Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.
Protein
Submitted name:

Osteoregulin

Gene

Mepe

Organism
Mus musculus (Mouse)
Status
Unreviewed-Annotation score: Annotation score: 1 out of 5-Experimental evidence at transcript leveli

Functioni

GO - Biological processi

  1. negative regulation of bone mineralization Source: MGI
  2. regulation of bone remodeling Source: Ensembl
  3. skeletal system development Source: MGI
Complete GO annotation...

Names & Taxonomyi

Protein namesi
Submitted name:
OsteoregulinImported
Submitted name:
Protein MepeImported
Gene namesi
Name:MepeImported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 5

Organism-specific databases

MGIiMGI:2137384. Mepe.

Subcellular locationi

GO - Cellular componenti

  1. proteinaceous extracellular matrix Source: MGI
Complete GO annotation...

Expressioni

Gene expression databases

GenevestigatoriQ8K4L6.

Interactioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065200.

Structurei

3D structure databases

ProteinModelPortaliQ8K4L6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Phylogenomic databases

GeneTreeiENSGT00390000010702.
HOVERGENiHBG004786.
OMAiQNAHQGK.
OrthoDBiEOG78SQJP.
TreeFamiTF338655.

Family and domain databases

InterProiIPR009837. Osteoregulin.
[Graphical view]
PANTHERiPTHR16510. PTHR16510. 1 hit.
PfamiPF07175. Osteoregulin. 1 hit.
[Graphical view]
ProDomiPD338624. Osteoregulin. 1 hit.
[Graphical view] [Entries sharing at least one domain]

Sequencei

Sequence statusi: Complete.

Q8K4L6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MTPEGLMKMQ AVSVGLLLFS MTWAAPMPNE DRSSCGNQDS IHKDLAASVY
60 70 80 90 100
PDPTVDEGTE DGQGALLHPP GQDRYGAALL RNITQPVKSL VTGAELRREG
110 120 130 140 150
NQEKRPQSVL SVIPADVNDA KVSLKDIKNQ ESYLLTQSSP VKSKHTKHTR
160 170 180 190 200
QTRRSTHYLT HLPQIKKTPS DLEGSGSPDL LVRGDNDVPP FSGDGQHFMH
210 220 230 240 250
IPGKGGAGSG PESSTSRPLS GSSKAEVIDP HMSGLGSNEI PGREGHGGSA
260 270 280 290 300
YATRDKAAQG AGSAGGSLVG GSNEITGSTN FRELPGKEGN RINAGSQNAH
310 320 330 340 350
QGKVEFHYPQ VASREKVKGG VEHAGRAGYN EIPKSSKGSS SKDAEESKGN
360 370 380 390 400
QLTLTASQRF PGKGKSQGPA LPSHSLSNEV KSEENHYVFH GQNNLTPNKG
410 420 430 440
MSQRRGSWPS RRPNSHRRAS TRQRDSSESS SSGSSSESHG D
Length:441
Mass (Da):46,872
Last modified:October 1, 2002 - v1
Checksum:iAA1947BFE9F2E300
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122775 Genomic DNA. No translation available.
AF298661 mRNA. Translation: AAM87687.1.
RefSeqiNP_444402.2. NM_053172.2.
UniGeneiMm.196672.

Genome annotation databases

EnsembliENSMUST00000066207; ENSMUSP00000065200; ENSMUSG00000053863.
GeneIDi94111.
KEGGimmu:94111.
UCSCiuc008ykh.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AC122775 Genomic DNA. No translation available.
AF298661 mRNA. Translation: AAM87687.1.
RefSeqiNP_444402.2. NM_053172.2.
UniGeneiMm.196672.

3D structure databases

ProteinModelPortaliQ8K4L6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000065200.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000066207; ENSMUSP00000065200; ENSMUSG00000053863.
GeneIDi94111.
KEGGimmu:94111.
UCSCiuc008ykh.2. mouse.

Organism-specific databases

CTDi56955.
MGIiMGI:2137384. Mepe.

Phylogenomic databases

GeneTreeiENSGT00390000010702.
HOVERGENiHBG004786.
OMAiQNAHQGK.
OrthoDBiEOG78SQJP.
TreeFamiTF338655.

Miscellaneous databases

NextBioi352099.
PROiQ8K4L6.
SOURCEiSearch...

Gene expression databases

GenevestigatoriQ8K4L6.

Family and domain databases

InterProiIPR009837. Osteoregulin.
[Graphical view]
PANTHERiPTHR16510. PTHR16510. 1 hit.
PfamiPF07175. Osteoregulin. 1 hit.
[Graphical view]
ProDomiPD338624. Osteoregulin. 1 hit.
[Graphical view] [Entries sharing at least one domain]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass."
    Gowen L.C., Petersen D.N., Mansolf A.L., Qi H., Stock J.L., Tkalcevic G.T., Simmons H.A., Crawford D.T., Chidsey-Frink K.L., Ke H.Z., McNeish J.D., Brown T.A.
    J. Biol. Chem. 278:1998-2007(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6JImported.
  3. Ensembl
    Submitted (FEB-2012) to UniProtKB
    Cited for: IDENTIFICATION.
    Strain: C57BL/6JImported.

Entry informationi

Entry nameiQ8K4L6_MOUSE
AccessioniPrimary (citable) accession number: Q8K4L6
Entry historyi
Integrated into UniProtKB/TrEMBL: October 1, 2002
Last sequence update: October 1, 2002
Last modified: February 4, 2015
This is version 58 of the entry and version 1 of the sequence. [Complete history]
Entry statusiUnreviewed (UniProtKB/TrEMBL)

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteomeImported

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.