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Protein

ATP-dependent RNA helicase DDX54

Gene

Ddx54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at protein leveli

Functioni

Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi139 – 1468ATPPROSITE-ProRule annotation

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Helicase, Hydrolase

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

ATP-binding, Nucleotide-binding, RNA-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX54 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 54
Gene namesi
Name:Ddx54
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919240. Ddx54.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 874874ATP-dependent RNA helicase DDX54PRO_0000055057Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei30 – 301PhosphothreonineCombined sources
Modified residuei33 – 331PhosphoserineCombined sources
Modified residuei38 – 381PhosphoserineCombined sources
Modified residuei40 – 401PhosphoserineCombined sources
Modified residuei74 – 741PhosphoserineCombined sources
Modified residuei688 – 6881PhosphoserineBy similarity
Modified residuei690 – 6901PhosphoserineBy similarity
Modified residuei774 – 7741PhosphoserineCombined sources
Modified residuei780 – 7801PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K4L0.
MaxQBiQ8K4L0.
PaxDbiQ8K4L0.
PRIDEiQ8K4L0.

PTM databases

iPTMnetiQ8K4L0.
PhosphoSiteiQ8K4L0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000029599.
CleanExiMM_DDX54.
GenevisibleiQ8K4L0. MM.

Interactioni

Subunit structurei

Interacts in a hormone-dependent manner with nuclear receptors.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215078. 2 interactions.
STRINGi10090.ENSMUSP00000031598.

Structurei

3D structure databases

ProteinModelPortaliQ8K4L0.
SMRiQ8K4L0. Positions 70-475.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini126 – 298173Helicase ATP-bindingPROSITE-ProRule annotationAdd
BLAST
Domaini328 – 472145Helicase C-terminalPROSITE-ProRule annotationAdd
BLAST

Motif

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Motifi95 – 12329Q motifAdd
BLAST
Motifi246 – 2494DEAD box

Sequence similaritiesi

Contains 1 helicase ATP-binding domain.PROSITE-ProRule annotation
Contains 1 helicase C-terminal domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiKOG0337. Eukaryota.
ENOG410XQE5. LUCA.
GeneTreeiENSGT00550000075100.
HOGENOMiHOG000246455.
HOVERGENiHBG051333.
InParanoidiQ8K4L0.
KOiK14808.
OMAiKLKQHVP.
OrthoDBiEOG091G053F.
PhylomeDBiQ8K4L0.
TreeFamiTF105707.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR012541. DBP10_C.
IPR033517. DDX54/DBP10.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PANTHERiPTHR24031:SF292. PTHR24031:SF292. 4 hits.
PfamiPF08147. DBP10CT. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
ProDomiPD024971. DBP10CT. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01123. DBP10CT. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGRRVGPG PPSRPTMAPW KKKRLRKRRT GASQGRDSDS DDGEFEIQAE
60 70 80 90 100
DDARARKLGP GRALPSFPTS ECVSDVEPDT REMVRAQNKK KKKSGGFQSM
110 120 130 140 150
GLSYPVFKGI MKKGYKVPTP IQRKTIPVIL DGKDVVAMAR TGSGKTACFL
160 170 180 190 200
LPMFERLKAR SAQTGARALI LSPTRELALQ TMKFTKELGK FTGLKTALIL
210 220 230 240 250
GGDKMEDQFA ALHENPDIII ATPGRLVHVA VEMNLKLQSV EYVVFDEADR
260 270 280 290 300
LFEMGFAEQL QEIIGRLPGG HQTVLFSATL PKLLVEFARA GLTEPVLIRL
310 320 330 340 350
DVDSKLNEQL KTSFLLVRED TKAAVLLYLL QNVVRPQDQT VVFVATKHHA
360 370 380 390 400
EYLTELLMGQ GVSCAHIYSA LDQTARKINL AKFTHNKCST LIVTDLAARG
410 420 430 440 450
LDIPLLDNVI NYSFPAKGKL FLHRVGRVAR AGRSGTAYSL VAPDEVPYLL
460 470 480 490 500
DLHLFLGRSV TLARPCEEPS VADAVGRDGV LGRVPQSVVD DEDSSLQTAM
510 520 530 540 550
GASLDLQGLH RVANNAQQQY VRSRPAPSPE SIKRAKELDL AELGLHPLFS
560 570 580 590 600
SCFEEGELQR LRLVDSIKNY RTRTTIFEIN ASSKDPSSQM MRAKRQRDRK
610 620 630 640 650
AVASFQQRRQ ERQEGPADPA PQRELPQEEE EEMVETVEGV FTEVVGQKRP
660 670 680 690 700
RPGPSQGAKR RRMETRQRDQ EFYVPYRPKD FDSERGLSVS GAGGAFEQQV
710 720 730 740 750
AGAVLDLMGD EAQNMSRGQQ QLKWDRKKKR FVGQSGQEDK KKIKTESGRF
760 770 780 790 800
ISSSYKRDLY QKWKQKQKID DRDSEEEGPS NQRGPGPRRG GKRGRSQGTS
810 820 830 840 850
QPRASSVPAG RMRSELKTKE QILKQRRQAQ KQRFLQRGGL KQLSARNRRR
860 870
AQELRQGAFG RGAPSRKGKM RKRM
Length:874
Mass (Da):97,748
Last modified:October 1, 2002 - v1
Checksum:iD25A478879368494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319547 mRNA. Translation: AAM47540.1.
BC043699 mRNA. Translation: AAH43699.1.
CCDSiCCDS39241.1.
RefSeqiNP_082317.1. NM_028041.2.
UniGeneiMm.24495.
Mm.491106.

