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Q8K4I6

- CBY1_RAT

UniProt

Q8K4I6 - CBY1_RAT

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Protein

Protein chibby homolog 1

Gene

Cby1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation (By similarity).By similarity

GO - Biological processi

  1. cardiac muscle cell differentiation Source: UniProtKB
  2. cilium assembly Source: Ensembl
  3. fat cell differentiation Source: UniProtKB
  4. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  5. negative regulation of transcription, DNA-templated Source: Ensembl
  6. protein localization Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiREACT_214025. deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein chibby homolog 1
Alternative name(s):
Cytosolic leucine-rich protein
PIGEA-14
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
Gene namesi
Name:Cby1
Synonyms:Cby, Pgea1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi708481. Cby1.

Subcellular locationi

Nucleus speckle By similarity. Golgi apparatustrans-Golgi network By similarity
Note: Nuclear, in a punctate manner. Also found in the trans-Golgi (By similarity).By similarity

GO - Cellular componenti

  1. ciliary basal body Source: Ensembl
  2. nucleus Source: UniProtKB-KW
  3. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Protein chibby homolog 1PRO_0000058356Add
BLAST

Proteomic databases

PaxDbiQ8K4I6.

Expressioni

Gene expression databases

GenevestigatoriQ8K4I6.

Interactioni

Subunit structurei

Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018787.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 11253Minimal region for the interaction with PKD2By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili68 – 11043Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the chibby family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39404.
GeneTreeiENSGT00510000047043.
HOGENOMiHOG000006694.
HOVERGENiHBG050816.
InParanoidiQ8K4I6.
OMAiLEYGTPT.
OrthoDBiEOG70KGRH.
PhylomeDBiQ8K4I6.
TreeFamiTF324419.

Family and domain databases

InterProiIPR028118. Chibby_fam.
[Graphical view]
PfamiPF14645. Chibby. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4I6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ
60 70 80 90 100
SLKFENGQWV ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD
110 120
MLSETTAESH LKDKELDELK ITNRRRK
Length:127
Mass (Da):14,549
Last modified:October 1, 2002 - v1
Checksum:i7CE38A48D045DE57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393211 mRNA. Translation: AAM73679.1.
RefSeqiNP_663709.1. NM_145676.1.
XP_006242029.1. XM_006241967.2.
UniGeneiRn.229691.

Genome annotation databases

EnsembliENSRNOT00000018787; ENSRNOP00000018787; ENSRNOG00000013892.
GeneIDi246768.
KEGGirno:246768.
UCSCiRGD:708481. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393211 mRNA. Translation: AAM73679.1 .
RefSeqi NP_663709.1. NM_145676.1.
XP_006242029.1. XM_006241967.2.
UniGenei Rn.229691.

3D structure databases

ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000018787.

Proteomic databases

PaxDbi Q8K4I6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000018787 ; ENSRNOP00000018787 ; ENSRNOG00000013892 .
GeneIDi 246768.
KEGGi rno:246768.
UCSCi RGD:708481. rat.

Organism-specific databases

CTDi 25776.
RGDi 708481. Cby1.

Phylogenomic databases

eggNOGi NOG39404.
GeneTreei ENSGT00510000047043.
HOGENOMi HOG000006694.
HOVERGENi HBG050816.
InParanoidi Q8K4I6.
OMAi LEYGTPT.
OrthoDBi EOG70KGRH.
PhylomeDBi Q8K4I6.
TreeFami TF324419.

Enzyme and pathway databases

Reactomei REACT_214025. deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

NextBioi 623835.
PROi Q8K4I6.

Gene expression databases

Genevestigatori Q8K4I6.

Family and domain databases

InterProi IPR028118. Chibby_fam.
[Graphical view ]
Pfami PF14645. Chibby. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A conserved cytosolic leucine-rich protein (LRP) in vertebrate animals."
    Huang C.-H.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCBY1_RAT
AccessioniPrimary (citable) accession number: Q8K4I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 75 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3