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Protein

Leucine-rich glioma-inactivated protein 1

Gene

Lgi1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Plays a role in suppressing the production of MMP1/3 through the phosphatidylinositol 3-kinase/ERK pathway (By similarity). Regulates voltage-gated potassium channels assembled from KCNA1, KCNA4 and KCNAB1. It slows down channel inactivation by precluding channel closure mediated by the KCNAB1 subunit. Ligand for ADAM22 that positively regulates synaptic transmission mediated by AMPA-type glutamate receptors.By similarity2 Publications

GO - Biological processi

  • axon guidance Source: Ensembl
  • positive regulation of cell growth Source: Ensembl
  • positive regulation of synaptic transmission Source: UniProtKB
  • protein homooligomerization Source: UniProtKB
Complete GO annotation...

Enzyme and pathway databases

ReactomeiR-RNO-5682910. LGI-ADAM interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Leucine-rich glioma-inactivated protein 1
Gene namesi
Name:Lgi1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 1

Organism-specific databases

RGDi628742. Lgi1.

Subcellular locationi

GO - Cellular componenti

  • cell junction Source: UniProtKB-KW
  • extracellular space Source: UniProtKB
  • synapse Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Secreted, Synapse

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Mutagenesisi383E → A: Fails to bind to ADAM22. 1 Publication1

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 34Sequence analysisAdd BLAST34
ChainiPRO_000001770735 – 557Leucine-rich glioma-inactivated protein 1Add BLAST523

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Glycosylationi192N-linked (GlcNAc...)Sequence analysis1
Glycosylationi277N-linked (GlcNAc...)Sequence analysis1
Glycosylationi422N-linked (GlcNAc...)Sequence analysis1

Post-translational modificationi

Glycosylated.By similarity

Keywords - PTMi

Glycoprotein

Proteomic databases

PaxDbiQ8K4Y5.
PRIDEiQ8K4Y5.

PTM databases

iPTMnetiQ8K4Y5.
PhosphoSitePlusiQ8K4Y5.
SwissPalmiQ8K4Y5.

Expressioni

Tissue specificityi

Expressed in brain. High levels found in hippocampus, thalamic nuclei, neocortex, and molecular and granule cell layers of the cerebellum.1 Publication

Gene expression databases

BgeeiENSRNOG00000014758.
GenevisibleiQ8K4Y5. RN.

Interactioni

Subunit structurei

Oligomer. Interacts with KCNA1 within a complex containing KCNA1, KCNA4 and KCNAB1. Can bind to ADAM11 and ADAM23 (By similarity). Part of a complex containing ADAM22, DLG4/PSD95 and CACNG2 (stargazin).By similarity2 Publications

Protein-protein interaction databases

BioGridi251653. 1 interactor.
STRINGi10116.ENSRNOP00000020411.

Structurei

3D structure databases

ProteinModelPortaliQ8K4Y5.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini35 – 72LRRNTAdd BLAST38
Repeati92 – 113LRR 1Add BLAST22
Repeati116 – 137LRR 2Add BLAST22
Repeati140 – 161LRR 3Add BLAST22
Domaini173 – 223LRRCTAdd BLAST51
Repeati224 – 267EAR 1Add BLAST44
Repeati270 – 313EAR 2Add BLAST44
Repeati316 – 364EAR 3Add BLAST49
Repeati365 – 415EAR 4Add BLAST51
Repeati418 – 462EAR 5Add BLAST45
Repeati463 – 506EAR 6Add BLAST44
Repeati509 – 552EAR 7Add BLAST44

Sequence similaritiesi

Contains 7 EAR repeats.PROSITE-ProRule annotation
Contains 3 LRR (leucine-rich) repeats.Curated
Contains 1 LRRCT domain.Curated
Contains 1 LRRNT domain.Curated

