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Protein

Proton-associated sugar transporter A

Gene

Slc45a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Mediates glucose uptake along the pH gradient.

GO - Molecular functioni

  • glucose transmembrane transporter activity Source: RGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

  • glucose transmembrane transport Source: GOC
  • glucose transport Source: RGD
Complete GO annotation...

Keywords - Biological processi

Sugar transport, Symport, Transport

Protein family/group databases

TCDBi2.A.2.4.4. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-associated sugar transporter A
Short name:
PAST-A
Alternative name(s):
Solute carrier family 45 member 1
Gene namesi
Name:Slc45a1
Synonyms:Dnb5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708502. Slc45a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei93 – 11321HelicalSequence analysisAdd
BLAST
Transmembranei123 – 14321HelicalSequence analysisAdd
BLAST
Transmembranei155 – 17521HelicalSequence analysisAdd
BLAST
Transmembranei191 – 21121HelicalSequence analysisAdd
BLAST
Transmembranei233 – 25321HelicalSequence analysisAdd
BLAST
Transmembranei268 – 28821HelicalSequence analysisAdd
BLAST
Transmembranei536 – 55621HelicalSequence analysisAdd
BLAST
Transmembranei576 – 59621HelicalSequence analysisAdd
BLAST
Transmembranei606 – 62621HelicalSequence analysisAdd
BLAST
Transmembranei630 – 65021HelicalSequence analysisAdd
BLAST
Transmembranei688 – 70821HelicalSequence analysisAdd
BLAST
Transmembranei710 – 73021HelicalSequence analysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 751751Proton-associated sugar transporter APRO_0000122516Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei500 – 5001PhosphothreonineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K4S3.
PRIDEiQ8K4S3.

Expressioni

Tissue specificityi

Predominantly expressed in brain.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024581.

Structurei

3D structure databases

ProteinModelPortaliQ8K4S3.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410Y28T. LUCA.
HOGENOMiHOG000231090.
HOVERGENiHBG053518.
InParanoidiQ8K4S3.
PhylomeDBiQ8K4S3.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.

Sequencei

Sequence statusi: Complete.

Q8K4S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPAGSTPP GEALIPSVAP QDFWRSPISG YSGSVTRHIS HRANNFKRHP
60 70 80 90 100
KRRKYIRPSP PPPPNTPCPI ELVDFEDLHP QRSFWELLFN GCILFGIEFS
110 120 130 140 150
YAMETAYVTP VLLQMGLPDQ LYSLVWFISP ILGFLLQPLL GAWSDRCTSR
160 170 180 190 200
FGRRRPFILV LAIGALLGLS LLLNGRDIGM ALADTATNHK WGILLTVCGV
210 220 230 240 250
VLMDFSADSA DNPSHAYMMD VCGPVDQDRG LNIHALMAGL GGGFGYVVGG
260 270 280 290 300
IHWDKTSFGR ALGGQLRVIY IFTAITLSVT TVFTLVSIPE RPLRPLGEKR
310 320 330 340 350
TAMKSPSLPL PPSPPVLLEE GAGDTLPSTT ATSLYASFSS PISPPSPLTP
360 370 380 390 400
KYGSFISRDS SLTGINEFAS SFGTSNIDSV LIDCFTAGHD NYLALPSSVP
410 420 430 440 450
RQAISVSFPR APDGFYCQER GLERREGPLT LGLDGDVLRV GSLDTSKPRA
460 470 480 490 500
SGILKRPQTL ALPDVAGGNG PETSRRRNVT FSQQVANILL NGVKYESELT
510 520 530 540 550
GSSEQSEQPL SLRRLCSTIY NMPRPVRNLC VNHFLGWLSF EGMLLFYTDF
560 570 580 590 600
MGEVVFQGDP KAPHASEAYQ KYNSGVTMGC WGMCIYAFSA AFYSAILEKL
610 620 630 640 650
EECLSVRTLY FIAYLLFGLG TGLATLSRNL YVVLSLCTHY GILFSTLCTL
660 670 680 690 700
PYSLLCDYYQ SKKFAGSSAD GTRRGMGVDI SLLSCQYFLA QILVSLVLGP
710 720 730 740 750
LTSAVGSANG VMYFASLVSF LGCLYSSLCV TYEIPSADAA DEERQPLLLN

V
Length:751
Mass (Da):81,752
Last modified:October 1, 2002 - v1
Checksum:i5C33E1C2E4A1B2EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075229 mRNA. Translation: BAB97313.1.
UniGeneiRn.203315.

Genome annotation databases

UCSCiRGD:708502. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075229 mRNA. Translation: BAB97313.1.
UniGeneiRn.203315.

3D structure databases

ProteinModelPortaliQ8K4S3.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024581.

Protein family/group databases

TCDBi2.A.2.4.4. the glycoside-pentoside-hexuronide (gph):cation symporter family.

Proteomic databases

PaxDbiQ8K4S3.
PRIDEiQ8K4S3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

UCSCiRGD:708502. rat.

Organism-specific databases

RGDi708502. Slc45a1.

Phylogenomic databases

eggNOGiKOG0637. Eukaryota.
ENOG410Y28T. LUCA.
HOGENOMiHOG000231090.
HOVERGENiHBG053518.
InParanoidiQ8K4S3.
PhylomeDBiQ8K4S3.

Miscellaneous databases

PROiQ8K4S3.

Family and domain databases

InterProiIPR011701. MFS.
IPR020846. MFS_dom.
[Graphical view]
PfamiPF07690. MFS_1. 1 hit.
[Graphical view]
SUPFAMiSSF103473. SSF103473. 2 hits.
ProtoNetiSearch...

Publicationsi

  1. "Past-A, a novel proton-associated sugar transporter, regulates glucose homeostasis in the brain."
    Shimokawa N., Okada J., Haglund K., Dikic I., Koibuchi N., Miura M.
    J. Neurosci. 22:9160-9165(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Brain.

Entry informationi

Entry nameiS45A1_RAT
AccessioniPrimary (citable) accession number: Q8K4S3
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2002
Last modified: November 11, 2015
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.