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Q8K4S1

- PLCE1_MOUSE

UniProt

Q8K4S1 - PLCE1_MOUSE

Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1

Gene

Plce1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 107 (01 Oct 2014)
      Sequence version 3 (27 Jul 2011)
      Previous versions | rss
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    Functioni

    The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. PLCE1 is a bifunctional enzyme which also regulates small GTPases of the Ras superfamily through its Ras guanine-exchange factor (RasGEF) activity. As an effector of heterotrimeric and small G-protein, it may play a role in cell survival, cell growth, actin organization and T-cell activation.4 Publications

    Catalytic activityi

    1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.1 Publication

    Cofactori

    Calcium.By similarity

    Enzyme regulationi

    Activated by the heterotrimeric G-protein subunits GNA12, GNA13 and GNB1-GNG2. Activated by HRAS, RAP1A, RHOA, RHOB, RHOC, RRAS and RRAS2. Activated by the G(s)-coupled GPCRs ADRB2, PTGER1 and CHRM3 through cyclic-AMP formation and RAP2B activation. Inhibited by G(i)-coupled GPCRs By similarity.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Active sitei1388 – 13881PROSITE-ProRule annotation
    Active sitei1433 – 14331PROSITE-ProRule annotation

    GO - Molecular functioni

    1. calcium ion binding Source: InterPro
    2. enzyme binding Source: UniProtKB
    3. guanyl-nucleotide exchange factor activity Source: UniProtKB-KW
    4. phosphatidylinositol phospholipase C activity Source: UniProtKB
    5. phospholipase C activity Source: UniProtKB
    6. signal transducer activity Source: UniProtKB-KW

    GO - Biological processi

    1. activation of MAPK activity Source: UniProtKB
    2. glomerulus development Source: Ensembl
    3. lipid catabolic process Source: UniProtKB-KW
    4. phospholipase C-activating G-protein coupled receptor signaling pathway Source: UniProtKB
    5. regulation of G-protein coupled receptor protein signaling pathway Source: UniProtKB
    6. regulation of protein kinase activity Source: UniProtKB
    7. regulation of Ras protein signal transduction Source: UniProtKB
    8. small GTPase mediated signal transduction Source: InterPro

    Keywords - Molecular functioni

    Guanine-nucleotide releasing factor, Hydrolase, Transducer

    Keywords - Biological processi

    Lipid degradation, Lipid metabolism

    Enzyme and pathway databases

    BRENDAi3.1.4.11. 3474.
    ReactomeiREACT_196473. Synthesis of IP3 and IP4 in the cytosol.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1 (EC:3.1.4.11)
    Alternative name(s):
    Phosphoinositide phospholipase C-epsilon-1
    Phospholipase C-epsilon-1
    Short name:
    PLC-epsilon-1
    Gene namesi
    Name:Plce1
    Synonyms:Kiaa1516, Plce
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 19

    Organism-specific databases

    MGIiMGI:1921305. Plce1.

    Subcellular locationi

    Cytoplasmcytosol By similarity. Cell membrane By similarity. Golgi apparatus membrane By similarity
    Note: Recruited to plasma membrane by activated HRAS and RAP2. Recruited to perinuclear membrane by activated RAP1A. Associates with Golgi membranes By similarity.By similarity

    GO - Cellular componenti

    1. cytosol Source: UniProtKB
    2. Golgi membrane Source: UniProtKB-SubCell
    3. plasma membrane Source: UniProtKB

    Keywords - Cellular componenti

    Cell membrane, Cytoplasm, Golgi apparatus, Membrane

    Pathology & Biotechi

    Disruption phenotypei

    Mice exhibit delayed onset and markedly reduced incidence of chemically induced skin squamous tumors. They also display cardiac malformations which mainly affects aortic and pulmonary valves and enhanced susceptibility to cardiac hypertrophy and fibrosis in response to chronic stress.2 Publications

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 228222821-phosphatidylinositol 4,5-bisphosphate phosphodiesterase epsilon-1PRO_0000256239Add
    BLAST

    Proteomic databases

    PaxDbiQ8K4S1.
    PRIDEiQ8K4S1.

    PTM databases

    PhosphoSiteiQ8K4S1.

