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Q8K4K3

- TRIB2_MOUSE

UniProt

Q8K4K3 - TRIB2_MOUSE

Protein

Tribbles homolog 2

Gene

Trib2

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 102 (01 Oct 2014)
      Sequence version 2 (06 Dec 2005)
      Previous versions | rss
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    Functioni

    Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity By similarity.By similarity

    GO - Molecular functioni

    1. protein kinase inhibitor activity Source: UniProtKB-KW
    2. transcription factor binding Source: BHF-UCL
    3. transferase activity, transferring phosphorus-containing groups Source: InterPro
    4. ubiquitin protein ligase binding Source: BHF-UCL
    5. ubiquitin-protein transferase regulator activity Source: BHF-UCL

    GO - Biological processi

    1. negative regulation of fat cell differentiation Source: BHF-UCL
    2. negative regulation of interleukin-10 biosynthetic process Source: Ensembl
    3. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
    4. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
    5. positive regulation of ubiquitin-protein transferase activity Source: BHF-UCL
    6. regulation of MAP kinase activity Source: UniProtKB

    Keywords - Molecular functioni

    Protein kinase inhibitor

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Tribbles homolog 2
    Short name:
    TRB-2
    Gene namesi
    Name:Trib2Imported
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 12

    Organism-specific databases

    MGIiMGI:2145021. Trib2.

    Subcellular locationi

    Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
    Note: May associate with the cytoskeleton.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: UniProtKB
    2. cytoskeleton Source: UniProtKB-SubCell
    3. nucleus Source: Ensembl

    Keywords - Cellular componenti

    Cytoplasm, Cytoskeleton

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 343343Tribbles homolog 2PRO_0000131864Add
    BLAST

    Proteomic databases

    PRIDEiQ8K4K3.

    PTM databases

    PhosphoSiteiQ8K4K3.

    Expressioni

    Gene expression databases

    BgeeiQ8K4K3.
    CleanExiMM_TRIB2.
    GenevestigatoriQ8K4K3.

    Interactioni

    Protein-protein interaction databases

    BioGridi229913. 2 interactions.
    IntActiQ8K4K3. 1 interaction.
    STRINGi10090.ENSMUSP00000020922.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4K3.
    SMRiQ8K4K3. Positions 61-341.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini61 – 308248Protein kinasePROSITE-ProRule annotationAdd
    BLAST

    Domaini

    The protein kinase domain is predicted to be catalytically inactive.

    Sequence similaritiesi

    Contains 1 protein kinase domain.PROSITE-ProRule annotation

    Phylogenomic databases

    eggNOGiCOG0515.
    GeneTreeiENSGT00740000114880.
    HOGENOMiHOG000231872.
    HOVERGENiHBG067729.
    InParanoidiQ8K4K3.
    KOiK08814.
    OMAiHCHDNGL.
    OrthoDBiEOG7RJPR4.
    PhylomeDBiQ8K4K3.
    TreeFamiTF329785.

    Family and domain databases

    InterProiIPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR024104. Tribbles/Ser_Thr_kinase_40.
    [Graphical view]
    PANTHERiPTHR22961. PTHR22961. 1 hit.
    PfamiPF00069. Pkinase. 1 hit.
    [Graphical view]
    SUPFAMiSSF56112. SSF56112. 1 hit.
    PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4K3-1 [UniParc]FASTAAdd to Basket

    « Hide

    MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE    50
    TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFEISCYQES 100
    LAPCFCLSAH SNINQITEIL LGETKAYVFF ERSYGDMHSF VRTCKKLREE 150
    EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY 200
    ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG 250
    RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ 300
    EILDHPWFST DFSVSNSGFG AKEACDQLVP DVNMEENLDP FFN 343
    Length:343
    Mass (Da):38,773
    Last modified:December 6, 2005 - v2
    Checksum:i9418B7AC19FCC23F
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti244 – 2441L → V in AAM45477. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358867 mRNA. Translation: AAM45477.1.
    AK044747 mRNA. Translation: BAC32063.1.
    AK080064 mRNA. Translation: BAC37820.1.
    AK082329 mRNA. Translation: BAC38467.1.
    AK144192 mRNA. Translation: BAE25758.1.
    BC027159 mRNA. Translation: AAH27159.1.
    BC034338 mRNA. Translation: AAH34338.1.
    BC037387 mRNA. Translation: AAH37387.1.
    CCDSiCCDS25821.1.
    RefSeqiNP_653134.2. NM_144551.5.
    XP_006515117.1. XM_006515054.1.
    UniGeneiMm.491136.

