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Protein

Sodium-dependent phosphate transport protein 2C

Gene

Slc34a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May be involved in actively transporting phosphate into cells via Na+ cotransport in the renal brush border membrane. Probably mediates 20-30% of the apical influx.

GO - Molecular functioni

  • inorganic phosphate transmembrane transporter activity Source: GO_Central
  • sodium:phosphate symporter activity Source: RGD
  • sodium-dependent phosphate transmembrane transporter activity Source: RGD

GO - Biological processi

  • cellular phosphate ion homeostasis Source: GO_Central
  • phosphate ion transport Source: RGD
  • response to magnesium ion Source: RGD
  • response to nutrient levels Source: RGD
Complete GO annotation...

Keywords - Biological processi

Ion transport, Sodium transport, Symport, Transport

Keywords - Ligandi

Sodium

Names & Taxonomyi

Protein namesi
Recommended name:
Sodium-dependent phosphate transport protein 2C
Short name:
Sodium-phosphate transport protein 2C
Alternative name(s):
Na(+)-dependent phosphate cotransporter 2C
Sodium/phosphate cotransporter 2C
Short name:
Na(+)/Pi cotransporter 2C
Short name:
NaPi-2c
Solute carrier family 34 member 3
Gene namesi
Name:Slc34a3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi708551. Slc34a3.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 7575CytoplasmicSequence analysisAdd
BLAST
Transmembranei76 – 9621Helical; Name=M1Sequence analysisAdd
BLAST
Topological domaini97 – 11014ExtracellularSequence analysisAdd
BLAST
Transmembranei111 – 13121Helical; Name=M2Sequence analysisAdd
BLAST
Topological domaini132 – 18756CytoplasmicSequence analysisAdd
BLAST
Transmembranei188 – 20821Helical; Name=M3Sequence analysisAdd
BLAST
Topological domaini209 – 324116ExtracellularSequence analysisAdd
BLAST
Transmembranei325 – 34521Helical; Name=M4Sequence analysisAdd
BLAST
Topological domaini346 – 36924CytoplasmicSequence analysisAdd
BLAST
Transmembranei370 – 39021Helical; Name=M5Sequence analysisAdd
BLAST
Topological domaini391 – 44757ExtracellularSequence analysisAdd
BLAST
Transmembranei448 – 46821Helical; Name=M6Sequence analysisAdd
BLAST
Topological domaini469 – 48719CytoplasmicSequence analysisAdd
BLAST
Transmembranei488 – 50821Helical; Name=M7Sequence analysisAdd
BLAST
Topological domaini509 – 5124ExtracellularSequence analysis
Transmembranei513 – 53321Helical; Name=M8Sequence analysisAdd
BLAST
Topological domaini534 – 60168CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • apical plasma membrane Source: RGD
  • brush border membrane Source: RGD
  • cytoplasmic vesicle Source: RGD
  • integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 601601Sodium-dependent phosphate transport protein 2CPRO_0000068619Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei4 – 41PhosphoserineCombined sources
Glycosylationi210 – 2101N-linked (GlcNAc...)Sequence analysis
Glycosylationi264 – 2641N-linked (GlcNAc...)Sequence analysis
Glycosylationi267 – 2671N-linked (GlcNAc...)Sequence analysis
Disulfide bondi275 ↔ 311By similarity
Glycosylationi299 – 2991N-linked (GlcNAc...)Sequence analysis

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8K4R8.
PRIDEiQ8K4R8.

PTM databases

iPTMnetiQ8K4R8.
PhosphoSiteiQ8K4R8.

Expressioni

Tissue specificityi

Highly expressed in the kidney. Not found in any of the other tested tissues.1 Publication

Developmental stagei

Highest kidney expression is found in weaning rat followed by adult. Lowest expression is found in suckling rat.1 Publication

Interactioni

Protein-protein interaction databases

IntActiQ8K4R8. 1 interaction.
STRINGi10116.ENSRNOP00000014060.