    Expressioni

    Tissue specificityi

    Highly expressed in neurons and to a lower extent in skin, skeletal muscle and heart (at protein level). Expressed in the epidermis.2 Publications

    Developmental stagei

    Specifically expressed in cells committed to the neuronal lineage (at protein level). Weakly expressed at E7, expression strongly increases at later embryonic stages. Expressed abundantly in almost all neural tissues at E12.5 and also detected in tongue muscles, genital tubercle and hand plate. At E15.5 a strong expression in skeletal muscles is detected together with the strong expression in neural tissues.1 Publication

    Inductioni

    Up-regulated during the differentiation of neural precursor cells into neurons but not glial cells. Up-regulated in heart upon induced hypertrophy.2 Publications

    Gene expression databases

    BgeeiQ8K4S1.
    CleanExiMM_PLCE1.
    GenevestigatoriQ8K4S1.

    Interactioni

    Subunit structurei

    Interacts with GTP-bound HRAS, RAP1A, RAP2A, RAP2B and RHOA By similarity. Interacts with IQGAP1.By similarity1 Publication

    Protein-protein interaction databases

    DIPiDIP-60738N.
    IntActiQ8K4S1. 2 interactions.
    MINTiMINT-4117894.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4S1.
    SMRiQ8K4S1. Positions 1986-2094, 2111-2226.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini528 – 781254Ras-GEFPROSITE-ProRule annotationAdd
    BLAST
    Domaini1373 – 1521149PI-PLC X-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini1710 – 1826117PI-PLC Y-boxPROSITE-ProRule annotationAdd
    BLAST
    Domaini1836 – 1936101C2PROSITE-ProRule annotationAdd
    BLAST
    Domaini1992 – 2094103Ras-associating 1PROSITE-ProRule annotationAdd
    BLAST
    Domaini2115 – 2218104Ras-associating 2PROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1667 – 174478Required for activation by RHOA, RHOB, GNA12, GNA13 and G-beta gammaBy similarityAdd
    BLAST

    Domaini

    The Ras-associating domain 1 is degenerated and may not bind HRAS. The Ras-associating domain 2 mediates interaction with GTP-bound HRAS, RAP1A, RAP2A and RAP2B and recruitment of HRAS to the cell membrane By similarity.By similarity
    The Ras-GEF domain has a GEF activity towards HRAS and RAP1A. Mediates activation of the mitogen-activated protein kinase pathway By similarity.By similarity

    Sequence similaritiesi

    Contains 1 C2 domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
    Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation
    Contains 2 Ras-associating domains.PROSITE-ProRule annotation
    Contains 1 Ras-GEF domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Repeat

    Phylogenomic databases

    eggNOGiNOG149692.
    GeneTreeiENSGT00730000110782.
    HOVERGENiHBG059220.
    InParanoidiQ8K4S1.
    KOiK05860.
    OrthoDBiEOG7SN8CX.
    TreeFamiTF314432.

    Family and domain databases

    Gene3Di1.10.238.10. 1 hit.
    1.10.840.10. 2 hits.
    2.60.40.150. 1 hit.
    3.20.20.190. 3 hits.
    InterProiIPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR028398. PLC-epsilon1.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    IPR000159. Ras-assoc.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view]
    PANTHERiPTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF6. PTHR10336:SF6. 1 hit.
    PfamiPF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    [Graphical view]
    PRINTSiPR00390. PHPHLIPASEC.
    SMARTiSM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    [Graphical view]
    SUPFAMiSSF48366. SSF48366. 2 hits.
    SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 3 hits.
    SSF54236. SSF54236. 2 hits.
    PROSITEiPS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    PS50200. RA. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4S1-1 [UniParc]FASTAAdd to Basket

