUST00000020062; ENSMUSP00000020062; ENSMUSG00000019905. [Q8K4Z6-1]
GeneIDi210198.
KEGGimmu:210198.
UCSCiuc007fau.1. mouse. [Q8K4Z6-1]
uc007fav.1. mouse. [Q8K4Z6-2]
uc007faw.1. mouse. [Q8K4Z6-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AY735399 mRNA. Translation: AAW68012.1 .
AY735400 mRNA. Translation: AAW68013.1 .
AY735401 mRNA. Translation: AAW68014.1 .
AY101365 mRNA. Translation: AAM22280.1 .
BC108998 mRNA. Translation: AAI08999.1 .
CCDSi CCDS23834.1. [Q8K4Z6-1 ]
RefSeqi NP_694711.1. NM_153071.1. [Q8K4Z6-1 ]
UniGenei Mm.221031.

3D structure databases

ProteinModelPortali Q8K4Z6.
SMRi Q8K4Z6. Positions 34-580, 584-846.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

MINTi MINT-4997775.

Chemistry

GuidetoPHARMACOLOGYi 55.

Protein family/group databases

GPCRDBi Search...

PTM databases

PhosphoSitei Q8K4Z6.

Proteomic databases

PRIDEi Q8K4Z6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020062 ; ENSMUSP00000020062 ; ENSMUSG00000019905 . [Q8K4Z6-1 ]
GeneIDi 210198.
KEGGi mmu:210198.
UCSCi uc007fau.1. mouse. [Q8K4Z6-1 ]
uc007fav.1. mouse. [Q8K4Z6-2 ]
uc007faw.1. mouse. [Q8K4Z6-3 ]

Organism-specific databases

CTDi 222545.
MGIi MGI:2429498. Gprc6a.

Phylogenomic databases

eggNOGi NOG295353.
GeneTreei ENSGT00750000117484.
HOGENOMi HOG000063697.
HOVERGENi HBG096042.
InParanoidi Q8K4Z6.
KOi K04622.
OMAi ETHWAPV.
OrthoDBi EOG7DZ8J8.
PhylomeDBi Q8K4Z6.
TreeFami TF331269.

Enzyme and pathway databases

Reactomei REACT_207651. G alpha (q) signalling events.

Miscellaneous databases

NextBioi 372908.
PROi Q8K4Z6.
SOURCEi Search...

Gene expression databases

Bgeei Q8K4Z6.
Genevestigatori Q8K4Z6.

Family and domain databases

InterProi IPR001828. ANF_lig-bd_rcpt.
IPR000337. GPCR_3.
IPR011500. GPCR_3_9-Cys_dom.
IPR017978. GPCR_3_C.
IPR017979. GPCR_3_CS.
IPR028082. Peripla_BP_I.
[Graphical view ]
Pfami PF00003. 7tm_3. 1 hit.
PF01094. ANF_receptor. 1 hit.
PF07562. NCD3G. 1 hit.
[Graphical view ]
PRINTSi PR00248. GPCRMGR.
SUPFAMi SSF53822. SSF53822. 1 hit.
PROSITEi PS00980. G_PROTEIN_RECEP_F3_2. 1 hit.
PS50259. G_PROTEIN_RECEP_F3_4. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Cloning and characterization of a family C orphan G-protein coupled receptor."
    Kuang D., Yao Y., Lam J., Tsushima R.G., Hampson D.R.
    J. Neurochem. 93:383-391(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), SUBCELLULAR LOCATION, SUBUNIT, GLYCOSYLATION, TISSUE SPECIFICITY.
    Strain: CD-1.
  2. "Cloning of a metabotropic glutamate/pheromone receptor (Gprc6a)."
    Lorenz-Depiereux B., Dorner M., Strom T.M.
    Submitted (APR-2002) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Swiss Webster / NIH.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
  4. "Deorphanization of GPRC6A: a promiscuous L-alpha-amino acid receptor with preference for basic amino acids."
    Wellendorph P., Hansen K.B., Balsgaard A., Greenwood J.R., Egebjerg J., Brauener-Osborne H.
    Mol. Pharmacol. 67:589-597(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION.
  5. Cited for: FUNCTION, TISSUE SPECIFICITY.
  6. Cited for: FUNCTION, DISRUPTION PHENOTYPE.
  7. "GPRC6A mediates the non-genomic effects of steroids."
    Pi M., Parrill A.L., Quarles L.D.
    J. Biol. Chem. 285:39953-39964(2010) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DISRUPTION PHENOTYPE.

Entry informationi

Entry nameiGPC6A_MOUSE
AccessioniPrimary (citable) accession number: Q8K4Z6
Secondary accession number(s): Q5DK51, Q5DK52
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. 7-transmembrane G-linked receptors
    List of 7-transmembrane G-linked receptor entries
  2. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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