Genome annotation databases

EnsembliENSMUST00000031598; ENSMUSP00000031598; ENSMUSG00000029599.
GeneIDi71990.
KEGGimmu:71990.
UCSCiuc008zhq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319547 mRNA. Translation: AAM47540.1.
BC043699 mRNA. Translation: AAH43699.1.
CCDSiCCDS39241.1.
RefSeqiNP_082317.1. NM_028041.2.
UniGeneiMm.24495.
Mm.491106.

3D structure databases

ProteinModelPortaliQ8K4L0.
SMRiQ8K4L0. Positions 70-475.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi215078. 2 interactions.
STRINGi10090.ENSMUSP00000031598.

PTM databases

iPTMnetiQ8K4L0.
PhosphoSiteiQ8K4L0.

Proteomic databases

EPDiQ8K4L0.
MaxQBiQ8K4L0.
PaxDbiQ8K4L0.
PRIDEiQ8K4L0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000031598; ENSMUSP00000031598; ENSMUSG00000029599.
GeneIDi71990.
KEGGimmu:71990.
UCSCiuc008zhq.1. mouse.

Organism-specific databases

CTDi79039.
MGIiMGI:1919240. Ddx54.

Phylogenomic databases

eggNOGiKOG0337. Eukaryota.
ENOG410XQE5. LUCA.
GeneTreeiENSGT00550000075100.
HOGENOMiHOG000246455.
HOVERGENiHBG051333.
InParanoidiQ8K4L0.
KOiK14808.
OMAiKLKQHVP.
OrthoDBiEOG091G053F.
PhylomeDBiQ8K4L0.
TreeFamiTF105707.

Miscellaneous databases

ChiTaRSiDdx54. mouse.
PROiQ8K4L0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000029599.
CleanExiMM_DDX54.
GenevisibleiQ8K4L0. MM.

Family and domain databases

Gene3Di3.40.50.300. 2 hits.
InterProiIPR012541. DBP10_C.
IPR033517. DDX54/DBP10.
IPR011545. DEAD/DEAH_box_helicase_dom.
IPR014001. Helicase_ATP-bd.
IPR001650. Helicase_C.
IPR027417. P-loop_NTPase.
IPR000629. RNA-helicase_DEAD-box_CS.
IPR014014. RNA_helicase_DEAD_Q_motif.
[Graphical view]
PANTHERiPTHR24031:SF292. PTHR24031:SF292. 4 hits.
PfamiPF08147. DBP10CT. 1 hit.
PF00270. DEAD. 1 hit.
PF00271. Helicase_C. 1 hit.
[Graphical view]
ProDomiPD024971. DBP10CT. 1 hit.
[Graphical view] [Entries sharing at least one domain]
SMARTiSM01123. DBP10CT. 1 hit.
SM00487. DEXDc. 1 hit.
SM00490. HELICc. 1 hit.
[Graphical view]
SUPFAMiSSF52540. SSF52540. 2 hits.
PROSITEiPS00039. DEAD_ATP_HELICASE. 1 hit.
PS51192. HELICASE_ATP_BIND_1. 1 hit.
PS51194. HELICASE_CTER. 1 hit.
PS51195. Q_MOTIF. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiDDX54_MOUSE
AccessioniPrimary (citable) accession number: Q8K4L0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 117 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.