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    MTSEEMAASV LIPVTQRKVA SAQSVAEERS VKVSDAGIPR ARAGRQGALI     50
    PPTISQWNKH KEESSRSDLS KVFSIARGEL VCDENSNEEG WEENAPDSPE 100
    NHAMNGNSLV QSHQHQFPRS QLCEARDSVT EDPCLQPGIP SPLERKVLPG 150
    IQLEMEDSPM DVSPAGSQPR IMESSGPHSD RNTAVFHFHY EADRTMSDAF 200
    HTLSENLILD DCANCVTLPG GQQNKNCMAY ACKLVELTRT CGSKNGQVQC 250
    EHCTSLRDEY LCFESSCSKA DEVCSGGGFC EDGFAHGPAA KTFLNPLEDF 300
    SDNCEDVDDF FKSKKERSTL LVRRFCKNDR EVKKSVYTGT RAIMRTLPSG 350
    CIGPAAWNYV DQKKAGLLWP CGNVMGTLSA MDIRQSGSQR LSEAQWCLIY 400
    SAVRRGEEIE DTVGSLLHCS TQLPNSETAH GRIEDGPCLK QCVRDTECEF 450
    RATLQRTSIA QYITGSLLEA TTSLGARSGL LSSFGGSTGR IMLKERQLGT 500
    SMANSNPVPS SSAGISKELI DLQPLIQFPE EVASILTEQE QNIYRRVLPM 550
    DYLCFLTRDL SSPECQRSLP RLKASISESI LTSQSGEHNA LEDLVMRFNE 600
    VSSWVTWLIL TAGSMEEKRE VFSYLVHVAK CCWNMGNYNA VMEFLAGLRS 650
    RKVLKMWQFM DQSDIETMRS LKDAMAQHES SVEYKKVVTR ALHIPGCKVV 700
    PFCGVFLKEL CEVLDGASGL LKLCPRYSSQ EEALEFVADY SGQDNFLQRV 750
    GQNGLKNSEK ELTVNSIFQV IRSCSRSLEM EEEDSASEGS GSRKNSLKDK 800
    ARWQFIIGDL LDSENDIFEK SKECDPHGSE ESQKAFDHGT ELIPWYVLSI 850
    QADVHQFLLQ GATVIHYDQD THLSARCFLQ LQPDNSTLTW MKPPTASPAG 900
    ARPKLGVLSN MAEPGKFPSP GNAGVSGLAE GILDLFSVKA VYMGHPGIDI 950
    HTVCVQNKLS SMLLSETGVT LLYGLQTTDN RLLHFVAPKH TAEMLFSGLL 1000
    ELTTAVRKIR RFPDQRQQWL RKQYVSLYQE DGRYEGPTLA HAVELFGGRR 1050
    WSTRNPSPGM SAKNAEKPNM QRNNTLGIST TKKKKKMLMR GESGEVTDDE 1100
    MATRKAKMYR ECRSRSGSDP QDVNEQEESE ANVITNPPNP LHSRRAYSLT 1150
    TAGSPNLATG MSSPISAWSS SSWHGRIRGG MQGFQSFMVS DSNMSFVEFV 1200
    ELFKSFSIRS RKDLKDIFDI YSVPCNRSAS ESAPLYTNLT IEENTSDLQP 1250
    DLDLLTRNVS DLGLFIKSKQ QLSDNQRQIS DAIAAASIVT NGTGIESTSL 1300
    GIFGVGILQL NDFLVNCQGE HCTYDEILSI IQKFEPSVSM CHQGLLSFEG 1350
    FARFLMDKDN FASKNDESRE NKKELQLPLS YYYIESSHNT YLTGHQLKGE 1400
    SSVELYSQVL LQGCRSIELD CWDGDDGMPI IYHGHTLTTK IPFKEVVEAI 1450
    DRSAFITSDL PIIISIENHC SLPQQRKMAE IFKSVFGEKL VAKFLFETDF 1500
    SDDPMLPSPD QLRRKVLLKN KKLKAHQTPV DILKQKAHQL ASMQAQAFTG 1550
    GNANPPPASN EEEEDEEDEY DYDYESLSDD NILEDRPENK SCADKLQFEY 1600
    NEEVPKRIKK ADNSSGNKGK VYDMELGEEF YLPQNKKESR QIAPELSDLV 1650
    IYCQAVKFPG LSTLNSSGSS RGKERKSRKS IFGNNPGRMS PGETAPFNRT 1700
    SGKGSCEGMR HTWEESSPLS PSTSLSAIIR TPKCYHISSL NENAAKRLCR 1750
    RGSQKLIQHT AYQLLRTYPA ATRIDSSNPN PIMFWLHGIQ LVALNYQTDD 1800
    LPLHLNAAMF EANGGCGYVL KPPVLWDKSC PMYQKFSPLE RDLDNLDPAI 1850
    YSLTIISGQN VCPSNSTGSP CIEVDVLGMP LDSCHFRTKP IHRNTLNPMW 1900
    NEQFLFRVHF EDLVFLRFAV VENNSSAITA QRIIPLRALK RGYRHLQLRN 1950
    LHNEILEISS LFINSRRMEE NPSGSSMPAS LMFNTEERKC SQTHKVTVHG 2000
    VPGPEPFAVF TINEGTKAKQ LLQQVLAVDQ DTKCTATDYF LMEEKHFISK 2050
    EKNECRKQPF QRAVGPEEDI VQILNSWFPE EGYVGRIVLK PQQETLEEKS 2100
    IVFDDKEVIL SSEEESFFVQ VHDVSPEQPR TVIKAPRVST AQDVIQQTLC 2150
    KAKYSYSILN NPNPCDYVLL EEVLKDAANK KSSTPKSSQR ILLDQECVFQ 2200
    AQSKWKGAGK FILKLKEQVQ ASREDKRRGI SFASELKKLT KSTKQSRGLP 2250
    SPPQLVASES VQSKEEKPVG ALSSSDTVGY QQ 2282
    Length:2,282
    Mass (Da):255,047
    Last modified:July 27, 2011 - v3
    Checksum:iAA288A76304E43ED
    GO

