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Q8K4K4

- TRIB1_MOUSE

UniProt

Q8K4K4 - TRIB1_MOUSE

Protein

Tribbles homolog 1

Gene

Trib1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 99 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity By similarity.By similarity

    GO - Molecular functioni

    1. protein kinase inhibitor activity Source: UniProtKB-KW
    2. transcription factor binding Source: BHF-UCL
    3. transferase activity, transferring phosphorus-containing groups Source: InterPro
    4. ubiquitin protein ligase binding Source: BHF-UCL
    5. ubiquitin-protein transferase regulator activity Source: BHF-UCL

    GO - Biological processi

    1. JNK cascade Source: Ensembl
    2. negative regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
    3. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    4. negative regulation of smooth muscle cell migration Source: Ensembl
    5. negative regulation of smooth muscle cell proliferation Source: Ensembl
    6. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    7. positive regulation of ubiquitin-protein transferase activity Source: BHF-UCL
    8. regulation of MAP kinase activity Source: UniProtKB
    9. response to lipopolysaccharide Source: BHF-UCL

    Keywords - Molecular functioni

    Protein kinase inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tribbles homolog 1
    Short name:
    TRB-1
    Gene namesi
    Name:Trib1Imported
    Synonyms:Trb1Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2443397. Trib1.

    Subcellular locationi

    GO - Cellular componenti

    1. cytoplasm Source: Ensembl
    2. nucleus Source: Ensembl

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 372372Tribbles homolog 1PRO_0000131860Add
    BLAST

    Proteomic databases

    PRIDEiQ8K4K4.

    PTM databases

    PhosphoSiteiQ8K4K4.

    Expressioni

    Gene expression databases

    BgeeiQ8K4K4.
    CleanExiMM_TRIB1.
    GenevestigatoriQ8K4K4.

    Interactioni

    Protein-protein interaction databases

    BioGridi229263. 3 interactions.
    IntActiQ8K4K4. 1 interaction.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4K4.
    SMRiQ8K4K4. Positions 113-370.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini1 – 338338Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000114880.
    HOGENOMiHOG000231872.
    HOVERGENiHBG067729.
    InParanoidiQ8K4K4.
    KOiK08814.
    OMAiAHCHQSA.
    OrthoDBiEOG7RJPR4.
    PhylomeDBiQ8K4K4.
    TreeFamiTF329785.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR024105. TRB1.
    IPR024104. Tribbles/Ser_Thr_kinase_40.
    [Graphical view]
    PANTHERiPTHR22961. PTHR22961. 1 hit.
    PTHR22961:SF10. PTHR22961:SF10. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 11 Publication (identifier: Q8K4K4-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MRVGPVRFAL SGASQPRGPG LLFPAARGTP AKRLLDTDDA GAVAAKCPRL    50
    SECSSPPDYL SPPGSPCSPQ PPPSTQGTGG SCVSSPGPSR IADYLLLPLA 100
    EREHVSRALC IHTGRELRCK EFPIKHYQDK IRPYIQLPSH SNITGIVEVL 150
    LGESKAYVFF EKDFGDMHSY VRSRKRLREE EAARLFKQIV SAVAHCHQSA 200
    IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IIKGEDDALS DKHGCPAYVS 250
    PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ 300
    FCIPEHVSPK ARCLIRSLLR REPSERLTAP QILLHPWFEY VLEPGYVDSE 350
    IGTSDQIVPE YQEDSDISSF FC 372
    Length:372
    Mass (Da):41,281
    Last modified:December 6, 2005 - v2
    Checksum:iAD29BB4E640B4B62
    GO
    Isoform 2Curated (identifier: Q8K4K4-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         219-372: Missing.

    Note: No experimental confirmation available.Curated

    Show »
    Length:218
    Mass (Da):23,907
    Checksum:iF3A5AFE16E3450A8
    GO

    Sequence cautioni

    The sequence BAC28245.1 differs from that shown. Reason: Erroneous initiation.
    The sequence BAC37854.1 differs from that shown. Reason: Erroneous initiation.

