Skip Header

You are using a version of Internet Explorer that may not display all features of this website. Please upgrade to a modern browser.
Contribute Send feedback
Read comments (?) or add your own

Q8K4T5 (DUS19_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 76. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Dual specificity protein phosphatase 19

EC=3.1.3.16
EC=3.1.3.48
Alternative name(s):
Protein phosphatase SKRP1
Stress-activated protein kinase pathway-regulating phosphatase 1
Gene names
Name:Dusp19
Synonyms:Skrp1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length220 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Has a dual specificity toward Ser/Thr and Tyr-containing proteins By similarity.

Catalytic activity

Protein tyrosine phosphate + H2O = protein tyrosine + phosphate.

[a protein]-serine/threonine phosphate + H2O = [a protein]-serine/threonine + phosphate.

Sequence similarities

Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.

Contains 1 tyrosine-protein phosphatase domain.

Ontologies

Keywords
   Molecular functionHydrolase
Protein phosphatase
   PTMAcetylation
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
   Biological_processJNK cascade

Inferred from direct assay PubMed 11959862. Source: MGI

inactivation of MAPK activity

Inferred from direct assay Ref.1. Source: MGI

negative regulation of JNK cascade

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

negative regulation of JUN kinase activity

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

negative regulation of protein kinase activity

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

positive regulation of JNK cascade

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

positive regulation of JUN kinase activity

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

positive regulation of MAPK cascade

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

positive regulation of protein kinase activity

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

protein dephosphorylation

Inferred from direct assay Ref.1. Source: MGI

   Cellular_componentcytoplasm

Inferred from direct assay Ref.1. Source: MGI

   Molecular_functionJUN kinase phosphatase activity

Inferred from direct assay Ref.1. Source: MGI

MAP-kinase scaffold activity

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

mitogen-activated protein kinase kinase binding

Inferred from physical interaction PubMed 11959862. Source: BHF-UCL

mitogen-activated protein kinase kinase kinase binding

Inferred from physical interaction PubMed 11959862. Source: BHF-UCL

protein binding

Inferred from physical interaction PubMed 11959862. Source: MGI

protein kinase activator activity

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

protein kinase inhibitor activity

Inferred from direct assay PubMed 11959862. Source: BHF-UCL

protein tyrosine phosphatase activity

Inferred from electronic annotation. Source: UniProtKB-EC

protein tyrosine/serine/threonine phosphatase activity

Inferred from direct assay PubMed 11432789. Source: MGI

protein tyrosine/threonine phosphatase activity

Inferred from direct assay Ref.1. Source: MGI

Complete GO annotation...

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 220220Dual specificity protein phosphatase 19
PRO_0000094833

Regions

Domain132 – 19665Tyrosine-protein phosphatase

Sites

Active site1491Phosphocysteine intermediate By similarity

Amino acid modifications

Modified residue11N-acetylmethionine By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K4T5 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 5977D907CA7D3EDD

FASTA22024,181
        10         20         30         40         50         60 
MHSLNQKIKA FSRDNLRKQC TRVTTLTGKK LIETWEDATV HVVETEPSGG GGCGYVQDLT 

        70         80         90        100        110        120 
LDLQVGVIKP WLLLGSQDAA HDLELLRKHK VTHILNVAYG VENAFLSEFT YKTISILDVP 

       130        140        150        160        170        180 
ETNILSYFPE CFEFIEQAKL KDGVVLVHCN AGVSRAAAIV IGFLMSSEEA TFTTALSLVK 

       190        200        210        220 
EARPSICPNP GFMEQLRTYQ VGKESNGGDK VPAEDTTHGL 

« Hide

References

[1]"A novel dual specificity phosphatase SKRP1 interacts with the MAPK kinase MKK7 and inactivates the JNK MAPK pathway. Implication for the precise regulation of the particular MAPK pathway."
Zama T., Aoki R., Kamimoto T., Inoue K., Ikeda Y., Hagiwara M.
J. Biol. Chem. 277:23909-23918(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AB051896 mRNA. Translation: BAC01163.1.
CCDSCCDS16178.1.
UniGeneMm.306818.

3D structure databases

ProteinModelPortalQ8K4T5.
SMRQ8K4T5. Positions 64-205.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K4T5.

Proteomic databases

MaxQBQ8K4T5.
PaxDbQ8K4T5.
PRIDEQ8K4T5.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Organism-specific databases

MGIMGI:1915332. Dusp19.

Phylogenomic databases

eggNOGCOG2453.
HOGENOMHOG000233765.
HOVERGENHBG051424.
InParanoidQ8K4T5.
PhylomeDBQ8K4T5.

Gene expression databases

CleanExMM_DUSP19.
GenevestigatorQ8K4T5.

Family and domain databases

Gene3D3.90.190.10. 1 hit.
InterProIPR020417. Atypical_DUSP.
IPR000340. Dual-sp_phosphatase_cat-dom.
IPR020422. Dual-sp_phosphatase_subgr_cat.
IPR024950. DUSP.
IPR029021. Prot-tyrosine_phosphatase-like.
IPR000387. Tyr/Dual-sp_Pase.
[Graphical view]
PANTHERPTHR10159. PTHR10159. 1 hit.
PfamPF00782. DSPc. 1 hit.
[Graphical view]
PRINTSPR01908. ADSPHPHTASE.
SMARTSM00195. DSPc. 1 hit.
[Graphical view]
SUPFAMSSF52799. SSF52799. 1 hit.
PROSITEPS50056. TYR_PHOSPHATASE_2. 1 hit.
PS50054. TYR_PHOSPHATASE_DUAL. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

PROQ8K4T5.
SOURCESearch...

Entry information

Entry nameDUS19_MOUSE
AccessionPrimary (citable) accession number: Q8K4T5
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2005
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot