Q8K4I6 (CBY1_RAT) Reviewed, UniProtKB/Swiss-Prot

Names and origin

Protein names

Recommended name:
Protein chibby homolog 1

Alternative name(s):
Cytosolic leucine-rich protein
PIGEA-14
PKD2 interactor, Golgi and endoplasmic reticulum-associated 1

Gene names

Name:	Cby1
Synonyms:	Cby, Pgea1

Organism

Rattus norvegicus (Rat) [Reference proteome]

Taxonomic identifier

10116 [NCBI]

Taxonomic lineage

cellular organisms › Eukaryota › Opisthokonta › Metazoa › Eumetazoa › Bilateria › Deuterostomia › Chordata › Craniata › Vertebrata › Gnathostomata › Teleostomi › Euteleostomi › Sarcopterygii › Tetrapoda › Amniota › Mammalia › Theria › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length	127 AA.
Sequence status	Complete.
Protein existence	Evidence at transcript level

General annotation (Comments)

Function	Inhibits the Wnt/Wingless pathway by binding to beta-catenin and inhibiting beta-catenin-mediated transcriptional activation through competition with TCF/LEF transcription factors. Has also been shown to play a role in regulating the intracellular trafficking of polycystin-2/PKD2 and possibly of other intracellular proteins. Promotes adipocyte and cardiomyocyte differentiation By similarity.
Subunit structure	Homodimer. Interacts with polycystin-2/PKD2 and GM130. Interacts with the C-terminal region of beta-catenin By similarity.
Subcellular location	Nucleus speckle By similarity. Golgi apparatus › trans-Golgi network By similarity. Note: Nuclear, in a punctate manner. Also found in the trans-Golgi By similarity.
Miscellaneous	'Chibby' is Japanese for 'small'; the gene was so named for the RNAi phenotype seen in flies.
Sequence similarities	Belongs to the chibby family.

Ontologies

Keywords
Biological process	Differentiation
Cellular component	Golgi apparatus Nucleus
Domain	Coiled coil
Technical term	Complete proteome Reference proteome
Gene Ontology (GO)
Biological_process	cardiac muscle cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB cilium assembly Inferred from electronic annotation. Source: Compara fat cell differentiation Inferred from sequence or structural similarity. Source: UniProtKB negative regulation of canonical Wnt receptor signaling pathway Inferred from electronic annotation. Source: Compara negative regulation of transcription, DNA-dependent Inferred from electronic annotation. Source: Compara protein localization Inferred from electronic annotation. Source: Compara
Cellular_component	Golgi apparatus Inferred from electronic annotation. Source: UniProtKB-SubCell microtubule basal body Inferred from electronic annotation. Source: Compara nuclear speck Inferred from electronic annotation. Source: UniProtKB-SubCell trans-Golgi network Inferred from electronic annotation. Source: Compara
Complete GO annotation...

Sequence annotation (Features)

	Feature key	Position(s)	Length	Description	Graphical view	Feature identifier
Molecule processing
	Chain	1 – 127	127	Protein chibby homolog 1		PRO_0000058356
Regions
	Region	60 – 112	53	Minimal region for the interaction with PKD2 By similarity
	Coiled coil	68 – 110	43	Potential

Sequences

	Sequence		Length	Mass (Da)
	Q8K4I6 [UniParc]. Last modified October 1, 2002. Version 1. Checksum: 7CE38A48D045DE57	FASTA	127	14,549
	10 20 30 40 50 60 MPLFGSIFSP KKTPPRKSAS LSNLHSLDRS TRELELGLDY GTPTMNLAGQ SLKFENGQWV 70 80 90 100 110 120 ADSVISGGVD RRETQRLRKR NQQLEEENNL LRLKVDILLD MLSETTAESH LKDKELDELK ITNRRRK

References

[1]	"A conserved cytosolic leucine-rich protein (LRP) in vertebrate animals." Huang C.-H. Submitted (JUN-2001) to the EMBL/GenBank/DDBJ databases Cited for: NUCLEOTIDE SEQUENCE [MRNA].
+	Additional computationally mapped references.

Cross-references

Sequence databases
EMBL GenBank DDBJ	AF393211 mRNA. Translation: AAM73679.1.
IPI	IPI00203281.
RefSeq	NP_663709.1. NM_145676.1.
UniGene	Rn.229691.
3D structure databases
ModBase	Search...
Protein-protein interaction databases
STRING	10116.ENSRNOP00000018787.
Proteomic databases
PaxDb	Q8K4I6.
Protocols and materials databases
StructuralBiologyKnowledgebase	Search...
Genome annotation databases
Ensembl	ENSRNOT00000018787; ENSRNOP00000018787; ENSRNOG00000013892.
GeneID	246768.
KEGG	rno:246768.
UCSC	RGD:708481. rat.
Organism-specific databases
CTD	25776.
RGD	708481. Cby1.
Phylogenomic databases
eggNOG	NOG39404.
GeneTree	ENSGT00510000047043.
HOGENOM	HOG000006694.
HOVERGEN	HBG050816.
InParanoid	Q8K4I6.
OMA	LRKRNQQ.
OrthoDB	EOG4JT072.
Gene expression databases
Genevestigator	Q8K4I6.
GermOnline	ENSRNOG00000013892. Rattus norvegicus.
Family and domain databases
ProtoNet	Search...
Other
NextBio	623835.

Entry information

Entry name

CBY1_RAT

Accession

Primary (citable) accession number: Q8K4I6

Entry history

Integrated into UniProtKB/Swiss-Prot:	August 16, 2004
Last sequence update:	October 1, 2002
Last modified:	April 3, 2013
This is version 64 of the entry and version 1 of the sequence. [Complete history]

Entry status

Reviewed (UniProtKB/Swiss-Prot)

Annotation program

Chordata Protein Annotation Program