Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Anion exchange protein 4

Gene

Slc4a9

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Probable apical anion exchanger of the alpha-intercalated cells of kidney. May participate in HCO3- absorption.1 Publication

GO - Molecular functioni

  • anion:anion antiporter activity Source: RGD
  • inorganic anion exchanger activity Source: InterPro

GO - Biological processi

  • anion transport Source: RGD
  • bicarbonate transport Source: GO_Central
  • regulation of intracellular pH Source: GO_Central
Complete GO annotation...

Keywords - Biological processi

Anion exchange, Antiport, Ion transport, Transport

Names & Taxonomyi

Protein namesi
Recommended name:
Anion exchange protein 4
Short name:
AE 4
Short name:
Anion exchanger 4
Alternative name(s):
Solute carrier family 4 member 9
Gene namesi
Name:Slc4a9
Synonyms:Ae4
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628811. Slc4a9.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 384CytoplasmicSequence analysisAdd BLAST384
Transmembranei385 – 405HelicalSequence analysisAdd BLAST21
Transmembranei413 – 433HelicalSequence analysisAdd BLAST21
Transmembranei435 – 455HelicalSequence analysisAdd BLAST21
Transmembranei470 – 490HelicalSequence analysisAdd BLAST21
Transmembranei501 – 521HelicalSequence analysisAdd BLAST21
Topological domaini522 – 593ExtracellularSequence analysisAdd BLAST72
Transmembranei594 – 614HelicalSequence analysisAdd BLAST21
Transmembranei635 – 655HelicalSequence analysisAdd BLAST21
Topological domaini656 – 681CytoplasmicSequence analysisAdd BLAST26
Transmembranei682 – 702HelicalSequence analysisAdd BLAST21
Transmembranei728 – 748HelicalSequence analysisAdd BLAST21
Transmembranei785 – 805HelicalSequence analysisAdd BLAST21
Transmembranei843 – 863HelicalSequence analysisAdd BLAST21
Transmembranei869 – 889HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

  • basolateral plasma membrane Source: RGD
  • integral component of plasma membrane Source: GO_Central
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000792251 – 953Anion exchange protein 4Add BLAST953

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi536 ↔ 538By similarity
Glycosylationi546N-linked (GlcNAc...)Sequence analysis1
Glycosylationi570N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi579 ↔ 591By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein

Proteomic databases

PaxDbiQ8K4V2.

PTM databases

iPTMnetiQ8K4V2.
PhosphoSitePlusiQ8K4V2.

Expressioni

Tissue specificityi

Expressed in kidney and gastrointestinal tract. In kidney, it is highly expressed in the cortex, expressed at intermediate level in the outer medulla and not expressed in the inner medulla. It is expressed in the cecum, while it is absent in other segments of gastrointestinal tract.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025137.

Structurei

3D structure databases

ProteinModelPortaliQ8K4V2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni385 – 953Membrane (anion exchange)Add BLAST569

