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Protein

Proton-associated sugar transporter A

Gene

Slc45a1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Proton-associated glucose transporter in the brain.1 Publication

GO - Molecular functioni

  • glucose transmembrane transporter activity Source: RGD
  • symporter activity Source: UniProtKB-KW

GO - Biological processi

Keywordsi

Biological processSugar transport, Symport, Transport

Protein family/group databases

TCDBi2.A.2.4.4 the glycoside-pentoside-hexuronide (gph):cation symporter family

Names & Taxonomyi

Protein namesi
Recommended name:
Proton-associated sugar transporter A1 Publication
Short name:
PAST-A1 Publication
Alternative name(s):
Solute carrier family 45 member 1
Gene namesi
Name:Slc45a1
Synonyms:Dnb5
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708502 Slc45a1

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei93 – 113HelicalSequence analysisAdd BLAST21
Transmembranei123 – 143HelicalSequence analysisAdd BLAST21
Transmembranei155 – 175HelicalSequence analysisAdd BLAST21
Transmembranei191 – 211HelicalSequence analysisAdd BLAST21
Transmembranei233 – 253HelicalSequence analysisAdd BLAST21
Transmembranei268 – 288HelicalSequence analysisAdd BLAST21
Transmembranei536 – 556HelicalSequence analysisAdd BLAST21
Transmembranei576 – 596HelicalSequence analysisAdd BLAST21
Transmembranei606 – 626HelicalSequence analysisAdd BLAST21
Transmembranei630 – 650HelicalSequence analysisAdd BLAST21
Transmembranei688 – 708HelicalSequence analysisAdd BLAST21
Transmembranei710 – 730HelicalSequence analysisAdd BLAST21

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00001225161 – 751Proton-associated sugar transporter AAdd BLAST751

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei500PhosphothreonineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

PaxDbiQ8K4S3
PRIDEiQ8K4S3

Expressioni

Tissue specificityi

Predominantly expressed in brain.1 Publication

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000024581

Structurei

3D structure databases

ProteinModelPortaliQ8K4S3
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG0637 Eukaryota
ENOG410Y28T LUCA
HOGENOMiHOG000231090
HOVERGENiHBG053518
InParanoidiQ8K4S3
PhylomeDBiQ8K4S3

Family and domain databases

InterProiView protein in InterPro
IPR011701 MFS
IPR036259 MFS_trans_sf
PfamiView protein in Pfam
PF07690 MFS_1, 1 hit
SUPFAMiSSF103473 SSF103473, 2 hits

Sequencei

Sequence statusi: Complete.

Q8K4S3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MIPPAGSTPP GEALIPSVAP QDFWRSPISG YSGSVTRHIS HRANNFKRHP
60 70 80 90 100
KRRKYIRPSP PPPPNTPCPI ELVDFEDLHP QRSFWELLFN GCILFGIEFS
110 120 130 140 150
YAMETAYVTP VLLQMGLPDQ LYSLVWFISP ILGFLLQPLL GAWSDRCTSR
160 170 180 190 200
FGRRRPFILV LAIGALLGLS LLLNGRDIGM ALADTATNHK WGILLTVCGV
210 220 230 240 250
VLMDFSADSA DNPSHAYMMD VCGPVDQDRG LNIHALMAGL GGGFGYVVGG
260 270 280 290 300
IHWDKTSFGR ALGGQLRVIY IFTAITLSVT TVFTLVSIPE RPLRPLGEKR
310 320 330 340 350
TAMKSPSLPL PPSPPVLLEE GAGDTLPSTT ATSLYASFSS PISPPSPLTP
360 370 380 390 400
KYGSFISRDS SLTGINEFAS SFGTSNIDSV LIDCFTAGHD NYLALPSSVP
410 420 430 440 450
RQAISVSFPR APDGFYCQER GLERREGPLT LGLDGDVLRV GSLDTSKPRA
460 470 480 490 500
SGILKRPQTL ALPDVAGGNG PETSRRRNVT FSQQVANILL NGVKYESELT
510 520 530 540 550
GSSEQSEQPL SLRRLCSTIY NMPRPVRNLC VNHFLGWLSF EGMLLFYTDF
560 570 580 590 600
MGEVVFQGDP KAPHASEAYQ KYNSGVTMGC WGMCIYAFSA AFYSAILEKL
610 620 630 640 650
EECLSVRTLY FIAYLLFGLG TGLATLSRNL YVVLSLCTHY GILFSTLCTL
660 670 680 690 700
PYSLLCDYYQ SKKFAGSSAD GTRRGMGVDI SLLSCQYFLA QILVSLVLGP
710 720 730 740 750
LTSAVGSANG VMYFASLVSF LGCLYSSLCV TYEIPSADAA DEERQPLLLN

V
Length:751
Mass (Da):81,752
Last modified:October 1, 2002 - v1
Checksum:i5C33E1C2E4A1B2EC
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB075229 mRNA Translation: BAB97313.1
UniGeneiRn.203315

Genome annotation databases

UCSCiRGD:708502 rat

Similar proteinsi

Entry informationi

Entry nameiS45A1_RAT
AccessioniPrimary (citable) accession number: Q8K4S3
Entry historyiIntegrated into UniProtKB/Swiss-Prot: October 24, 2003
Last sequence update: October 1, 2002
Last modified: April 25, 2018
This is version 81 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health