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Protein

Actin-binding LIM protein 1

Gene

Ablim1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at protein leveli

Functioni

May act as scaffold protein (By similarity). May play a role in the development of the retina. Has been suggested to play a role in axon guidance.By similarity2 Publications

GO - Molecular functioni

  • actin binding Source: MGI
  • zinc ion binding Source: InterPro

GO - Biological processi

  • axon guidance Source: MGI
  • cilium assembly Source: MGI
  • cytoskeleton organization Source: InterPro
  • lamellipodium assembly Source: MGI
  • positive regulation of transcription from RNA polymerase II promoter Source: MGI
Complete GO annotation...

Keywords - Ligandi

Actin-binding, Metal-binding, Zinc

Names & Taxonomyi

Protein namesi
Recommended name:
Actin-binding LIM protein 1
Short name:
abLIM-1
Alternative name(s):
Actin-binding LIM protein family member 1
Gene namesi
Name:Ablim1
Synonyms:Ablim, Kiaa0059
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 19

Organism-specific databases

MGIiMGI:1194500. Ablim1.

Subcellular locationi

  • Cytoplasm 1 Publication
  • Cytoplasmcytoskeleton 1 Publication

  • Note: In a striped pattern along the myofibril axis in cardiac myocytes. Associated with the cytoskeleton.

GO - Cellular componenti

  • actin cytoskeleton Source: MGI
  • cytoplasm Source: UniProtKB-SubCell
  • lamellipodium Source: MGI
  • neuronal postsynaptic density Source: MGI
  • stress fiber Source: MGI
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Cytoskeleton

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 861861Actin-binding LIM protein 1PRO_0000075698Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei216 – 2161PhosphoserineCombined sources
Modified residuei411 – 4111PhosphoserineCombined sources
Modified residuei417 – 4171PhosphotyrosineBy similarity
Modified residuei440 – 4401PhosphotyrosineCombined sources
Modified residuei466 – 4661PhosphoserineCombined sources
Modified residuei470 – 4701PhosphoserineCombined sources
Modified residuei475 – 4751PhosphoserineCombined sources
Modified residuei477 – 4771PhosphothreonineBy similarity
Modified residuei479 – 4791PhosphoserineCombined sources
Modified residuei483 – 4831PhosphotyrosineBy similarity
Modified residuei499 – 4991PhosphoserineCombined sources
Modified residuei502 – 5021PhosphoserineCombined sources
Modified residuei582 – 5821PhosphoserineCombined sources
Modified residuei671 – 6711PhosphoserineCombined sources
Modified residuei723 – 7231PhosphoserineBy similarity
Modified residuei738 – 7381PhosphoserineBy similarity
Modified residuei760 – 7601PhosphoserineCombined sources
Modified residuei789 – 7891PhosphoserineBy similarity

Keywords - PTMi

Phosphoprotein

Proteomic databases

EPDiQ8K4G5.
MaxQBiQ8K4G5.
PaxDbiQ8K4G5.
PRIDEiQ8K4G5.

PTM databases

iPTMnetiQ8K4G5.
PhosphoSiteiQ8K4G5.

Expressioni

Tissue specificityi

Isoform 1 is detected in adult retina, where it is highly expressed in the ganglion layer. Detected in rod inner segment. Isoform 2 is highly expressed in adult retina, brain, kidney and heart. Isoform 3 is highly expressed in adult retina, brain, kidney, liver, skeletal muscle, spleen and heart. Detected in embryonic retina, brain, spinal cord, peripheral sensory ganglia and thymus.3 Publications

Developmental stagei

Isoform 1 is detected at low levels starting from E12 and remains constant until birth. After this levels increase strongly and expression remains high in adults. Isoform 2 and isoform 3 are expressed at a constant high level throughout development.2 Publications

Gene expression databases

BgeeiQ8K4G5.
CleanExiMM_ABLIM1.
ExpressionAtlasiQ8K4G5. baseline and differential.
GenevisibleiQ8K4G5. MM.

Interactioni

Subunit structurei

Binds F-actin. Interacts with ABRA (By similarity).By similarity

Binary interactionsi

WithEntry#Exp.IntActNotes
Dlg4Q621084EBI-2307994,EBI-300895

GO - Molecular functioni

  • actin binding Source: MGI

Protein-protein interaction databases

BioGridi230492. 1 interaction.
IntActiQ8K4G5. 2 interactions.
MINTiMINT-4086493.
STRINGi10090.ENSMUSP00000078336.

Structurei

3D structure databases

ProteinModelPortaliQ8K4G5.
SMRiQ8K4G5. Positions 77-344, 797-861.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini97 – 15660LIM zinc-binding 1PROSITE-ProRule annotationAdd
BLAST
Domaini156 – 21661LIM zinc-binding 2PROSITE-ProRule annotationAdd
BLAST
Domaini224 – 28360LIM zinc-binding 3PROSITE-ProRule annotationAdd
BLAST
Domaini283 – 34361LIM zinc-binding 4PROSITE-ProRule annotationAdd
BLAST
Domaini793 – 86169HPPROSITE-ProRule annotationAdd
BLAST

Coiled coil

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Coiled coili673 – 72351Sequence analysisAdd
BLAST

Sequence similaritiesi

Contains 1 HP (headpiece) domain.PROSITE-ProRule annotation
Contains 4 LIM zinc-binding domains.PROSITE-ProRule annotation

Keywords - Domaini

Coiled coil, LIM domain, Repeat

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiQ8K4G5.
KOiK07520.
PhylomeDBiQ8K4G5.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
2.10.110.10. 4 hits.
InterProiIPR028448. ABLIM1.
IPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24213:SF18. PTHR24213:SF18. 1 hit.
PfamiPF16182. AbLIM_anchor. 1 hit.
PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]

Sequences (5)i

Sequence statusi: Complete.

This entry describes 5 isoformsi produced by alternative splicing. AlignAdd to basket

Isoform 1 (identifier: Q8K4G5-1) [UniParc]FASTAAdd to basket

Also known as: AbLIM-L

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MPSLLGLKCL GKLCSSEIGK VPSPERASLR NSHRRLLIED LSVPETPDPA
60 70 80 90 100
HRRRGTVIHL VYLYSAGCGP PELRFSSYDP SVAHPQDPHH SSEKPVIHCH
110 120 130 140 150
KCGEPCKGEV LRVQTKHFHI KCFTCKVCGC DLAQGGFFIK NGDYLCTLDY
160 170 180 190 200
QRMYGTRCHG CGEFVEGEVV TALGKTYHPN CFACTICKRP FPPGDRVTFN
210 220 230 240 250
GRDCLCQLCA QPMSSSPKEA SCSSNCAGCG RDIKNGQALL ALDKQWHLGC
260 270 280 290 300
FKCKSCGKVL TGEYISKDGS PYCEKDYQGL FGVKCEACHQ FITGKVLEAG
310 320 330 340 350
DKHYHPSCAR CSRCNQMFTE GEEMYLQGST VWHPDCKQST KTEEKLRPPN
360 370 380 390 400
IPRSSSDFFY PKSLIRRTGR SPALQLLSPP CLTNSNKNPR QPTRTSSESI
410 420 430 440 450
YSRPGSSIPG SPGHTIYAKV DNEILDYKDL AAIPKVKAIY DIERPDLITY
460 470 480 490 500
EPFYTSGYED KQERQSLGES PRTLSPTPSA EGYQDVRDRM IHRSTSQGSI
510 520 530 540 550
NSPVYSRHSY TPTTSRSPQH FHRPELLSPG VHRWSPLRTS SFSSTHSDSR
560 570 580 590 600
PNPPFRHHFL PHVKGNEPSS GRNSPLPYRP DSRPLTPTYA QAPKHFHVPD
610 620 630 640 650
QGINIYRKPP IYKQHAALAA QSKASEDIIK FSKFPAAQAP DPNEIPKIET
660 670 680 690 700
DHWPGPPSLA AVGTDPRRRS SGREEDEEEL LRRRQLQEEQ LMKLNSGLGQ
710 720 730 740 750
LILKEEMEKE SRERASLASR YDSPLHSASH APSSKTSSLP GYGKNGLHRP
760 770 780 790 800
VSTDFAQYNS YGDISGGVRD YQTLPDGHMP AVRMDRGVSM PNMLEPKIFP
810 820 830 840 850
YEMLMVTNRG RNKILRDVDR TRLERHLAPE VFWEIFGMSI QEFDKLPLWR
860
RNDMKKKAKL F
Length:861
Mass (Da):96,805
Last modified:October 1, 2002 - v1
Checksum:i5E045F7CEF1D91EF
GO
Isoform 2 (identifier: Q8K4G5-2) [UniParc]FASTAAdd to basket

