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Protein

Tribbles homolog 2

Gene

Trib2

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 4 out of 5-Experimental evidence at transcript leveli

Functioni

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity (By similarity).By similarity

GO - Molecular functioni

  1. protein kinase inhibitor activity Source: UniProtKB-KW
  2. transcription factor binding Source: BHF-UCL
  3. transferase activity, transferring phosphorus-containing groups Source: InterPro
  4. ubiquitin protein ligase binding Source: BHF-UCL
  5. ubiquitin-protein transferase regulator activity Source: BHF-UCL

GO - Biological processi

  1. negative regulation of fat cell differentiation Source: BHF-UCL
  2. negative regulation of interleukin-10 biosynthetic process Source: MGI
  3. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  4. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  5. positive regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  6. regulation of MAP kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 2
Short name:
TRB-2
Gene namesi
Name:Trib2Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 12

Organism-specific databases

MGIiMGI:2145021. Trib2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
Note: May associate with the cytoskeleton.By similarity

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoskeleton Source: UniProtKB-SubCell
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Tribbles homolog 2PRO_0000131864Add
BLAST

Proteomic databases

PRIDEiQ8K4K3.

PTM databases

PhosphoSiteiQ8K4K3.

Expressioni

Gene expression databases

BgeeiQ8K4K3.
CleanExiMM_TRIB2.
GenevestigatoriQ8K4K3.

Interactioni

Protein-protein interaction databases

BioGridi229913. 2 interactions.
IntActiQ8K4K3. 1 interaction.
STRINGi10090.ENSMUSP00000020922.

Structurei

3D structure databases

ProteinModelPortaliQ8K4K3.
SMRiQ8K4K3. Positions 63-341.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 308248Protein kinasePROSITE-ProRule annotationAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Contains 1 protein kinase domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121915.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ8K4K3.
KOiK08814.
OMAiHCHDNGL.
OrthoDBiEOG7RJPR4.
PhylomeDBiQ8K4K3.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4K3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE
60 70 80 90 100
TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFEISCYQES
110 120 130 140 150
LAPCFCLSAH SNINQITEIL LGETKAYVFF ERSYGDMHSF VRTCKKLREE
160 170 180 190 200
EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY
210 220 230 240 250
ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG
260 270 280 290 300
RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ
310 320 330 340
EILDHPWFST DFSVSNSGFG AKEACDQLVP DVNMEENLDP FFN
Length:343
Mass (Da):38,773
Last modified:December 5, 2005 - v2
Checksum:i9418B7AC19FCC23F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441L → V in AAM45477 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358867 mRNA. Translation: AAM45477.1.
AK044747 mRNA. Translation: BAC32063.1.
AK080064 mRNA. Translation: BAC37820.1.
AK082329 mRNA. Translation: BAC38467.1.
AK144192 mRNA. Translation: BAE25758.1.
BC027159 mRNA. Translation: AAH27159.1.
BC034338 mRNA. Translation: AAH34338.1.
BC037387 mRNA. Translation: AAH37387.1.
CCDSiCCDS25821.1.
RefSeqiNP_653134.2. NM_144551.5.
XP_006515117.1. XM_006515054.1.
UniGeneiMm.491136.

Genome annotation databases

EnsembliENSMUST00000020922; ENSMUSP00000020922; ENSMUSG00000020601.
GeneIDi217410.
KEGGimmu:217410.
UCSCiuc007nbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF358867 mRNA. Translation: AAM45477.1.
AK044747 mRNA. Translation: BAC32063.1.
AK080064 mRNA. Translation: BAC37820.1.
AK082329 mRNA. Translation: BAC38467.1.
AK144192 mRNA. Translation: BAE25758.1.
BC027159 mRNA. Translation: AAH27159.1.
BC034338 mRNA. Translation: AAH34338.1.
BC037387 mRNA. Translation: AAH37387.1.
CCDSiCCDS25821.1.
RefSeqiNP_653134.2. NM_144551.5.
XP_006515117.1. XM_006515054.1.
UniGeneiMm.491136.

3D structure databases

ProteinModelPortaliQ8K4K3.
SMRiQ8K4K3. Positions 63-341.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi229913. 2 interactions.
IntActiQ8K4K3. 1 interaction.
STRINGi10090.ENSMUSP00000020922.

PTM databases

PhosphoSiteiQ8K4K3.

Proteomic databases

PRIDEiQ8K4K3.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000020922; ENSMUSP00000020922; ENSMUSG00000020601.
GeneIDi217410.
KEGGimmu:217410.
UCSCiuc007nbq.1. mouse.

Organism-specific databases

CTDi28951.
MGIiMGI:2145021. Trib2.

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00780000121915.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ8K4K3.
KOiK08814.
OMAiHCHDNGL.
OrthoDBiEOG7RJPR4.
PhylomeDBiQ8K4K3.
TreeFamiTF329785.

Miscellaneous databases

ChiTaRSiTrib2. mouse.
NextBioi375849.
PROiQ8K4K3.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K4K3.
CleanExiMM_TRIB2.
GenevestigatoriQ8K4K3.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian homologs of Drosophila tribbles (htrb) control mitogen activated protein kinase signaling."
    Kiss-Toth E., Dempsey C., Jozsa V., Caunt J., Oxley K.M., Bagstaff S.M., Wyllie D.H., Harte M., O'Neill L.A.J., Qwarnstrom E.E., Dower S.K.
    Submitted (FEB-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6JImported.
    Tissue: AortaImported, CerebellumImported, ColonImported, RetinaImported and VeinImported.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/NImported.
    Tissue: EyeImported, KidneyImported and Mammary glandImported.

Entry informationi

Entry nameiTRIB2_MOUSE
AccessioniPrimary (citable) accession number: Q8K4K3
Secondary accession number(s): Q8K017, Q8R2V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 5, 2005
Last sequence update: December 5, 2005
Last modified: February 3, 2015
This is version 106 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.