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Protein

Transcription factor COE4

Gene

Ebf4

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Seems to weakly activate transcription. Binds an Olf-1 consensus site in vitro.

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17120C5-typeSequence analysisAdd
BLAST

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Activator, Developmental protein

Keywords - Biological processi

Transcription, Transcription regulation

Keywords - Ligandi

DNA-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Transcription factor COE4
Alternative name(s):
Early B-cell factor 4
Short name:
EBF-4
Olf-1/EBF-like 4
Short name:
O/E-4
Short name:
OE-4
Gene namesi
Name:Ebf4
Synonyms:Coe4
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 2

Organism-specific databases

MGIiMGI:2385972. Ebf4.

Subcellular locationi

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 599599Transcription factor COE4PRO_0000107836Add
BLAST

Proteomic databases

MaxQBiQ8K4J2.
PaxDbiQ8K4J2.
PRIDEiQ8K4J2.

PTM databases

PhosphoSiteiQ8K4J2.

Expressioni

Tissue specificityi

Expressed in the neuronal and basal cell layers of olfactory epithelium. Absent in the vomeronasal organ.1 Publication

Gene expression databases

BgeeiENSMUSG00000053552.
CleanExiMM_EBF4.
ExpressionAtlasiQ8K4J2. baseline and differential.
GenevisibleiQ8K4J2. MM.

Interactioni

Subunit structurei

Forms either a homodimer or a heterodimer with a related family member.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei164 – 1641Interaction with DNABy similarity
Sitei173 – 1731Interaction with DNABy similarity

GO - Molecular functioni

  • transcription factor binding Source: MGI

Protein-protein interaction databases

BioGridi230746. 2 interactions.
STRINGi10090.ENSMUSP00000105915.

Structurei

3D structure databases

ProteinModelPortaliQ8K4J2.
SMRiQ8K4J2. Positions 37-387.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini256 – 33984IPT/TIGAdd
BLAST

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni64 – 674Interaction with DNABy similarity
Regioni198 – 2058Interaction with DNABy similarity
Regioni237 – 2404Interaction with DNABy similarity

Sequence similaritiesi

Belongs to the COE family.Curated
Contains 1 IPT/TIG domain.Curated

Zinc finger

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Zinc fingeri152 – 17120C5-typeSequence analysisAdd
BLAST

Keywords - Domaini

Zinc-finger

Phylogenomic databases

eggNOGiKOG3836. Eukaryota.
ENOG410XQ9Z. LUCA.
GeneTreeiENSGT00390000014051.
HOVERGENiHBG005108.
InParanoidiQ8K4J2.
KOiK09103.
TreeFamiTF313391.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 3 (identifier: Q8K4J2-1) [UniParc]FASTAAdd to basket
Also known as: 4-23

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MFPAQDALPR GGLHLKEEPL LPSSLGSVRS WMQSAGILDS NTAAQSGVGL
60 70 80 90 100
ARAHFEKQPP SNLRKSNFFH FVLAMYDRQG QPVEVERTAF IDFVEKDREP
110 120 130 140 150
GTEKTNNGIH YRLRLVYNNG LRTEQDLYVR LIDSMSKQAI IYEGQDKNPE
160 170 180 190 200
MCRVLLTHEI MCSRCCDRKS CGNRNETPSD PVIIDRFFLK FFLKCNQNCL
210 220 230 240 250
KNAGNPRDMR RFQVVVSTTV SVDGHVLAVS DNMFVHNNSK HGRRARRLDP
260 270 280 290 300
SEAATPCIKA ISPGEGWTTG GATVIIIGDN FFDGLQVVFG NVLLWSELIT
310 320 330 340 350
PHAIRVQTPP RHIPGVVEVT LSYKSKQFCK GAPGRFVYTA LNEPTIDYGF
360 370 380 390 400
QRLQKVIPRH PGDPERLPKE VLLKRAADLA EALYGVPSSN QELLLKRAAD
410 420 430 440 450
VAEALYSAPR APAPLGPLAP SHPHPAVVGI NAFSSPLAIA VGDTTPEPGY
460 470 480 490 500
ARSCGSASPR FAPSPGSQQS SYGSGLGAGL GSYGAPGVTG LGVPGSPSFL
510 520 530 540 550
NGSTATSPFA IMPSSPPLAA ASSMSLPAAA PTTSVFSFSP VNMICAVKQR
560 570 580 590
SAFAPVLRPP SSPSQACPRA HREGLPDQPF EDTDKFHSAA RGLQGLAYS
Length:599
Mass (Da):64,624
Last modified:October 1, 2002 - v1
Checksum:i76748B3E04D42260
GO
Isoform 1 (identifier: Q8K4J2-2) [UniParc]FASTAAdd to basket
Also known as: 4-11

