ID   POF1B_MOUSE             Reviewed;         587 AA.
AC   Q8K4L4; A2ANY1; Q8C3A2; Q8R4R8;
DT   17-OCT-2006, integrated into UniProtKB/Swiss-Prot.
DT   03-MAY-2011, sequence version 3.
DT   27-MAR-2024, entry version 112.
DE   RecName: Full=Protein POF1B;
GN   Name=Pof1b;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, AND DEVELOPMENTAL STAGE.
RC   STRAIN=C57BL/6J, and Swiss Webster / NIH;
RX   PubMed=15459172; DOI=10.1093/humrep/deh502;
RA   Bione S., Rizzolio F., Sala C., Ricotti R., Goegan M., Manzini M.C.,
RA   Battaglia R., Marozzi A., Vegetti W., Dalpra L., Crosignani P.G.,
RA   Ginelli E., Nappi R., Bernabini S., Bruni V., Torricelli F., Zuffardi O.,
RA   Toniolo D.;
RT   "Mutation analysis of two candidate genes for premature ovarian failure,
RT   DACH2 and POF1B.";
RL   Hum. Reprod. 19:2759-2766(2004).
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
RN   [3]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RA   Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.;
RL   Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases.
RN   [4]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-428.
RC   STRAIN=C57BL/6J; TISSUE=Head;
RX   PubMed=16141072; DOI=10.1126/science.1112014;
RA   Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N.,
RA   Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K.,
RA   Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.,
RA   Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R.,
RA   Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T.,
RA   Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A.,
RA   Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B.,
RA   Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M.,
RA   Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S.,
RA   Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E.,
RA   Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D.,
RA   Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M.,
RA   Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H.,
RA   Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V.,
RA   Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S.,
RA   Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H.,
RA   Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N.,
RA   Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F.,
RA   Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G.,
RA   Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z.,
RA   Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C.,
RA   Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y.,
RA   Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S.,
RA   Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K.,
RA   Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R.,
RA   van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H.,
RA   Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M.,
RA   Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C.,
RA   Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S.,
RA   Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K.,
RA   Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M.,
RA   Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C.,
RA   Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A.,
RA   Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.;
RT   "The transcriptional landscape of the mammalian genome.";
RL   Science 309:1559-1563(2005).
CC   -!- FUNCTION: Plays a key role in the organization of epithelial monolayers
CC       by regulating the actin cytoskeleton. May be involved in ovary
CC       development (By similarity). {ECO:0000250}.
CC   -!- SUBUNIT: Interacts with nonmuscle actin. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell junction, tight junction {ECO:0000250}.
CC   -!- TISSUE SPECIFICITY: Expression absent in adult ovary.
CC       {ECO:0000269|PubMed:15459172}.
CC   -!- DEVELOPMENTAL STAGE: Expressed in ovary between 16.5 dpc and P5.
CC       {ECO:0000269|PubMed:15459172}.
CC   -!- CAUTION: It is uncertain whether Met-1 or Met-2 is the initiator. The
CC       first methionine is not conserved among other organisms, but rat. It
CC       could be rodent-specific. {ECO:0000305}.
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DR   EMBL; AF309775; AAM93271.1; -; mRNA.
DR   EMBL; AF408412; AAM00425.1; -; mRNA.
DR   EMBL; AL831771; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; CH466564; EDL14003.1; -; Genomic_DNA.
DR   EMBL; AK086511; BAC39681.1; -; mRNA.
DR   CCDS; CCDS30362.1; -.
DR   RefSeq; NP_853557.1; NM_181579.1.
DR   AlphaFoldDB; Q8K4L4; -.
DR   SMR; Q8K4L4; -.
DR   BioGRID; 213618; 3.
DR   STRING; 10090.ENSMUSP00000047655; -.
DR   iPTMnet; Q8K4L4; -.
DR   PhosphoSitePlus; Q8K4L4; -.
DR   MaxQB; Q8K4L4; -.
DR   PaxDb; 10090-ENSMUSP00000047655; -.
DR   PeptideAtlas; Q8K4L4; -.
DR   ProteomicsDB; 289778; -.
DR   Pumba; Q8K4L4; -.
DR   Antibodypedia; 453; 112 antibodies from 22 providers.
DR   DNASU; 69693; -.