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti224 – 2241E → G in AAM45478. (PubMed:15299019)Curated
    Sequence conflicti278 – 2781L → W in AAM45478. (PubMed:15299019)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei219 – 372154Missing in isoform 2. 1 PublicationVSP_051888Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358866 mRNA. Translation: AAM45478.1.
    AK028626 mRNA. Translation: BAC26038.1.
    AK033358 mRNA. Translation: BAC28245.1. Different initiation.
    AK040738 mRNA. Translation: BAC30688.1.
    AK041212 mRNA. Translation: BAC30865.1.
    AK080228 mRNA. Translation: BAC37854.1. Different initiation.
    AK162876 mRNA. Translation: BAE37097.1.
    BC006800 mRNA. Translation: AAH06800.1.
    CCDSiCCDS27499.1. [Q8K4K4-1]
    RefSeqiNP_653132.1. NM_144549.4. [Q8K4K4-1]
    UniGeneiMm.40298.

    Genome annotation databases

    EnsembliENSMUST00000067543; ENSMUSP00000068834; ENSMUSG00000032501. [Q8K4K4-1]
    ENSMUST00000118228; ENSMUSP00000112828; ENSMUSG00000032501. [Q8K4K4-2]
    GeneIDi211770.
    KEGGimmu:211770.
    UCSCiuc007vxw.1. mouse. [Q8K4K4-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358866 mRNA. Translation: AAM45478.1 .
    AK028626 mRNA. Translation: BAC26038.1 .
    AK033358 mRNA. Translation: BAC28245.1 . Different initiation.
    AK040738 mRNA. Translation: BAC30688.1 .
    AK041212 mRNA. Translation: BAC30865.1 .
    AK080228 mRNA. Translation: BAC37854.1 . Different initiation.
    AK162876 mRNA. Translation: BAE37097.1 .
    BC006800 mRNA. Translation: AAH06800.1 .
    CCDSi CCDS27499.1. [Q8K4K4-1 ]
    RefSeqi NP_653132.1. NM_144549.4. [Q8K4K4-1 ]
    UniGenei Mm.40298.

    3D structure databases

    ProteinModelPortali Q8K4K4.
    SMRi Q8K4K4. Positions 113-370.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229263. 3 interactions.
    IntActi Q8K4K4. 1 interaction.

    PTM databases

    PhosphoSitei Q8K4K4.

    Proteomic databases

    PRIDEi Q8K4K4.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000067543 ; ENSMUSP00000068834 ; ENSMUSG00000032501 . [Q8K4K4-1 ]
    ENSMUST00000118228 ; ENSMUSP00000112828 ; ENSMUSG00000032501 . [Q8K4K4-2 ]
    GeneIDi 211770.
    KEGGi mmu:211770.
    UCSCi uc007vxw.1. mouse. [Q8K4K4-1 ]

    Organism-specific databases

    CTDi 10221.
    MGIi MGI:2443397. Trib1.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000114880.
    HOGENOMi HOG000231872.
    HOVERGENi HBG067729.
    InParanoidi Q8K4K4.
    KOi K08814.
    OMAi AHCHQSA.
    OrthoDBi EOG7RJPR4.
    PhylomeDBi Q8K4K4.
    TreeFami TF329785.

    Miscellaneous databases

    NextBioi 373352.
    PROi Q8K4K4.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K4K4.
    CleanExi MM_TRIB1.
    Genevestigatori Q8K4K4.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR024105. TRB1.
    IPR024104. Tribbles/Ser_Thr_kinase_40.
    [Graphical view ]
    PANTHERi PTHR22961. PTHR22961. 1 hit.
    PTHR22961:SF10. PTHR22961:SF10. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
      Strain: C57BL/6JImported.
      Tissue: AortaImported, HypothalamusImported, LungImported, SkinImported and VeinImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
      Strain: FVB/N-3Imported.
      Tissue: Mammary glandImported.

    Entry informationi

    Entry nameiTRIB1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4K4
    Secondary accession number(s): Q8BFS7
    , Q8BJR9, Q8BZX3, Q91W04
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 99 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3