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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Gene

Plce1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.4 Publications

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.1 Publication

Cofactori

Ca2+By similarity

Enzyme regulationi

Activated by the heterotrimeric G-protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs (By similarity).By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei1388 – 13881PROSITE-ProRule annotation
Active sitei1433 – 14331PROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Guanine-nucleotide releasing factor, Hydrolase, Transducer

Keywords - Biological processi

Lipid degradation, Lipid metabolism

Enzyme and pathway databases

BRENDAi3.1.4.11. 3474.
ReactomeiREACT_321652. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-epsilon-1
Phospholipase C-epsilon-1
Short name:
PLC-epsilon-1
Gene namesi
Name:Plce1
Synonyms:Kiaa1516, Plce
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1921305. Plce1.

Subcellular locationi

  • Cytoplasmcytosol By similarity
  • Cell membrane By similarity
  • Golgi apparatus membrane By similarity

  • Note: Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Associates with Golgi membranes (By similarity).By similarity

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Cytoplasm, Golgi apparatus, Membrane

Pathology & Biotechi

Disruption phenotypei

Mice exhibit delayed onset and markedly reduced incidence of chemically induced skin squamous tumors. They also display cardiac malformations which mainly affects aortic and pulmonary valves and enhanced susceptibility to cardiac hypertrophy and fibrosis in response to chronic stress.2 Publications

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 228222821-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1PRO_0000256239Add
BLAST

Proteomic databases

MaxQBiQ8K4S1.
PaxDbiQ8K4S1.
PRIDEiQ8K4S1.

PTM databases

PhosphoSiteiQ8K4S1.

Expressioni

Tissue specificityi

Highly expressed in neurons and to a lower extent in skin, skeletal muscle and heart (at protein level). Expressed in the epidermis.2 Publications

Developmental stagei

Specifically expressed in cells committed to the neuronal lineage (at protein level). Weakly expressed at E7, expression strongly increases at later embryonic stages. Expressed abundantly in almost all neural tissues at E12.5 and also detected in tongue muscles, genital tubercle and hand plate. At E15.5 a strong expression in skeletal muscles is detected together with the strong expression in neural tissues.1 Publication

Inductioni

Up-regulated during the differentiation of neural precursor cells into neurons but not glial cells. Up-regulated in heart upon induced hypertrophy.2 Publications

Gene expression databases

BgeeiQ8K4S1.
CleanExiMM_PLCE1.
ExpressionAtlasiQ8K4S1. baseline and differential.
GenevestigatoriQ8K4S1.

Interactioni

Subunit structurei

Interacts with GTP-bound HRAS, RAP1A, RAP2A, RAP2B and RHOA (By similarity). Interacts with IQGAP1.By similarity1 Publication

Protein-protein interaction databases

DIPiDIP-60738N.
IntActiQ8K4S1. 2 interactions.
MINTiMINT-4117894.

Structurei

3D structure databases

ProteinModelPortaliQ8K4S1.
SMRiQ8K4S1. Positions 1986-2094, 2111-2226.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini528 – 781254Ras-GEFPROSITE-ProRule annotationAdd
BLAST
Domaini1373 – 1521149PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST
Domaini1710 – 1826117PI-PLC Y-boxPROSITE-ProRule annotationAdd
BLAST
Domaini1836 – 1936101C2PROSITE-ProRule annotationAdd
BLAST
Domaini1992 – 2094103Ras-associating 1PROSITE-ProRule annotationAdd
BLAST
Domaini2115 – 2218104Ras-associating 2PROSITE-ProRule annotationAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni1667 – 174478Required for activation by RHOA, RHOB, GNA12, GNA13 and G-beta gammaBy similarityAdd
BLAST

Domaini

The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane (By similarity).By similarity
The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway (By similarity).By similarity

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation
Contains 2 Ras-associating domains.PROSITE-ProRule annotation
Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

