ID   CONA1_MOUSE             Reviewed;         532 AA.
AC   Q8K4G2; Q5SUQ0;
DT   11-JUL-2006, integrated into UniProtKB/Swiss-Prot.
DT   11-JUL-2006, sequence version 2.
DT   27-MAR-2024, entry version 144.
DE   RecName: Full=Collagen alpha-1(XXIII) chain;
GN   Name=Col23a1;
OS   Mus musculus (Mouse).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia;
OC   Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae;
OC   Murinae; Mus; Mus.
OX   NCBI_TaxID=10090;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   TISSUE=Cartilage;
RA   Koch M., Jin W., Burgeson R.E.;
RT   "Alpha 1(XXIII), a new member of the transmembrane collagens.";
RL   Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases.
RN   [2]
RP   NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
RC   STRAIN=C57BL/6J;
RX   PubMed=19468303; DOI=10.1371/journal.pbio.1000112;
RA   Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X.,
RA   Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y.,
RA   Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S.,
RA   Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R.,
RA   Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K.,
RA   Eichler E.E., Ponting C.P.;
RT   "Lineage-specific biology revealed by a finished genome assembly of the
RT   mouse.";
RL   PLoS Biol. 7:E1000112-E1000112(2009).
CC   -!- SUBUNIT: Homotrimer. {ECO:0000250}.
CC   -!- SUBCELLULAR LOCATION: Cell membrane {ECO:0000250}; Single-pass type II
CC       membrane protein {ECO:0000250}; Extracellular side {ECO:0000250}.
CC   -!- PTM: Undergoes proteolytic cleavage by furin protease to yield a 60 kDa
CC       soluble form that forms a homotrimer and exhibits a low affinity
CC       interaction with heparin. {ECO:0000250}.
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DR   EMBL; AF410792; AAN03649.1; -; mRNA.
DR   EMBL; AL645907; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   EMBL; AL662843; -; NOT_ANNOTATED_CDS; Genomic_DNA.
DR   CCDS; CCDS24652.1; -.
DR   RefSeq; NP_700442.2; NM_153393.2.
DR   AlphaFoldDB; Q8K4G2; -.
DR   SMR; Q8K4G2; -.
DR   BioGRID; 231903; 3.
DR   ComplexPortal; CPX-3005; Collagen type XXIII trimer.
DR   STRING; 10090.ENSMUSP00000099826; -.
DR   iPTMnet; Q8K4G2; -.
DR   PhosphoSitePlus; Q8K4G2; -.
DR   PaxDb; 10090-ENSMUSP00000099826; -.
DR   ProteomicsDB; 283604; -.
DR   Antibodypedia; 29441; 164 antibodies from 27 providers.
DR   DNASU; 237759; -.
DR   Ensembl; ENSMUST00000102765.9; ENSMUSP00000099826.3; ENSMUSG00000063564.14.
DR   GeneID; 237759; -.
DR   KEGG; mmu:237759; -.
DR   UCSC; uc033fvj.1; mouse.
DR   AGR; MGI:2653243; -.
DR   CTD; 91522; -.
DR   MGI; MGI:2653243; Col23a1.
DR   VEuPathDB; HostDB:ENSMUSG00000063564; -.
DR   eggNOG; KOG3544; Eukaryota.
DR   GeneTree; ENSGT00940000162238; -.
DR   HOGENOM; CLU_001074_21_2_1; -.
DR   InParanoid; Q8K4G2; -.
DR   OMA; PRMVFPH; -.
DR   OrthoDB; 5324524at2759; -.
DR   PhylomeDB; Q8K4G2; -.
DR   TreeFam; TF338175; -.
DR   Reactome; R-MMU-1650814; Collagen biosynthesis and modifying enzymes.
DR   Reactome; R-MMU-8948216; Collagen chain trimerization.
DR   BioGRID-ORCS; 237759; 3 hits in 76 CRISPR screens.
DR   PRO; PR:Q8K4G2; -.
DR   Proteomes; UP000000589; Chromosome 11.
DR   RNAct; Q8K4G2; Protein.
DR   Bgee; ENSMUSG00000063564; Expressed in median eminence of neurohypophysis and 214 other cell types or tissues.
DR   ExpressionAtlas; Q8K4G2; baseline and differential.
