Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

Gap junction alpha-8 protein

Gene

Gja8

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.By similarity

GO - Biological processi

  • cell-cell signaling Source: RGD
  • lens development in camera-type eye Source: Ensembl
  • protein homooligomerization Source: RGD
  • transmembrane transport Source: GOC
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Gap junction alpha-8 protein
Alternative name(s):
Connexin-50
Short name:
Cx50
Gene namesi
Name:Gja8
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 2

Organism-specific databases

RGDi628890. Gja8.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini2 – 2322CytoplasmicSequence analysisAdd
BLAST
Transmembranei24 – 4623HelicalSequence analysisAdd
BLAST
Topological domaini47 – 7630ExtracellularSequence analysisAdd
BLAST
Transmembranei77 – 9923HelicalSequence analysisAdd
BLAST
Topological domaini100 – 15758CytoplasmicSequence analysisAdd
BLAST
Transmembranei158 – 18023HelicalSequence analysisAdd
BLAST
Topological domaini181 – 20929ExtracellularSequence analysisAdd
BLAST
Transmembranei210 – 22920HelicalSequence analysisAdd
BLAST
Topological domaini230 – 440211CytoplasmicSequence analysisAdd
BLAST

GO - Cellular componenti

  • connexon complex Source: RGD
  • integral component of membrane Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cell junction, Cell membrane, Gap junction, Membrane

Pathology & Biotechi

Involvement in diseasei

Defects in Gja8 are the cause of cataract.

Keywords - Diseasei

Disease mutation

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methionineiRemovedBy similarity
Chaini2 – 440439Gap junction alpha-8 proteinPRO_0000313005Add
BLAST

Proteomic databases

PaxDbiQ8K4Q9.

Expressioni

Gene expression databases

BgeeiENSRNOG00000046703.
ExpressionAtlasiQ8K4Q9. baseline.

Interactioni

Subunit structurei

A connexon is composed of a hexamer of connexins.By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066975.

Family & Domainsi

Sequence similaritiesi

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IF3Z. Eukaryota.
ENOG410ZC96. LUCA.
GeneTreeiENSGT00840000129674.
HOVERGENiHBG009576.
InParanoidiQ8K4Q9.
OMAiMYVGHAV.
OrthoDBiEOG091G0FKH.
PhylomeDBiQ8K4Q9.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PTHR11984:SF19. PTHR11984:SF19. 2 hits.
PfamiPF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4Q9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGDWSFLGNI LEEVNEHSTV IGRVWLTVLF IFRILILGTA AEFVWGDEQS
60 70 80 90 100
DFVCNTQQPG CENVCYDEAF PISHIRLWVL QIIFVSTPSL MYVGHAVHHV
110 120 130 140 150
RMEEKRKDRE AEELCQQSRS NGGERVPIAP DQASIRKSSS SSKGTKKFRL
160 170 180 190 200
EGTLLRTYVC HIIFKTLFEV GFIVGHYFLY GFRILPLYRC SRWPCPNVVD
210 220 230 240 250
CFVSRPTEKT IFILFMLSVA FVSLFLNIME MSHLGMKGIR SAFKRPAEQP
260 270 280 290 300
LGEIAEKSLH SIAVSSIQKA KGYQLLEEEK IVSHYFPLTE VGMVETSPLS
310 320 330 340 350
AKPFSQFEEK IGTGPLADMS RGYQETLPSY AQVGAQEVER EEQPVEEAVE
360 370 380 390 400
PEVGEKKQEA EKVAPEGQET VAVPDGEKVE TPGVGKDDEK EELQAEKVTK
410 420 430 440
QGLSAEKAPT LCPELTTDDN RPLSRLSKAS SRARSDDLTI
Length:440
Mass (Da):49,401
Last modified:October 1, 2002 - v1
Checksum:iDDF57B9D6E1016AF
GO

Natural variant

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Natural varianti340 – 3401R → W in cataract. 1 Publication

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078344 Genomic DNA. Translation: BAC06574.1.
UniGeneiRn.86658.

Genome annotation databases

EnsembliENSRNOT00000071622; ENSRNOP00000066975; ENSRNOG00000046703.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB078344 Genomic DNA. Translation: BAC06574.1.
UniGeneiRn.86658.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000066975.

Proteomic databases

PaxDbiQ8K4Q9.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000071622; ENSRNOP00000066975; ENSRNOG00000046703.

Organism-specific databases

RGDi628890. Gja8.

Phylogenomic databases

eggNOGiENOG410IF3Z. Eukaryota.
ENOG410ZC96. LUCA.
GeneTreeiENSGT00840000129674.
HOVERGENiHBG009576.
InParanoidiQ8K4Q9.
OMAiMYVGHAV.
OrthoDBiEOG091G0FKH.
PhylomeDBiQ8K4Q9.

Miscellaneous databases

PROiQ8K4Q9.

Gene expression databases

BgeeiENSRNOG00000046703.
ExpressionAtlasiQ8K4Q9. baseline.

Family and domain databases

InterProiIPR000500. Connexin.
IPR002266. Connexin50.
IPR019570. Connexin_CCC.
IPR017990. Connexin_CS.
IPR013092. Connexin_N.
[Graphical view]
PANTHERiPTHR11984. PTHR11984. 2 hits.
PTHR11984:SF19. PTHR11984:SF19. 2 hits.
PfamiPF00029. Connexin. 1 hit.
PF03509. Connexin50. 1 hit.
[Graphical view]
PRINTSiPR00206. CONNEXIN.
PR01137. CONNEXINA8.
SMARTiSM00037. CNX. 1 hit.
SM01089. Connexin_CCC. 1 hit.
[Graphical view]
PROSITEiPS00407. CONNEXINS_1. 1 hit.
PS00408. CONNEXINS_2. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCXA8_RAT
AccessioniPrimary (citable) accession number: Q8K4Q9
Entry historyi
Integrated into UniProtKB/Swiss-Prot: January 15, 2008
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.