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Q8K4K3

- TRIB2_MOUSE

UniProt

Q8K4K3 - TRIB2_MOUSE

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Protein

Tribbles homolog 2

Gene
Trib2
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Interacts with MAPK kinases and regulates activation of MAP kinases. Does not display kinase activity By similarity.By similarity

GO - Molecular functioni

  1. protein kinase inhibitor activity Source: UniProtKB-KW
  2. transcription factor binding Source: BHF-UCL
  3. transferase activity, transferring phosphorus-containing groups Source: InterPro
  4. ubiquitin protein ligase binding Source: BHF-UCL
  5. ubiquitin-protein transferase regulator activity Source: BHF-UCL

GO - Biological processi

  1. negative regulation of fat cell differentiation Source: BHF-UCL
  2. negative regulation of interleukin-10 biosynthetic process Source: Ensembl
  3. negative regulation of sequence-specific DNA binding transcription factor activity Source: BHF-UCL
  4. positive regulation of proteasomal ubiquitin-dependent protein catabolic process Source: BHF-UCL
  5. positive regulation of ubiquitin-protein transferase activity Source: BHF-UCL
  6. regulation of MAP kinase activity Source: UniProtKB
Complete GO annotation...

Keywords - Molecular functioni

Protein kinase inhibitor

Names & Taxonomyi

Protein namesi
Recommended name:
Tribbles homolog 2
Short name:
TRB-2
Gene namesi
Name:Trib2
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 12

Organism-specific databases

MGIiMGI:2145021. Trib2.

Subcellular locationi

Cytoplasm By similarity. Cytoplasmcytoskeleton By similarity
Note: May associate with the cytoskeleton By similarity.

GO - Cellular componenti

  1. cytoplasm Source: UniProtKB
  2. cytoskeleton Source: UniProtKB-SubCell
  3. nucleus Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 343343Tribbles homolog 2PRO_0000131864Add
BLAST

Proteomic databases

PRIDEiQ8K4K3.

PTM databases

PhosphoSiteiQ8K4K3.

Expressioni

Gene expression databases

BgeeiQ8K4K3.
CleanExiMM_TRIB2.
GenevestigatoriQ8K4K3.

Interactioni

Protein-protein interaction databases

BioGridi229913. 2 interactions.
IntActiQ8K4K3. 1 interaction.
STRINGi10090.ENSMUSP00000020922.

Structurei

3D structure databases

ProteinModelPortaliQ8K4K3.
SMRiQ8K4K3. Positions 61-341.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini61 – 308248Protein kinaseAdd
BLAST

Domaini

The protein kinase domain is predicted to be catalytically inactive.

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG0515.
GeneTreeiENSGT00740000114880.
HOGENOMiHOG000231872.
HOVERGENiHBG067729.
InParanoidiQ8K4K3.
KOiK08814.
OMAiHCHDNGL.
OrthoDBiEOG7RJPR4.
PhylomeDBiQ8K4K3.
TreeFamiTF329785.

Family and domain databases

InterProiIPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view]
PANTHERiPTHR22961. PTHR22961. 1 hit.
PfamiPF00069. Pkinase. 1 hit.
[Graphical view]
SUPFAMiSSF56112. SSF56112. 1 hit.
PROSITEiPS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4K3-1 [UniParc]FASTAAdd to Basket

« Hide

MNIHRSTPIT IARYGRSRNK TQDFEELSSI RSAEPSQSFS PNLGSPSPPE    50
TPNLSHCVSC IGKYLLLEPL EGDHVFRAVH LHSGEELVCK VFEISCYQES 100
LAPCFCLSAH SNINQITEIL LGETKAYVFF ERSYGDMHSF VRTCKKLREE 150
EAARLFYQIA SAVAHCHDGG LVLRDLKLRK FIFKDEERTR VKLESLEDAY 200
ILRGDDDSLS DKHGCPAYVS PEILNTSGSY SGKAADVWSL GVMLYTMLVG 250
RYPFHDIEPS SLFSKIRRGQ FNIPETLSPK AKCLIRSILR REPSERLTSQ 300
EILDHPWFST DFSVSNSGFG AKEACDQLVP DVNMEENLDP FFN 343
Length:343
Mass (Da):38,773
Last modified:December 6, 2005 - v2
Checksum:i9418B7AC19FCC23F
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti244 – 2441L → V in AAM45477. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF358867 mRNA. Translation: AAM45477.1.
AK044747 mRNA. Translation: BAC32063.1.
AK080064 mRNA. Translation: BAC37820.1.
AK082329 mRNA. Translation: BAC38467.1.
AK144192 mRNA. Translation: BAE25758.1.
BC027159 mRNA. Translation: AAH27159.1.
BC034338 mRNA. Translation: AAH34338.1.
BC037387 mRNA. Translation: AAH37387.1.
CCDSiCCDS25821.1.
RefSeqiNP_653134.2. NM_144551.5.
XP_006515117.1. XM_006515054.1.
UniGeneiMm.491136.

