Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Dual specificity protein phosphatase 19

Gene

Dusp19

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Has a dual specificity toward Ser/Thr and Tyr-containing proteins.By similarity

Catalytic activityi

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.
[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei149 – 1491Phosphocysteine intermediateBy similarity

GO - Molecular functioni

  1. JUN kinase phosphatase activity Source: MGI
  2. MAP-kinase scaffold activity Source: BHF-UCL
  3. mitogen-activated protein kinase kinase binding Source: BHF-UCL
  4. mitogen-activated protein kinase kinase kinase binding Source: BHF-UCL
  5. protein kinase activator activity Source: BHF-UCL
  6. protein kinase inhibitor activity Source: BHF-UCL
  7. protein tyrosine/serine/threonine phosphatase activity Source: MGI
  8. protein tyrosine/threonine phosphatase activity Source: MGI
  9. protein tyrosine phosphatase activity Source: UniProtKB-EC

GO - Biological processi

  1. inactivation of MAPK activity Source: MGI
  2. JNK cascade Source: MGI
  3. negative regulation of JNK cascade Source: BHF-UCL
  4. negative regulation of JUN kinase activity Source: BHF-UCL
  5. negative regulation of protein kinase activity Source: BHF-UCL
  6. positive regulation of JNK cascade Source: BHF-UCL
  7. positive regulation of JUN kinase activity Source: BHF-UCL
  8. positive regulation of MAPK cascade Source: BHF-UCL
  9. positive regulation of protein kinase activity Source: BHF-UCL
  10. protein dephosphorylation Source: MGI
Complete GO annotation...

Keywords - Molecular functioni

Hydrolase, Protein phosphatase

Names & Taxonomyi

Protein namesi
Recommended name:
Dual specificity protein phosphatase 19 (EC:3.1.3.16, EC:3.1.3.48)
Alternative name(s):
Protein phosphatase SKRP1
Stress-activated protein kinase pathway-regulating phosphatase 1
Gene namesi
Name:Dusp19
Synonyms:Skrp1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1915332. Dusp19.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 220220Dual specificity protein phosphatase 19PRO_0000094833Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei1 – 11N-acetylmethionineBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

MaxQBiQ8K4T5.
PaxDbiQ8K4T5.
PRIDEiQ8K4T5.

PTM databases

PhosphoSiteiQ8K4T5.

Expressioni

Gene expression databases

CleanExiMM_DUSP19.
GenevestigatoriQ8K4T5.

Structurei

3D structure databases

ProteinModelPortaliQ8K4T5.
SMRiQ8K4T5. Positions 64-205.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini132 – 19665Tyrosine-protein phosphataseAdd
BLAST

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000233765.
HOVERGENiHBG051424.
InParanoidiQ8K4T5.
PhylomeDBiQ8K4T5.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4T5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MHSLNQKIKA FSRDNLRKQC TRVTTLTGKK LIETWEDATV HVVETEPSGG
60 70 80 90 100
GGCGYVQDLT LDLQVGVIKP WLLLGSQDAA HDLELLRKHK VTHILNVAYG
110 120 130 140 150
VENAFLSEFT YKTISILDVP ETNILSYFPE CFEFIEQAKL KDGVVLVHCN
160 170 180 190 200
AGVSRAAAIV IGFLMSSEEA TFTTALSLVK EARPSICPNP GFMEQLRTYQ
210 220
VGKESNGGDK VPAEDTTHGL
Length:220
Mass (Da):24,181
Last modified:October 1, 2002 - v1
Checksum:i5977D907CA7D3EDD
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051896 mRNA. Translation: BAC01163.1.
CCDSiCCDS16178.1.
UniGeneiMm.306818.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB051896 mRNA. Translation: BAC01163.1.
CCDSiCCDS16178.1.
UniGeneiMm.306818.

3D structure databases

ProteinModelPortaliQ8K4T5.
SMRiQ8K4T5. Positions 64-205.
ModBaseiSearch...
MobiDBiSearch...

PTM databases

PhosphoSiteiQ8K4T5.

Proteomic databases

MaxQBiQ8K4T5.
PaxDbiQ8K4T5.
PRIDEiQ8K4T5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Organism-specific databases

MGIiMGI:1915332. Dusp19.

Phylogenomic databases

eggNOGiCOG2453.
HOGENOMiHOG000233765.
HOVERGENiHBG051424.
InParanoidiQ8K4T5.
PhylomeDBiQ8K4T5.

Miscellaneous databases

PROiQ8K4T5.
SOURCEiSearch...

Gene expression databases

CleanExiMM_DUSP19.
GenevestigatoriQ8K4T5.

Family and domain databases

Gene3Di3.90.190.10. 1 hit.
InterProiIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERiPTHR10159. PTHR10159. 1 hit.
PfamiPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSiPR01908. ADSPHPHTASE.
SMARTiSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMiSSF52799. SSF52799. 1 hit.
PROSITEiPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway."
    Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.
    J. Biol. Chem. 277:23909-23918(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiDUS19_MOUSE
AccessioniPrimary (citable) accession number: Q8K4T5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: March 4, 2015
This is version 80 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.