Keywords - Domaini

Repeat

Phylogenomic databases

eggNOGiNOG149692.
GeneTreeiENSGT00730000110782.
HOVERGENiHBG059220.
InParanoidiQ8K4S1.
KOiK05860.
OrthoDBiEOG7SN8CX.
TreeFamiTF314432.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.840.10. 2 hits.
2.60.40.150. 1 hit.
3.20.20.190. 3 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR028398. PLC-epsilon1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000159. Ras-assoc.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF6. PTHR10336:SF6. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 3 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4S1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MTSEEMAASV LIPVTQRKVA SAQSVAEERS VKVSDAGIPR ARAGRQGALI
60 70 80 90 100
PPTISQWNKH KEESSRSDLS KVFSIARGEL VCDENSNEEG WEENAPDSPE
110 120 130 140 150
NHAMNGNSLV QSHQHQFPRS QLCEARDSVT EDPCLQPGIP SPLERKVLPG
160 170 180 190 200
IQLEMEDSPM DVSPAGSQPR IMESSGPHSD RNTAVFHFHY EADRTMSDAF
210 220 230 240 250
HTLSENLILD DCANCVTLPG GQQNKNCMAY ACKLVELTRT CGSKNGQVQC
260 270 280 290 300
EHCTSLRDEY LCFESSCSKA DEVCSGGGFC EDGFAHGPAA KTFLNPLEDF
310 320 330 340 350
SDNCEDVDDF FKSKKERSTL LVRRFCKNDR EVKKSVYTGT RAIMRTLPSG
360 370 380 390 400
CIGPAAWNYV DQKKAGLLWP CGNVMGTLSA MDIRQSGSQR LSEAQWCLIY
410 420 430 440 450
SAVRRGEEIE DTVGSLLHCS TQLPNSETAH GRIEDGPCLK QCVRDTECEF
460 470 480 490 500
RATLQRTSIA QYITGSLLEA TTSLGARSGL LSSFGGSTGR IMLKERQLGT
510 520 530 540 550
SMANSNPVPS SSAGISKELI DLQPLIQFPE EVASILTEQE QNIYRRVLPM
560 570 580 590 600
DYLCFLTRDL SSPECQRSLP RLKASISESI LTSQSGEHNA LEDLVMRFNE
610 620 630 640 650
VSSWVTWLIL TAGSMEEKRE VFSYLVHVAK CCWNMGNYNA VMEFLAGLRS
660 670 680 690 700
RKVLKMWQFM DQSDIETMRS LKDAMAQHES SVEYKKVVTR ALHIPGCKVV
710 720 730 740 750
PFCGVFLKEL CEVLDGASGL LKLCPRYSSQ EEALEFVADY SGQDNFLQRV
760 770 780 790 800
GQNGLKNSEK ELTVNSIFQV IRSCSRSLEM EEEDSASEGS GSRKNSLKDK
810 820 830 840 850
ARWQFIIGDL LDSENDIFEK SKECDPHGSE ESQKAFDHGT ELIPWYVLSI
860 870 880 890 900
QADVHQFLLQ GATVIHYDQD THLSARCFLQ LQPDNSTLTW MKPPTASPAG
910 920 930 940 950
ARPKLGVLSN MAEPGKFPSP GNAGVSGLAE GILDLFSVKA VYMGHPGIDI
960 970 980 990 1000
HTVCVQNKLS SMLLSETGVT LLYGLQTTDN RLLHFVAPKH TAEMLFSGLL
1010 1020 1030 1040 1050
ELTTAVRKIR RFPDQRQQWL RKQYVSLYQE DGRYEGPTLA HAVELFGGRR
1060 1070 1080 1090 1100
WSTRNPSPGM SAKNAEKPNM QRNNTLGIST TKKKKKMLMR GESGEVTDDE
1110 1120 1130 1140 1150
MATRKAKMYR ECRSRSGSDP QDVNEQEESE ANVITNPPNP LHSRRAYSLT
1160 1170 1180 1190 1200
TAGSPNLATG MSSPISAWSS SSWHGRIRGG MQGFQSFMVS DSNMSFVEFV
1210 1220 1230 1240 1250
ELFKSFSIRS RKDLKDIFDI YSVPCNRSAS ESAPLYTNLT IEENTSDLQP
1260 1270 1280 1290 1300
DLDLLTRNVS DLGLFIKSKQ QLSDNQRQIS DAIAAASIVT NGTGIESTSL
1310 1320 1330 1340 1350
GIFGVGILQL NDFLVNCQGE HCTYDEILSI IQKFEPSVSM CHQGLLSFEG
1360 1370 1380 1390 1400
FARFLMDKDN FASKNDESRE NKKELQLPLS YYYIESSHNT YLTGHQLKGE
1410 1420 1430 1440 1450
SSVELYSQVL LQGCRSIELD CWDGDDGMPI IYHGHTLTTK IPFKEVVEAI
1460 1470 1480 1490 1500
DRSAFITSDL PIIISIENHC SLPQQRKMAE IFKSVFGEKL VAKFLFETDF
1510 1520 1530 1540 1550
SDDPMLPSPD QLRRKVLLKN KKLKAHQTPV DILKQKAHQL ASMQAQAFTG
1560 1570 1580 1590 1600
GNANPPPASN EEEEDEEDEY DYDYESLSDD NILEDRPENK SCADKLQFEY
1610 1620 1630 1640 1650
NEEVPKRIKK ADNSSGNKGK VYDMELGEEF YLPQNKKESR QIAPELSDLV
1660 1670 1680 1690 1700
IYCQAVKFPG LSTLNSSGSS RGKERKSRKS IFGNNPGRMS PGETAPFNRT
1710 1720 1730 1740 1750
SGKGSCEGMR HTWEESSPLS PSTSLSAIIR TPKCYHISSL NENAAKRLCR
1760 1770 1780 1790 1800
RGSQKLIQHT AYQLLRTYPA ATRIDSSNPN PIMFWLHGIQ LVALNYQTDD
1810 1820 1830 1840 1850
LPLHLNAAMF EANGGCGYVL KPPVLWDKSC PMYQKFSPLE RDLDNLDPAI
1860 1870 1880 1890 1900
YSLTIISGQN VCPSNSTGSP CIEVDVLGMP LDSCHFRTKP IHRNTLNPMW
1910 1920 1930 1940 1950
NEQFLFRVHF EDLVFLRFAV VENNSSAITA QRIIPLRALK RGYRHLQLRN
1960 1970 1980 1990 2000
LHNEILEISS LFINSRRMEE NPSGSSMPAS LMFNTEERKC SQTHKVTVHG
2010 2020 2030 2040 2050
VPGPEPFAVF TINEGTKAKQ LLQQVLAVDQ DTKCTATDYF LMEEKHFISK
2060 2070 2080 2090 2100
EKNECRKQPF QRAVGPEEDI VQILNSWFPE EGYVGRIVLK PQQETLEEKS
2110 2120 2130 2140 2150
IVFDDKEVIL SSEEESFFVQ VHDVSPEQPR TVIKAPRVST AQDVIQQTLC
2160 2170 2180 2190 2200
KAKYSYSILN NPNPCDYVLL EEVLKDAANK KSSTPKSSQR ILLDQECVFQ
2210 2220 2230 2240 2250
AQSKWKGAGK FILKLKEQVQ ASREDKRRGI SFASELKKLT KSTKQSRGLP
2260 2270 2280
SPPQLVASES VQSKEEKPVG ALSSSDTVGY QQ
Length:2,282
Mass (Da):255,047
Last modified:July 27, 2011 - v3
Checksum:iAA288A76304E43ED
GO