    Genome annotation databases

    EnsembliENSMUST00000020922; ENSMUSP00000020922; ENSMUSG00000020601.
    GeneIDi217410.
    KEGGimmu:217410.
    UCSCiuc007nbq.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF358867 mRNA. Translation: AAM45477.1 .
    AK044747 mRNA. Translation: BAC32063.1 .
    AK080064 mRNA. Translation: BAC37820.1 .
    AK082329 mRNA. Translation: BAC38467.1 .
    AK144192 mRNA. Translation: BAE25758.1 .
    BC027159 mRNA. Translation: AAH27159.1 .
    BC034338 mRNA. Translation: AAH34338.1 .
    BC037387 mRNA. Translation: AAH37387.1 .
    CCDSi CCDS25821.1.
    RefSeqi NP_653134.2. NM_144551.5.
    XP_006515117.1. XM_006515054.1.
    UniGenei Mm.491136.

    3D structure databases

    ProteinModelPortali Q8K4K3.
    SMRi Q8K4K3. Positions 61-341.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 229913. 2 interactions.
    IntActi Q8K4K3. 1 interaction.
    STRINGi 10090.ENSMUSP00000020922.

    PTM databases

    PhosphoSitei Q8K4K3.

    Proteomic databases

    PRIDEi Q8K4K3.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000020922 ; ENSMUSP00000020922 ; ENSMUSG00000020601 .
    GeneIDi 217410.
    KEGGi mmu:217410.
    UCSCi uc007nbq.1. mouse.

    Organism-specific databases

    CTDi 28951.
    MGIi MGI:2145021. Trib2.

    Phylogenomic databases

    eggNOGi COG0515.
    GeneTreei ENSGT00740000114880.
    HOGENOMi HOG000231872.
    HOVERGENi HBG067729.
    InParanoidi Q8K4K3.
    KOi K08814.
    OMAi HCHDNGL.
    OrthoDBi EOG7RJPR4.
    PhylomeDBi Q8K4K3.
    TreeFami TF329785.

    Miscellaneous databases

    ChiTaRSi TRIB2. mouse.
    NextBioi 375849.
    PROi Q8K4K3.
    SOURCEi Search...

    Gene expression databases

    Bgeei Q8K4K3.
    CleanExi MM_TRIB2.
    Genevestigatori Q8K4K3.

    Family and domain databases

    InterProi IPR011009. Kinase-like_dom.
    IPR000719. Prot_kinase_dom.
    IPR024104. Tribbles/Ser_Thr_kinase_40.
    [Graphical view ]
    PANTHERi PTHR22961. PTHR22961. 1 hit.
    Pfami PF00069. Pkinase. 1 hit.
    [Graphical view ]
    SUPFAMi SSF56112. SSF56112. 1 hit.
    PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Mammalian homologs of Drosophila tribbles (htrb) control mitogen activated protein kinase signaling."
      Kiss-Toth E., Dempsey C., Jozsa V., Caunt J., Oxley K.M., Bagstaff S.M., Wyllie D.H., Harte M., O'Neill L.A.J., Qwarnstrom E.E., Dower S.K.
      Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    2. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: C57BL/6JImported.
      Tissue: AortaImported, CerebellumImported, ColonImported, RetinaImported and VeinImported.
    3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
      Strain: FVB/NImported.
      Tissue: EyeImported, KidneyImported and Mammary glandImported.

    Entry informationi

    Entry nameiTRIB2_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4K3
    Secondary accession number(s): Q8K017, Q8R2V8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: December 6, 2005
    Last sequence update: December 6, 2005
    Last modified: October 1, 2014
    This is version 102 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. Human and mouse protein kinases
      Human and mouse protein kinases: classification and index
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3