Reviewed, UniProtKB/Swiss-Prot Q8K4T5 (DUS19_MOUSE)

Names and origin

Protein names

Recommended name:
    Dual specificity protein phosphatase 19
    EC=3.1.3.48
    EC=3.1.3.16
Alternative name(s):
    Stress-activated protein kinase pathway-regulating phosphatase 1
    Protein phosphatase SKRP1

Gene names

Name:	Dusp19
Synonyms:	Skrp1

Organism

Mus musculus (Mouse)

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus

Protein attributes

Sequence length	220 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level.

General annotation (Comments)

Function	Has a dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.
Catalytic activity	Protein tyrosine phosphate + H2O = protein tyrosine + phosphate. A phosphoprotein + H2O = a protein + phosphate.
Sequence similarities	Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
Molecular function	Hydrolase Protein phosphatase
Gene Ontology (GO)
Biological process	JNK cascade Inferred from direct assay. Source: MGI inactivation of MAPK activity Ref.1 Inferred from direct assay. Source: MGI protein amino acid dephosphorylation Ref.1 Inferred from direct assay. Source: MGI
Cellular component	cytoplasm Ref.1 Inferred from direct assay. Source: MGI
Molecular function	JUN kinase phosphatase activity Ref.1 Inferred from direct assay. Source: MGI protein binding Inferred from physical interaction. Source: MGI protein tyrosine phosphatase activity Inferred from electronic annotation. Source: EC protein tyrosine/threonine phosphatase activity Ref.1 Inferred from direct assay. Source: MGI
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 220	220	Dual specificity protein phosphatase 19		PRO_0000094833
Regions
	Domain	132 – 196	65	Tyrosine-protein phosphatase
Sites
	Active site	149	1	Phosphocysteine intermediate By similarity

Sequences

	Sequence		Length	Mass (Da)
	Q8K4T5-1 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 5977D907CA7D3EDD	FASTA	220	24,181
	10 20 30 40 50 60 MHSLNQKIKA FSRDNLRKQC TRVTTLTGKK LIETWEDATV HVVETEPSGG GGCGYVQDLT 70 80 90 100 110 120 LDLQVGVIKP WLLLGSQDAA HDLELLRKHK VTHILNVAYG VENAFLSEFT YKTISILDVP 130 140 150 160 170 180 ETNILSYFPE CFEFIEQAKL KDGVVLVHCN AGVSRAAAIV IGFLMSSEEA TFTTALSLVK 190 200 210 220 EARPSICPNP GFMEQLRTYQ VGKESNGGDK VPAEDTTHGL

References

[1]	"A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway." Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M. J. Biol. Chem. 277:23909-23918(2002) [PubMed: 11959861] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AB051896 mRNA. Translation: BAC01163.1.
IPI	IPI00463211.
UniGene	Mm.306818
3D structure databases
SMR	Q8K4T5. Positions 66-201.
ModBase	Search...
Protein-protein interaction databases
STRING	Q8K4T5.
Proteomic databases
PRIDE	Q8K4T5.
Genome annotation databases
Ensembl	ENSMUST00000028384; ENSMUSP00000028384; ENSMUSG00000027001; Mus musculus. [Genome view]
Organism-specific databases
MGI	MGI:1915332. Dusp19.
Phylogenomic databases
eggNOG	roNOG06325.
HOGENOM	HBG717377.
HOVERGEN	Q8K4T5.
InParanoid	Q8K4T5.
Enzyme and pathway databases
BRENDA	3.1.3.16. 244. 3.1.3.48. 244.
Gene expression databases
ArrayExpress	Q8K4T5.
Bgee	Q8K4T5.
CleanEx	MM_DUSP19.
Genevestigator	Q8K4T5.
GermOnline	ENSMUSG00000027001. Mus musculus.
Family and domain databases
InterPro	IPR000387. Dual-sp/Tyr_phosphatase. IPR020417. Dual-sp_phosphatase. IPR000340. Dual-sp_phosphatase_cat-dom. IPR020422. Dual-sp_phosphatase_subgr_cat. [Graphical view]
Pfam	PF00782. DSPc. 1 hit. [Graphical view]
PRINTS	PR01908. ADSPHPHTASE.
SMART	SM00195. DSPc. 1 hit. [Graphical view]
PROSITE	PS00383. TYR_PHOSPHATASE_1. False negative. PS50056. TYR_PHOSPHATASE_2. 1 hit. PS50054. TYR_PHOSPHATASE_DUAL. 1 hit. [Graphical view]
ProtoNet	Search...
Other Resources
SOURCE	Search...

Entry information

Entry name

DUS19_MOUSE

Accession

Primary (citable) accession number: Q8K4T5

Entry history

Integrated into UniProtKB/Swiss-Prot:	June 7, 2005
Last sequence update:	October 1, 2002
Last modified:	January 19, 2010
This is version 47 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation project

HPI (Human Proteome Initiative)