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Protein

Protein chibby homolog 1

Gene

Cby1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation (By similarity).By similarity

GO - Biological processi

  1. cardiac muscle cell differentiation Source: UniProtKB
  2. cilium assembly Source: Ensembl
  3. fat cell differentiation Source: UniProtKB
  4. negative regulation of canonical Wnt signaling pathway Source: Ensembl
  5. negative regulation of transcription, DNA-templated Source: Ensembl
  6. protein localization Source: Ensembl
Complete GO annotation...

Keywords - Biological processi

Differentiation

Enzyme and pathway databases

ReactomeiREACT_214025. deactivation of the beta-catenin transactivating complex.

Names & Taxonomyi

Protein namesi
Recommended name:
Protein chibby homolog 1
Alternative name(s):
Cytosolic leucine-rich protein
PIGEA-14
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1
Gene namesi
Name:Cby1
Synonyms:Cby, Pgea1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 7

Organism-specific databases

RGDi708481. Cby1.

Subcellular locationi

Nucleus speckle By similarity. Golgi apparatustrans-Golgi network By similarity
Note: Nuclear, in a punctate manner. Also found in the trans-Golgi (By similarity).By similarity

GO - Cellular componenti

  1. ciliary basal body Source: Ensembl
  2. nuclear speck Source: UniProtKB-SubCell
  3. trans-Golgi network Source: Ensembl
Complete GO annotation...

Keywords - Cellular componenti

Golgi apparatus, Nucleus

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 127127Protein chibby homolog 1PRO_0000058356Add
BLAST

Proteomic databases

PaxDbiQ8K4I6.

Expressioni

Gene expression databases

GenevestigatoriQ8K4I6.

Interactioni

Subunit structurei

Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin (By similarity).By similarity

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018787.

Family & Domainsi

Region

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Regioni60 – 11253Minimal region for the interaction with PKD2By similarityAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili68 – 11043Sequence AnalysisAdd
BLAST

Sequence similaritiesi

Belongs to the chibby family.Curated

Keywords - Domaini

Coiled coil

Phylogenomic databases

eggNOGiNOG39404.
GeneTreeiENSGT00510000047043.
HOGENOMiHOG000006694.
HOVERGENiHBG050816.
InParanoidiQ8K4I6.
OMAiLEYGTPT.
OrthoDBiEOG70KGRH.
PhylomeDBiQ8K4I6.
TreeFamiTF324419.

Family and domain databases

InterProiIPR028118. Chibby_fam.
[Graphical view]
PfamiPF14645. Chibby. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4I6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ
60 70 80 90 100
SLKFENGQWV ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD
110 120
MLSETTAESH LKDKELDELK ITNRRRK
Length:127
Mass (Da):14,549
Last modified:October 1, 2002 - v1
Checksum:i7CE38A48D045DE57
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393211 mRNA. Translation: AAM73679.1.
RefSeqiNP_663709.1. NM_145676.1.
XP_006242029.1. XM_006241967.2.
UniGeneiRn.229691.

Genome annotation databases

EnsembliENSRNOT00000018787; ENSRNOP00000018787; ENSRNOG00000013892.
GeneIDi246768.
KEGGirno:246768.
UCSCiRGD:708481. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393211 mRNA. Translation: AAM73679.1.
RefSeqiNP_663709.1. NM_145676.1.
XP_006242029.1. XM_006241967.2.
UniGeneiRn.229691.

3D structure databases

ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000018787.

Proteomic databases

PaxDbiQ8K4I6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000018787; ENSRNOP00000018787; ENSRNOG00000013892.
GeneIDi246768.
KEGGirno:246768.
UCSCiRGD:708481. rat.

Organism-specific databases

CTDi25776.
RGDi708481. Cby1.

Phylogenomic databases

eggNOGiNOG39404.
GeneTreeiENSGT00510000047043.
HOGENOMiHOG000006694.
HOVERGENiHBG050816.
InParanoidiQ8K4I6.
OMAiLEYGTPT.
OrthoDBiEOG70KGRH.
PhylomeDBiQ8K4I6.
TreeFamiTF324419.

Enzyme and pathway databases

ReactomeiREACT_214025. deactivation of the beta-catenin transactivating complex.

Miscellaneous databases

NextBioi623835.
PROiQ8K4I6.

Gene expression databases

GenevestigatoriQ8K4I6.

Family and domain databases

InterProiIPR028118. Chibby_fam.
[Graphical view]
PfamiPF14645. Chibby. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A conserved cytosolic leucine-rich protein (LRP) in vertebrate animals."
    Huang C.-H.
    Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].

Entry informationi

Entry nameiCBY1_RAT
AccessioniPrimary (citable) accession number: Q8K4I6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: August 16, 2004
Last sequence update: October 1, 2002
Last modified: January 7, 2015
This is version 76 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.