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Q8K4L4 (POF1B_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 68. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein POF1B
Gene names
Name:Pof1b
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length587 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development By similarity.

Subunit structure

Interacts with nonmuscle actin By similarity.

Subcellular location

Cell junctiontight junction By similarity.

Tissue specificity

Expression absent in adult ovary. Ref.1

Developmental stage

Expressed in ovary between 16.5 dpc and P5. Ref.1

Caution

It is uncertain whether Met-1 or Met-2 is the initiator. The first methionine is not conserved among other organisms, but rat. It could be rodent-specific.

Ontologies

Keywords
   Cellular componentCell junction
Tight junction
   DomainCoiled coil
   LigandActin-binding
   Technical termComplete proteome
Reference proteome
Gene Ontology (GO)
None. [Check GOA]

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 587587Protein POF1B
PRO_0000253912

Regions

Coiled coil331 – 529199 Potential

Experimental info

Sequence conflict911S → N in BAC39681. Ref.4

Sequences

Sequence LengthMass (Da)Tools
Q8K4L4 [UniParc].

Last modified May 3, 2011. Version 3.
Checksum: 02ED686CB63107AD

FASTA58767,785
        10         20         30         40         50         60 
MMSSSYWSET SSSSCGTQQP TEVLQCQPQH YHYYHQPSQA QQPPEKNVVY ERVRTYSGPM 

        70         80         90        100        110        120 
NKVVQALDPL GSREVLSPLK PASSYQSLVW SDHSQELYSP TLKISTCAPS TLHITQNAEQ 

       130        140        150        160        170        180 
ELHSPTVKVT TYPQTTIRRY IVQNPEQEPL SPFLRGSQFF PGNNVIYEKT IRKVEKLNTD 

       190        200        210        220        230        240 
QECCPQIQCH HHVIQQPQII HSPHCQQSHS SHQIQCITEN DSNIGHELCH GGPSQIHEQV 

       250        260        270        280        290        300 
IIQDDGPEKL DPKYFGELLA DLSRKNTDLY HCLLEHLERI GGSKQDFEST DTSEDIESLI 

       310        320        330        340        350        360 
PKGLSEFTKQ QIRYILQMRG MSDKSLRLVL STFSNIREEL GHLQNDLTSL ENDKIRLEKD 

       370        380        390        400        410        420 
LAFKENQMKE YEELLASVRA NNRQQQQGLQ DSSAKCQSLE ENNLSLRHTL SDLEYRLKEL 

       430        440        450        460        470        480 
EYCKRNLEQE NKNLRIQVSE TCTGPTLQAK MDEIGNHYME MVKNLRLDKD REISKLRSQL 

       490        500        510        520        530        540 
NQYQKDVSKR EGSCSDFQFK LHELTSLLEE KDSLIKRQSE ELSKLRQEIY SSHNQPSCGG 

       550        560        570        580 
RTTITTKKYR TQYPILGLLY DDYEYIPPGS DTQTIVIEKT EDKWTCP 

« Hide

References

« Hide 'large scale' references
[1]"Mutation analysis of two candidate genes for premature ovarian failure, DACH2 and POF1B."
Bione S., Rizzolio F., Sala C., Ricotti R., Goegan M., Manzini M.C., Battaglia R., Marozzi A., Vegetti W., Dalpra L., Crosignani P.G., Ginelli E., Nappi R., Bernabini S., Bruni V., Torricelli F., Zuffardi O., Toniolo D.
Hum. Reprod. 19:2759-2766(2004) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
Strain: C57BL/6 and Swiss Webster / NIH.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
[3]Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
[4]"The transcriptional landscape of the mammalian genome."
Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J. expand/collapse author list , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-428.
Strain: C57BL/6J.
Tissue: Head.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF309775 mRNA. Translation: AAM93271.1.
AF408412 mRNA. Translation: AAM00425.1.
AL831771 Genomic DNA. Translation: CAM21383.1.
CH466564 Genomic DNA. Translation: EDL14003.1.
AK086511 mRNA. Translation: BAC39681.1.
CCDSCCDS30362.1.
RefSeqNP_853557.1. NM_181579.1.
UniGeneMm.34964.

3D structure databases

ProteinModelPortalQ8K4L4.
SMRQ8K4L4. Positions 471-529.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K4L4.

Proteomic databases

MaxQBQ8K4L4.
PRIDEQ8K4L4.

Protocols and materials databases

DNASU69693.
StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000039887; ENSMUSP00000047655; ENSMUSG00000034607.
GeneID69693.
KEGGmmu:69693.
UCSCuc009udm.1. mouse.

Organism-specific databases

CTD79983.
MGIMGI:1916943. Pof1b.

Phylogenomic databases

eggNOGNOG28199.
GeneTreeENSGT00390000000141.
HOGENOMHOG000115604.
HOVERGENHBG080408.
InParanoidQ8R4R8.
OMAEQVIIQD.
OrthoDBEOG7S21XZ.
TreeFamTF331412.

Gene expression databases

BgeeQ8K4L4.
CleanExMM_POF1B.
GenevestigatorQ8K4L4.

Family and domain databases

InterProIPR026186. POF1B.
[Graphical view]
PANTHERPTHR22546. PTHR22546. 1 hit.
ProtoNetSearch...

Other

NextBio330096.
PROQ8K4L4.
SOURCESearch...

Entry information

Entry namePOF1B_MOUSE
AccessionPrimary (citable) accession number: Q8K4L4
Secondary accession number(s): A2ANY1, Q8C3A2, Q8R4R8
Entry history
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot