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Q8K4J6

- MKL1_MOUSE

UniProt

Q8K4J6 - MKL1_MOUSE

Protein

MKL/myocardin-like protein 1

Gene

Mkl1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli
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    • History
      Entry version 111 (01 Oct 2014)
      Sequence version 2 (27 Jun 2003)
      Previous versions | rss
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    Functioni

    Transcriptional coactivator of serum response factor (SRF) with the potential to modulate SRF target genes. Suppresses TNF-induced cell death by inhibiting activation of caspases; its transcriptional activity is indispensable for the antiapoptotic function. It may up-regulate antiapoptotic molecules, which in turn inhibit caspase activation.1 Publication

    GO - Molecular functioni

    1. actin binding Source: MGI
    2. actin monomer binding Source: UniProtKB
    3. protein binding Source: UniProtKB
    4. sequence-specific DNA binding transcription factor activity Source: MGI
    5. transcription coactivator activity Source: UniProtKB
    6. transcription regulatory region sequence-specific DNA binding Source: MGI

    GO - Biological processi

    1. negative regulation of apoptotic signaling pathway Source: MGI
    2. negative regulation of cysteine-type endopeptidase activity involved in apoptotic process Source: MGI
    3. positive regulation of transcription, DNA-templated Source: MGI
    4. positive regulation of transcription from RNA polymerase II promoter Source: MGI
    5. positive regulation of transcription via serum response element binding Source: UniProtKB
    6. smooth muscle cell differentiation Source: Ensembl
    7. transcription, DNA-templated Source: UniProtKB-KW

    Keywords - Biological processi

    Transcription, Transcription regulation

    Keywords - Ligandi

    Actin-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    MKL/myocardin-like protein 1
    Alternative name(s):
    Basic SAP coiled-coil transcription activator
    Megakaryoblastic leukemia 1 protein homolog
    Myocardin-related transcription factor A
    Short name:
    MRTF-A
    Gene namesi
    Name:Mkl1
    Synonyms:Bsac
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 15

    Organism-specific databases

    MGIiMGI:2384495. Mkl1.

    Subcellular locationi

    Cytoplasm. Nucleus
    Note: Binding to globular actin is required to maintain cytoplasmic localization. Nuclear localization is regulated by MICAL2, which mediates depolymerization of nuclear globular actin, promoting retention of MKL1 in the nucleus and subsequent formation of an active complex with SRF By similarity.By similarity

    GO - Cellular componenti

    1. cytoplasm Source: MGI
    2. nucleus Source: MGI

    Keywords - Cellular componenti

    Cytoplasm, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 964964MKL/myocardin-like protein 1PRO_0000126626Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei41 – 411PhosphoserineBy similarity
    Modified residuei488 – 4881PhosphothreonineBy similarity
    Modified residuei492 – 4921PhosphoserineBy similarity

    Keywords - PTMi

    Phosphoprotein

    Proteomic databases

    PaxDbiQ8K4J6.
    PRIDEiQ8K4J6.

    PTM databases

    PhosphoSiteiQ8K4J6.

    Expressioni

    Tissue specificityi

    Expressed in heart, brain, spleen, lung, liver, muscle, kidney and testis.

    Developmental stagei

    Detected throughout the embryo at 10.5 dpc; higher expression is found at 13.5 dpc in neural mesenchymal cells, skeletal muscle of the tongue, and epithelial cells of the colon and small intestine; at 15.5 dpc, expression in epithelial cells of lung, kidney, bladder, and colon is also detected.

    Gene expression databases

    ArrayExpressiQ8K4J6.
    BgeeiQ8K4J6.
    CleanExiMM_MKL1.
    GenevestigatoriQ8K4J6.

    Interactioni

    Subunit structurei

    Forms with SCAI and SRF a nuclear ternary complex which binds the CArG consensus motif (CArG box) on DNA via SRF. Some authors (PubMed:12019265) have found contradictory results, they could not demonstrate that it forms a complex with the CArG boxes, even in the presence of SRF. Interacts with ACTB; interaction with ACTB prevents interaction with SCAI. Interacts with MKL2.3 Publications

    Binary interactionsi

    WithEntry#Exp.IntActNotes
    ACTA1P6813515EBI-8291665,EBI-367540From a different organism.
    ACTBP607093EBI-8291665,EBI-353944From a different organism.
    KPNA3O005059EBI-8291665,EBI-358297From a different organism.
    KPNB1Q149745EBI-8291665,EBI-286758From a different organism.