Family & Domainsi

Compositional bias

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Compositional biasi426 – 4294Poly-Thr

Sequence similaritiesi

Belongs to the SLC34A transporter family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IE8P. Eukaryota.
COG1283. LUCA.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ8K4R8.
KOiK14683.
PhylomeDBiQ8K4R8.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
IPR029850. Na/Pi_transpt_2C.
[Graphical view]
PANTHERiPTHR10010:SF35. PTHR10010:SF35. 2 hits.
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K4R8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPNSLAGDQV PNPTLDAIGL VDWSLRNAGT SGSTPGLEEG GTDPWTFSQL
60 70 80 90 100
KNTDQLKEVG TASKLHQVVS GFLKACGLLG SLYFFICSLD ILSSAFQLLG
110 120 130 140 150
SKMAGDIFKD NVVLSNPVAG LVIGVVVTVL VQSSSTSSSI VVSMVASKSL
160 170 180 190 200
TVQASVPIIM GVNVGTSITS TLVSMAQSGD RDEFQRAFGG SAVHGIFNWL
210 220 230 240 250
TVLVLLPLEN ATAALERLSE LALGAASLQP GGQAPDILKA LTRPFTHLII
260 270 280 290 300
QLDSSVVTSS ITSNTTNSSL IKHWCGFRGE TPQGSSEECD LSGSCTERNS
310 320 330 340 350
SASPGEDRLL CHHLFAGSEL TDLAVGFILL AGSLLVLCVC LVLIVKLLNS
360 370 380 390 400
VLRGRIAQAV KTVINADFPF PFGWLSGYLA ILVGAGLTFL LQSSSVFTAA
410 420 430 440 450
IVPLMGVGVI NLERAYPLFL GSNIGTTTTA LLAALASPAD TLLFAVQVAL
460 470 480 490 500
IHFFFNLAGI LLWYLVPVLR LPIPLAKRFG DLTAQYRWVA IVYLLLTFLL
510 520 530 540 550
LPLAAFGLSL AGGSVLAAVG GPLVGLVLLI ILVNVLQRHR PSWLPRRLQS
560 570 580 590 600
WAWLPLWLHS LEPWDRLVTG CCPFKAYSNS HMTSKVAHCY ENPQVIASQQ

L
Length:601
Mass (Da):63,846
Last modified:October 1, 2002 - v1
Checksum:i0F77AD6BFB4755A8
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077042 mRNA. Translation: BAB96817.1.
RefSeqiNP_647554.1. NM_139338.2.
UniGeneiRn.15318.

Genome annotation databases

GeneIDi246234.
KEGGirno:246234.
UCSCiRGD:708551. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB077042 mRNA. Translation: BAB96817.1.
RefSeqiNP_647554.1. NM_139338.2.
UniGeneiRn.15318.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

IntActiQ8K4R8. 1 interaction.
STRINGi10116.ENSRNOP00000014060.

PTM databases

iPTMnetiQ8K4R8.
PhosphoSiteiQ8K4R8.

Proteomic databases

PaxDbiQ8K4R8.
PRIDEiQ8K4R8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi246234.
KEGGirno:246234.
UCSCiRGD:708551. rat.

Organism-specific databases

CTDi142680.
RGDi708551. Slc34a3.

Phylogenomic databases

eggNOGiENOG410IE8P. Eukaryota.
COG1283. LUCA.
HOGENOMiHOG000006550.
HOVERGENiHBG006527.
InParanoidiQ8K4R8.
KOiK14683.
PhylomeDBiQ8K4R8.

Miscellaneous databases

PROiQ8K4R8.

Family and domain databases

InterProiIPR003841. Na/Pi_transpt.
IPR029850. Na/Pi_transpt_2C.
[Graphical view]
PANTHERiPTHR10010:SF35. PTHR10010:SF35. 2 hits.
PfamiPF02690. Na_Pi_cotrans. 2 hits.
[Graphical view]
TIGRFAMsiTIGR01013. 2a58. 1 hit.
ProtoNetiSearch...

Entry informationi

Entry nameiNPT2C_RAT
AccessioniPrimary (citable) accession number: Q8K4R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 20, 2005
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 74 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.