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Protein

Rho guanine nucleotide exchange factor 6

Gene

Arhgef6

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at protein leveli

Functioni

Acts as a RAC1 guanine nucleotide exchange factor (GEF).By similarity

GO - Molecular functioni

GO - Biological processi

  • intracellular signal transduction Source: InterPro
  • lamellipodium assembly Source: UniProtKB
  • regulation of Rho protein signal transduction Source: InterPro

Keywordsi

Molecular functionGuanine-nucleotide releasing factor

Names & Taxonomyi

Protein namesi
Recommended name:
Rho guanine nucleotide exchange factor 6
Alternative name(s):
Alpha-PIX
Rac/Cdc42 guanine nucleotide exchange factor 6
Gene namesi
Name:Arhgef6
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Unplaced

Organism-specific databases

MGIiMGI:1920591 Arhgef6

Subcellular locationi

Keywords - Cellular componenti

Cell projection

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00000809181 – 771Rho guanine nucleotide exchange factor 6Add BLAST771

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Modified residuei126PhosphoserineBy similarity1
Modified residuei133PhosphothreonineBy similarity1
Modified residuei224PhosphoserineBy similarity1
Modified residuei487PhosphoserineCombined sources1
Modified residuei639PhosphoserineCombined sources1
Modified residuei679PhosphoserineCombined sources1

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K4I3
MaxQBiQ8K4I3
PaxDbiQ8K4I3
PRIDEiQ8K4I3

PTM databases

iPTMnetiQ8K4I3
PhosphoSitePlusiQ8K4I3

Expressioni

Tissue specificityi

Detected in adult heart, spleen, lung, skeletal muscle, kidney and testis. Detected throughout embryogenesis.1 Publication

Interactioni

Subunit structurei

Interacts with PAK kinases through the SH3 domain. Interacts with GIT1. Component of cytoplasmic complexes, which also contain PXN, GIT1 and PAK1. Interacts with BIN2. Identified in a complex with BIN2 and GIT2 (By similarity). Interacts with PARVB.By similarity1 Publication

Binary interactionsi

WithEntry#Exp.IntActNotes
PARVBQ9HBI13EBI-6272809,EBI-1047679From Homo sapiens.

GO - Molecular functioni

Protein-protein interaction databases

BioGridi215941, 7 interactors
IntActiQ8K4I3, 6 interactors
MINTiQ8K4I3
STRINGi10090.ENSMUSP00000033468

Structurei

Secondary structure

1771
Legend: HelixTurnBeta strandPDB Structure known for this area
Show more details
Feature keyPosition(s)DescriptionActionsGraphical viewLength
Turni430 – 432Combined sources3
Turni444 – 446Combined sources3
Beta strandi452 – 457Combined sources6
Beta strandi460 – 463Combined sources4
Beta strandi467 – 472Combined sources6
Beta strandi477 – 481Combined sources5
Beta strandi483 – 487Combined sources5
Beta strandi490 – 495Combined sources6
Turni497 – 499Combined sources3
Beta strandi507 – 511Combined sources5
Beta strandi515 – 518Combined sources4
Beta strandi520 – 522Combined sources3
Beta strandi524 – 527Combined sources4
Helixi533 – 546Combined sources14

3D structure databases

Select the link destinations:
PDBei
RCSB PDBi
PDBji
Links Updated
PDB entryMethodResolution (Å)ChainPositionsPDBsum
1V61NMR-A429-547[»]
ProteinModelPortaliQ8K4I3
SMRiQ8K4I3
ModBaseiSearch...
MobiDBiSearch...

Miscellaneous databases

EvolutionaryTraceiQ8K4I3

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini1 – 111Calponin-homology (CH)PROSITE-ProRule annotationAdd BLAST111
Domaini159 – 218SH3PROSITE-ProRule annotationAdd BLAST60
Domaini240 – 420DHPROSITE-ProRule annotationAdd BLAST181
Domaini442 – 547PHPROSITE-ProRule annotationAdd BLAST106

Keywords - Domaini

SH3 domain

Phylogenomic databases

eggNOGiKOG2070 Eukaryota
ENOG410XNNP LUCA
HOGENOMiHOG000231381
HOVERGENiHBG050569
InParanoidiQ8K4I3
KOiK05729
PhylomeDBiQ8K4I3