Sequence cautioni

The sequence BAC29099.1 differs from that shown.Probable cloning artifact.Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti295 – 2951N → S in BAC00906 (PubMed:12752375).Curated
Sequence conflicti295 – 2951N → S in AAI38350 (PubMed:15489334).Curated
Sequence conflicti295 – 2951N → S in AAI38351 (PubMed:15489334).Curated
Sequence conflicti1798 – 17981T → A in AAF40208 (PubMed:11146508).Curated
Sequence conflicti1829 – 18291S → N in AAF40208 (PubMed:11146508).Curated
Sequence conflicti2215 – 22173LKE → VKD in BAC29099 (PubMed:16141072).Curated
Sequence conflicti2233 – 22331A → G in BAC29099 (PubMed:16141072).Curated
Sequence conflicti2236 – 22361L → V in BAC29099 (PubMed:16141072).Curated
Sequence conflicti2239 – 22391L → V in BAC29099 (PubMed:16141072).Curated
Sequence conflicti2275 – 22751S → T in BAC29099 (PubMed:16141072).Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076247 mRNA. Translation: BAC00906.1.
AC111023 Genomic DNA. No translation available.
AC158905 Genomic DNA. No translation available.
BC138349 mRNA. Translation: AAI38350.1.
BC138350 mRNA. Translation: AAI38351.1.
AK122521 mRNA. Translation: BAC65803.1.
AK035546 mRNA. Translation: BAC29099.1. Sequence problems.
AK162236 mRNA. Translation: BAE36807.1.
AF233885 mRNA. Translation: AAF40208.1.
CCDSiCCDS37973.1.
RefSeqiNP_062534.2. NM_019588.2.
UniGeneiMm.34031.

