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Q8K4L4

- POF1B_MOUSE

UniProt

Q8K4L4 - POF1B_MOUSE

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Protein
Protein POF1B
Gene
Pof1b
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Plays a key role in the organization of epithelial monolayers by regulating the actin cytoskeleton. May be involved in ovary development By similarity.

Keywords - Ligandi

Actin-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Protein POF1B
Gene namesi
Name:Pof1b
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome X

Organism-specific databases

MGIiMGI:1916943. Pof1b.

Subcellular locationi

Cell junctiontight junction By similarity

Keywords - Cellular componenti

Cell junction, Tight junction

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 587587Protein POF1B
PRO_0000253912Add
BLAST

Proteomic databases

MaxQBiQ8K4L4.
PRIDEiQ8K4L4.

PTM databases

PhosphoSiteiQ8K4L4.

Expressioni

Tissue specificityi

Expression absent in adult ovary.1 Publication

Developmental stagei

Expressed in ovary between 16.5 dpc and P5.1 Publication

Gene expression databases

BgeeiQ8K4L4.
CleanExiMM_POF1B.
GenevestigatoriQ8K4L4.

Interactioni

Subunit structurei

Interacts with nonmuscle actin By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8K4L4.
SMRiQ8K4L4. Positions 471-529.

Family & Domainsi

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili331 – 529199 Reviewed prediction
Add
BLAST

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG28199.
GeneTreeiENSGT00390000000141.
HOGENOMiHOG000115604.
HOVERGENiHBG080408.
InParanoidiQ8R4R8.
OMAiEQVIIQD.
OrthoDBiEOG7S21XZ.
TreeFamiTF331412.

Family and domain databases

InterProiIPR026186. POF1B.
[Graphical view]
PANTHERiPTHR22546. PTHR22546. 1 hit.

Sequencei

Sequence statusi: Complete.

Q8K4L4-1 [UniParc]FASTAAdd to Basket

« Hide

MMSSSYWSET SSSSCGTQQP TEVLQCQPQH YHYYHQPSQA QQPPEKNVVY    50
ERVRTYSGPM NKVVQALDPL GSREVLSPLK PASSYQSLVW SDHSQELYSP 100
TLKISTCAPS TLHITQNAEQ ELHSPTVKVT TYPQTTIRRY IVQNPEQEPL 150
SPFLRGSQFF PGNNVIYEKT IRKVEKLNTD QECCPQIQCH HHVIQQPQII 200
HSPHCQQSHS SHQIQCITEN DSNIGHELCH GGPSQIHEQV IIQDDGPEKL 250
DPKYFGELLA DLSRKNTDLY HCLLEHLERI GGSKQDFEST DTSEDIESLI 300
PKGLSEFTKQ QIRYILQMRG MSDKSLRLVL STFSNIREEL GHLQNDLTSL 350
ENDKIRLEKD LAFKENQMKE YEELLASVRA NNRQQQQGLQ DSSAKCQSLE 400
ENNLSLRHTL SDLEYRLKEL EYCKRNLEQE NKNLRIQVSE TCTGPTLQAK 450
MDEIGNHYME MVKNLRLDKD REISKLRSQL NQYQKDVSKR EGSCSDFQFK 500
LHELTSLLEE KDSLIKRQSE ELSKLRQEIY SSHNQPSCGG RTTITTKKYR 550
TQYPILGLLY DDYEYIPPGS DTQTIVIEKT EDKWTCP 587
Length:587
Mass (Da):67,785
Last modified:May 3, 2011 - v3
Checksum:i02ED686CB63107AD
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti91 – 911S → N in BAC39681. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309775 mRNA. Translation: AAM93271.1.
AF408412 mRNA. Translation: AAM00425.1.
AL831771 Genomic DNA. Translation: CAM21383.1.
CH466564 Genomic DNA. Translation: EDL14003.1.
AK086511 mRNA. Translation: BAC39681.1.
CCDSiCCDS30362.1.
RefSeqiNP_853557.1. NM_181579.1.
UniGeneiMm.34964.

Genome annotation databases

EnsembliENSMUST00000039887; ENSMUSP00000047655; ENSMUSG00000034607.
GeneIDi69693.
KEGGimmu:69693.
UCSCiuc009udm.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF309775 mRNA. Translation: AAM93271.1 .
AF408412 mRNA. Translation: AAM00425.1 .
AL831771 Genomic DNA. Translation: CAM21383.1 .
CH466564 Genomic DNA. Translation: EDL14003.1 .
AK086511 mRNA. Translation: BAC39681.1 .
CCDSi CCDS30362.1.
RefSeqi NP_853557.1. NM_181579.1.
UniGenei Mm.34964.

3D structure databases

ProteinModelPortali Q8K4L4.
SMRi Q8K4L4. Positions 471-529.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K4L4.

Proteomic databases

MaxQBi Q8K4L4.
PRIDEi Q8K4L4.

Protocols and materials databases

DNASUi 69693.
Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000039887 ; ENSMUSP00000047655 ; ENSMUSG00000034607 .
GeneIDi 69693.
KEGGi mmu:69693.
UCSCi uc009udm.1. mouse.

Organism-specific databases

CTDi 79983.
MGIi MGI:1916943. Pof1b.

Phylogenomic databases

eggNOGi NOG28199.
GeneTreei ENSGT00390000000141.
HOGENOMi HOG000115604.
HOVERGENi HBG080408.
InParanoidi Q8R4R8.
OMAi EQVIIQD.
OrthoDBi EOG7S21XZ.
TreeFami TF331412.

Miscellaneous databases

NextBioi 330096.
PROi Q8K4L4.
SOURCEi Search...

Gene expression databases

Bgeei Q8K4L4.
CleanExi MM_POF1B.
Genevestigatori Q8K4L4.

Family and domain databases

InterProi IPR026186. POF1B.
[Graphical view ]
PANTHERi PTHR22546. PTHR22546. 1 hit.
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY, DEVELOPMENTAL STAGE.
    Strain: C57BL/6 and Swiss Webster / NIH.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.
  3. Mural R.J., Adams M.D., Myers E.W., Smith H.O., Venter J.C.
    Submitted (SEP-2005) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
  4. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] OF 1-428.
    Strain: C57BL/6J.
    Tissue: Head.

Entry informationi

Entry nameiPOF1B_MOUSE
AccessioniPrimary (citable) accession number: Q8K4L4
Secondary accession number(s): A2ANY1, Q8C3A2, Q8R4R8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: October 17, 2006
Last sequence update: May 3, 2011
Last modified: July 9, 2014
This is version 68 of the entry and version 3 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Caution

It is uncertain whether Met-1 or Met-2 is the initiator. The first methionine is not conserved among other organisms, but rat. It could be rodent-specific.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot

External Data

Dasty 3

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