Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein

COMM domain-containing protein 1

Gene

Commd1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Proposed scaffold protein that is implicated in diverse physiological processes and whose function may be in part linked to its ability to regulate ubiquitination of specific cellular proteins. Can modulate activity of cullin-RING E3 ubiquitin ligase (CRL) complexes by displacing CAND1; in vitro promotes CRL E3 activity and dissociates CAND1 from CUL1 and CUL2. Promotes ubiquitination of NF-kappa-B subunit RELA and its subsequent proteasomal degradation. Down-regulates NF-kappa-B activity. Involved in the regulation of membrane expression and ubiquitination of SLC12A2. Modulates Na+ transport in epithelial cells by regulation of apical cell surface expression of amiloride-sensitive sodium channel (ENaC) subunits and by promoting their ubiquitination presumably involving NEDD4L. Promotes the localization of SCNN1D to recycling endosomes. Promotes CFTR cell surface expression through regulation of its ubiquitination. Down-regulates SOD1 activity by interfering with its homodimerization. Plays a role in copper ion homeostasis. Involved in copper-dependent ATP7A trafficking between the trans-Golgi network and vesicles in the cell periphery; the function is proposed to depend on its association within the CCC complex and cooperation with the WASH complex on early endosomes. Can bind one copper ion per monomer. May function to facilitate biliary copper excretion within hepatocytes. Binds to phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2). Involved in the regulation of HIF1A-mediated transcription; competes with ARNT/Hif-1-beta for binding to HIF1A resulting in decreased DNA binding and impaired transcriptional activation by HIF-1.By similarity

Sites

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Metal bindingi100CopperSequence analysis1
Metal bindingi109CopperSequence analysis1
Metal bindingi133CopperSequence analysis1

GO - Molecular functioni

GO - Biological processi

  • cellular copper ion homeostasis Source: MGI
  • cholesterol homeostasis Source: MGI
  • copper ion homeostasis Source: UniProtKB
  • Golgi to plasma membrane transport Source: MGI
  • low-density lipoprotein particle clearance Source: MGI
  • negative regulation of hypoxia-inducible factor-1alpha signaling pathway Source: MGI
  • negative regulation of NF-kappaB transcription factor activity Source: UniProtKB
  • negative regulation of protein localization to cell surface Source: MGI
  • negative regulation of sodium ion transmembrane transport Source: MGI
  • plasma membrane to endosome transport Source: MGI
  • positive regulation of cholesterol import Source: MGI
  • positive regulation of endosome to plasma membrane protein transport Source: MGI
  • positive regulation of protein localization to cell surface Source: MGI
  • positive regulation of protein ubiquitination Source: UniProtKB
  • protein destabilization Source: MGI
  • protein transport Source: UniProtKB-KW
  • regulation of plasma lipoprotein particle levels Source: MGI
  • regulation of proteasomal ubiquitin-dependent protein catabolic process Source: UniProtKB
  • transcription, DNA-templated Source: UniProtKB-KW

Keywordsi

Biological processProtein transport, Transcription, Transcription regulation, Transport, Ubl conjugation pathway
LigandCopper, Metal-binding

Enzyme and pathway databases

ReactomeiR-MMU-8951664 Neddylation

Names & Taxonomyi

Protein namesi
Recommended name:
COMM domain-containing protein 1
Alternative name(s):
Protein Murr1
Gene namesi
Name:Commd1
Synonyms:Murr1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:109474 Commd1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Cytoplasm, Cytoplasmic vesicle, Endosome, Membrane, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000773851 – 188COMM domain-containing protein 1Add BLAST188

Post-translational modificationi

Ubiquitinated; undergoes both 'Lys-63'- and 'Lys-48'-linked polyubiquitination. Ubiquitinated by XIAP, leading to its proteasomal degradation (By similarity).By similarity

Keywords - PTMi

Ubl conjugation

Proteomic databases

EPDiQ8K4M5
MaxQBiQ8K4M5
PaxDbiQ8K4M5
PRIDEiQ8K4M5

PTM databases

iPTMnetiQ8K4M5
PhosphoSitePlusiQ8K4M5

Expressioni

Gene expression databases

BgeeiENSMUSG00000051355
CleanExiMM_COMMD1
ExpressionAtlasiQ8K4M5 baseline and differential
GenevisibleiQ8K4M5 MM