The sequence of this isoform differs from the canonical sequence as follows:
     577-582: DQPFED → AQRTGR
     583-599: Missing.

Show »
Length:582
Mass (Da):62,758
Checksum:i22EEC610A093175F
GO
Isoform 2 (identifier: Q8K4J2-3) [UniParc]FASTAAdd to basket
Also known as: 4-14

The sequence of this isoform differs from the canonical sequence as follows:
     481-508: GSYGAPGVTGLGVPGSPSFLNGSTATSP → APRWRLPPPCPFRPPPPPPASSPSRLST
     509-599: Missing.

Show »
Length:508
Mass (Da):55,639
Checksum:iAC940A674C5DE872
GO
Isoform 4 (identifier: Q8K4J2-4) [UniParc]FASTAAdd to basket
Also known as: 4-132

The sequence of this isoform differs from the canonical sequence as follows:
     511-541: IMPSSPPLAAASSMSLPAAAPTTSVFSFSPV → KERLRPCAAPTQFPIAGLPQSPQRGASRPAF
     542-599: Missing.

Note: May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
Show »
Length:541
Mass (Da):58,661
Checksum:i18915B375F4C5E1A
GO
Isoform 5 (identifier: Q8K4J2-5) [UniParc]FASTAAdd to basket
Also known as: 4S

The sequence of this isoform differs from the canonical sequence as follows:
     392-426: ELLLKRAADVAEALYSAPRAPAPLGPLAPSHPHPA → VWRLCPPPSARGRGSDPAPAAAPAVPRSCLRRSSS
     427-599: Missing.

Show »
Length:426
Mass (Da):47,445
Checksum:i28C18C1A9B677A2B
GO

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei392 – 42635ELLLK…HPHPA → VWRLCPPPSARGRGSDPAPA AAPAVPRSCLRRSSS in isoform 5. 1 PublicationVSP_001119Add
BLAST
Alternative sequencei427 – 599173Missing in isoform 5. 1 PublicationVSP_001120Add
BLAST
Alternative sequencei481 – 50828GSYGA…TATSP → APRWRLPPPCPFRPPPPPPA SSPSRLST in isoform 2. 1 PublicationVSP_001121Add
BLAST
Alternative sequencei509 – 59991Missing in isoform 2. 1 PublicationVSP_001122Add
BLAST
Alternative sequencei511 – 54131IMPSS…SFSPV → KERLRPCAAPTQFPIAGLPQ SPQRGASRPAF in isoform 4. 1 PublicationVSP_001123Add
BLAST
Alternative sequencei542 – 59958Missing in isoform 4. 1 PublicationVSP_001124Add
BLAST
Alternative sequencei577 – 5826DQPFED → AQRTGR in isoform 1. 1 PublicationVSP_001125
Alternative sequencei583 – 59917Missing in isoform 1. 1 PublicationVSP_001126Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387630 mRNA. Translation: AAM97580.1.
AF387631 mRNA. Translation: AAM97581.1.
AF387632 mRNA. Translation: AAM97582.1.
AF387633 mRNA. Translation: AAM97583.1.
AF387634 mRNA. Translation: AAM97584.1.
BX890605, BX936285 Genomic DNA. Translation: CAM20114.1.
BX936285, BX890605 Genomic DNA. Translation: CAM15942.1.
CCDSiCCDS50709.1. [Q8K4J2-1]
RefSeqiNP_001103983.1. NM_001110513.1. [Q8K4J2-1]
XP_011237773.1. XM_011239471.1. [Q8K4J2-2]
XP_011237774.1. XM_011239472.1. [Q8K4J2-3]
UniGeneiMm.32582.

