Reviewed,
UniProtKB/Swiss-Prot Q8K4T5 (DUS19_MOUSE)
Last modified
January 19, 2010.
Version 47.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Dual specificity protein phosphatase 19 EC=3.1.3.48 EC=3.1.3.16 Alternative name(s): Stress-activated protein kinase pathway-regulating phosphatase 1 Protein phosphatase SKRP1 | ||||
| Gene names |
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| Organism | Mus musculus (Mouse) | ||||
| Taxonomic identifier | 10090 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus |
Protein attributes
| Sequence length | 220 AA. |
| Sequence status | Complete. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Has a dual specificity toward Ser/Thr and Tyr-containing proteins By similarity. |
| Catalytic activity | Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate. |
| Sequence similarities | Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain. |
Ontologies
| Keywords | |
|---|---|
| Molecular function | Hydrolase Protein phosphatase |
| Gene Ontology (GO) | |
| Biological process | JNK cascade Inferred from direct assay. Source: MGI inactivation of MAPK activity Ref.1Inferred from direct assay. Source: MGI protein amino acid dephosphorylation Ref.1Inferred from direct assay. Source: MGI |
| Cellular component | cytoplasm Ref.1 Inferred from direct assay. Source: MGI |
| Molecular function | JUN kinase phosphatase activity Ref.1 Inferred from direct assay. Source: MGI protein bindingInferred from physical interaction. Source: MGI protein tyrosine phosphatase activityInferred from electronic annotation. Source: EC protein tyrosine/threonine phosphatase activity Ref.1Inferred from direct assay. Source: MGI |
| Complete GO annotation... | |
Sequence annotation (Features)
Sequences
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References
| [1] | "A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway." Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M. J. Biol. Chem. 277:23909-23918(2002) [PubMed: 11959861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AB051896 mRNA. Translation: BAC01163.1. |
| IPI | IPI00463211. |
| UniGene | Mm.306818 |
3D structure databases | |
| SMR | Q8K4T5. Positions 66-201. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8K4T5. |
Proteomic databases | |
| PRIDE | Q8K4T5. |
Genome annotation databases | |
| Ensembl | ENSMUST00000028384; ENSMUSP00000028384; ENSMUSG00000027001; Mus musculus. [Genome view] |
Organism-specific databases | |
| MGI | MGI:1915332. Dusp19. |
Phylogenomic databases | |
| eggNOG | roNOG06325. |
| HOGENOM | HBG717377. |
| HOVERGEN | Q8K4T5. |
| InParanoid | Q8K4T5. |
Enzyme and pathway databases | |
| BRENDA | 3.1.3.16. 244. 3.1.3.48. 244. |
Gene expression databases | |
| ArrayExpress | Q8K4T5. |
| Bgee | Q8K4T5. |
| CleanEx | MM_DUSP19. |
| Genevestigator | Q8K4T5. |
| GermOnline | ENSMUSG00000027001. Mus musculus. |
Family and domain databases | |
| InterPro | IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. [Graphical view] |
| Pfam | PF00782. DSPc. 1 hit. [Graphical view] |
| PRINTS | PR01908. ADSPHPHTASE. |
| SMART | SM00195. DSPc. 1 hit. [Graphical view] |
| PROSITE | PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| SOURCE | Search... |
Entry information
| Entry name | DUS19_MOUSE | ||||||||
| Accession | Primary (citable) accession number: Q8K4T5 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| MGD cross-references Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot |
| SIMILARITY comments Index of protein domains and families |

Clusters with