    Protein-protein interaction databases

    BioGridi230180. 2 interactions.
    DIPiDIP-60884N.
    IntActiQ8K4J6. 4 interactions.

    Structurei

    Secondary structure

    1
    964
    Legend: HelixTurnBeta strand
    Show more details
    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Helixi16 – 238
    Helixi27 – 326
    Beta strandi39 – 413
    Helixi59 – 668
    Helixi71 – 766
    Helixi87 – 11024
    Helixi115 – 1206

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    EntryMethodResolution (Å)ChainPositionsPDBsum
    2V51X-ray2.35E/F16-41[»]
    2V52X-ray1.45M54-85[»]
    2YJEX-ray3.10M16-142[»]
    2YJFX-ray3.50M16-142[»]
    ProteinModelPortaliQ8K4J6.
    SMRiQ8K4J6. Positions 14-126, 371-433.
    ModBaseiSearch...
    MobiDBiSearch...

    Miscellaneous databases

    EvolutionaryTraceiQ8K4J6.

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Repeati15 – 4026RPEL 1Add
    BLAST
    Repeati59 – 8426RPEL 2Add
    BLAST
    Repeati103 – 12826RPEL 3Add
    BLAST
    Domaini385 – 41935SAPPROSITE-ProRule annotationAdd
    BLAST

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni1 – 291291Mediates interaction with SCAI and ACTBAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili552 – 60049Sequence AnalysisAdd
    BLAST

    Compositional bias

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Compositional biasi299 – 32527Gln-richAdd
    BLAST
    Compositional biasi712 – 844133Pro-richAdd
    BLAST

    Domaini

    The N-terminal region is required for nuclear localization and the C-terminal region mediates transcriptional activity.
    The RPEL repeats mediate binding to globular actin.

    Sequence similaritiesi

    Contains 3 RPEL repeats.PROSITE-ProRule annotation
    Contains 1 SAP domain.PROSITE-ProRule annotation

    Keywords - Domaini

    Coiled coil, Repeat

    Phylogenomic databases

    eggNOGiNOG82832.
    GeneTreeiENSGT00530000063195.
    HOGENOMiHOG000038001.
    HOVERGENiHBG036493.
    InParanoidiQ642U1.
    OMAiAQMDLEH.
    OrthoDBiEOG7FR7G1.
    PhylomeDBiQ8K4J6.
    TreeFamiTF326024.

    Family and domain databases

    Gene3Di1.10.720.30. 1 hit.
    InterProiIPR004018. RPEL_repeat.
    IPR003034. SAP_dom.
    [Graphical view]
    PfamiPF02755. RPEL. 3 hits.
    PF02037. SAP. 1 hit.
    [Graphical view]
    SMARTiSM00707. RPEL. 3 hits.
    SM00513. SAP. 1 hit.
    [Graphical view]
    PROSITEiPS51073. RPEL. 3 hits.
    PS50800. SAP. 1 hit.
    [Graphical view]

    Sequences (2)i

    Sequence statusi: Complete.

    This entry describes 2 isoformsi produced by alternative splicing. Align

    Isoform 1 (identifier: Q8K4J6-1) [UniParc]FASTAAdd to Basket

    This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

    « Hide

    MTLLEPEMLM MAVQSVLQLK LQQRRTREEL VSQGIMPPLK SPAAFHEQRR    50
    SLERARTEDY LKRKIRSRPE RAELVRMHIL EETSAEPSLQ AKQLKLKRAR 100
    LADDLNEKIA QRPGPMELVE KNILPVESSL KEAIIVGQVN YPKVADSSSF 150
    DEDSSDALSP EQPASHESQG SVPSPLESRV SDPLPSATSI SPTQVLSQLP 200
    MAPDPGETLF LAEQPPLPPA PLLPPSLANG SIVPTAKPAP TLIKQSQPKS 250
    ASEKSQRSKK AKELKPKVKK LKYHQYIPPD QKQDKGAPAM DSSYAKILQQ 300
    QQLFLQLQIL NQQQQQQQQQ HYNYQAILPA PPKPSAETPG SSAPTPSRSL 350
    STSSSPSSGT PGPSGLARQS STALAAKPGA LPANLDDMKV AELKQELKLR 400
    SLPVSGTKTE LIERLRAYQD QVSPAPGAPK APATTSVLSK AGEVVVAFPA 450
    ALLSTGSALV TAGLAPAEMV VATVTSNGMV KFGSTGSTPP VSPTPSERSL 500
    LSTGDENSTP GDAFGEMVTS PLTQLTLQAS PLQIVKEEGA RAASCCLSPG 550
    ARAELEGLDK DQMLQEKDKQ IEELTRMLQQ KQQLVELLRL QLEQQKRAQQ 600
    PAPASSPVKR ESGFSSCQLS CQPQGSAHAF GSGLVVPTTN HGDTQAPAPE 650
    SPPVVVKQEA GPPEPDLAPS SQLLLGSQGT SFLKRVSPPT LVTDSTGTHL 700
    ILTVTNKSAD GPGLPAGSPQ QPLSQPGSPA PGPPAQMDLE HPPQPPFATP 750
    TSLLKKEPPG YEETVTQQPK QQENGSSSQH MDDLFDILIQ SGEISADFKE 800
    PPSLPGKEKS PPAAAAYGPP LTPQPSPLSE LPQAAPPPGS PTLPGRLEDF 850
    LESSTGLPLL TSGHEGPEPL SLIDDLHSQM LSSSAILDHP PSPMDTSELH 900
    FAPEPSSGMG LDLAVGHLDS MDWLELSSGG PVLSLAPLST AAPSLFSMDF 950
    LDGHDLQLHW DSCL 964
    Length:964
    Mass (Da):102,546
    Last modified:June 27, 2003 - v2
    Checksum:iAFAEA328A1860CE5
    GO
    Isoform 2 (identifier: Q8K4J6-2) [UniParc]FASTAAdd to Basket

