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Protein

ATP-dependent RNA helicase DDX54

Gene

Ddx54

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Has RNA-dependent ATPase activity. Represses the transcriptional activity of nuclear receptors (By similarity).By similarity

Catalytic activityi

ATP + H2O = ADP + phosphate.

Regions

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Nucleotide bindingi139 – 146ATPPROSITE-ProRule annotation8

GO - Molecular functioni

GO - Biological processi

Keywordsi

Molecular functionHelicase, Hydrolase, RNA-binding
Biological processTranscription, Transcription regulation
LigandATP-binding, Nucleotide-binding

Names & Taxonomyi

Protein namesi
Recommended name:
ATP-dependent RNA helicase DDX54 (EC:3.6.4.13)
Alternative name(s):
DEAD box protein 54
Gene namesi
Name:Ddx54
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 5

Organism-specific databases

MGIiMGI:1919240 Ddx54

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000550571 – 874ATP-dependent RNA helicase DDX54Add BLAST874

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei30PhosphothreonineCombined sources1
Modified residuei33PhosphoserineCombined sources1
Modified residuei38PhosphoserineCombined sources1
Modified residuei40PhosphoserineCombined sources1
Modified residuei74PhosphoserineCombined sources1
Modified residuei688PhosphoserineBy similarity1
Modified residuei690PhosphoserineBy similarity1
Modified residuei774PhosphoserineCombined sources1
Modified residuei780PhosphoserineBy similarity1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K4L0
MaxQBiQ8K4L0
PaxDbiQ8K4L0
PRIDEiQ8K4L0

PTM databases

iPTMnetiQ8K4L0
PhosphoSitePlusiQ8K4L0

Expressioni

Gene expression databases

BgeeiENSMUSG00000029599
CleanExiMM_DDX54
GenevisibleiQ8K4L0 MM

Interactioni

Subunit structurei

Interacts in a hormone-dependent manner with nuclear receptors.By similarity

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215078, 3 interactors
STRINGi10090.ENSMUSP00000031598

Structurei

3D structure databases

ProteinModelPortaliQ8K4L0
SMRiQ8K4L0
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini126 – 298Helicase ATP-bindingPROSITE-ProRule annotationAdd BLAST173
Domaini328 – 472Helicase C-terminalPROSITE-ProRule annotationAdd BLAST145

Motif

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Motifi95 – 123Q motifAdd BLAST29
Motifi246 – 249DEAD box4

Sequence similaritiesi

Phylogenomic databases

eggNOGiKOG0337 Eukaryota
ENOG410XQE5 LUCA
GeneTreeiENSGT00550000075100
HOGENOMiHOG000246455
HOVERGENiHBG051333
InParanoidiQ8K4L0
KOiK14808
OMAiLHLCVEM
OrthoDBiEOG091G053F
PhylomeDBiQ8K4L0
TreeFamiTF105707

Family and domain databases

CDDicd00079 HELICc, 1 hit
InterProiView protein in InterPro
IPR012541 DBP10_C
IPR033517 DDX54/DBP10
IPR011545 DEAD/DEAH_box_helicase_dom
IPR014001 Helicase_ATP-bd
IPR001650 Helicase_C
IPR027417 P-loop_NTPase
IPR000629 RNA-helicase_DEAD-box_CS
IPR014014 RNA_helicase_DEAD_Q_motif
PANTHERiPTHR24031:SF292 PTHR24031:SF292, 1 hit
PfamiView protein in Pfam
PF08147 DBP10CT, 1 hit
PF00270 DEAD, 1 hit
PF00271 Helicase_C, 1 hit
ProDomiView protein in ProDom or Entries sharing at least one domain
PD024971 DBP10CT, 1 hit
SMARTiView protein in SMART
SM01123 DBP10CT, 1 hit
SM00487 DEXDc, 1 hit
SM00490 HELICc, 1 hit
SUPFAMiSSF52540 SSF52540, 2 hits
PROSITEiView protein in PROSITE
PS00039 DEAD_ATP_HELICASE, 1 hit
PS51192 HELICASE_ATP_BIND_1, 1 hit
PS51194 HELICASE_CTER, 1 hit
PS51195 Q_MOTIF, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K4L0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAAGRRVGPG PPSRPTMAPW KKKRLRKRRT GASQGRDSDS DDGEFEIQAE
60 70 80 90 100
DDARARKLGP GRALPSFPTS ECVSDVEPDT REMVRAQNKK KKKSGGFQSM
110 120 130 140 150
GLSYPVFKGI MKKGYKVPTP IQRKTIPVIL DGKDVVAMAR TGSGKTACFL
160 170 180 190 200
LPMFERLKAR SAQTGARALI LSPTRELALQ TMKFTKELGK FTGLKTALIL
210 220 230 240 250
GGDKMEDQFA ALHENPDIII ATPGRLVHVA VEMNLKLQSV EYVVFDEADR
260 270 280 290 300
LFEMGFAEQL QEIIGRLPGG HQTVLFSATL PKLLVEFARA GLTEPVLIRL
310 320 330 340 350
DVDSKLNEQL KTSFLLVRED TKAAVLLYLL QNVVRPQDQT VVFVATKHHA
360 370 380 390 400
EYLTELLMGQ GVSCAHIYSA LDQTARKINL AKFTHNKCST LIVTDLAARG
410 420 430 440 450
LDIPLLDNVI NYSFPAKGKL FLHRVGRVAR AGRSGTAYSL VAPDEVPYLL
460 470 480 490 500
DLHLFLGRSV TLARPCEEPS VADAVGRDGV LGRVPQSVVD DEDSSLQTAM
510 520 530 540 550
GASLDLQGLH RVANNAQQQY VRSRPAPSPE SIKRAKELDL AELGLHPLFS
560 570 580 590 600
SCFEEGELQR LRLVDSIKNY RTRTTIFEIN ASSKDPSSQM MRAKRQRDRK
610 620 630 640 650
AVASFQQRRQ ERQEGPADPA PQRELPQEEE EEMVETVEGV FTEVVGQKRP
660 670 680 690 700
RPGPSQGAKR RRMETRQRDQ EFYVPYRPKD FDSERGLSVS GAGGAFEQQV
710 720 730 740 750
AGAVLDLMGD EAQNMSRGQQ QLKWDRKKKR FVGQSGQEDK KKIKTESGRF
760 770 780 790 800
ISSSYKRDLY QKWKQKQKID DRDSEEEGPS NQRGPGPRRG GKRGRSQGTS
810 820 830 840 850
QPRASSVPAG RMRSELKTKE QILKQRRQAQ KQRFLQRGGL KQLSARNRRR
860 870
AQELRQGAFG RGAPSRKGKM RKRM
Length:874
Mass (Da):97,748
Last modified:October 1, 2002 - v1
Checksum:iD25A478879368494
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF319547 mRNA Translation: AAM47540.1
BC043699 mRNA Translation: AAH43699.1
CCDSiCCDS39241.1
RefSeqiNP_082317.1, NM_028041.2
UniGeneiMm.24495
Mm.491106

Genome annotation databases

EnsembliENSMUST00000031598; ENSMUSP00000031598; ENSMUSG00000029599
GeneIDi71990
KEGGimmu:71990
UCSCiuc008zhq.1 mouse

Similar proteinsi

Entry informationi

Entry nameiDDX54_MOUSE
AccessioniPrimary (citable) accession number: Q8K4L0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: April 26, 2004
Last sequence update: October 1, 2002
Last modified: May 23, 2018
This is version 129 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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