Keywords - Domaini

Leucine-rich repeat, Repeat, Signal

Phylogenomic databases

eggNOGiENOG410IIXR. Eukaryota.
ENOG410XSZV. LUCA.
GeneTreeiENSGT00860000133701.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8K4Y5.
OMAiAFNCDCK.
OrthoDBiEOG091G03ZX.
PhylomeDBiQ8K4Y5.
TreeFamiTF333155.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4Y5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MESESIRRMG NACIPLKRIA YFLCLFSVVL LTEGKKPAKP KCPAVCTCSK
60 70 80 90 100
DNALCENARS IPRTVPPDVI SLSFVRSGFT EISEGSFLFT PSLQLLLFTS
110 120 130 140 150
NSFDVISDDA FIGLPHLEYL FIENNNIKSI SRHTFRGLKS LIHLSLANNN
160 170 180 190 200
LQTLPKDIFK GLDSLTNVDL RGNSFNCDCK LKWLVEWLGH TNATVEDIYC
210 220 230 240 250
EGPPEYKKRK INSLSPKDFD CIITEFAKSQ DLPYQSLSID TFSYLNDEYV
260 270 280 290 300
VIAQPFTGKC IFLEWDHVEK TFRNYDNITG TSTVVCKPIV IDTQLYVIVA
310 320 330 340 350
QLFGGSHIYK RDGFANKFIK IQDIEVLKIR KPNDIETFKI EDNWYFVVAD
360 370 380 390 400
SSKAGFTTIY KWNGNGFYSH QSLHAWYRDT DVEYLEIARP PLTLRTPHLI
410 420 430 440 450
LSSSSQRPVI YQWSKATQLF INQTDIPNME DVYAVKHFSV KGDVYICLTR
460 470 480 490 500
FIGDSKVMKW GGSSFQDIQR MPSRGSMVFQ PLQINNYQYA ILGSDYSFTQ
510 520 530 540 550
VYNWDAEKAK FVKFQELNVQ APRSFTHVSI NKRNFLFASS FKGNTQIYKH

VIVDLSA
Length:557
Mass (Da):63,728
Last modified:October 1, 2002 - v1
Checksum:i2296F36B6C91C32B
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487517 mRNA. Translation: CAD31785.1.
BC089222 mRNA. Translation: AAH89222.1.
RefSeqiNP_665712.1. NM_145769.3.
UniGeneiRn.83615.

Genome annotation databases

EnsembliENSRNOT00000020411; ENSRNOP00000020411; ENSRNOG00000014758.
GeneIDi252892.
KEGGirno:252892.
UCSCiRGD:628742. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AJ487517 mRNA. Translation: CAD31785.1.
BC089222 mRNA. Translation: AAH89222.1.
RefSeqiNP_665712.1. NM_145769.3.
UniGeneiRn.83615.

3D structure databases

ProteinModelPortaliQ8K4Y5.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi251653. 1 interactor.
STRINGi10116.ENSRNOP00000020411.

PTM databases

iPTMnetiQ8K4Y5.
PhosphoSitePlusiQ8K4Y5.
SwissPalmiQ8K4Y5.

Proteomic databases

PaxDbiQ8K4Y5.
PRIDEiQ8K4Y5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000020411; ENSRNOP00000020411; ENSRNOG00000014758.
GeneIDi252892.
KEGGirno:252892.
UCSCiRGD:628742. rat.

Organism-specific databases

CTDi9211.
RGDi628742. Lgi1.

Phylogenomic databases

eggNOGiENOG410IIXR. Eukaryota.
ENOG410XSZV. LUCA.
GeneTreeiENSGT00860000133701.
HOGENOMiHOG000286015.
HOVERGENiHBG036744.
InParanoidiQ8K4Y5.
OMAiAFNCDCK.
OrthoDBiEOG091G03ZX.
PhylomeDBiQ8K4Y5.
TreeFamiTF333155.

Enzyme and pathway databases

ReactomeiR-RNO-5682910. LGI-ADAM interactions.

Miscellaneous databases

PROiQ8K4Y5.

Gene expression databases

BgeeiENSRNOG00000014758.
GenevisibleiQ8K4Y5. RN.

Family and domain databases

Gene3Di3.80.10.10. 1 hit.
InterProiIPR000483. Cys-rich_flank_reg_C.
IPR009039. EAR.
IPR005492. EPTP.
IPR032675. L_dom-like.
IPR001611. Leu-rich_rpt.
IPR003591. Leu-rich_rpt_typical-subtyp.
[Graphical view]
PfamiPF03736. EPTP. 7 hits.
PF13855. LRR_8. 1 hit.
[Graphical view]
SMARTiSM00369. LRR_TYP. 3 hits.
SM00082. LRRCT. 1 hit.
[Graphical view]
SUPFAMiSSF52058. SSF52058. 1 hit.
PROSITEiPS50912. EAR. 7 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiLGI1_RAT
AccessioniPrimary (citable) accession number: Q8K4Y5
Secondary accession number(s): Q5FWS7
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 3, 2003
Last sequence update: October 1, 2002
Last modified: November 30, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.