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Protein

Neuropeptide B

Gene

Npb

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

May be involved in the regulation of feeding, neuroendocrine system, memory and learning. May be involved in the afferent pain pathway (By similarity).By similarity

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide B
Alternative name(s):
Preproprotein L7
Short name:
rPPL7
Cleaved into the following chain:
Neuropeptide B-29
Short name:
NPB29
Alternative name(s):
L7C
Gene namesi
Name:Npb
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Chromosome 10

Organism-specific databases

RGDi708513. Npb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 21Sequence analysisAdd BLAST21
PeptideiPRO_000001984122 – 50Neuropeptide B-29Add BLAST29
PropeptideiPRO_000001984253 – 119Sequence analysisAdd BLAST67

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8K4P2.

Expressioni

Tissue specificityi

Detected in a variety of tissues. High levels are found in the lymphoid organs, central nervous system, mammary gland and uterus.

Gene expression databases

BgeeiENSRNOG00000036685.

Interactioni

GO - Molecular functioni

  • G-protein coupled receptor binding Source: RGD

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051836.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8K4P2.
KOiK05267.
OMAiWYKPAAG.
OrthoDBiEOG091G0VSK.
PhylomeDBiQ8K4P2.
TreeFamiTF333179.

Family and domain databases

InterProiIPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiPD685249. PD685249. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4P2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MVRCRTLVAA ALALLLTPAL AWYKPAAGSH HYSVGRAAGL LSSFHRFPST
60 70 80 90 100
RRSESPALRV GTVPLRNLEM RPSVRSLALC VKDVTPNLQS CQRQLNSRGT
110
FQCKADVFLS LHKAECQSA
Length:119
Mass (Da):13,019
Last modified:October 1, 2002 - v1
Checksum:i6C2F5B9E6251CAC6
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085944 mRNA. Translation: BAC07177.1.
RefSeqiNP_695205.1. NM_153293.1.
UniGeneiRn.66426.

Genome annotation databases

EnsembliENSRNOT00000054953; ENSRNOP00000051836; ENSRNOG00000036685.
GeneIDi259222.
KEGGirno:259222.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085944 mRNA. Translation: BAC07177.1.
RefSeqiNP_695205.1. NM_153293.1.
UniGeneiRn.66426.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000051836.

Proteomic databases

PaxDbiQ8K4P2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000054953; ENSRNOP00000051836; ENSRNOG00000036685.
GeneIDi259222.
KEGGirno:259222.

Organism-specific databases

CTDi256933.
RGDi708513. Npb.

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8K4P2.
KOiK05267.
OMAiWYKPAAG.
OrthoDBiEOG091G0VSK.
PhylomeDBiQ8K4P2.
TreeFamiTF333179.

Enzyme and pathway databases

ReactomeiR-RNO-375276. Peptide ligand-binding receptors.
R-RNO-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ8K4P2.

Gene expression databases

BgeeiENSRNOG00000036685.

Family and domain databases

InterProiIPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiPD685249. PD685249. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNPB_RAT
AccessioniPrimary (citable) accession number: Q8K4P2
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 81 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.