Also known as: AbLIM-M

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPSLLGLKCL...ELRFSSYDPS → MVKEK
     348-391: Missing.
     525-564: Missing.

Show »
Length:701
Mass (Da):78,960
Checksum:i5B5B038DC13E8335
GO
Isoform 3 (identifier: Q8K4G5-3) [UniParc]FASTAAdd to basket

Also known as: AbLIM-S

The sequence of this isoform differs from the canonical sequence as follows:
     1-316: Missing.

Show »
Length:545
Mass (Da):62,004
Checksum:i4AC77999CAE0228B
GO
Isoform 4 (identifier: Q8K4G5-4) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-81: MPSLLGLKCL...ELRFSSYDPS → MVKEK
     348-391: Missing.
     525-564: Missing.
     616-662: Missing.

Note: No experimental confirmation available.
Show »
Length:654
Mass (Da):74,052
Checksum:i90BFFB081F2BF1D2
GO
Isoform 5 (identifier: Q8K4G5-5) [UniParc]FASTAAdd to basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-77: Missing.
     78-81: YDPS → MSTR
     301-345: DKHYHPSCAR...CKQSTKTEEK → VTEASRTWSH...SAREWFALSA
     346-861: Missing.

Note: No experimental confirmation available.
Show »
Length:268
Mass (Da):29,911
Checksum:i08A6BFFDC99BB56B
GO

Sequence cautioni

The sequence BAC65478.1 differs from that shown. Reason: Erroneous initiation. Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 316316Missing in isoform 3. 1 PublicationVSP_012103Add
BLAST
Alternative sequencei1 – 8181MPSLL…SYDPS → MVKEK in isoform 2 and isoform 4. 2 PublicationsVSP_012104Add
BLAST
Alternative sequencei1 – 7777Missing in isoform 5. 1 PublicationVSP_012105Add
BLAST
Alternative sequencei78 – 814YDPS → MSTR in isoform 5. 1 PublicationVSP_012106
Alternative sequencei301 – 34545DKHYH…KTEEK → VTEASRTWSHIDLRWQGRSE ELRAWRHSIQSLRHQSAREW FALSA in isoform 5. 1 PublicationVSP_012107Add
BLAST
Alternative sequencei346 – 861516Missing in isoform 5. 1 PublicationVSP_012109Add
BLAST
Alternative sequencei348 – 39144Missing in isoform 2 and isoform 4. 2 PublicationsVSP_012108Add
BLAST
Alternative sequencei525 – 56440Missing in isoform 2 and isoform 4. 2 PublicationsVSP_012110Add
BLAST
Alternative sequencei616 – 66247Missing in isoform 4. 1 PublicationVSP_012111Add
BLAST

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404774 mRNA. Translation: AAM73705.1.
AF404775 mRNA. Translation: AAM73706.1.
AF404776 mRNA. Translation: AAM73707.1.
AK122196 mRNA. Translation: BAC65478.1. Different initiation.
AK029371 mRNA. Translation: BAC26424.1.
CCDSiCCDS38027.1. [Q8K4G5-1]
CCDS50478.1. [Q8K4G5-3]
CCDS50479.1. [Q8K4G5-2]
CCDS70964.1. [Q8K4G5-4]
RefSeqiNP_001096647.1. NM_001103177.2. [Q8K4G5-2]
NP_001096648.1. NM_001103178.2.
NP_001277742.1. NM_001290813.1.
NP_001277744.1. NM_001290815.1. [Q8K4G5-4]
NP_848803.3. NM_178688.3.
UniGeneiMm.217161.
Mm.446592.

