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Protein

Anion exchange protein 4

Gene

Slc4a9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Probable apical anion exchanger of the alpha-intercalated cells of kidney. May participate in HCO3- absorption.1 Publication

GO - Molecular functioni

GO - Biological processi

  • anion transport Source: RGD
  • regulation of intracellular pH Source: GO_Central

Keywordsi

Biological processAnion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 4
Short name:
AE 4
Short name:
Anion exchanger 4
Alternative name(s):
Solute carrier family 4 member 9
Gene namesi
Name:Slc4a9
Synonyms:Ae4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628811 Slc4a9

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 384CytoplasmicSequence analysisAdd BLAST384
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 593ExtracellularSequence analysisAdd BLAST72
Transmembranei594 – 614HelicalSequence analysisAdd BLAST21
Transmembranei635 – 655HelicalSequence analysisAdd BLAST21
Topological domaini656 – 681CytoplasmicSequence analysisAdd BLAST26
Transmembranei682 – 702HelicalSequence analysisAdd BLAST21
Transmembranei728 – 748HelicalSequence analysisAdd BLAST21
Transmembranei785 – 805HelicalSequence analysisAdd BLAST21
Transmembranei843 – 863HelicalSequence analysisAdd BLAST21
Transmembranei869 – 889HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792251 – 953Anion exchange protein 4Add BLAST953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi536 ↔ 538By similarity
Glycosylationi546N-linked (GlcNAc...) asparagineSequence analysis1
Glycosylationi570N-linked (GlcNAc...) asparagineSequence analysis1
Disulfide bondi579 ↔ 591By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K4V2
PRIDEiQ8K4V2

PTM databases

iPTMnetiQ8K4V2
PhosphoSitePlusiQ8K4V2

Expressioni

Tissue specificityi

Expressed in kidney and gastrointestinal tract. In kidney, it is highly expressed in the cortex, expressed at intermediate level in the outer medulla and not expressed in the inner medulla. It is expressed in the cecum, while it is absent in other segments of gastrointestinal tract.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025137

Structurei

3D structure databases

ProteinModelPortaliQ8K4V2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni385 – 953Membrane (anion exchange)Add BLAST569

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172 Eukaryota
ENOG410XPHD LUCA
HOGENOMiHOG000280684
HOVERGENiHBG004326
InParanoidiQ8K4V2
KOiK13860
PhylomeDBiQ8K4V2

Family and domain databases

Gene3Di3.40.930.10, 1 hit
InterProiView protein in InterPro
IPR013769 Band3_cytoplasmic_dom
IPR011531 HCO3_transpt_C
IPR003020 HCO3_transpt_euk
IPR003024 Na/HCO3_transpt
IPR016152 PTrfase/Anion_transptr
PANTHERiPTHR11453 PTHR11453, 1 hit
PfamiView protein in Pfam
PF07565 Band_3_cyto, 2 hits
PF00955 HCO3_cotransp, 1 hit
PRINTSiPR01231 HCO3TRNSPORT
PR01232 NAHCO3TRSPRT
SUPFAMiSSF55804 SSF55804, 1 hit
TIGRFAMsiTIGR00834 ae, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K4V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPGQEDFE GSDAHENVCS EQLDGDLGPG SGLDGPSDID NGKAQGCKDP
60 70 80 90 100
LLFIQLNELL GWPQALEWRE TGRWLLFEEK LDIGAGRWSA PHVPTLALPS
110 120 130 140 150
LQKLRGLLAE GIVLLDCPAR SLLELVEQVV RVESLSPELR GQLQALLLQR
160 170 180 190 200
PQHHIQTTGI RPCRRSNAFR KASRDEDTLL KHQNPLRQKL PPGAEAAAVL
210 220 230 240 250
AGELGFLEQP LAAFVRLQNP VVLEPLTEVV LPSRFFCLLL GPSTLGRSYH
260 270 280 290 300
ETGRAAAVLL SDPQFQWSVR RASNLHDLLA ALDAFLQEVT ALPPGRWDRT
310 320 330 340 350
ARIPPPKCLP SQHKRFPSKL QEVTSLSRQS AALAENKHHH GPHTPIPELQ
360 370 380 390 400
RTGRLFGGLV QDVRRKACWY PSDFLDALHP QCFSAVLYIY LATVTNAITF
410 420 430 440 450
GGLLGDATEG AQGVLESFLG TAVAGATFCL MAGQPLTILS STGPVLVFER
460 470 480 490 500
LLFSFSRDYS LDYLPFRLWV GIWVATFCLA LVATEASLLV RYFTRFTEEG
510 520 530 540 550
FCALISLIFI YDAVGKMLNL IRAYPIQRPG SPAYSCFCQY PGTGGNASEF
560 570 580 590 600
DSTMFKDTED VLNVHPGLVN ASFLPPSECI RQGGYPRGPS CHTVPDIAFF
610 620 630 640 650
SLLLFFTSFL CAIALKHVKN SRLFPSVVRK VFSDFSSVLA ILLGCGLDAF
660 670 680 690 700
LGLATPKLLV PTEFKPTLPG RGWLVSPFGA NPWWLSVAAA LPALLLSILI
710 720 730 740 750
FMDQQITAVI LNRAEYRLQK GAGFHLDLFC VAVLMLFTSA LGLPWYVSAT
760 770 780 790 800
VISLAHMDSL RRESKACVPG EDPNFLGIRE QRLTGLVVFI LTGVSIFLAP
810 820 830 840 850
VLKFIPMPVL YGIFLYMGVA ALSSMQFMKR VQLLLMPRKH QPDVLLLRHV
860 870 880 890 900
PLIRVHLFTA IQLACLGLLW VIKSTPAAIV FPLMLLGLVA VRKALEWIFS
910 920 930 940 950
PQELLWLDEL MPEEEKTIPE NRPEPEHLFS GNDSENSELM YQPKAPEINI

SVN
Length:953
Mass (Da):105,320
Last modified:October 1, 2002 - v1
Checksum:i625A98A969821F85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024339 mRNA Translation: BAC10662.1
RefSeqiNP_690921.1, NM_152938.1
UniGeneiRn.47849

Genome annotation databases

GeneIDi266612
KEGGirno:266612
UCSCiRGD:628811 rat

Similar proteinsi

Entry informationi

Entry nameiB3A4_RAT
AccessioniPrimary (citable) accession number: Q8K4V2
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 103 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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