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Q8K4K4

- TRIB1_MOUSE

UniProt

Q8K4K4 - TRIB1_MOUSE

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Protein
Tribbles homolog 1
Gene
Trib1, Trb1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5 - Experimental evidence at transcript leveli

Functioni

Interacts with MAPK kinases and regulates activation of MAP kinases. May not display kinase activity By similarity.By similarity

GO - Molecular functioni

  1. protein kinase inhibitor activity Source: UniProtKB-KW
  2. transcription factor binding Source: BHF-UCL
  3. transferase activity, transferring phosphorus-containing groups Source: InterPro
  4. ubiquitin protein ligase binding Source: BHF-UCL
  5. ubiquitin-protein transferase regulator activity Source: BHF-UCL

GO - Biological processi

  1. JNK cascade Source: Ensembl
  2. negative regulation of lipopolysaccharide-mediated signaling pathway Source: Ensembl
  3. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  4. negative regulation of smooth muscle cell migration Source: Ensembl
  5. negative regulation of smooth muscle cell proliferation Source: Ensembl
  6. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  7. positive regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  8. regulation of MAP kinase activity Source: UniProtKB
  9. response to lipopolysaccharide Source: BHF-UCL
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 1
Short name:
TRB-1
Gene namesi
Name:Trib1
Synonyms:Trb1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 15

Organism-specific databases

MGIiMGI:2443397. Trib1.

Subcellular locationi

GO - Cellular componenti

  1. cytoplasm Source: Ensembl
  2. nucleus Source: Ensembl
Complete GO annotation...

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 372372Tribbles homolog 1
PRO_0000131860Add
BLAST

Proteomic databases

PRIDEiQ8K4K4.

PTM databases

PhosphoSiteiQ8K4K4.

Expressioni

Gene expression databases

BgeeiQ8K4K4.
CleanExiMM_TRIB1.
GenevestigatoriQ8K4K4.

Interactioni

Protein-protein interaction databases

BioGridi229263. 3 interactions.
IntActiQ8K4K4. 1 interaction.

Structurei

3D structure databases

ProteinModelPortaliQ8K4K4.
SMRiQ8K4K4. Positions 113-370.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini1 – 338338Protein kinase
Add
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00740000114880.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ8K4K4.
KOiK08814.
OMAiAHCHQSA.
OrthoDBiEOG7RJPR4.
PhylomeDBiQ8K4K4.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024105. TRB1.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PTHR22961:SF10. PTHR22961:SF10. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 11 Publication (identifier: Q8K4K4-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

MRVGPVRFAL SGASQPRGPG LLFPAARGTP AKRLLDTDDA GAVAAKCPRL    50
SECSSPPDYL SPPGSPCSPQ PPPSTQGTGG SCVSSPGPSR IADYLLLPLA 100
EREHVSRALC IHTGRELRCK EFPIKHYQDK IRPYIQLPSH SNITGIVEVL 150
LGESKAYVFF EKDFGDMHSY VRSRKRLREE EAARLFKQIV SAVAHCHQSA 200
IVLGDLKLRK FVFSTEERTQ LRLESLEDTH IIKGEDDALS DKHGCPAYVS 250
PEILNTTGTY SGKAADVWSL GVMLYTLLVG RYPFHDSDPS ALFSKIRRGQ 300
FCIPEHVSPK ARCLIRSLLR REPSERLTAP QILLHPWFEY VLEPGYVDSE 350
IGTSDQIVPE YQEDSDISSF FC 372
Length:372
Mass (Da):41,281
Last modified:December 6, 2005 - v2
Checksum:iAD29BB4E640B4B62
GO
Isoform 2 (identifier: Q8K4K4-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     219-372: Missing.

Note: No experimental confirmation available.

Show »
Length:218
Mass (Da):23,907
Checksum:iF3A5AFE16E3450A8
GO

Sequence cautioni

The sequence BAC28245.1 differs from that shown. Reason: Erroneous initiation.
The sequence BAC37854.1 differs from that shown. Reason: Erroneous initiation.