    The sequence of this isoform differs from the canonical sequence as follows:
         1-35: Missing.

    Show »
    Length:929
    Mass (Da):98,463
    Checksum:iB13D0985013B6E49
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti53 – 531E → Q in BAC31809. (PubMed:16141072)Curated
    Sequence conflicti724 – 7241S → D in BAC40873. (PubMed:16141072)Curated
    Sequence conflicti728 – 7281S → F in AAM94258. (PubMed:12019265)Curated

    Alternative sequence

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Alternative sequencei1 – 3535Missing in isoform 2. 3 PublicationsVSP_007652Add
    BLAST

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF385582 mRNA. Translation: AAM94258.1.
    AF532597 mRNA. Translation: AAN33041.1.
    AK044188 mRNA. Translation: BAC31809.1.
    AK089416 mRNA. Translation: BAC40873.1.
    BC050941 mRNA. Translation: AAH50941.1.
    CCDSiCCDS37147.1. [Q8K4J6-1]
    CCDS49674.1. [Q8K4J6-2]
    RefSeqiNP_001076005.1. NM_001082536.1. [Q8K4J6-2]
    NP_694629.2. NM_153049.3. [Q8K4J6-1]
    UniGeneiMm.439814.

    Genome annotation databases

    EnsembliENSMUST00000109579; ENSMUSP00000105207; ENSMUSG00000042292. [Q8K4J6-1]
    ENSMUST00000134469; ENSMUSP00000119530; ENSMUSG00000042292. [Q8K4J6-2]
    ENSMUST00000149582; ENSMUSP00000117745; ENSMUSG00000042292. [Q8K4J6-2]
    GeneIDi223701.
    KEGGimmu:223701.
    UCSCiuc007wwc.1. mouse. [Q8K4J6-1]

    Keywords - Coding sequence diversityi

    Alternative splicing

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF385582 mRNA. Translation: AAM94258.1 .
    AF532597 mRNA. Translation: AAN33041.1 .
    AK044188 mRNA. Translation: BAC31809.1 .
    AK089416 mRNA. Translation: BAC40873.1 .
    BC050941 mRNA. Translation: AAH50941.1 .
    CCDSi CCDS37147.1. [Q8K4J6-1 ]
    CCDS49674.1. [Q8K4J6-2 ]
    RefSeqi NP_001076005.1. NM_001082536.1. [Q8K4J6-2 ]
    NP_694629.2. NM_153049.3. [Q8K4J6-1 ]
    UniGenei Mm.439814.

    3D structure databases

    Select the link destinations:
    PDBe
    RCSB PDB
    PDBj
    Links Updated
    Entry Method Resolution (Å) Chain Positions PDBsum
    2V51 X-ray 2.35 E/F 16-41 [» ]
    2V52 X-ray 1.45 M 54-85 [» ]
    2YJE X-ray 3.10 M 16-142 [» ]
    2YJF X-ray 3.50 M 16-142 [» ]
    ProteinModelPortali Q8K4J6.
    SMRi Q8K4J6. Positions 14-126, 371-433.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    BioGridi 230180. 2 interactions.
    DIPi DIP-60884N.
    IntActi Q8K4J6. 4 interactions.

