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Protein

Collagen alpha-1(XXIII) chain

Gene

Col23a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: -Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiR-MMU-1650814 Collagen biosynthesis and modifying enzymes
R-MMU-8948216 Collagen chain trimerization

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXIII) chain
Gene namesi
Name:Col23a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaMyomorphaMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2653243 Col23a1

Subcellular locationi

Extracellular region or secreted Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi apparatus Nucleus Mitochondrion Manual annotation Automatic computational assertionGraphics by Christian Stolte; Source: COMPARTMENTS

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini1 – 23CytoplasmicSequence analysisAdd BLAST23
Transmembranei24 – 45Helical; Signal-anchor for type II membrane proteinSequence analysisAdd BLAST22
Topological domaini46 – 532ExtracellularSequence analysisAdd BLAST487

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
ChainiPRO_00002452271 – 532Collagen alpha-1(XXIII) chainAdd BLAST532

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.By similarity

Proteomic databases

PaxDbiQ8K4G2
PRIDEiQ8K4G2

PTM databases

iPTMnetiQ8K4G2
PhosphoSitePlusiQ8K4G2

Expressioni

Gene expression databases

BgeeiENSMUSG00000063564
CleanExiMM_COL23A1
ExpressionAtlasiQ8K4G2 baseline and differential
GenevisibleiQ8K4G2 MM

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099826

Structurei

3D structure databases

ProteinModelPortaliQ8K4G2
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini108 – 166Collagen-like 1Add BLAST59
Domaini173 – 232Collagen-like 2Add BLAST60
Domaini240 – 298Collagen-like 3Add BLAST59
Domaini313 – 372Collagen-like 4Add BLAST60
Domaini404 – 452Collagen-like 5Add BLAST49
Domaini455 – 514Collagen-like 6Add BLAST60

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiKOG3544 Eukaryota
ENOG410XNMM LUCA
GeneTreeiENSGT00900000140850
HOGENOMiHOG000085653
HOVERGENiHBG004933
InParanoidiQ8K4G2
OMAiVPGRKGM
OrthoDBiEOG091G0G3Y
PhylomeDBiQ8K4G2
TreeFamiTF338175

Family and domain databases

InterProiView protein in InterPro
IPR008160 Collagen
PfamiView protein in Pfam
PF01391 Collagen, 7 hits

Sequencei

Sequence statusi: Complete.

Q8K4G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGERAAGG GGAQDPGAGC GSRALSALCL LLSVGSAAAC LLLGAQAAAL
60 70 80 90 100
HGRVAALEQE RELLRHAGPS GALAAWAETH LERLLREKLD GVAKLRTVRE
110 120 130 140 150
APSECICPPG PPGRRGKPGR RGDPGPPGQS GRDGYPGPLG LDGKPGLPGP
160 170 180 190 200
KGEKGTPGDF GPRGAQGQDG VAGPPGPPGP PGARGPPGDT GKDGPRGAQG
210 220 230 240 250
PAGPRGEPGQ DGEMGPKGPP GPKGEPGIPG KKGDDGMANQ PGLPGPPGPK
260 270 280 290 300
GEPGDVGPRG ENGVDGIPGL KGEPGHPGVD GATGPRGAPG LKGEQGDTVV
310 320 330 340 350
IDYDGRILDA LKGPPGPQGA PGPPGIPGAK GELGLPGAPG IDGEKGPKGP
360 370 380 390 400
KGDPGEPGPA GPKGETGEMG LSGLPGADGP KGEKGESASD HLQESLAQII
410 420 430 440 450
VEPGPPGPPG PPGPMGLQGI QGPKGLDGAK GEKGTSGERG PHGLPGPVGP
460 470 480 490 500
PGLIGLPGTK GEKGRPGEPG LDGFPGPRGE KGDRSERGEK GERGVPGRKG
510 520 530
VKGQKGEPGP PGLDQPCPVG PDGLPVPGCW HK
Length:532
Mass (Da):51,476
Last modified:July 11, 2006 - v2
Checksum:i035E8538D5642486
GO

Experimental Info

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Sequence conflicti288A → P in AAN03649 (Ref. 1) Curated1

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410792 mRNA Translation: AAN03649.1
AL645907, AL662843 Genomic DNA Translation: CAI26117.1
AL662843, AL645907 Genomic DNA Translation: CAI35929.1
CCDSiCCDS24652.1
RefSeqiNP_700442.2, NM_153393.2
UniGeneiMm.154093

Genome annotation databases

EnsembliENSMUST00000102765; ENSMUSP00000099826; ENSMUSG00000063564
GeneIDi237759
KEGGimmu:237759
UCSCiuc033fvj.1 mouse

Similar proteinsi

Entry informationi

Entry nameiCONA1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4G2
Secondary accession number(s): Q5SUQ0
Entry historyiIntegrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: March 28, 2018
This is version 113 of the entry and version 2 of the sequence. See complete history.
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

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