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Q8K4G2

- CONA1_MOUSE

UniProt

Q8K4G2 - CONA1_MOUSE

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Protein
Collagen alpha-1(XXIII) chain
Gene
Col23a1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5 - Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXIII) chain
Gene namesi
Name:Col23a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2653243. Col23a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323Cytoplasmic Reviewed prediction
Add
BLAST
Transmembranei24 – 4522Helical; Signal-anchor for type II membrane protein; Reviewed prediction
Add
BLAST
Topological domaini46 – 532487Extracellular Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Collagen alpha-1(XXIII) chain
PRO_0000245227Add
BLAST

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin By similarity.

Proteomic databases

PRIDEiQ8K4G2.

PTM databases

PhosphoSiteiQ8K4G2.

Expressioni

Gene expression databases

ArrayExpressiQ8K4G2.
BgeeiQ8K4G2.
CleanExiMM_COL23A1.
GenevestigatoriQ8K4G2.

Interactioni

Subunit structurei

Homotrimer By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8K4G2.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 16659Collagen-like 1
Add
BLAST
Domaini173 – 23260Collagen-like 2
Add
BLAST
Domaini240 – 29859Collagen-like 3
Add
BLAST
Domaini313 – 37260Collagen-like 4
Add
BLAST
Domaini404 – 45249Collagen-like 5
Add
BLAST
Domaini455 – 51460Collagen-like 6
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320189.
GeneTreeiENSGT00750000117303.
HOGENOMiHOG000085653.
HOVERGENiHBG004933.
InParanoidiQ8K4G2.
OMAiIPGRKGV.
OrthoDBiEOG7D59P1.
PhylomeDBiQ8K4G2.
TreeFamiTF338175.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4G2-1 [UniParc]FASTAAdd to Basket

« Hide

MGAGERAAGG GGAQDPGAGC GSRALSALCL LLSVGSAAAC LLLGAQAAAL    50
HGRVAALEQE RELLRHAGPS GALAAWAETH LERLLREKLD GVAKLRTVRE 100
APSECICPPG PPGRRGKPGR RGDPGPPGQS GRDGYPGPLG LDGKPGLPGP 150
KGEKGTPGDF GPRGAQGQDG VAGPPGPPGP PGARGPPGDT GKDGPRGAQG 200
PAGPRGEPGQ DGEMGPKGPP GPKGEPGIPG KKGDDGMANQ PGLPGPPGPK 250
GEPGDVGPRG ENGVDGIPGL KGEPGHPGVD GATGPRGAPG LKGEQGDTVV 300
IDYDGRILDA LKGPPGPQGA PGPPGIPGAK GELGLPGAPG IDGEKGPKGP 350
KGDPGEPGPA GPKGETGEMG LSGLPGADGP KGEKGESASD HLQESLAQII 400
VEPGPPGPPG PPGPMGLQGI QGPKGLDGAK GEKGTSGERG PHGLPGPVGP 450
PGLIGLPGTK GEKGRPGEPG LDGFPGPRGE KGDRSERGEK GERGVPGRKG 500
VKGQKGEPGP PGLDQPCPVG PDGLPVPGCW HK 532
Length:532
Mass (Da):51,476
Last modified:July 11, 2006 - v2
Checksum:i035E8538D5642486
GO

Sequence conflict

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881A → P in AAN03649. 1 Publication

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410792 mRNA. Translation: AAN03649.1.
AL645907, AL662843 Genomic DNA. Translation: CAI26117.1.
AL662843, AL645907 Genomic DNA. Translation: CAI35929.1.
CCDSiCCDS24652.1.
RefSeqiNP_700442.2. NM_153393.2.
UniGeneiMm.154093.

Genome annotation databases

EnsembliENSMUST00000102765; ENSMUSP00000099826; ENSMUSG00000063564.
GeneIDi237759.
KEGGimmu:237759.
UCSCiuc007itv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF410792 mRNA. Translation: AAN03649.1 .
AL645907 , AL662843 Genomic DNA. Translation: CAI26117.1 .
AL662843 , AL645907 Genomic DNA. Translation: CAI35929.1 .
CCDSi CCDS24652.1.
RefSeqi NP_700442.2. NM_153393.2.
UniGenei Mm.154093.

3D structure databases

ProteinModelPortali Q8K4G2.
ModBasei Search...

PTM databases

PhosphoSitei Q8K4G2.

Proteomic databases

PRIDEi Q8K4G2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102765 ; ENSMUSP00000099826 ; ENSMUSG00000063564 .
GeneIDi 237759.
KEGGi mmu:237759.
UCSCi uc007itv.2. mouse.

Organism-specific databases

CTDi 91522.
MGIi MGI:2653243. Col23a1.

Phylogenomic databases

eggNOGi NOG320189.
GeneTreei ENSGT00750000117303.
HOGENOMi HOG000085653.
HOVERGENi HBG004933.
InParanoidi Q8K4G2.
OMAi IPGRKGV.
OrthoDBi EOG7D59P1.
PhylomeDBi Q8K4G2.
TreeFami TF338175.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 383470.
PROi Q8K4G2.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K4G2.
Bgeei Q8K4G2.
CleanExi MM_COL23A1.
Genevestigatori Q8K4G2.

Family and domain databases

InterProi IPR008160. Collagen.
[Graphical view ]
Pfami PF01391. Collagen. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alpha 1(XXIII), a new member of the transmembrane collagens."
    Koch M., Jin W., Burgeson R.E.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cartilage.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCONA1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4G2
Secondary accession number(s): Q5SUQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: September 3, 2014
This is version 84 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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