ID   DUS19_MOUSE             Reviewed;         220 AA.
AC   Q8K4T5;
DT   07-JUN-2005, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   10-FEB-2009, entry version 41.
DE   RecName: Full=Dual specificity protein phosphatase 19;
DE            EC=3.1.3.48;
DE            EC=3.1.3.16;
DE   AltName: Full=Stress-activated protein kinase pathway-regulating phosphatase 1;
DE   AltName: Full=Protein phosphatase SKRP1;
GN   Name=Dusp19; Synonyms=Skrp1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RX   MEDLINE=22075131; PubMed=11959861; DOI=10.1074/jbc.M200837200;
RA   Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.;
RT   "A novel dual specificity phosphatase SKRP1 interacts with the MAPK
RT   kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the
RT   precise regulation of the particular MAPK pathway.";
RL   J. Biol. Chem. 277:23909-23918(2002).
CC   -!- FUNCTION: Has a dual specificity toward Ser/Thr and Tyr-containing
CC       proteins (By similarity).
CC   -!- CATALYTIC ACTIVITY: Protein tyrosine phosphate + H(2)O = protein
CC       tyrosine + phosphate.
CC   -!- CATALYTIC ACTIVITY: A phosphoprotein + H(2)O = a protein +
CC       phosphate.
CC   -!- SIMILARITY: Belongs to the protein-tyrosine phosphatase family.
CC       Non-receptor class dual specificity subfamily.
CC   -!- SIMILARITY: Contains 1 tyrosine-protein phosphatase domain.
CC   -----------------------------------------------------------------------
CC   Copyrighted by the UniProt Consortium, see http://www.uniprot.org/terms
CC   Distributed under the Creative Commons Attribution-NoDerivs License
CC   -----------------------------------------------------------------------
DR   EMBL; AB051896; BAC01163.1; -; mRNA.
DR   IPI; IPI00463211; -.
DR   UniGene; Mm.306818; -.
DR   HSSP; Q05923; 1M3G.
DR   PRIDE; Q8K4T5; -.
DR   Ensembl; ENSMUSG00000027001; Mus musculus.
DR   MGI; MGI:1915332; Dusp19.
DR   HOGENOM; Q8K4T5; -.
DR   HOVERGEN; Q8K4T5; -.
DR   BRENDA; 3.1.3.16; 244.
DR   BRENDA; 3.1.3.48; 244.
DR   ArrayExpress; Q8K4T5; -.
DR   Bgee; Q8K4T5; -.
DR   CleanEx; MM_DUSP19; -.
DR   GermOnline; ENSMUSG00000027001; Mus musculus.
DR   GO; GO:0005737; C:cytoplasm; IDA:MGI.
DR   GO; GO:0008579; F:JUN kinase phosphatase activity; IDA:MGI.
DR   GO; GO:0005515; F:protein binding; IPI:MGI.
DR   GO; GO:0004725; F:protein tyrosine phosphatase activity; IEA:EC.
DR   GO; GO:0008330; F:protein tyrosine/threonine phosphatase acti...; IDA:MGI.
DR   GO; GO:0000188; P:inactivation of MAPK activity; IDA:MGI.
DR   GO; GO:0007254; P:JNK cascade; IDA:MGI.
DR   GO; GO:0006470; P:protein amino acid dephosphorylation; IDA:MGI.
DR   InterPro; IPR000387; Tyr_Pase.
DR   InterPro; IPR016130; Tyr_Pase_AS.
DR   InterPro; IPR000340; Tyr_Pase_dual_specific.
DR   Pfam; PF00782; DSPc; 1.
DR   SMART; SM00195; DSPc; 1.
DR   PROSITE; PS00383; TYR_PHOSPHATASE_1; FALSE_NEG.
DR   PROSITE; PS50056; TYR_PHOSPHATASE_2; 1.
DR   PROSITE; PS50054; TYR_PHOSPHATASE_DUAL; 1.
PE   2: Evidence at transcript level;
KW   Hydrolase; Protein phosphatase.
FT   CHAIN         1    220       Dual specificity protein phosphatase 19.
FT                                /FTId=PRO_0000094833.
FT   DOMAIN      132    196       Tyrosine-protein phosphatase.
FT   ACT_SITE    149    149       Phosphocysteine intermediate (By
FT                                similarity).
SQ   SEQUENCE   220 AA;  24181 MW;  5977D907CA7D3EDD CRC64;
     MHSLNQKIKA FSRDNLRKQC TRVTTLTGKK LIETWEDATV HVVETEPSGG GGCGYVQDLT
     LDLQVGVIKP WLLLGSQDAA HDLELLRKHK VTHILNVAYG VENAFLSEFT YKTISILDVP
     ETNILSYFPE CFEFIEQAKL KDGVVLVHCN AGVSRAAAIV IGFLMSSEEA TFTTALSLVK
     EARPSICPNP GFMEQLRTYQ VGKESNGGDK VPAEDTTHGL
//