    Sequence cautioni

    The sequence BAC29099.1 differs from that shown. Reason: Probable cloning artifact.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti295 – 2951N → S in BAC00906. (PubMed:12752375)Curated
    Sequence conflicti295 – 2951N → S in AAI38350. (PubMed:15489334)Curated
    Sequence conflicti295 – 2951N → S in AAI38351. (PubMed:15489334)Curated
    Sequence conflicti1798 – 17981T → A in AAF40208. (PubMed:11146508)Curated
    Sequence conflicti1829 – 18291S → N in AAF40208. (PubMed:11146508)Curated
    Sequence conflicti2215 – 22173LKE → VKD in BAC29099. (PubMed:16141072)Curated
    Sequence conflicti2233 – 22331A → G in BAC29099. (PubMed:16141072)Curated
    Sequence conflicti2236 – 22361L → V in BAC29099. (PubMed:16141072)Curated
    Sequence conflicti2239 – 22391L → V in BAC29099. (PubMed:16141072)Curated
    Sequence conflicti2275 – 22751S → T in BAC29099. (PubMed:16141072)Curated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076247 mRNA. Translation: BAC00906.1.
    AC111023 Genomic DNA. No translation available.
    AC158905 Genomic DNA. No translation available.
    BC138349 mRNA. Translation: AAI38350.1.
    BC138350 mRNA. Translation: AAI38351.1.
    AK122521 mRNA. Translation: BAC65803.1.
    AK035546 mRNA. Translation: BAC29099.1. Sequence problems.
    AK162236 mRNA. Translation: BAE36807.1.
    AF233885 mRNA. Translation: AAF40208.1.
    CCDSiCCDS37973.1.
    RefSeqiNP_062534.2. NM_019588.2.
    UniGeneiMm.34031.

    Genome annotation databases

    EnsembliENSMUST00000169713; ENSMUSP00000130604; ENSMUSG00000024998.
    ENSMUST00000182481; ENSMUSP00000138360; ENSMUSG00000024998.
    GeneIDi74055.
    KEGGimmu:74055.
    UCSCiuc008hjp.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB076247 mRNA. Translation: BAC00906.1 .
    AC111023 Genomic DNA. No translation available.
    AC158905 Genomic DNA. No translation available.
    BC138349 mRNA. Translation: AAI38350.1 .
    BC138350 mRNA. Translation: AAI38351.1 .
    AK122521 mRNA. Translation: BAC65803.1 .
    AK035546 mRNA. Translation: BAC29099.1 . Sequence problems.
    AK162236 mRNA. Translation: BAE36807.1 .
    AF233885 mRNA. Translation: AAF40208.1 .
    CCDSi CCDS37973.1.
    RefSeqi NP_062534.2. NM_019588.2.
    UniGenei Mm.34031.

    3D structure databases

    ProteinModelPortali Q8K4S1.
    SMRi Q8K4S1. Positions 1986-2094, 2111-2226.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    DIPi DIP-60738N.
    IntActi Q8K4S1. 2 interactions.
    MINTi MINT-4117894.

    PTM databases

    PhosphoSitei Q8K4S1.

    Proteomic databases

    PaxDbi Q8K4S1.
    PRIDEi Q8K4S1.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000169713 ; ENSMUSP00000130604 ; ENSMUSG00000024998 .
    ENSMUST00000182481 ; ENSMUSP00000138360 ; ENSMUSG00000024998 .
    GeneIDi 74055.
    KEGGi mmu:74055.
    UCSCi uc008hjp.1. mouse.

    Organism-specific databases

    CTDi 51196.
    MGIi MGI:1921305. Plce1.
    Rougei Search...

    Phylogenomic databases

    eggNOGi NOG149692.
    GeneTreei ENSGT00730000110782.
    HOVERGENi HBG059220.
    InParanoidi Q8K4S1.
    KOi K05860.
    OrthoDBi EOG7SN8CX.
    TreeFami TF314432.

    Enzyme and pathway databases

    BRENDAi 3.1.4.11. 3474.
    Reactomei REACT_196473. Synthesis of IP3 and IP4 in the cytosol.

