Q8K4L6 (Q8K4L6_MOUSE) Unreviewed, UniProtKB/TrEMBL

Names and origin

Protein names

Submitted name:
Osteoregulin EMBL AAM87687.1

Submitted name:
Protein Mepe Ensembl ENSMUSP00000065200

Gene names

Name:

Mepe Ensembl ENSMUSP00000065200 MGI 2137384

Organism

Mus musculus (Mouse) [Reference proteome]

Taxonomic identifier

10090 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Mus › Mus

Protein attributes

Sequence length	441 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

Ontologies

Keywords
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	negative regulation of bone mineralization Inferred from direct assay PubMed 22766095. Source: MGI skeletal system development Traceable author statement PubMed 11414762. Source: MGI
Cellular_component	proteinaceous extracellular matrix Inferred from sequence orthology PubMed 11414762. Source: MGI
Complete GO annotation...

Sequences

	Sequence		Length	Mass (Da)
	Q8K4L6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: AA1947BFE9F2E300	FASTA	441	46,872
	10 20 30 40 50 60 MTPEGLMKMQ AVSVGLLLFS MTWAAPMPNE DRSSCGNQDS IHKDLAASVY PDPTVDEGTE 70 80 90 100 110 120 DGQGALLHPP GQDRYGAALL RNITQPVKSL VTGAELRREG NQEKRPQSVL SVIPADVNDA 130 140 150 160 170 180 KVSLKDIKNQ ESYLLTQSSP VKSKHTKHTR QTRRSTHYLT HLPQIKKTPS DLEGSGSPDL 190 200 210 220 230 240 LVRGDNDVPP FSGDGQHFMH IPGKGGAGSG PESSTSRPLS GSSKAEVIDP HMSGLGSNEI 250 260 270 280 290 300 PGREGHGGSA YATRDKAAQG AGSAGGSLVG GSNEITGSTN FRELPGKEGN RINAGSQNAH 310 320 330 340 350 360 QGKVEFHYPQ VASREKVKGG VEHAGRAGYN EIPKSSKGSS SKDAEESKGN QLTLTASQRF 370 380 390 400 410 420 PGKGKSQGPA LPSHSLSNEV KSEENHYVFH GQNNLTPNKG MSQRRGSWPS RRPNSHRRAS 430 440 TRQRDSSESS SSGSSSESHG D

References

	« Hide 'large scale' referencesShow 'large scale' references »
[1]	"Targeted disruption of the osteoblast/osteocyte factor 45 gene (OF45) results in increased bone formation and bone mass." Gowen L.C., Petersen D.N., Mansolf A.L., Qi H., Stock J.L., Tkalcevic G.T., Simmons H.A., Crawford D.T., Chidsey-Frink K.L., Ke H.Z., McNeish J.D., Brown T.A. J. Biol. Chem. 278:1998-2007(2003) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE.
[2]	"Lineage-specific biology revealed by a finished genome assembly of the mouse." Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P. PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA]. Strain: C57BL/6J Ensembl ENSMUSP00000065200.
[3]	Ensembl Submitted (FEB-2012) to UniProtKB Cited for: IDENTIFICATION. Strain: C57BL/6J Ensembl ENSMUSP00000065200.
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AC122775 Genomic DNA. No translation available. AF298661 mRNA. Translation: AAM87687.1.
IPI	IPI00172266.
RefSeq	NP_444402.2. NM_053172.2.
UniGene	Mm.196672.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10090.ENSMUSP00000065200.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSMUST00000066207; ENSMUSP00000065200; ENSMUSG00000053863.
GeneID	94111.
KEGG	mmu:94111.
Organism-specific databases
CTD	56955.
MGI	MGI:2137384. Mepe.
Phylogenomic databases
GeneTree	ENSGT00390000010702.
HOVERGEN	HBG004786.
InParanoid	Q8K4L6.
OMA	QNAHQGK.
Gene expression databases
Genevestigator	Q8K4L6.
Family and domain databases
InterPro	IPR009837. Osteoregulin. [Graphical view]
PANTHER	PTHR16510. PTHR16510. 1 hit.
Pfam	PF07175. Osteoregulin. 1 hit. [Graphical view]
ProDom	PD338624. Osteoregulin. 1 hit. [Graphical view] [Entries sharing at least one domain]
ProtoNet	Search...
Other
NextBio	352099.
SOURCE	Search...

Entry information

Entry name

Q8K4L6_MOUSE

Accession

Primary (citable) accession number: Q8K4L6

Entry history

Integrated into UniProtKB/TrEMBL:	October 1, 2002
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 49 of the entry and version 1 of the sequence. [Complete history]

Entry status

Unreviewed (UniProtKB/TrEMBL)