Genome annotation databases

EnsembliENSMUST00000110286; ENSMUSP00000105915; ENSMUSG00000053552. [Q8K4J2-1]
ENSMUST00000126740; ENSMUSP00000133528; ENSMUSG00000053552. [Q8K4J2-2]
ENSMUST00000140169; ENSMUSP00000134520; ENSMUSG00000053552. [Q8K4J2-4]
GeneIDi228598.
KEGGimmu:228598.
UCSCiuc008miq.2. mouse. [Q8K4J2-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF387630 mRNA. Translation: AAM97580.1.
AF387631 mRNA. Translation: AAM97581.1.
AF387632 mRNA. Translation: AAM97582.1.
AF387633 mRNA. Translation: AAM97583.1.
AF387634 mRNA. Translation: AAM97584.1.
BX890605, BX936285 Genomic DNA. Translation: CAM20114.1.
BX936285, BX890605 Genomic DNA. Translation: CAM15942.1.
CCDSiCCDS50709.1. [Q8K4J2-1]
RefSeqiNP_001103983.1. NM_001110513.1. [Q8K4J2-1]
XP_011237773.1. XM_011239471.1. [Q8K4J2-2]
XP_011237774.1. XM_011239472.1. [Q8K4J2-3]
UniGeneiMm.32582.

3D structure databases

ProteinModelPortaliQ8K4J2.
SMRiQ8K4J2. Positions 37-387.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230746. 2 interactions.
STRINGi10090.ENSMUSP00000105915.

PTM databases

PhosphoSiteiQ8K4J2.

Proteomic databases

MaxQBiQ8K4J2.
PaxDbiQ8K4J2.
PRIDEiQ8K4J2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000110286; ENSMUSP00000105915; ENSMUSG00000053552. [Q8K4J2-1]
ENSMUST00000126740; ENSMUSP00000133528; ENSMUSG00000053552. [Q8K4J2-2]
ENSMUST00000140169; ENSMUSP00000134520; ENSMUSG00000053552. [Q8K4J2-4]
GeneIDi228598.
KEGGimmu:228598.
UCSCiuc008miq.2. mouse. [Q8K4J2-1]

Organism-specific databases

CTDi57593.
MGIiMGI:2385972. Ebf4.

Phylogenomic databases

eggNOGiKOG3836. Eukaryota.
ENOG410XQ9Z. LUCA.
GeneTreeiENSGT00390000014051.
HOVERGENiHBG005108.
InParanoidiQ8K4J2.
KOiK09103.
TreeFamiTF313391.

Miscellaneous databases

PROiQ8K4J2.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000053552.
CleanExiMM_EBF4.
ExpressionAtlasiQ8K4J2. baseline and differential.
GenevisibleiQ8K4J2. MM.

Family and domain databases

Gene3Di2.60.40.10. 1 hit.
InterProiIPR032200. COE_DBD.
IPR032201. COE_HLH.
IPR013783. Ig-like_fold.
IPR014756. Ig_E-set.
IPR002909. IPT.
IPR003523. Transcription_factor_COE.
IPR018350. Transcription_factor_COE_CS.
[Graphical view]
PANTHERiPTHR10747. PTHR10747. 1 hit.
PfamiPF16422. COE1_DBD. 1 hit.
PF16423. COE1_HLH. 1 hit.
PF01833. TIG. 1 hit.
[Graphical view]
SMARTiSM00429. IPT. 1 hit.
[Graphical view]
SUPFAMiSSF81296. SSF81296. 1 hit.
PROSITEiPS01345. COE. 1 hit.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCOE4_MOUSE
AccessioniPrimary (citable) accession number: Q8K4J2
Secondary accession number(s): A2BI82
, A2BI83, Q8K4J1, Q8K4J3, Q8K4J4, Q8K4J5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: November 28, 2002
Last sequence update: October 1, 2002
Last modified: September 7, 2016
This is version 105 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.