    Miscellaneous databases

    NextBioi 339656.
    PROi Q8K4S1.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K4S1.
    CleanExi MM_PLCE1.
    Genevestigatori Q8K4S1.

    Family and domain databases

    Gene3Di 1.10.238.10. 1 hit.
    1.10.840.10. 2 hits.
    2.60.40.150. 1 hit.
    3.20.20.190. 3 hits.
    InterProi IPR000008. C2_dom.
    IPR011992. EF-hand-dom_pair.
    IPR001192. PI-PLC_fam.
    IPR028398. PLC-epsilon1.
    IPR017946. PLC-like_Pdiesterase_TIM-brl.
    IPR015359. PLipase_C_EF-hand-like.
    IPR000909. PLipase_C_PInositol-sp_X_dom.
    IPR001711. PLipase_C_Pinositol-sp_Y.
    IPR000159. Ras-assoc.
    IPR023578. Ras_GEF_dom.
    IPR001895. RasGRF_CDC25.
    IPR029071. Ubiquitin-rel_dom.
    [Graphical view ]
    PANTHERi PTHR10336. PTHR10336. 1 hit.
    PTHR10336:SF6. PTHR10336:SF6. 1 hit.
    Pfami PF00168. C2. 1 hit.
    PF09279. EF-hand_like. 1 hit.
    PF00388. PI-PLC-X. 1 hit.
    PF00387. PI-PLC-Y. 1 hit.
    PF00788. RA. 1 hit.
    PF00617. RasGEF. 1 hit.
    [Graphical view ]
    PRINTSi PR00390. PHPHLIPASEC.
    SMARTi SM00239. C2. 1 hit.
    SM00148. PLCXc. 1 hit.
    SM00149. PLCYc. 1 hit.
    SM00314. RA. 1 hit.
    SM00147. RasGEF. 1 hit.
    [Graphical view ]
    SUPFAMi SSF48366. SSF48366. 2 hits.
    SSF49562. SSF49562. 1 hit.
    SSF51695. SSF51695. 3 hits.
    SSF54236. SSF54236. 2 hits.
    PROSITEi PS50004. C2. 1 hit.
    PS50007. PIPLC_X_DOMAIN. 1 hit.
    PS50008. PIPLC_Y_DOMAIN. 1 hit.
    PS50200. RA. 1 hit.
    PS50009. RASGEF_CAT. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Neuronal lineage-specific induction of phospholipase Cepsilon expression in the developing mouse brain."
      Wu D., Tadano M., Edamatsu H., Masago-Toda M., Yamawaki-Kataoka Y., Terashima T., Mizoguchi A., Minami Y., Satoh T., Kataoka T.
      Eur. J. Neurosci. 17:1571-1580(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], CATALYTIC ACTIVITY, DEVELOPMENTAL STAGE, INDUCTION.
      Tissue: Embryo.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Tissue: Brain.
    4. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
      Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
      DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 919-2282.
      Tissue: Brain.
    5. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1166-2282.
      Strain: C57BL/6J.
      Tissue: Egg and Urinary bladder.
    6. "A novel transgenic marker for migrating limb muscle precursors and for vascular smooth muscle cells."
      Tidhar A., Reichenstein M., Cohen D., Faerman A., Copeland N.G., Gilbert D.J., Jenkins N.A., Shani M.
      Dev. Dyn. 220:60-73(2001) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] OF 1661-2282.
    7. Cited for: FUNCTION.
    8. "Crucial role of phospholipase Cepsilon in chemical carcinogen-induced skin tumor development."
      Bai Y., Edamatsu H., Maeda S., Saito H., Suzuki N., Satoh T., Kataoka T.
      Cancer Res. 64:8808-8810(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    9. "Phospholipase C epsilon modulates beta-adrenergic receptor-dependent cardiac contraction and inhibits cardiac hypertrophy."
      Wang H., Oestreich E.A., Maekawa N., Bullard T.A., Vikstrom K.L., Dirksen R.T., Kelley G.G., Blaxall B.C., Smrcka A.V.
      Circ. Res. 97:1305-1313(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INDUCTION.
    10. Cited for: FUNCTION, TISSUE SPECIFICITY, DISRUPTION PHENOTYPE.
    11. Cited for: INTERACTION WITH IQGAP1.

    Entry informationi

    Entry nameiPLCE1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4S1
    Secondary accession number(s): B9EHS1
    , E9Q5G0, Q3TS68, Q80TC4, Q8BZF3, Q9JKM2
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: October 31, 2006
    Last sequence update: July 27, 2011
    Last modified: October 1, 2014
    This is version 107 of the entry and version 3 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3