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Q8K4T5

- DUS19_MOUSE

UniProt

Q8K4T5 - DUS19_MOUSE

Protein

Dual specificity protein phosphatase 19

Gene

Dusp19

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 77 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

    Catalytic activityi

    Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
    [a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei149 – 1491Phosphocysteine intermediateBy similarity

    GO - Molecular functioni

    1. JUN kinase phosphatase activity Source: MGI
    2. MAP-kinase scaffold activity Source: BHF-UCL
    3. mitogen-activated protein kinase kinase binding Source: BHF-UCL
    4. mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL
    5. protein binding Source: MGI
    6. protein kinase activator activity Source: BHF-UCL
    7. protein kinase inhibitor activity Source: BHF-UCL
    8. protein tyrosine/serine/threonine phosphatase activity Source: MGI
    9. protein tyrosine/threonine phosphatase activity Source: MGI
    10. protein tyrosine phosphatase activity Source: UniProtKB-EC

    GO - Biological processi

    1. inactivation of MAPK activity Source: MGI
    2. JNK cascade Source: MGI
    3. negative regulation of JNK cascade Source: BHF-UCL
    4. negative regulation of JUN kinase activity Source: BHF-UCL
    5. negative regulation of protein kinase activity Source: BHF-UCL
    6. positive regulation of JNK cascade Source: BHF-UCL
    7. positive regulation of JUN kinase activity Source: BHF-UCL
    8. positive regulation of MAPK cascade Source: BHF-UCL
    9. positive regulation of protein kinase activity Source: BHF-UCL
    10. protein dephosphorylation Source: MGI

    Keywords - Molecular functioni

    Hydrolase, Protein phosphatase

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Dual specificity protein phosphatase 19 (EC:3.1.3.16, EC:3.1.3.48)
    Alternative name(s):
    Protein phosphatase SKRP1
    Stress-activated protein kinase pathway-regulating phosphatase 1
    Gene namesi
    Name:Dusp19
    Synonyms:Skrp1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Unplaced

    Organism-specific databases

    MGIiMGI:1915332. Dusp19.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: MGI

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 220220Dual specificity protein phosphatase 19PRO_0000094833Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei1 – 11N-acetylmethionineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    MaxQBiQ8K4T5.
    PaxDbiQ8K4T5.
    PRIDEiQ8K4T5.

    PTM databases

    PhosphoSiteiQ8K4T5.

    Expressioni

    Gene expression databases

    CleanExiMM_DUSP19.
    GenevestigatoriQ8K4T5.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4T5.
    SMRiQ8K4T5. Positions 64-205.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini132 – 19665Tyrosine-protein phosphataseAdd
    BLAST

    Sequence similaritiesi

    Phylogenomic databases

    eggNOGiCOG2453.
    HOGENOMiHOG000233765.
    HOVERGENiHBG051424.
    InParanoidiQ8K4T5.
    PhylomeDBiQ8K4T5.

    Family and domain databases

    Gene3Di3.90.190.10. 1 hit.
    InterProiIPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view]
    PANTHERiPTHR10159. PTHR10159. 1 hit.
    PfamiPF00782. DSPc. 1 hit.
    [Graphical view]
    PRINTSiPR01908. ADSPHPHTASE.
    SMARTiSM00195. DSPc. 1 hit.
    [Graphical view]
    SUPFAMiSSF52799. SSF52799. 1 hit.
    PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4T5-1 [UniParc]FASTAAdd to Basket

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    MHSLNQKIKA FSRDNLRKQC TRVTTLTGKK LIETWEDATV HVVETEPSGG    50
    GGCGYVQDLT LDLQVGVIKP WLLLGSQDAA HDLELLRKHK VTHILNVAYG 100
    VENAFLSEFT YKTISILDVP ETNILSYFPE CFEFIEQAKL KDGVVLVHCN 150
    AGVSRAAAIV IGFLMSSEEA TFTTALSLVK EARPSICPNP GFMEQLRTYQ 200
    VGKESNGGDK VPAEDTTHGL 220
    Length:220
    Mass (Da):24,181
    Last modified:October 1, 2002 - v1
    Checksum:i5977D907CA7D3EDD
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051896 mRNA. Translation: BAC01163.1.
    CCDSiCCDS16178.1.
    UniGeneiMm.306818.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB051896 mRNA. Translation: BAC01163.1 .
    CCDSi CCDS16178.1.
    UniGenei Mm.306818.

    3D structure databases

    ProteinModelPortali Q8K4T5.
    SMRi Q8K4T5. Positions 64-205.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K4T5.

    Proteomic databases

    MaxQBi Q8K4T5.
    PaxDbi Q8K4T5.
    PRIDEi Q8K4T5.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:1915332. Dusp19.

    Phylogenomic databases

    eggNOGi COG2453.
    HOGENOMi HOG000233765.
    HOVERGENi HBG051424.
    InParanoidi Q8K4T5.
    PhylomeDBi Q8K4T5.

    Miscellaneous databases

    PROi Q8K4T5.
    SOURCEi Search...

    Gene expression databases

    CleanExi MM_DUSP19.
    Genevestigatori Q8K4T5.

    Family and domain databases

    Gene3Di 3.90.190.10. 1 hit.
    InterProi IPR020417. Atypical_DUSP.
    IPR000340. Dual-sp_phosphatase_cat-dom.
    IPR020422. Dual-sp_phosphatase_subgr_cat.
    IPR024950. DUSP.
    IPR029021. Prot-tyrosine_phosphatase-like.
    IPR000387. Tyr/Dual-sp_Pase.
    [Graphical view ]
    PANTHERi PTHR10159. PTHR10159. 1 hit.
    Pfami PF00782. DSPc. 1 hit.
    [Graphical view ]
    PRINTSi PR01908. ADSPHPHTASE.
    SMARTi SM00195. DSPc. 1 hit.
    [Graphical view ]
    SUPFAMi SSF52799. SSF52799. 1 hit.
    PROSITEi PS50056. TYR_PHOSPHATASE_2. 1 hit.
    PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway."
      Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.
      J. Biol. Chem. 277:23909-23918(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiDUS19_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4T5
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2005
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 77 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3