Family and domain databases

CDDicd00014 CH, 1 hit
cd00160 RhoGEF, 1 hit
cd12060 SH3_alphaPIX, 1 hit
Gene3Di1.10.418.10, 1 hit
1.20.900.10, 1 hit
2.30.29.30, 1 hit
InterProiView protein in InterPro
IPR035788 AlphaPIX_SH3
IPR001715 CH-domain
IPR036872 CH_dom_sf
IPR035899 DBL_dom_sf
IPR000219 DH-domain
IPR001331 GDS_CDC24_CS
IPR032409 GEF_CC
IPR011993 PH-like_dom_sf
IPR001849 PH_domain
IPR036028 SH3-like_dom_sf
IPR001452 SH3_domain
IPR003096 SM22_calponin
PfamiView protein in Pfam
PF16523 betaPIX_CC, 1 hit
PF00307 CH, 1 hit
PF00169 PH, 1 hit
PF00621 RhoGEF, 1 hit
PF14604 SH3_9, 1 hit
PRINTSiPR00452 SH3DOMAIN
PR00888 SM22CALPONIN
SMARTiView protein in SMART
SM00033 CH, 1 hit
SM00233 PH, 1 hit
SM00325 RhoGEF, 1 hit
SM00326 SH3, 1 hit
SUPFAMiSSF47576 SSF47576, 1 hit
SSF48065 SSF48065, 1 hit
SSF50044 SSF50044, 1 hit
PROSITEiView protein in PROSITE
PS50021 CH, 1 hit
PS00741 DH_1, 1 hit
PS50010 DH_2, 1 hit
PS50003 PH_DOMAIN, 1 hit
PS50002 SH3, 1 hit

Sequencei

Sequence statusi: Complete.

Q8K4I3-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MNPEERLVTW LISLGVLESP KKTVCDPEEF LKSSLKNGVV LCKLINRLLP
60 70 80 90 100
GSVEKYCLEP QTEADCIDNI NDFLKGCATL QVEVFEPDDL YSGANFSKVL
110 120 130 140 150
NTLLAVNKAT EDQLSERPCG RSSSLSAATS SQTNPQVAVP STAPEQHSEE
160 170 180 190 200
KAEMTENGSH QLIVKARFNF KQTNEDELSV CKGDIIYVTR VEEGGWWEGT
210 220 230 240 250
LNGRTGWFPS NYVREIKPSE RPLSPKAIKG FDTAPLTKNY YTVVLQNILD
260 270 280 290 300
TEKEYAKELQ SLLVTYLRPL QSNNNLSTVE FTCLLGNFEE VCTFQQTLCQ
310 320 330 340 350
ALEECSKFPE NQHKVGGCLL NLMPHFKSMY LAYCANHPSA VNVLTQHSDD
360 370 380 390 400
LERFMENQGA SSPGILILTT SLSKPFMRLE KYVTLLQELE RHMEDTHPDH
410 420 430 440 450
QDILKAIIAF KTLMGQCQDL RKRKQLELQI LSEPIQAWEG DDIKTLGNVI
460 470 480 490 500
FMSQVVMQHG ACEEKEERYF LLFSSVLIML SASPRMSGFM YQGKIPIAGM
510 520 530 540 550
VVNRLDEIEG SDCMFEITGS TVERIVVHCN NNQDFQEWME QLNRLTKGPT
560 570 580 590 600
SCGSLSKTSS SSCSTHSSFS STGQPRGPLE PPQIIKPWSL SCLRPAPPLR
610 620 630 640 650
PSAALGYKER MSYILKESSK SPKTMKKFLH KRKTERKASE EEYVIRKSTA
660 670 680 690 700
ALEEDAQILK VIEAYCTSAS FQQGTRKDSV PQVLLPEEEK LIIEETRSNG
710 720 730 740 750
QTIIEEKSLV DTVYALKDEV KELKQENKKM KQCLEEELKS RKDLEKLVRK
760 770
LLKQTDECIR SESSSKTSIL Q
Length:771
Mass (Da):87,051
Last modified:October 1, 2002 - v1
Checksum:i3A408B7D0D6FCEAE
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF393831 mRNA Translation: AAM94903.1
AK040468 mRNA Translation: BAC30599.1
RefSeqiNP_690014.2, NM_152801.2
UniGeneiMm.261443

Genome annotation databases

GeneIDi73341
KEGGimmu:73341

Similar proteinsi

Entry informationi

Entry nameiARHG6_MOUSE
AccessioniPrimary (citable) accession number: Q8K4I3
Secondary accession number(s): Q8C9V4
Entry historyiIntegrated into UniProtKB/Swiss-Prot: September 27, 2005
Last sequence update: October 1, 2002
Last modified: March 28, 2018
This is version 127 of the entry and version 1 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

3D-structure, Complete proteome, Reference proteome
UniProt is an ELIXIR core data resource
Main funding by: National Institutes of Health