Genome annotation databases

EnsembliENSMUST00000020922; ENSMUSP00000020922; ENSMUSG00000020601.
GeneIDi217410.
KEGGimmu:217410.
UCSCiuc007nbq.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF358867 mRNA. Translation: AAM45477.1 .
AK044747 mRNA. Translation: BAC32063.1 .
AK080064 mRNA. Translation: BAC37820.1 .
AK082329 mRNA. Translation: BAC38467.1 .
AK144192 mRNA. Translation: BAE25758.1 .
BC027159 mRNA. Translation: AAH27159.1 .
BC034338 mRNA. Translation: AAH34338.1 .
BC037387 mRNA. Translation: AAH37387.1 .
CCDSi CCDS25821.1.
RefSeqi NP_653134.2. NM_144551.5.
XP_006515117.1. XM_006515054.1.
UniGenei Mm.491136.

3D structure databases

ProteinModelPortali Q8K4K3.
SMRi Q8K4K3. Positions 61-341.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

BioGridi 229913. 2 interactions.
IntActi Q8K4K3. 1 interaction.
STRINGi 10090.ENSMUSP00000020922.

PTM databases

PhosphoSitei Q8K4K3.

Proteomic databases

PRIDEi Q8K4K3.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000020922 ; ENSMUSP00000020922 ; ENSMUSG00000020601 .
GeneIDi 217410.
KEGGi mmu:217410.
UCSCi uc007nbq.1. mouse.

Organism-specific databases

CTDi 28951.
MGIi MGI:2145021. Trib2.

Phylogenomic databases

eggNOGi COG0515.
GeneTreei ENSGT00740000114880.
HOGENOMi HOG000231872.
HOVERGENi HBG067729.
InParanoidi Q8K4K3.
KOi K08814.
OMAi HCHDNGL.
OrthoDBi EOG7RJPR4.
PhylomeDBi Q8K4K3.
TreeFami TF329785.

Miscellaneous databases

ChiTaRSi TRIB2. mouse.
NextBioi 375849.
PROi Q8K4K3.
SOURCEi Search...

Gene expression databases

Bgeei Q8K4K3.
CleanExi MM_TRIB2.
Genevestigatori Q8K4K3.

Family and domain databases

InterProi IPR011009. Kinase-like_dom.
IPR000719. Prot_kinase_dom.
IPR024104. Tribbles/Ser_Thr_kinase_40.
[Graphical view ]
PANTHERi PTHR22961. PTHR22961. 1 hit.
Pfami PF00069. Pkinase. 1 hit.
[Graphical view ]
SUPFAMi SSF56112. SSF56112. 1 hit.
PROSITEi PS50011. PROTEIN_KINASE_DOM. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Mammalian homologs of Drosophila tribbles (htrb) control mitogen activated protein kinase signaling."
    Kiss-Toth E., Dempsey C., Jozsa V., Caunt J., Oxley K.M., Bagstaff S.M., Wyllie D.H., Harte M., O'Neill L.A.J., Qwarnstrom E.E., Dower S.K.
    Submitted (MAR-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
  2. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: C57BL/6J.
    Tissue: Aorta, Cerebellum, Colon, Retina and Vein.
  3. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA].
    Strain: FVB/N.
    Tissue: Eye, Kidney and Mammary gland.

Entry informationi

Entry nameiTRIB2_MOUSE
AccessioniPrimary (citable) accession number: Q8K4K3
Secondary accession number(s): Q8K017, Q8R2V8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 6, 2005
Last sequence update: December 6, 2005
Last modified: September 3, 2014
This is version 101 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. Human and mouse protein kinases
    Human and mouse protein kinases: classification and index
  3. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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