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Q8K4Q1

- Q8K4Q1_MOUSE

UniProt

Q8K4Q1 - Q8K4Q1_MOUSE

Protein
Submitted name:

Pax1 protein

Gene

Pax1

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 80 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Molecular functioni

    1. DNA binding Source: UniProtKB-KW
    2. sequence-specific DNA binding transcription factor activity Source: MGI

    GO - Biological processi

    1. bone morphogenesis Source: MGI
    2. CD4-positive, alpha-beta T cell differentiation Source: MGI
    3. CD8-positive, alpha-beta T cell differentiation Source: MGI
    4. cell proliferation Source: MGI
    5. organ morphogenesis Source: MGI
    6. parathyroid gland development Source: MGI
    7. pattern specification process Source: MGI
    8. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    9. regulation of transcription, DNA-templated Source: MGI
    10. skeletal system development Source: MGI
    11. somitogenesis Source: MGI
    12. thymus development Source: MGI
    13. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Molecular functioni

    Developmental proteinUniRule annotationSAAS annotation

    Keywords - Biological processi

    Transcription, Transcription regulationUniRule annotationSAAS annotation

    Keywords - Ligandi

    DNA-bindingUniRule annotationSAAS annotation

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    Pax1 proteinImported
    Gene namesi
    Name:Pax1Imported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

    Organism-specific databases

    MGIiMGI:97485. Pax1.

    Subcellular locationi

    Nucleus UniRule annotationSAAS annotation

    GO - Cellular componenti

    1. nucleus Source: UniProtKB-SubCell
    2. transcription factor complex Source: MGI

    Keywords - Cellular componenti

    NucleusUniRule annotationSAAS annotation

    Expressioni

    Gene expression databases

    BgeeiQ8K4Q1.
    GenevestigatoriQ8K4Q1.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4Q1.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Contains 1 paired domain.UniRule annotation
    Contains paired domain.SAAS annotation

    Keywords - Domaini

    Paired boxUniRule annotationSAAS annotation

    Phylogenomic databases

    HOVERGENiHBG009115.
    InParanoidiQ8K4Q1.

    Family and domain databases

    Gene3Di1.10.10.10. 2 hits.
    InterProiIPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view]
    PfamiPF00292. PAX. 1 hit.
    [Graphical view]
    PRINTSiPR00027. PAIREDBOX.
    SMARTiSM00351. PAX. 1 hit.
    [Graphical view]
    SUPFAMiSSF46689. SSF46689. 1 hit.
    PROSITEiPS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Fragment.

    Q8K4Q1-1 [UniParc]FASTAAdd to Basket

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    MEQTYGEVNQ LGGVFVNGRP LPNAIRLRIV ELAQLGIRPC DISRQLRVSH    50
    GCVSKILARY NETGSILPGA IGGSKPRVTT PNVVKHIRDY KQGDPGIFAW 100
    EIRDRLLADG VCDKYNVPSV SSISRILRNK IGSLAQPGPY EASKQPPPQP 150
    ALPYNHIYQY PYPSPVSPTG TKMGTHPGVP GSAGHVSIPR SWPSAHSVSN 200
    ILGIRTFMEQ TG 212
    Length:212
    Mass (Da):23,026
    Last modified:October 1, 2002 - v1
    Checksum:i72749EF6802C164B
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Non-terminal residuei212 – 2121Imported

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080657 mRNA. Translation: BAC10688.1.
    UniGeneiMm.315502.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AB080657 mRNA. Translation: BAC10688.1 .
    UniGenei Mm.315502.

    3D structure databases

    ProteinModelPortali Q8K4Q1.
    ModBasei Search...
    MobiDBi Search...

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Organism-specific databases

    MGIi MGI:97485. Pax1.

    Phylogenomic databases

    HOVERGENi HBG009115.
    InParanoidi Q8K4Q1.

    Miscellaneous databases

    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K4Q1.
    Genevestigatori Q8K4Q1.

    Family and domain databases

    Gene3Di 1.10.10.10. 2 hits.
    InterProi IPR009057. Homeodomain-like.
    IPR001523. Paired_dom.
    IPR011991. WHTH_DNA-bd_dom.
    [Graphical view ]
    Pfami PF00292. PAX. 1 hit.
    [Graphical view ]
    PRINTSi PR00027. PAIREDBOX.
    SMARTi SM00351. PAX. 1 hit.
    [Graphical view ]
    SUPFAMi SSF46689. SSF46689. 1 hit.
    PROSITEi PS00034. PAIRED_1. 1 hit.
    PS51057. PAIRED_2. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Normalization and subtraction of cap-trapper-selected cDNAs to prepare full-length cDNA libraries for rapid discovery of new genes."
      Carninci P., Shibata Y., Hayatsu N., Sugahara Y., Shibata K., Itoh M., Konno H., Okazaki Y., Muramatsu M., Hayashizaki Y.
      Genome Res. 10:1617-1630(2000) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.
    2. "Undulated short-tail deletion mutation in the mouse ablates Pax1 and leads to ectopic activation of neighboring Nkx2-2 in domains that normally express Pax1."
      Kokubu C., Wilm B., Kokubu T., Wahl M., Rodrigo I., Sakai N., Santagati F., Hayashizaki Y., Suzuki M., Yamamura K., Abe K., Imai K.
      Genetics 165:299-307(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8K4Q1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4Q1
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 80 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)