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ8K4V2.
KOiK13860.
PhylomeDBiQ8K4V2.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K4V2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MKLPGQEDFE GSDAHENVCS EQLDGDLGPG SGLDGPSDID NGKAQGCKDP
60 70 80 90 100
LLFIQLNELL GWPQALEWRE TGRWLLFEEK LDIGAGRWSA PHVPTLALPS
110 120 130 140 150
LQKLRGLLAE GIVLLDCPAR SLLELVEQVV RVESLSPELR GQLQALLLQR
160 170 180 190 200
PQHHIQTTGI RPCRRSNAFR KASRDEDTLL KHQNPLRQKL PPGAEAAAVL
210 220 230 240 250
AGELGFLEQP LAAFVRLQNP VVLEPLTEVV LPSRFFCLLL GPSTLGRSYH
260 270 280 290 300
ETGRAAAVLL SDPQFQWSVR RASNLHDLLA ALDAFLQEVT ALPPGRWDRT
310 320 330 340 350
ARIPPPKCLP SQHKRFPSKL QEVTSLSRQS AALAENKHHH GPHTPIPELQ
360 370 380 390 400
RTGRLFGGLV QDVRRKACWY PSDFLDALHP QCFSAVLYIY LATVTNAITF
410 420 430 440 450
GGLLGDATEG AQGVLESFLG TAVAGATFCL MAGQPLTILS STGPVLVFER
460 470 480 490 500
LLFSFSRDYS LDYLPFRLWV GIWVATFCLA LVATEASLLV RYFTRFTEEG
510 520 530 540 550
FCALISLIFI YDAVGKMLNL IRAYPIQRPG SPAYSCFCQY PGTGGNASEF
560 570 580 590 600
DSTMFKDTED VLNVHPGLVN ASFLPPSECI RQGGYPRGPS CHTVPDIAFF
610 620 630 640 650
SLLLFFTSFL CAIALKHVKN SRLFPSVVRK VFSDFSSVLA ILLGCGLDAF
660 670 680 690 700
LGLATPKLLV PTEFKPTLPG RGWLVSPFGA NPWWLSVAAA LPALLLSILI
710 720 730 740 750
FMDQQITAVI LNRAEYRLQK GAGFHLDLFC VAVLMLFTSA LGLPWYVSAT
760 770 780 790 800
VISLAHMDSL RRESKACVPG EDPNFLGIRE QRLTGLVVFI LTGVSIFLAP
810 820 830 840 850
VLKFIPMPVL YGIFLYMGVA ALSSMQFMKR VQLLLMPRKH QPDVLLLRHV
860 870 880 890 900
PLIRVHLFTA IQLACLGLLW VIKSTPAAIV FPLMLLGLVA VRKALEWIFS
910 920 930 940 950
PQELLWLDEL MPEEEKTIPE NRPEPEHLFS GNDSENSELM YQPKAPEINI

SVN
Length:953
Mass (Da):105,320
Last modified:October 1, 2002 - v1
Checksum:i625A98A969821F85
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024339 mRNA. Translation: BAC10662.1.
RefSeqiNP_690921.1. NM_152938.1.
UniGeneiRn.47849.

Genome annotation databases

GeneIDi266612.
KEGGirno:266612.
UCSCiRGD:628811. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB024339 mRNA. Translation: BAC10662.1.
RefSeqiNP_690921.1. NM_152938.1.
UniGeneiRn.47849.

3D structure databases

ProteinModelPortaliQ8K4V2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000025137.

PTM databases

iPTMnetiQ8K4V2.
PhosphoSitePlusiQ8K4V2.

Proteomic databases

PaxDbiQ8K4V2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266612.
KEGGirno:266612.
UCSCiRGD:628811. rat.

Organism-specific databases

CTDi83697.
RGDi628811. Slc4a9.

Phylogenomic databases

eggNOGiKOG1172. Eukaryota.
ENOG410XPHD. LUCA.
HOGENOMiHOG000280684.
HOVERGENiHBG004326.
InParanoidiQ8K4V2.
KOiK13860.
PhylomeDBiQ8K4V2.

Miscellaneous databases

PROiQ8K4V2.

Family and domain databases

Gene3Di3.40.1100.10. 1 hit.
InterProiIPR013769. Band3_cytoplasmic_dom.
IPR011531. HCO3_transpt_C.
IPR003020. HCO3_transpt_euk.
IPR003024. Na/HCO3_transpt.
IPR016152. PTrfase/Anion_transptr.
[Graphical view]
PANTHERiPTHR11453. PTHR11453. 1 hit.
PfamiPF07565. Band_3_cyto. 2 hits.
PF00955. HCO3_cotransp. 1 hit.
[Graphical view]
PRINTSiPR01231. HCO3TRNSPORT.
PR01232. NAHCO3TRSPRT.
SUPFAMiSSF55804. SSF55804. 1 hit.
TIGRFAMsiTIGR00834. ae. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiB3A4_RAT
AccessioniPrimary (citable) accession number: Q8K4V2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: March 28, 2003
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 98 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.