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Protein

Suppressor of tumorigenicity 7 protein-like

Gene

St7l

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  • extracellular matrix organization Source: BHF-UCL
  • negative regulation of cell growth Source: BHF-UCL
  • regulation of cell differentiation Source: BHF-UCL
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Recommended name:
Suppressor of tumorigenicity 7 protein-like
Alternative name(s):
ST7-related protein
Gene namesi
Name:St7l
Synonyms:St7r
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 3

Organism-specific databases

MGIiMGI:2386964. St7l.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Transmembranei39 – 59HelicalSequence analysisAdd BLAST21
Transmembranei83 – 103HelicalSequence analysisAdd BLAST21
Transmembranei513 – 533HelicalSequence analysisAdd BLAST21

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00003392281 – 559Suppressor of tumorigenicity 7 protein-likeAdd BLAST559

Proteomic databases

PaxDbiQ8K4P7.
PeptideAtlasiQ8K4P7.
PRIDEiQ8K4P7.

PTM databases

iPTMnetiQ8K4P7.
PhosphoSitePlusiQ8K4P7.

Expressioni

Tissue specificityi

Ubiquitously expressed.1 Publication

Gene expression databases

BgeeiENSMUSG00000045576.
ExpressionAtlasiQ8K4P7. baseline and differential.
GenevisibleiQ8K4P7. MM.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058455.

Structurei

3D structure databases

ProteinModelPortaliQ8K4P7.
SMRiQ8K4P7.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the ST7 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3807. Eukaryota.
ENOG410XQ2Z. LUCA.
GeneTreeiENSGT00390000000873.
HOGENOMiHOG000036528.
HOVERGENiHBG054916.
InParanoidiQ8K4P7.
OMAiPEIMGIF.
OrthoDBiEOG091G05WJ.
PhylomeDBiQ8K4P7.
TreeFamiTF314162.

Family and domain databases

InterProiIPR007311. ST7.
[Graphical view]
PANTHERiPTHR12745. PTHR12745. 1 hit.
PfamiPF04184. ST7. 1 hit.
[Graphical view]

Sequences (3)i

Sequence statusi: Complete.

This entry describes 3 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K4P7-1) [UniParc]FASTAAdd to basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MADGDYFAEA ARAVGCPHAP VPGLGLGPPL GWKERLKAGL ANSGSTLWFL
60 70 80 90 100
AGLGLLYALR VPLRLCDNVT AVTGFLSSLT PKFYVALTGT SSLISGLIFI
110 120 130 140 150
FEWWYFHKHG TSFIEQVSIS HLRPLMGGTE SSISEPGSPA NSRESETLRH
160 170 180 190 200
HHLSECKVWR NPLNLFRGAE YRRYTWVTGK EPLTYYDMNL SAQDHQTFFT
210 220 230 240 250
CETDFLRPSD TVMQKAWRER NPPARIKAAY QALELNNDCA TAYVLLAEEE
260 270 280 290 300
ATTIVDAERL FKQALRAGEI IYRRSQQCQH QSPQHEAQLR RDTNVLVYIK
310 320 330 340 350
RRLAMCARKL GRIREAVKIM RDLMKEFPPL TMLNIHENLL ESLLELQAYA
360 370 380 390 400
DVQAVLAKYD DISLPKSAAI CYTAALLKTR TVSDKFSPET AFRKGLSTAE
410 420 430 440 450
INAVEAIHRA VEFNPHVPKY LLEMKSLILP PEHILKRGDS EAIAYAFFHL
460 470 480 490 500
QHWKRIEGAL NLLQCTWEGT FRMIPYPLEK GHLFYPYPSC TETADRELLP
510 520 530 540 550
TFHHVSVYPK KELPFFIHFT AGLCSSTAML AFLTHQFPEV MGVFAKAVSM

ISRTCVEYL
Length:559
Mass (Da):63,368
Last modified:October 1, 2002 - v1
Checksum:i27065D795A9C304B
GO
Isoform 2 (identifier: Q8K4P7-2) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     420-451: Missing.