DR   Ensembl; ENSMUST00000039887.4; ENSMUSP00000047655.4; ENSMUSG00000034607.7.
DR   GeneID; 69693; -.
DR   KEGG; mmu:69693; -.
DR   UCSC; uc009udm.1; mouse.
DR   AGR; MGI:1916943; -.
DR   CTD; 79983; -.
DR   MGI; MGI:1916943; Pof1b.
DR   VEuPathDB; HostDB:ENSMUSG00000034607; -.
DR   eggNOG; ENOG502QRUE; Eukaryota.
DR   GeneTree; ENSGT00390000000141; -.
DR   HOGENOM; CLU_031293_0_0_1; -.
DR   InParanoid; Q8K4L4; -.
DR   OMA; HHYYRRQ; -.
DR   OrthoDB; 4606750at2759; -.
DR   TreeFam; TF331412; -.
DR   BioGRID-ORCS; 69693; 1 hit in 76 CRISPR screens.
DR   PRO; PR:Q8K4L4; -.
DR   Proteomes; UP000000589; Chromosome X.
DR   RNAct; Q8K4L4; Protein.
DR   Bgee; ENSMUSG00000034607; Expressed in tail skin and 95 other cell types or tissues.
DR   GO; GO:0005884; C:actin filament; ISO:MGI.
DR   GO; GO:0005912; C:adherens junction; ISO:MGI.
DR   GO; GO:0005923; C:bicellular tight junction; ISO:MGI.
DR   GO; GO:0030057; C:desmosome; IDA:MGI.
DR   GO; GO:0051015; F:actin filament binding; ISO:MGI.
DR   GO; GO:0030036; P:actin cytoskeleton organization; ISO:MGI.
DR   GO; GO:0007015; P:actin filament organization; ISO:MGI.
DR   GO; GO:0070830; P:bicellular tight junction assembly; ISO:MGI.
DR   GO; GO:0003382; P:epithelial cell morphogenesis; ISO:MGI.
DR   InterPro; IPR026186; POF1B.
DR   PANTHER; PTHR22546; PREMATURE OVARIAN FAILURE, 1B; 1.
DR   PANTHER; PTHR22546:SF0; PROTEIN POF1B; 1.
DR   Genevisible; Q8K4L4; MM.
PE   2: Evidence at transcript level;
KW   Actin-binding; Cell junction; Coiled coil; Reference proteome;
KW   Tight junction.
FT   CHAIN           1..587
FT                   /note="Protein POF1B"
FT                   /id="PRO_0000253912"
FT   COILED          331..529
FT                   /evidence="ECO:0000255"
FT   CONFLICT        91
FT                   /note="S -> N (in Ref. 4; BAC39681)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   587 AA;  67785 MW;  02ED686CB63107AD CRC64;
     MMSSSYWSET SSSSCGTQQP TEVLQCQPQH YHYYHQPSQA QQPPEKNVVY ERVRTYSGPM
     NKVVQALDPL GSREVLSPLK PASSYQSLVW SDHSQELYSP TLKISTCAPS TLHITQNAEQ
     ELHSPTVKVT TYPQTTIRRY IVQNPEQEPL SPFLRGSQFF PGNNVIYEKT IRKVEKLNTD
     QECCPQIQCH HHVIQQPQII HSPHCQQSHS SHQIQCITEN DSNIGHELCH GGPSQIHEQV
     IIQDDGPEKL DPKYFGELLA DLSRKNTDLY HCLLEHLERI GGSKQDFEST DTSEDIESLI
     PKGLSEFTKQ QIRYILQMRG MSDKSLRLVL STFSNIREEL GHLQNDLTSL ENDKIRLEKD
     LAFKENQMKE YEELLASVRA NNRQQQQGLQ DSSAKCQSLE ENNLSLRHTL SDLEYRLKEL
     EYCKRNLEQE NKNLRIQVSE TCTGPTLQAK MDEIGNHYME MVKNLRLDKD REISKLRSQL
     NQYQKDVSKR EGSCSDFQFK LHELTSLLEE KDSLIKRQSE ELSKLRQEIY SSHNQPSCGG
     RTTITTKKYR TQYPILGLLY DDYEYIPPGS DTQTIVIEKT EDKWTCP
//