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Protein

Tribbles homolog 1

Gene

Trib1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity (By similarity).By similarity

GO - Molecular functioni

  1. mitogen-activated protein kinase kinase binding Source: MGI
  2. protein kinase inhibitor activity Source: MGI
  3. transcription factor binding Source: BHF-UCL
  4. transferase activity, transferring phosphorus-containing groups Source: InterPro
  5. ubiquitin protein ligase binding Source: BHF-UCL
  6. ubiquitin-protein transferase regulator activity Source: BHF-UCL

GO - Biological processi

  1. JNK cascade Source: MGI
  2. negative regulation of lipopolysaccharide-mediated signaling pathway Source: MGI
  3. negative regulation of protein kinase activity Source: MGI
  4. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  5. negative regulation of smooth muscle cell migration Source: MGI
  6. negative regulation of smooth muscle cell proliferation Source: MGI
  7. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  8. positive regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  9. regulation of MAP kinase activity Source: UniProtKB
  10. response to lipopolysaccharide Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 1
Short name:
TRB-1
Gene namesi
Name:Trib1Imported
Synonyms:Trb1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2443397. Trib1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: MGI
  2. nucleus Source: MGI
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Tribbles homolog 1PRO_0000131860Add
BLAST

Proteomic databases

PRIDEiQ8K4K4.

PTM databases

PhosphoSiteiQ8K4K4.

Expressioni

Gene expression databases

BgeeiQ8K4K4.
CleanExiMM_TRIB1.
GenevestigatoriQ8K4K4.

Interactioni

Protein-protein interaction databases

BioGridi229263. 3 interactions.
IntActiQ8K4K4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K4K4.
SMRiQ8K4K4. Positions 103-370.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 338338Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121915.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ8K4K4.
KOiK08814.
OMAiAHCHQSA.
OrthoDBiEOG7RJPR4.
PhylomeDBiQ8K4K4.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024105. TRB1.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF10. PTHR22961:SF10. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8K4K4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MRVGPVRFAL SGASQPRGPG LLFPAARGTP AKRLLDTDDA GAVAAKCPRL
60 70 80 90 100
SECSSPPDYL SPPGSPCSPQ PPPSTQGTGG SCVSSPGPSR IADYLLLPLA
110 120 130 140 150
EREHVSRALC IHTGRELRCK EFPIKHYQDK IRPYIQLPSH SNITGIVEVL
160 170 180 190 200
LGESKAYVFF EKDFGDMHSY VRSRKRLREE EAARLFKQIV SAVAHCHQSA
210 220 230 240 250
IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IIKGEDDALS DKHGCPAYVS
260 270 280 290 300
PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ
310 320 330 340 350
FCIPEHVSPK ARCLIRSLLR REPSERLTAP QILLHPWFEY VLEPGYVDSE
360 370
IGTSDQIVPE YQEDSDISSF FC
Length:372
Mass (Da):41,281
Last modified:December 6, 2005 - v2
Checksum:iAD29BB4E640B4B62
GO
Isoform 2Curated (identifier: Q8K4K4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-372: Missing.

Note: No experimental confirmation available.Curated

Show »
Length:218
Mass (Da):23,907
Checksum:iF3A5AFE16E3450A8
GO

Sequence cautioni

The sequence BAC28245.1 differs from that shown. Reason: Erroneous initiation. Curated
The sequence BAC37854.1 differs from that shown. Reason: Erroneous initiation. Curated

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241E → G in AAM45478. (PubMed:15299019)Curated
Sequence conflicti278 – 2781L → W in AAM45478. (PubMed:15299019)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei219 – 372154Missing in isoform 2. 1 PublicationVSP_051888Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358866 mRNA. Translation: AAM45478.1.
AK028626 mRNA. Translation: BAC26038.1.
AK033358 mRNA. Translation: BAC28245.1. Different initiation.
AK040738 mRNA. Translation: BAC30688.1.
AK041212 mRNA. Translation: BAC30865.1.
AK080228 mRNA. Translation: BAC37854.1. Different initiation.
AK162876 mRNA. Translation: BAE37097.1.
BC006800 mRNA. Translation: AAH06800.1.
CCDSiCCDS27499.1. [Q8K4K4-1]
RefSeqiNP_653132.1. NM_144549.4. [Q8K4K4-1]
UniGeneiMm.40298.

Genome annotation databases

EnsembliENSMUST00000067543; ENSMUSP00000068834; ENSMUSG00000032501. [Q8K4K4-1]
ENSMUST00000118228; ENSMUSP00000112828; ENSMUSG00000032501. [Q8K4K4-2]
GeneIDi211770.
KEGGimmu:211770.
UCSCiuc007vxw.1. mouse. [Q8K4K4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358866 mRNA. Translation: AAM45478.1.
AK028626 mRNA. Translation: BAC26038.1.
AK033358 mRNA. Translation: BAC28245.1. Different initiation.
AK040738 mRNA. Translation: BAC30688.1.
AK041212 mRNA. Translation: BAC30865.1.
AK080228 mRNA. Translation: BAC37854.1. Different initiation.
AK162876 mRNA. Translation: BAE37097.1.
BC006800 mRNA. Translation: AAH06800.1.
CCDSiCCDS27499.1. [Q8K4K4-1]
RefSeqiNP_653132.1. NM_144549.4. [Q8K4K4-1]
UniGeneiMm.40298.

3D structure databases

ProteinModelPortaliQ8K4K4.
SMRiQ8K4K4. Positions 103-370.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229263. 3 interactions.
IntActiQ8K4K4. 1 interaction.

PTM databases

PhosphoSiteiQ8K4K4.

Proteomic databases

PRIDEiQ8K4K4.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000067543; ENSMUSP00000068834; ENSMUSG00000032501. [Q8K4K4-1]
ENSMUST00000118228; ENSMUSP00000112828; ENSMUSG00000032501. [Q8K4K4-2]
GeneIDi211770.
KEGGimmu:211770.
UCSCiuc007vxw.1. mouse. [Q8K4K4-1]

Organism-specific databases

CTDi10221.
MGIiMGI:2443397. Trib1.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121915.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ8K4K4.
KOiK08814.
OMAiAHCHQSA.
OrthoDBiEOG7RJPR4.
PhylomeDBiQ8K4K4.
TreeFamiTF329785.

Miscellaneous databases

ChiTaRSiTrib1. mouse.
NextBioi373352.
PROiQ8K4K4.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K4K4.
CleanExiMM_TRIB1.
GenevestigatoriQ8K4K4.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024105. TRB1.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF10. PTHR22961:SF10. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6JImported.
    Tissue: AortaImported, HypothalamusImported, LungImported, SkinImported and VeinImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3Imported.
    Tissue: Mammary glandImported.

Entry informationi

Entry nameiTRIB1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4K4
Secondary accession number(s): Q8BFS7
, Q8BJR9, Q8BZX3, Q91W04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: February 4, 2015
This is version 103 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.