    PTM databases

    PhosphoSitei Q8K4J6.

    Proteomic databases

    PaxDbi Q8K4J6.
    PRIDEi Q8K4J6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000109579 ; ENSMUSP00000105207 ; ENSMUSG00000042292 . [Q8K4J6-1 ]
    ENSMUST00000134469 ; ENSMUSP00000119530 ; ENSMUSG00000042292 . [Q8K4J6-2 ]
    ENSMUST00000149582 ; ENSMUSP00000117745 ; ENSMUSG00000042292 . [Q8K4J6-2 ]
    GeneIDi 223701.
    KEGGi mmu:223701.
    UCSCi uc007wwc.1. mouse. [Q8K4J6-1 ]

    Organism-specific databases

    CTDi 57591.
    MGIi MGI:2384495. Mkl1.

    Phylogenomic databases

    eggNOGi NOG82832.
    GeneTreei ENSGT00530000063195.
    HOGENOMi HOG000038001.
    HOVERGENi HBG036493.
    InParanoidi Q642U1.
    OMAi AQMDLEH.
    OrthoDBi EOG7FR7G1.
    PhylomeDBi Q8K4J6.
    TreeFami TF326024.

    Miscellaneous databases

    ChiTaRSi MKL1. mouse.
    EvolutionaryTracei Q8K4J6.
    NextBioi 376834.
    PROi Q8K4J6.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K4J6.
    Bgeei Q8K4J6.
    CleanExi MM_MKL1.
    Genevestigatori Q8K4J6.

    Family and domain databases

    Gene3Di 1.10.720.30. 1 hit.
    InterProi IPR004018. RPEL_repeat.
    IPR003034. SAP_dom.
    [Graphical view ]
    Pfami PF02755. RPEL. 3 hits.
    PF02037. SAP. 1 hit.
    [Graphical view ]
    SMARTi SM00707. RPEL. 3 hits.
    SM00513. SAP. 1 hit.
    [Graphical view ]
    PROSITEi PS51073. RPEL. 3 hits.
    PS50800. SAP. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel transcriptional activator, BSAC, by a functional cloning to inhibit tumor necrosis factor-induced cell death."
      Sasazuki T., Sawada Y., Sakon S., Kitamura T., Kishi T., Okazaki T., Katano M., Tanaka M., Watanabe M., Yagita H., Okumura K., Nakano H.
      J. Biol. Chem. 277:28853-28860(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1).
      Tissue: Spleen.
    2. "Potentiation of serum response factor activity by a family of myocardin-related transcription factors."
      Wang D.-Z., Li S., Hockemeyer D., Sutherland L., Wang Z., Schratt G., Richardson J.A., Nordheim A., Olson E.N.
      Proc. Natl. Acad. Sci. U.S.A. 99:14855-14860(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 2).
      Strain: C57BL/6.
    3. "The transcriptional landscape of the mammalian genome."
      Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
      , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
      Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6J.
      Tissue: Brain cortex.
    4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
      The MGC Project Team
      Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
      Strain: C57BL/6.
      Tissue: Brain.
    5. "SCAI acts as a suppressor of cancer cell invasion through the transcriptional control of beta1-integrin."
      Brandt D.T., Baarlink C., Kitzing T.M., Kremmer E., Ivaska J., Nollau P., Grosse R.
      Nat. Cell Biol. 11:557-568(2009) [PubMed] [Europe PMC] [Abstract]
      Cited for: FUNCTION, INTERACTION WITH ACTB; SCAI AND SRF, SUBCELLULAR LOCATION.
    6. "Molecular basis for G-actin binding to RPEL motifs from the serum response factor coactivator MAL."
      Mouilleron S., Guettler S., Langer C.A., Treisman R., McDonald N.Q.
      EMBO J. 27:3198-3208(2008) [PubMed] [Europe PMC] [Abstract]
      Cited for: X-RAY CRYSTALLOGRAPHY (1.45 ANGSTROMS) OF 54-85 IN COMPLEX WITH G-ACTIN, X-RAY CRYSTALLOGRAPHY (2.35 ANGSTROMS) OF 16-41 IN COMPLEX WITH G-ACTIN, SUBCELLULAR LOCATION.

    Entry informationi

    Entry nameiMKL1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4J6
    Secondary accession number(s): Q642U1
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 27, 2003
    Last sequence update: June 27, 2003
    Last modified: October 1, 2014
    This is version 111 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    3D-structure, Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. PDB cross-references
      Index of Protein Data Bank (PDB) cross-references
    3. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3