Genome annotation databases

EnsembliENSMUST00000099294; ENSMUSP00000096897; ENSMUSG00000025085. [Q8K4G5-4]
ENSMUST00000111524; ENSMUSP00000107149; ENSMUSG00000025085. [Q8K4G5-5]
ENSMUST00000111546; ENSMUSP00000107172; ENSMUSG00000025085. [Q8K4G5-2]
GeneIDi226251.
KEGGimmu:226251.
UCSCiuc008hzz.1. mouse. [Q8K4G5-5]
uc033hkz.2. mouse. [Q8K4G5-2]
uc033hld.2. mouse. [Q8K4G5-4]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF404774 mRNA. Translation: AAM73705.1.
AF404775 mRNA. Translation: AAM73706.1.
AF404776 mRNA. Translation: AAM73707.1.
AK122196 mRNA. Translation: BAC65478.1. Different initiation.
AK029371 mRNA. Translation: BAC26424.1.
CCDSiCCDS38027.1. [Q8K4G5-1]
CCDS50478.1. [Q8K4G5-3]
CCDS50479.1. [Q8K4G5-2]
CCDS70964.1. [Q8K4G5-4]
RefSeqiNP_001096647.1. NM_001103177.2. [Q8K4G5-2]
NP_001096648.1. NM_001103178.2.
NP_001277742.1. NM_001290813.1.
NP_001277744.1. NM_001290815.1. [Q8K4G5-4]
NP_848803.3. NM_178688.3.
UniGeneiMm.217161.
Mm.446592.

3D structure databases

ProteinModelPortaliQ8K4G5.
SMRiQ8K4G5. Positions 77-344, 797-861.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

BioGridi230492. 1 interaction.
IntActiQ8K4G5. 2 interactions.
MINTiMINT-4086493.
STRINGi10090.ENSMUSP00000078336.

PTM databases

iPTMnetiQ8K4G5.
PhosphoSiteiQ8K4G5.

Proteomic databases

EPDiQ8K4G5.
MaxQBiQ8K4G5.
PaxDbiQ8K4G5.
PRIDEiQ8K4G5.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000099294; ENSMUSP00000096897; ENSMUSG00000025085. [Q8K4G5-4]
ENSMUST00000111524; ENSMUSP00000107149; ENSMUSG00000025085. [Q8K4G5-5]
ENSMUST00000111546; ENSMUSP00000107172; ENSMUSG00000025085. [Q8K4G5-2]
GeneIDi226251.
KEGGimmu:226251.
UCSCiuc008hzz.1. mouse. [Q8K4G5-5]
uc033hkz.2. mouse. [Q8K4G5-2]
uc033hld.2. mouse. [Q8K4G5-4]

Organism-specific databases

CTDi3983.
MGIiMGI:1194500. Ablim1.
RougeiSearch...

Phylogenomic databases

eggNOGiKOG1044. Eukaryota.
ENOG410XRPY. LUCA.
GeneTreeiENSGT00760000119039.
HOGENOMiHOG000285997.
HOVERGENiHBG031499.
InParanoidiQ8K4G5.
KOiK07520.
PhylomeDBiQ8K4G5.

Miscellaneous databases

PROiQ8K4G5.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K4G5.
CleanExiMM_ABLIM1.
ExpressionAtlasiQ8K4G5. baseline and differential.
GenevisibleiQ8K4G5. MM.

