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Q8K4I6 (CBY1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 72. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Protein chibby homolog 1
Alternative name(s):
Cytosolic leucine-rich protein
PIGEA-14
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
Gene names
Name:Cby1
Synonyms:Cby, Pgea1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus

Protein attributes

Sequence length127 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation By similarity.

Subunit structure

Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin By similarity.

Subcellular location

Nucleus speckle By similarity. Golgi apparatustrans-Golgi network By similarity. Note: Nuclear, in a punctate manner. Also found in the trans-Golgi By similarity.

Miscellaneous

'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

Sequence similarities

Belongs to the chibby family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 127127Protein chibby homolog 1
PRO_0000058356

Regions

Region60 – 11253Minimal region for the interaction with PKD2 By similarity
Coiled coil68 – 11043 Potential

Sequences

Sequence LengthMass (Da)Tools
Q8K4I6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: 7CE38A48D045DE57

FASTA12714,549
        10         20         30         40         50         60 
MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ SLKFENGQWV 

        70         80         90        100        110        120 
ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD MLSETTAESH LKDKELDELK 


ITNRRRK 

« Hide

References

[1]"A conserved cytosolic leucine-rich protein (LRP) in vertebrate animals."
Huang C.-H.
Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF393211 mRNA. Translation: AAM73679.1.
RefSeqNP_663709.1. NM_145676.1.
XP_006242029.1. XM_006241967.1.
XP_006242030.1. XM_006241968.1.
XP_006242031.1. XM_006241969.1.
UniGeneRn.229691.

3D structure databases

ModBaseSearch...
MobiDBSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000018787.

Proteomic databases

PaxDbQ8K4I6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000018787; ENSRNOP00000018787; ENSRNOG00000013892.
GeneID246768.
KEGGrno:246768.
UCSCRGD:708481. rat.

Organism-specific databases

CTD25776.
RGD708481. Cby1.

Phylogenomic databases

eggNOGNOG39404.
GeneTreeENSGT00510000047043.
HOGENOMHOG000006694.
HOVERGENHBG050816.
InParanoidQ8K4I6.
OMALEYGTPT.
OrthoDBEOG70KGRH.
PhylomeDBQ8K4I6.
TreeFamTF324419.

Gene expression databases

GenevestigatorQ8K4I6.

Family and domain databases

InterProIPR028118. Chibby_fam.
[Graphical view]
PfamPF14645. Chibby. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio623835.
PROQ8K4I6.

Entry information

Entry nameCBY1_RAT
AccessionPrimary (citable) accession number: Q8K4I6
Entry history
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: July 9, 2014
This is version 72 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families