Genome annotation databases

EnsembliENSMUST00000169713; ENSMUSP00000130604; ENSMUSG00000024998.
ENSMUST00000182481; ENSMUSP00000138360; ENSMUSG00000024998.
GeneIDi74055.
KEGGimmu:74055.
UCSCiuc008hjp.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB076247 mRNA. Translation: BAC00906.1.
AC111023 Genomic DNA. No translation available.
AC158905 Genomic DNA. No translation available.
BC138349 mRNA. Translation: AAI38350.1.
BC138350 mRNA. Translation: AAI38351.1.
AK122521 mRNA. Translation: BAC65803.1.
AK035546 mRNA. Translation: BAC29099.1. Sequence problems.
AK162236 mRNA. Translation: BAE36807.1.
AF233885 mRNA. Translation: AAF40208.1.
CCDSiCCDS37973.1.
RefSeqiNP_062534.2. NM_019588.2.
UniGeneiMm.34031.

3D structure databases

ProteinModelPortaliQ8K4S1.
SMRiQ8K4S1. Positions 1986-2094, 2111-2226.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

DIPiDIP-60738N.
IntActiQ8K4S1. 2 interactions.
MINTiMINT-4117894.

PTM databases

PhosphoSiteiQ8K4S1.

Proteomic databases

MaxQBiQ8K4S1.
PaxDbiQ8K4S1.
PRIDEiQ8K4S1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000169713; ENSMUSP00000130604; ENSMUSG00000024998.
ENSMUST00000182481; ENSMUSP00000138360; ENSMUSG00000024998.
GeneIDi74055.
KEGGimmu:74055.
UCSCiuc008hjp.1. mouse.

Organism-specific databases

CTDi51196.
MGIiMGI:1921305. Plce1.
RougeiSearch...

Phylogenomic databases

eggNOGiNOG149692.
GeneTreeiENSGT00730000110782.
HOVERGENiHBG059220.
InParanoidiQ8K4S1.
KOiK05860.
OrthoDBiEOG7SN8CX.
TreeFamiTF314432.

Enzyme and pathway databases

BRENDAi3.1.4.11. 3474.
ReactomeiREACT_321652. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

NextBioi339656.
PROiQ8K4S1.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K4S1.
CleanExiMM_PLCE1.
ExpressionAtlasiQ8K4S1. baseline and differential.
GenevestigatoriQ8K4S1.

Family and domain databases

Gene3Di1.10.238.10. 1 hit.
1.10.840.10. 2 hits.
2.60.40.150. 1 hit.
3.20.20.190. 3 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR001192. PI-PLC_fam.
IPR028398. PLC-epsilon1.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
IPR000159. Ras-assoc.
IPR023578. Ras_GEF_dom.
IPR001895. RASGEF_cat_dom.
IPR029071. Ubiquitin-rel_dom.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF6. PTHR10336:SF6. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
PF00788. RA. 1 hit.
PF00617. RasGEF. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
SM00314. RA. 1 hit.
SM00147. RasGEF. 1 hit.
[Graphical view]
SUPFAMiSSF48366. SSF48366. 2 hits.
SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 3 hits.
SSF54236. SSF54236. 2 hits.
PROSITEiPS50004. C2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
PS50200. RA. 1 hit.
PS50009. RASGEF_CAT. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain."
    Wu D., Tadano M., Edamatsu H., Masago-Toda M., Yamawaki-Kataoka Y., Terashima T., Mizoguchi A., Minami Y., Satoh T., Kataoka T.
    Eur. J. Neurosci. 17:1571-1580(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, DEVELOPMENTAL STAGE, INDUCTION.
    Tissue: Embryo.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Tissue: Brain.
  4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 919-2282.
    Tissue: Brain.
  5. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1166-2282.
    Strain: C57BL/6J.
    Tissue: Egg and Urinary bladder.
  6. "A novel transgenic marker for migrating limb muscle precursors and for vascular smooth muscle cells."
    Tidhar A., Reichenstein M., Cohen D., Faerman A., Copeland N.G., Gilbert D.J., Jenkins N.A., Shani M.
    Dev. Dyn. 220:60-73(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1661-2282.
  7. Cited for: FUNCTION.
  8. "Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development."
    Bai Y., Edamatsu H., Maeda S., Saito H., Suzuki N., Satoh T., Kataoka T.
    Cancer Res. 64:8808-8810(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  9. "Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy."
    Wang H., Oestreich E.A., Maekawa N., Bullard T.A., Vikstrom K.L., Dirksen R.T., Kelley G.G., Blaxall B.C., Smrcka A.V.
    Circ. Res. 97:1305-1313(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, INDUCTION.
  10. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
  11. Cited for: INTERACTION WITH IQGAP1.

Entry informationi

Entry nameiPLCE1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4S1
Secondary accession number(s): B9EHS1
, E9Q5G0, Q3TS68, Q80TC4, Q8BZF3, Q9JKM2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 31, 2006
Last sequence update: July 27, 2011
Last modified: April 29, 2015
This is version 113 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.