Family and domain databases

Gene3Di1.10.950.10. 1 hit.
2.10.110.10. 4 hits.
InterProiIPR028448. ABLIM1.
IPR032402. AbLIM_anchor.
IPR003128. Villin_headpiece.
IPR001781. Znf_LIM.
[Graphical view]
PANTHERiPTHR24213:SF18. PTHR24213:SF18. 1 hit.
PfamiPF16182. AbLIM_anchor. 1 hit.
PF00412. LIM. 4 hits.
PF02209. VHP. 1 hit.
[Graphical view]
SMARTiSM00132. LIM. 4 hits.
SM00153. VHP. 1 hit.
[Graphical view]
SUPFAMiSSF47050. SSF47050. 1 hit.
PROSITEiPS51089. HP. 1 hit.
PS00478. LIM_DOMAIN_1. 4 hits.
PS50023. LIM_DOMAIN_2. 4 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Molecular characterization of abLIM, a novel actin-binding and double zinc finger protein."
    Roof D.J., Hayes A., Adamian M., Chishti A.H., Li T.
    J. Cell Biol. 138:575-588(1997) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1; 2 AND 3), TISSUE SPECIFICITY, DEVELOPMENTAL STAGE, SUBCELLULAR LOCATION, PHOSPHORYLATION.
    Strain: C57BL/6J.
  2. "Prediction of the coding sequences of mouse homologues of KIAA gene: II. The complete nucleotide sequences of 400 mouse KIAA-homologous cDNAs identified by screening of terminal sequences of cDNA clones randomly sampled from size-fractionated libraries."
    Okazaki N., Kikuno R., Ohara R., Inamoto S., Aizawa H., Yuasa S., Nakajima D., Nagase T., Ohara O., Koga H.
    DNA Res. 10:35-48(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 4).
    Tissue: Brain.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 5).
    Strain: C57BL/6J.
    Tissue: Head.
  4. "A POU domain transcription factor-dependent program regulates axon pathfinding in the vertebrate visual system."
    Erkman L., Yates P.A., McLaughlin T., McEvilly R.J., Whisenhunt T., O'Connell S.M., Krones A.I., Kirby M.A., Rapaport D.H., Bermingham J.R. Jr., O'Leary D.D.M., Rosenfeld M.G.
    Neuron 28:779-792(2000) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, TISSUE SPECIFICITY.
  5. "Normal retinal development and retinofugal projections in mice lacking the retina-specific variant of actin-binding LIM domain protein."
    Lu C., Huang X., Ma H.F., Gooley J.J., Aparacio J., Roof D.J., Chen C., Chen D.F., Li T.
    Neuroscience 120:121-131(2003) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DEVELOPMENTAL STAGE, TISSUE SPECIFICITY, ALTERNATIVE SPLICING (ISOFORMS 1; 2 AND 3).
    Strain: C57BL/6J.
  6. Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Embryonic brain.
  7. "Comprehensive identification of phosphorylation sites in postsynaptic density preparations."
    Trinidad J.C., Specht C.G., Thalhammer A., Schoepfer R., Burlingame A.L.
    Mol. Cell. Proteomics 5:914-922(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  8. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-411 AND SER-499, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  9. "Large-scale identification and evolution indexing of tyrosine phosphorylation sites from murine brain."
    Ballif B.A., Carey G.R., Sunyaev S.R., Gygi S.P.
    J. Proteome Res. 7:311-318(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT TYR-440, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain.
  10. "Specific phosphopeptide enrichment with immobilized titanium ion affinity chromatography adsorbent for phosphoproteome analysis."
    Zhou H., Ye M., Dong J., Han G., Jiang X., Wu R., Zou H.
    J. Proteome Res. 7:3957-3967(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Liver.
  11. Cited for: PHOSPHORYLATION [LARGE SCALE ANALYSIS] AT SER-216; SER-411; SER-466; SER-470; SER-475; SER-479; SER-499; SER-502; SER-582; SER-671 AND SER-760, IDENTIFICATION BY MASS SPECTROMETRY [LARGE SCALE ANALYSIS].
    Tissue: Brain, Brown adipose tissue, Heart, Kidney, Liver, Lung, Pancreas, Spleen and Testis.

Entry informationi

Entry nameiABLM1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4G5
Secondary accession number(s): Q80U86
, Q8BIR9, Q8K4G3, Q8K4G4
Entry historyi
Integrated into UniProtKB/Swiss-Prot: December 7, 2004
Last sequence update: October 1, 2002
Last modified: June 8, 2016
This is version 126 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Isoform 1 is not necessary for normal axon guidance.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.