DR   GO; GO:0005604; C:basement membrane; IBA:GO_Central.
DR   GO; GO:0009986; C:cell surface; ISO:MGI.
DR   GO; GO:0005581; C:collagen trimer; IEA:UniProtKB-KW.
DR   GO; GO:0062023; C:collagen-containing extracellular matrix; HDA:BHF-UCL.
DR   GO; GO:0005576; C:extracellular region; TAS:Reactome.
DR   GO; GO:0005615; C:extracellular space; ISO:MGI.
DR   GO; GO:0005886; C:plasma membrane; TAS:Reactome.
DR   GO; GO:0030020; F:extracellular matrix structural constituent conferring tensile strength; IBA:GO_Central.
DR   GO; GO:0008201; F:heparin binding; ISO:MGI.
DR   GO; GO:0042802; F:identical protein binding; ISO:MGI.
DR   GO; GO:0030198; P:extracellular matrix organization; IBA:GO_Central.
DR   InterPro; IPR008160; Collagen.
DR   PANTHER; PTHR37456:SF5; -; 1.
DR   PANTHER; PTHR37456; SI:CH211-266K2.1; 1.
DR   Pfam; PF01391; Collagen; 6.
DR   Genevisible; Q8K4G2; MM.
PE   2: Evidence at transcript level;
KW   Cell membrane; Collagen; Membrane; Reference proteome; Repeat;
KW   Signal-anchor; Transmembrane; Transmembrane helix.
FT   CHAIN           1..532
FT                   /note="Collagen alpha-1(XXIII) chain"
FT                   /id="PRO_0000245227"
FT   TOPO_DOM        1..23
FT                   /note="Cytoplasmic"
FT                   /evidence="ECO:0000255"
FT   TRANSMEM        24..45
FT                   /note="Helical; Signal-anchor for type II membrane protein"
FT                   /evidence="ECO:0000255"
FT   TOPO_DOM        46..532
FT                   /note="Extracellular"
FT                   /evidence="ECO:0000255"
FT   DOMAIN          108..166
FT                   /note="Collagen-like 1"
FT   DOMAIN          173..232
FT                   /note="Collagen-like 2"
FT   DOMAIN          240..298
FT                   /note="Collagen-like 3"
FT   DOMAIN          313..372
FT                   /note="Collagen-like 4"
FT   DOMAIN          404..452
FT                   /note="Collagen-like 5"
FT   DOMAIN          455..514
FT                   /note="Collagen-like 6"
FT   REGION          102..296
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   REGION          308..532
FT                   /note="Disordered"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        402..416
FT                   /note="Pro residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   COMPBIAS        477..500
FT                   /note="Basic and acidic residues"
FT                   /evidence="ECO:0000256|SAM:MobiDB-lite"
FT   CONFLICT        288
FT                   /note="A -> P (in Ref. 1; AAN03649)"
FT                   /evidence="ECO:0000305"
SQ   SEQUENCE   532 AA;  51476 MW;  035E8538D5642486 CRC64;
     MGAGERAAGG GGAQDPGAGC GSRALSALCL LLSVGSAAAC LLLGAQAAAL HGRVAALEQE
     RELLRHAGPS GALAAWAETH LERLLREKLD GVAKLRTVRE APSECICPPG PPGRRGKPGR
     RGDPGPPGQS GRDGYPGPLG LDGKPGLPGP KGEKGTPGDF GPRGAQGQDG VAGPPGPPGP
     PGARGPPGDT GKDGPRGAQG PAGPRGEPGQ DGEMGPKGPP GPKGEPGIPG KKGDDGMANQ
     PGLPGPPGPK GEPGDVGPRG ENGVDGIPGL KGEPGHPGVD GATGPRGAPG LKGEQGDTVV
     IDYDGRILDA LKGPPGPQGA PGPPGIPGAK GELGLPGAPG IDGEKGPKGP KGDPGEPGPA
     GPKGETGEMG LSGLPGADGP KGEKGESASD HLQESLAQII VEPGPPGPPG PPGPMGLQGI
     QGPKGLDGAK GEKGTSGERG PHGLPGPVGP PGLIGLPGTK GEKGRPGEPG LDGFPGPRGE
     KGDRSERGEK GERGVPGRKG VKGQKGEPGP PGLDQPCPVG PDGLPVPGCW HK
//