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Q8K4L6

- Q8K4L6_MOUSE

UniProt

Q8K4L6 - Q8K4L6_MOUSE

Protein
Submitted name:

Osteoregulin

Gene

Mepe

Organism
Mus musculus (Mouse)
Status
Unreviewed - Annotation score: 1 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 55 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    GO - Biological processi

    1. negative regulation of bone mineralization Source: MGI
    2. regulation of bone remodeling Source: Ensembl
    3. skeletal system development Source: MGI

    Names & Taxonomyi

    Protein namesi
    Submitted name:
    OsteoregulinImported
    Submitted name:
    Protein MepeImported
    Gene namesi
    Name:MepeImported
    OrganismiMus musculus (Mouse)Imported
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 5

    Organism-specific databases

    MGIiMGI:2137384. Mepe.

    Subcellular locationi

    GO - Cellular componenti

    1. proteinaceous extracellular matrix Source: MGI

    Expressioni

    Gene expression databases

    GenevestigatoriQ8K4L6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10090.ENSMUSP00000065200.

    Family & Domainsi

    Phylogenomic databases

    GeneTreeiENSGT00390000010702.
    HOVERGENiHBG004786.
    InParanoidiQ8K4L6.
    OMAiQNAHQGK.
    OrthoDBiEOG78SQJP.
    TreeFamiTF338655.

    Family and domain databases

    InterProiIPR009837. Osteoregulin.
    [Graphical view]
    PANTHERiPTHR16510. PTHR16510. 1 hit.
    PfamiPF07175. Osteoregulin. 1 hit.
    [Graphical view]
    ProDomiPD338624. Osteoregulin. 1 hit.
    [Graphical view] [Entries sharing at least one domain]

    Sequencei

    Sequence statusi: Complete.

    Q8K4L6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MTPEGLMKMQ AVSVGLLLFS MTWAAPMPNE DRSSCGNQDS IHKDLAASVY    50
    PDPTVDEGTE DGQGALLHPP GQDRYGAALL RNITQPVKSL VTGAELRREG 100
    NQEKRPQSVL SVIPADVNDA KVSLKDIKNQ ESYLLTQSSP VKSKHTKHTR 150
    QTRRSTHYLT HLPQIKKTPS DLEGSGSPDL LVRGDNDVPP FSGDGQHFMH 200
    IPGKGGAGSG PESSTSRPLS GSSKAEVIDP HMSGLGSNEI PGREGHGGSA 250
    YATRDKAAQG AGSAGGSLVG GSNEITGSTN FRELPGKEGN RINAGSQNAH 300
    QGKVEFHYPQ VASREKVKGG VEHAGRAGYN EIPKSSKGSS SKDAEESKGN 350
    QLTLTASQRF PGKGKSQGPA LPSHSLSNEV KSEENHYVFH GQNNLTPNKG 400
    MSQRRGSWPS RRPNSHRRAS TRQRDSSESS SSGSSSESHG D 441
    Length:441
    Mass (Da):46,872
    Last modified:October 1, 2002 - v1
    Checksum:iAA1947BFE9F2E300
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122775 Genomic DNA. No translation available.
    AF298661 mRNA. Translation: AAM87687.1.
    RefSeqiNP_444402.2. NM_053172.2.
    UniGeneiMm.196672.

    Genome annotation databases

    EnsembliENSMUST00000066207; ENSMUSP00000065200; ENSMUSG00000053863.
    GeneIDi94111.
    KEGGimmu:94111.
    UCSCiuc008ykh.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AC122775 Genomic DNA. No translation available.
    AF298661 mRNA. Translation: AAM87687.1 .
    RefSeqi NP_444402.2. NM_053172.2.
    UniGenei Mm.196672.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10090.ENSMUSP00000065200.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000066207 ; ENSMUSP00000065200 ; ENSMUSG00000053863 .
    GeneIDi 94111.
    KEGGi mmu:94111.
    UCSCi uc008ykh.2. mouse.

    Organism-specific databases

    CTDi 56955.
    MGIi MGI:2137384. Mepe.

    Phylogenomic databases

    GeneTreei ENSGT00390000010702.
    HOVERGENi HBG004786.
    InParanoidi Q8K4L6.
    OMAi QNAHQGK.
    OrthoDBi EOG78SQJP.
    TreeFami TF338655.

    Miscellaneous databases

    NextBioi 352099.
    PROi Q8K4L6.
    SOURCEi Search...

    Gene expression databases

    Genevestigatori Q8K4L6.

    Family and domain databases

    InterProi IPR009837. Osteoregulin.
    [Graphical view ]
    PANTHERi PTHR16510. PTHR16510. 1 hit.
    Pfami PF07175. Osteoregulin. 1 hit.
    [Graphical view ]
    ProDomi PD338624. Osteoregulin. 1 hit.
    [Graphical view ] [Entries sharing at least one domain ]
    ProtoNeti Search...

    Publicationsi

    1. "Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass."
      Gowen L.C., Petersen D.N., Mansolf A.L., Qi H., Stock J.L., Tkalcevic G.T., Simmons H.A., Crawford D.T., Chidsey-Frink K.L., Ke H.Z., McNeish J.D., Brown T.A.
      J. Biol. Chem. 278:1998-2007(2003) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6JImported.
    3. Ensembl
      Submitted (FEB-2012) to UniProtKB
      Cited for: IDENTIFICATION.
      Strain: C57BL/6JImported.

    Entry informationi

    Entry nameiQ8K4L6_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4L6
    Entry historyi
    Integrated into UniProtKB/TrEMBL: October 1, 2002
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 55 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiUnreviewed (UniProtKB/TrEMBL)

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteomeImported

    External Data

    Dasty 3