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Protein

Neuropeptide B

Gene

Npb

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Has an effect in food intake, on locomotor activity and has an analgesic effect, (in vivo pharmacological studies). May be involved in the regulation of neuroendocrine system, memory and learning (By similarity).By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Neuropeptide

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Names & Taxonomyi

Protein namesi
Recommended name:
Neuropeptide B
Alternative name(s):
Preproprotein L7
Short name:
mPPL7
Cleaved into the following chain:
Neuropeptide B-29
Short name:
NPB29
Alternative name(s):
L7C
Gene namesi
Name:Npb
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2387153. Npb.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Secreted

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 2121Sequence analysisAdd
BLAST
Peptidei22 – 5029Neuropeptide B-29PRO_0000019839Add
BLAST
Propeptidei53 – 11967Sequence analysisPRO_0000019840Add
BLAST

Keywords - PTMi

Cleavage on pair of basic residues

Proteomic databases

PaxDbiQ8K4P1.
PRIDEiQ8K4P1.

PTM databases

iPTMnetiQ8K4P1.
PhosphoSiteiQ8K4P1.

Expressioni

Tissue specificityi

Detected in brain; more specifically in paraventricular hypothalamic nucleus, hippocampus and several nuclei in midbrain and brainstem.1 Publication

Gene expression databases

BgeeiENSMUSG00000044034.
CleanExiMM_NPB.
ExpressionAtlasiQ8K4P1. baseline and differential.
GenevisibleiQ8K4P1. MM.

Interactioni

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101801.

Family & Domainsi

Sequence similaritiesi

Belongs to the neuropeptide B/W family.Curated

Keywords - Domaini

Signal

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8K4P1.
KOiK05267.
OMAiWYKPAAG.
OrthoDBiEOG091G0VSK.
PhylomeDBiQ8K4P1.
TreeFamiTF333179.

Family and domain databases

InterProiIPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiPD685249. PD685249. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4P1-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MARCRTLVAA ALALLLPPAL AWYKPAAGPH HYSVGRASGL LSSFHRFPST
60 70 80 90 100
RRSESPALRV GTGPLRNLEM RPSVRSLALC VKDVTPNLQS CQRQLNSRGT
110
FQCKADVFLS LHETDCQST
Length:119
Mass (Da):13,018
Last modified:October 1, 2002 - v1
Checksum:iAFC5531BCF884224
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085945 mRNA. Translation: BAC07178.1.
CCDSiCCDS25746.1.
RefSeqiNP_695020.1. NM_153288.3.
UniGeneiMm.29444.

Genome annotation databases

EnsembliENSMUST00000106195; ENSMUSP00000101801; ENSMUSG00000044034.
GeneIDi208990.
KEGGimmu:208990.
UCSCiuc007mto.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB085945 mRNA. Translation: BAC07178.1.
CCDSiCCDS25746.1.
RefSeqiNP_695020.1. NM_153288.3.
UniGeneiMm.29444.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000101801.

PTM databases

iPTMnetiQ8K4P1.
PhosphoSiteiQ8K4P1.

Proteomic databases

PaxDbiQ8K4P1.
PRIDEiQ8K4P1.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000106195; ENSMUSP00000101801; ENSMUSG00000044034.
GeneIDi208990.
KEGGimmu:208990.
UCSCiuc007mto.1. mouse.

Organism-specific databases

CTDi256933.
MGIiMGI:2387153. Npb.

Phylogenomic databases

eggNOGiENOG410J07G. Eukaryota.
ENOG41120QH. LUCA.
GeneTreeiENSGT00390000013683.
HOGENOMiHOG000231239.
HOVERGENiHBG039578.
InParanoidiQ8K4P1.
KOiK05267.
OMAiWYKPAAG.
OrthoDBiEOG091G0VSK.
PhylomeDBiQ8K4P1.
TreeFamiTF333179.

Enzyme and pathway databases

ReactomeiR-MMU-375276. Peptide ligand-binding receptors.
R-MMU-418594. G alpha (i) signalling events.

Miscellaneous databases

PROiQ8K4P1.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000044034.
CleanExiMM_NPB.
ExpressionAtlasiQ8K4P1. baseline and differential.
GenevisibleiQ8K4P1. MM.

Family and domain databases

InterProiIPR013298. Neuropept_B_pre.
IPR013297. Neuropept_BW_pre.
[Graphical view]
PfamiPF15180. NPBW. 1 hit.
[Graphical view]
PRINTSiPR01888. NROPEPTIDEBW.
PR01889. PPNRPEPTIDEB.
ProDomiPD685249. PD685249. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Entry informationi

Entry nameiNPB_MOUSE
AccessioniPrimary (citable) accession number: Q8K4P1
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 25, 2003
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 93 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.