Show »
Length:527
Mass (Da):59,642
Checksum:i93CB0D118F47C222
GO
Isoform 3 (identifier: Q8K4P7-3) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     212-290: VMQKAWRERN...QSPQHEAQLR → G

Show »
Length:481
Mass (Da):54,306
Checksum:i226BFBDBE4293ABC
GO

Alternative sequence

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Alternative sequenceiVSP_034137212 – 290VMQKA…EAQLR → G in isoform 3. 1 PublicationAdd BLAST79
Alternative sequenceiVSP_034138420 – 451Missing in isoform 2. 1 PublicationAdd BLAST32

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084518 mRNA. Translation: BAB91408.1.
AK144075 mRNA. Translation: BAE25686.1.
AK172102 mRNA. Translation: BAE42827.1.
AK172218 mRNA. Translation: BAE42888.1.
BC058781 mRNA. Translation: AAH58781.1.
BC107394 mRNA. Translation: AAI07395.1.
BC145950 mRNA. Translation: AAI45951.1.
CCDSiCCDS17705.1. [Q8K4P7-1]
CCDS57250.1. [Q8K4P7-2]
CCDS79994.1. [Q8K4P7-3]
RefSeqiNP_001240631.1. NM_001253702.1. [Q8K4P7-2]
NP_001240632.1. NM_001253703.1. [Q8K4P7-3]
NP_694731.1. NM_153091.3. [Q8K4P7-1]
UniGeneiMm.206379.

Genome annotation databases

EnsembliENSMUST00000059271; ENSMUSP00000058455; ENSMUSG00000045576. [Q8K4P7-1]
ENSMUST00000106769; ENSMUSP00000102380; ENSMUSG00000045576. [Q8K4P7-2]
ENSMUST00000200132; ENSMUSP00000143759; ENSMUSG00000045576. [Q8K4P7-3]
GeneIDi229681.
KEGGimmu:229681.
UCSCiuc008qur.2. mouse. [Q8K4P7-1]
uc008qus.2. mouse. [Q8K4P7-2]
uc012cvm.2. mouse. [Q8K4P7-3]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB084518 mRNA. Translation: BAB91408.1.
AK144075 mRNA. Translation: BAE25686.1.
AK172102 mRNA. Translation: BAE42827.1.
AK172218 mRNA. Translation: BAE42888.1.
BC058781 mRNA. Translation: AAH58781.1.
BC107394 mRNA. Translation: AAI07395.1.
BC145950 mRNA. Translation: AAI45951.1.
CCDSiCCDS17705.1. [Q8K4P7-1]
CCDS57250.1. [Q8K4P7-2]
CCDS79994.1. [Q8K4P7-3]
RefSeqiNP_001240631.1. NM_001253702.1. [Q8K4P7-2]
NP_001240632.1. NM_001253703.1. [Q8K4P7-3]
NP_694731.1. NM_153091.3. [Q8K4P7-1]
UniGeneiMm.206379.

3D structure databases

ProteinModelPortaliQ8K4P7.
SMRiQ8K4P7.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000058455.

PTM databases

iPTMnetiQ8K4P7.
PhosphoSitePlusiQ8K4P7.

Proteomic databases

PaxDbiQ8K4P7.
PeptideAtlasiQ8K4P7.
PRIDEiQ8K4P7.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000059271; ENSMUSP00000058455; ENSMUSG00000045576. [Q8K4P7-1]
ENSMUST00000106769; ENSMUSP00000102380; ENSMUSG00000045576. [Q8K4P7-2]
ENSMUST00000200132; ENSMUSP00000143759; ENSMUSG00000045576. [Q8K4P7-3]
GeneIDi229681.
KEGGimmu:229681.
UCSCiuc008qur.2. mouse. [Q8K4P7-1]
uc008qus.2. mouse. [Q8K4P7-2]
uc012cvm.2. mouse. [Q8K4P7-3]

Organism-specific databases

CTDi54879.
MGIiMGI:2386964. St7l.

Phylogenomic databases

eggNOGiKOG3807. Eukaryota.
ENOG410XQ2Z. LUCA.
GeneTreeiENSGT00390000000873.
HOGENOMiHOG000036528.
HOVERGENiHBG054916.
InParanoidiQ8K4P7.
OMAiPEIMGIF.
OrthoDBiEOG091G05WJ.
PhylomeDBiQ8K4P7.
TreeFamiTF314162.

Miscellaneous databases

ChiTaRSiSt7l. mouse.
PROiQ8K4P7.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000045576.
ExpressionAtlasiQ8K4P7. baseline and differential.
GenevisibleiQ8K4P7. MM.

Family and domain databases

InterProiIPR007311. ST7.
[Graphical view]
PANTHERiPTHR12745. PTHR12745. 1 hit.
PfamiPF04184. ST7. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiST7L_MOUSE
AccessioniPrimary (citable) accession number: Q8K4P7
Secondary accession number(s): Q3T9Y2, Q3UNR1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 10, 2008
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 104 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.