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Q8K4I6

- CBY1_RAT

UniProt

Q8K4I6 - CBY1_RAT

Protein

Protein chibby homolog 1

Gene

Cby1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
  1. Functioni

    Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation By similarity.By similarity

    GO - Biological processi

    1. cardiac muscle cell differentiation Source: UniProtKB
    2. cilium assembly Source: Ensembl
    3. fat cell differentiation Source: UniProtKB
    4. negative regulation of canonical Wnt signaling pathway Source: Ensembl
    5. negative regulation of transcription, DNA-templated Source: Ensembl
    6. protein localization Source: Ensembl

    Keywords - Biological processi

    Differentiation

    Enzyme and pathway databases

    ReactomeiREACT_214025. deactivation of the beta-catenin transactivating complex.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Protein chibby homolog 1
    Alternative name(s):
    Cytosolic leucine-rich protein
    PIGEA-14
    PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
    Gene namesi
    Name:Cby1
    Synonyms:Cby, Pgea1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 7

    Organism-specific databases

    RGDi708481. Cby1.

    Subcellular locationi

    Nucleus speckle By similarity. Golgi apparatustrans-Golgi network By similarity
    Note: Nuclear, in a punctate manner. Also found in the trans-Golgi By similarity.By similarity

    GO - Cellular componenti

    1. nuclear speck Source: UniProtKB-SubCell
    2. trans-Golgi network Source: Ensembl

    Keywords - Cellular componenti

    Golgi apparatus, Nucleus

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 127127Protein chibby homolog 1PRO_0000058356Add
    BLAST

    Proteomic databases

    PaxDbiQ8K4I6.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8K4I6.

    Interactioni

    Subunit structurei

    Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin By similarity.By similarity

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000018787.

    Family & Domainsi

    Region

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Regioni60 – 11253Minimal region for the interaction with PKD2By similarityAdd
    BLAST

    Coiled coil

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Coiled coili68 – 11043Sequence AnalysisAdd
    BLAST

    Sequence similaritiesi

    Belongs to the chibby family.Curated

    Keywords - Domaini

    Coiled coil

    Phylogenomic databases

    eggNOGiNOG39404.
    GeneTreeiENSGT00510000047043.
    HOGENOMiHOG000006694.
    HOVERGENiHBG050816.
    InParanoidiQ8K4I6.
    OMAiLEYGTPT.
    OrthoDBiEOG70KGRH.
    PhylomeDBiQ8K4I6.
    TreeFamiTF324419.

    Family and domain databases

    InterProiIPR028118. Chibby_fam.
    [Graphical view]
    PfamiPF14645. Chibby. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4I6-1 [UniParc]FASTAAdd to Basket

    « Hide

    MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ    50
    SLKFENGQWV ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD 100
    MLSETTAESH LKDKELDELK ITNRRRK 127
    Length:127
    Mass (Da):14,549
    Last modified:October 1, 2002 - v1
    Checksum:i7CE38A48D045DE57
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF393211 mRNA. Translation: AAM73679.1.
    RefSeqiNP_663709.1. NM_145676.1.
    XP_006242029.1. XM_006241967.1.
    XP_006242030.1. XM_006241968.1.
    XP_006242031.1. XM_006241969.1.
    UniGeneiRn.229691.

    Genome annotation databases

    EnsembliENSRNOT00000018787; ENSRNOP00000018787; ENSRNOG00000013892.
    GeneIDi246768.
    KEGGirno:246768.
    UCSCiRGD:708481. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF393211 mRNA. Translation: AAM73679.1 .
    RefSeqi NP_663709.1. NM_145676.1.
    XP_006242029.1. XM_006241967.1.
    XP_006242030.1. XM_006241968.1.
    XP_006242031.1. XM_006241969.1.
    UniGenei Rn.229691.

    3D structure databases

    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000018787.

    Proteomic databases

    PaxDbi Q8K4I6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000018787 ; ENSRNOP00000018787 ; ENSRNOG00000013892 .
    GeneIDi 246768.
    KEGGi rno:246768.
    UCSCi RGD:708481. rat.

    Organism-specific databases

    CTDi 25776.
    RGDi 708481. Cby1.

    Phylogenomic databases

    eggNOGi NOG39404.
    GeneTreei ENSGT00510000047043.
    HOGENOMi HOG000006694.
    HOVERGENi HBG050816.
    InParanoidi Q8K4I6.
    OMAi LEYGTPT.
    OrthoDBi EOG70KGRH.
    PhylomeDBi Q8K4I6.
    TreeFami TF324419.

    Enzyme and pathway databases

    Reactomei REACT_214025. deactivation of the beta-catenin transactivating complex.

    Miscellaneous databases

    NextBioi 623835.
    PROi Q8K4I6.

    Gene expression databases

    Genevestigatori Q8K4I6.

    Family and domain databases

    InterProi IPR028118. Chibby_fam.
    [Graphical view ]
    Pfami PF14645. Chibby. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A conserved cytosolic leucine-rich protein (LRP) in vertebrate animals."
      Huang C.-H.
      Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].

    Entry informationi

    Entry nameiCBY1_RAT
    AccessioniPrimary (citable) accession number: Q8K4I6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: August 16, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 74 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Miscellaneous

    'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3