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Protein

Oxysterol-binding protein-related protein 1

Gene

Osbpl1a

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at protein leveli

Functioni

Binds phospholipids; exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Stabilizes GTP-bound RAB7A on late endosomes/lysosomes and alters functional properties of late endocytic compartments via its interaction with RAB7A. Binds 25-hydroxycholesterol and cholesterol.By similarity

GO - Molecular functioni

GO - Biological processi

Keywordsi

Biological processLipid transport, Transport
LigandLipid-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Oxysterol-binding protein-related protein 1
Short name:
ORP-1
Short name:
OSBP-related protein 1
Gene namesi
Name:Osbpl1a
Synonyms:Orp1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeRattus
Proteomesi
  • UP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628888. Osbpl1a.

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Endosome

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002288461 – 950Oxysterol-binding protein-related protein 1Add BLAST950

Proteomic databases

PaxDbiQ8K4M9.
PRIDEiQ8K4M9.

PTM databases

PhosphoSitePlusiQ8K4M9.

Expressioni

Tissue specificityi

Detected in prostate and liver.1 Publication

Interactioni

Subunit structurei

Interacts with VAPA. Interacts with the GTP-bound form of RAB7A (By similarity). Interacts with OAS1B (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
VapaQ9Z2706EBI-15554439,EBI-2909425

Protein-protein interaction databases

DIPiDIP-48447N.
ELMiQ8K4M9.
IntActiQ8K4M9. 1 interactor.
STRINGi10116.ENSRNOP00000065976.

Structurei

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1Z9OX-ray1.90G/H/I/J/K/L472-481[»]
ProteinModelPortaliQ8K4M9.
SMRiQ8K4M9.
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8K4M9.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Repeati47 – 76ANK 1Add BLAST30
Repeati80 – 109ANK 2Add BLAST30
Repeati175 – 204ANK 3Add BLAST30
Domaini235 – 334PHPROSITE-ProRule annotationAdd BLAST100

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 237Interaction with RAB7ABy similarityAdd BLAST237

Coiled coil

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Coiled coili430 – 463Sequence analysisAdd BLAST34
Coiled coili877 – 913Sequence analysisAdd BLAST37

Sequence similaritiesi

Belongs to the OSBP family.Curated

Keywords - Domaini

ANK repeat, Coiled coil, Repeat

Phylogenomic databases

eggNOGiKOG1737. Eukaryota.
ENOG410XP9E. LUCA.
HOVERGENiHBG082087.
InParanoidiQ8K4M9.
KOiK20174.
PhylomeDBiQ8K4M9.

Family and domain databases

CDDicd00204. ANK. 1 hit.
Gene3Di1.25.40.20. 2 hits.
2.30.29.30. 1 hit.
InterProiView protein in InterPro
IPR002110. Ankyrin_rpt.
IPR020683. Ankyrin_rpt-contain_dom.
IPR036770. Ankyrin_rpt-contain_sf.
IPR037239. OSBP_sf.
IPR000648. Oxysterol-bd.
IPR018494. Oxysterol-bd_CS.
IPR011993. PH-like_dom_sf.
IPR001849. PH_domain.
PANTHERiPTHR10972. PTHR10972. 3 hits.
PfamiView protein in Pfam
PF12796. Ank_2. 1 hit.
PF01237. Oxysterol_BP. 1 hit.
PRINTSiPR01415. ANKYRIN.
SMARTiView protein in SMART
SM00248. ANK. 3 hits.
SM00233. PH. 1 hit.
SUPFAMiSSF144000. SSF144000. 2 hits.
SSF48403. SSF48403. 1 hit.
SSF50729. SSF50729. 1 hit.
PROSITEiView protein in PROSITE
PS50297. ANK_REP_REGION. 1 hit.
PS50088. ANK_REPEAT. 3 hits.
PS01013. OSBP. 1 hit.
PS50003. PH_DOMAIN. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K4M9-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNTEAEQQLL HHARNGNAEE VRKLLEAMAR AEVVADIDCK GRSKSNLGWT
60 70 80 90 100
PLHLACYFGH KQVVQDLLKA GAKVNMLNDM GDTPLHRAAF TGRKELVMLL
110 120 130 140 150
LEYNADTTVV NGSGQTAKEA THDKEIRQML EAVERTQQRK LEELLLGAAR
160 170 180 190 200
EGRTAEVSAL LSRPNPPDVN CSDQLGNTPL HCAAYRAHKQ CVLKLLRSGA
210 220 230 240 250
DPSLKNKNDQ KPLDLAHGTE MKHILVGNKV VHKALKRFEG PLWKSSRFFG
260 270 280 290 300
WKLFWVVLEH GVLSWYRKQP DAVHNSYRQG CKHLTQAVCT VKPTDGCLFS
310 320 330 340 350
VRCFDDTVHG FRVPKNSLQQ SREKWLEAIE EHSAYSTHYC SQDQVTDDEE
360 370 380 390 400
EDVASAMDLK ESLARAQTCQ QRLDREIYNF LKMIKECDVA KDMLPSFLQK
410 420 430 440 450
ADVLSEASRE TCVALSDCLN LFTKQEGVRN FKLEQEQEKN KILSEALETL
460 470 480 490 500
ATEHHELERS LVEGSPPVSI LSEDEFYDAL SGSESEGSLT CLEAVTARAF
510 520 530 540 550
EENEVPANSG KHRMSEGKDC GGGDALSNGI KKHRTSLPSP MFSRNDFSIW
560 570 580 590 600
SILRKCIGME LSKITMPVIF NEPLSFLQRL TEYMEHTYLI HKASSFSDPV
610 620 630 640 650
ERMQCVAAFA VSAVASQWER TGKPFNPLLG ETYELVRDDL GFRLISEQVS
660 670 680 690 700
HHPPISAFHA EGLNNDFIFH GSIYPKLKFW GKSVEAEPKG TITLELLEHN
710 720 730 740 750
EAYTWTNPTC CVHNIIVGKL WIEQYGNVEI INHKTGDKCV LNFKPCGLFG
760 770 780 790 800
KELHKVEGYI QDKSKKKLCA LYGKWTECLY SVDPATFDAY KKNDKKNTEE
810 820 830 840 850
KKTSKQASTS EESDEMPVPD SESVFVIPGS ALLWRIAPRP PNSAQMYNFT
860 870 880 890 900
SFAMVLNEVD KEMETVIPKT DCRLRPDIRA MENGEIDQAS EEKKRLEEKQ
910 920 930 940 950
RAARKNRSKS EEDWKTRWFH QGPNPYSGAQ DWIYSGSYWD RNYFNLPDIY
Length:950
Mass (Da):107,765
Last modified:October 1, 2002 - v1
Checksum:iCA312E8C7326B61F
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AB089316 mRNA. Translation: BAC07227.1.
RefSeqiNP_742020.1. NM_172023.1.
UniGeneiRn.178664.

Genome annotation databases

GeneIDi259221.
KEGGirno:259221.

Similar proteinsi

Entry informationi

Entry nameiOSBL1_RAT
AccessioniPrimary (citable) accession number: Q8K4M9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: March 21, 2006
Last sequence update: October 1, 2002
Last modified: November 22, 2017
This is version 85 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome

Documents

  1. PDB cross-references
    Index of Protein Data Bank (PDB) cross-references
  2. SIMILARITY comments
    Index of protein domains and families