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei219 – 372154Missing in isoform 2.
VSP_051888Add
BLAST

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti224 – 2241E → G in AAM45478. 1 Publication
Sequence conflicti278 – 2781L → W in AAM45478. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF358866 mRNA. Translation: AAM45478.1.
AK028626 mRNA. Translation: BAC26038.1.
AK033358 mRNA. Translation: BAC28245.1. Different initiation.
AK040738 mRNA. Translation: BAC30688.1.
AK041212 mRNA. Translation: BAC30865.1.
AK080228 mRNA. Translation: BAC37854.1. Different initiation.
AK162876 mRNA. Translation: BAE37097.1.
BC006800 mRNA. Translation: AAH06800.1.
CCDSiCCDS27499.1. [Q8K4K4-1]
RefSeqiNP_653132.1. NM_144549.4. [Q8K4K4-1]
UniGeneiMm.40298.

Genome annotation databases

EnsembliENSMUST00000067543; ENSMUSP00000068834; ENSMUSG00000032501. [Q8K4K4-1]
ENSMUST00000118228; ENSMUSP00000112828; ENSMUSG00000032501. [Q8K4K4-2]
GeneIDi211770.
KEGGimmu:211770.
UCSCiuc007vxw.1. mouse. [Q8K4K4-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF358866 mRNA. Translation: AAM45478.1 .
AK028626 mRNA. Translation: BAC26038.1 .
AK033358 mRNA. Translation: BAC28245.1 . Different initiation.
AK040738 mRNA. Translation: BAC30688.1 .
AK041212 mRNA. Translation: BAC30865.1 .
AK080228 mRNA. Translation: BAC37854.1 . Different initiation.
AK162876 mRNA. Translation: BAE37097.1 .
BC006800 mRNA. Translation: AAH06800.1 .
CCDSi CCDS27499.1. [Q8K4K4-1 ]
RefSeqi NP_653132.1. NM_144549.4. [Q8K4K4-1 ]
UniGenei Mm.40298.

3D structure databases

ProteinModelPortali Q8K4K4.
SMRi Q8K4K4. Positions 113-370.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229263. 3 interactions.
IntActi Q8K4K4. 1 interaction.

PTM databases

PhosphoSitei Q8K4K4.

Proteomic databases

PRIDEi Q8K4K4.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000067543 ; ENSMUSP00000068834 ; ENSMUSG00000032501 . [Q8K4K4-1 ]
ENSMUST00000118228 ; ENSMUSP00000112828 ; ENSMUSG00000032501 . [Q8K4K4-2 ]
GeneIDi 211770.
KEGGi mmu:211770.
UCSCi uc007vxw.1. mouse. [Q8K4K4-1 ]

Organism-specific databases

CTDi 10221.
MGIi MGI:2443397. Trib1.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00740000114880.
HOGENOMi HOG000231872.
HOVERGENi HBG067729.
InParanoidi Q8K4K4.
KOi K08814.
OMAi AHCHQSA.
OrthoDBi EOG7RJPR4.
PhylomeDBi Q8K4K4.
TreeFami TF329785.

Miscellaneous databases

NextBioi 373352.
PROi Q8K4K4.
SOURCEi Search...

Gene expression databases

Bgeei Q8K4K4.
CleanExi MM_TRIB1.
Genevestigatori Q8K4K4.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024105. TRB1.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view ]
PANTHERi PTHR22961. PTHR22961. 1 hit.
PTHR22961:SF10. PTHR22961:SF10. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORMS 1 AND 2).
    Strain: C57BL/6J.
    Tissue: Aorta, Hypothalamus, Lung, Skin and Vein.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
    Strain: FVB/N-3.
    Tissue: Mammary gland.

Entry informationi

Entry nameiTRIB1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4K4
Secondary accession number(s): Q8BFS7
, Q8BJR9, Q8BZX3, Q91W04
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 98 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi