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Q8K4T5 (DUS19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 3, 2013. Version 67. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 19
EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Protein phosphatase SKRP1
Stress-activated protein kinase pathway-regulating phosphatase 1
Gene names
Name:Dusp19
Synonyms:Skrp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has a dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

A phosphoprotein + H2O = a protein + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Dual specificity protein phosphatase 19
PRO_0000094833

Regions

Domain132 – 19665Tyrosine-protein phosphatase

Sites

Active site1491Phosphocysteine intermediate By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K4T5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 5977D907CA7D3EDD

FASTA22024,181
        10         20         30         40         50         60 
MHSLNQKIKA FSRDNLRKQC TRVTTLTGKK LIETWEDATV HVVETEPSGG GGCGYVQDLT 

        70         80         90        100        110        120 
LDLQVGVIKP WLLLGSQDAA HDLELLRKHK VTHILNVAYG VENAFLSEFT YKTISILDVP 

       130        140        150        160        170        180 
ETNILSYFPE CFEFIEQAKL KDGVVLVHCN AGVSRAAAIV IGFLMSSEEA TFTTALSLVK 

       190        200        210        220 
EARPSICPNP GFMEQLRTYQ VGKESNGGDK VPAEDTTHGL

« Hide

References

[1]"A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway."
Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.
J. Biol. Chem. 277:23909-23918(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AB051896 mRNA. Translation: BAC01163.1.
IPIIPI00463211.
UniGeneMm.306818.

3D structure databases

ProteinModelPortalQ8K4T5.
SMRQ8K4T5. Positions 64-205.
ModBaseSearch...

PTM databases

PhosphoSiteQ8K4T5.

Proteomic databases

PaxDbQ8K4T5.
PRIDEQ8K4T5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1915332. Dusp19.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000233765.
HOVERGENHBG051424.
InParanoidQ8K4T5.
OrthoDBEOG41RPW9.

Gene expression databases

CleanExMM_DUSP19.
GenevestigatorQ8K4T5.
GermOnlineENSMUSG00000027001. Mus musculus.

Family and domain databases

InterProIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
PROSITEPS00383. TYR_PHOSPHATASE_1. False negative.
PS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

SOURCESearch...

Entry information

Entry nameDUS19_MOUSE
AccessionPrimary (citable) accession number: Q8K4T5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: April 3, 2013
This is version 67 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

SIMILARITY comments

Index of protein domains and families

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