Interactioni

Subunit structurei

Monomer, homodimer. Can form heterodimers with other COMM domain-containing proteins but only certain combinations may exist in vivo. Interacts (via COMM domain) with COMMD2, COMMD3, COMMD4, COMMD5, COMMD6, COMMD7, COMMD8 and COMMD10 (via COMM domain). Identified in a complex with an E3 ubiquitin ligase complex composed of TCEB1/elongin C, CUL2, SOCS1 and RBX1; in the complex interacts directly with SOCS1 and CUL2. Interacts directly with ATP7B (via the N-terminal region). Interacts with CCS, CDKN2A, RELA, REL, RELB, NFKB1/p105, NFKB2/p100, NFKBIB, SCNN1D, SCNN1B, CFTR, CLU, SGK1, AKT1, CUL1, CUL2, CUL3, CUL4A, CUL4B, CUL5, CUL7, HIF1A. Identified in a complex with NF-kappa-B. Interacts directly with SLC12A2. Interacts with CCDC22, CCDC93 and C16orf62 homolog; proposed to be a component of the CCC (COMMD/CCDC22/CCDC93) complex which contains at least COMMD1 (and possibly other COMM domain-containing proteins), CCDC22, CCDC93 and C16orf62 homolog. Interacts with ATP7A (By similarity).By similarity

GO - Molecular functioni

Protein-protein interaction databases

IntActiQ8K4M5, 1 interactor
MINTiQ8K4M5
STRINGi10090.ENSMUSP00000124719

Structurei

3D structure databases

ProteinModelPortaliQ8K4M5
SMRiQ8K4M5
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini117 – 185COMMPROSITE-ProRule annotationAdd BLAST69

Region

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Regioni1 – 122Sufficient for interaction with SLC12A2By similarityAdd BLAST122
Regioni124 – 188Required for binding to PtdIns(4,5)P2By similarityAdd BLAST65

Phylogenomic databases

eggNOGiENOG410IWFF Eukaryota
ENOG4111IWI LUCA
GeneTreeiENSGT00390000012029
HOVERGENiHBG051067
InParanoidiQ8K4M5
KOiK22557
OMAiSRWDSGL
PhylomeDBiQ8K4M5
TreeFamiTF332823

Family and domain databases

CDDicd04749 Commd1_MURR1, 1 hit
InterProiView protein in InterPro
IPR017920 COMM
IPR033776 COMMD1_N
IPR037351 Murr1
PANTHERiPTHR21199 PTHR21199, 1 hit
PfamiView protein in Pfam
PF07258 COMM_domain, 1 hit
PF17221 COMMD1_N, 1 hit
PROSITEiView protein in PROSITE
PS51269 COMM, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K4M5-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAGDLEGGKS LSGLLSGLAQ NAFHGHSGVT EELLHSQLYP EVPPEEFRPF
60 70 80 90 100
LAKMRGLLKS IASADMDFNQ LEAFLTAQTK KQGGITSEQA AVISKFWKSH
110 120 130 140 150
KIKIRESLMK QSRWDNGLRG LSWRVDGKSQ SRHSTQIHSP VAIIELEFGK
160 170 180
NGQESEFLCL EFDEVKVKQI LKKLSEVEES INRLMQAA
Length:188
Mass (Da):20,996
Last modified:August 16, 2004 - v2
Checksum:iEEEC6489BC59B483
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti5L → H in AAH51210 (PubMed:15489334).Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AK133507 mRNA Translation: BAE21693.1
AB089806 Genomic DNA Translation: BAC07535.1
AB104816 mRNA Translation: BAC57942.1
BC030052 mRNA Translation: AAH30052.1
BC051210 mRNA Translation: AAH51210.1
CCDSiCCDS24472.1
RefSeqiNP_653097.2, NM_144514.2
UniGeneiMm.259903
Mm.451238

Genome annotation databases

EnsembliENSMUST00000159081; ENSMUSP00000124719; ENSMUSG00000051355
GeneIDi17846
KEGGimmu:17846
UCSCiuc007iel.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCOMD1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4M5
Secondary accession number(s): Q3V012
, Q80WG2, Q80Z41, Q8BNL9, Q8K2S9
Entry historyiIntegrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: August 16, 2004
Last modified: May 23, 2018
This is version 102 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health