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Q8K4G2

- CONA1_MOUSE

UniProt

Q8K4G2 - CONA1_MOUSE

Protein

Collagen alpha-1(XXIII) chain

Gene

Col23a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 2 (11 Jul 2006)
      Previous versions | rss
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    Functioni

    Enzyme and pathway databases

    ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Collagen alpha-1(XXIII) chain
    Gene namesi
    Name:Col23a1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 11

    Organism-specific databases

    MGIiMGI:2653243. Col23a1.

    Subcellular locationi

    Cell membrane By similarity; Single-pass type II membrane protein By similarity; Extracellular side By similarity

    GO - Cellular componenti

    1. collagen trimer Source: UniProtKB-KW
    2. extracellular region Source: Reactome
    3. integral component of membrane Source: UniProtKB-KW
    4. plasma membrane Source: Reactome

    Keywords - Cellular componenti

    Cell membrane, Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 532532Collagen alpha-1(XXIII) chainPRO_0000245227Add
    BLAST

    Post-translational modificationi

    Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.By similarity

    Proteomic databases

    PRIDEiQ8K4G2.

    PTM databases

    PhosphoSiteiQ8K4G2.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K4G2.
    BgeeiQ8K4G2.
    CleanExiMM_COL23A1.
    GenevestigatoriQ8K4G2.

    Interactioni

    Subunit structurei

    Homotrimer.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4G2.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
    BLAST
    Topological domaini46 – 532487ExtracellularSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei24 – 4522Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini108 – 16659Collagen-like 1Add
    BLAST
    Domaini173 – 23260Collagen-like 2Add
    BLAST
    Domaini240 – 29859Collagen-like 3Add
    BLAST
    Domaini313 – 37260Collagen-like 4Add
    BLAST
    Domaini404 – 45249Collagen-like 5Add
    BLAST
    Domaini455 – 51460Collagen-like 6Add
    BLAST

    Sequence similaritiesi

    Contains 6 collagen-like domains.Curated

    Keywords - Domaini

    Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG320189.
    GeneTreeiENSGT00750000117303.
    HOGENOMiHOG000085653.
    HOVERGENiHBG004933.
    InParanoidiQ8K4G2.
    OMAiIPGRKGV.
    OrthoDBiEOG7D59P1.
    PhylomeDBiQ8K4G2.
    TreeFamiTF338175.

    Family and domain databases

    InterProiIPR008160. Collagen.
    [Graphical view]
    PfamiPF01391. Collagen. 7 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4G2-1 [UniParc]FASTAAdd to Basket

    « Hide

    MGAGERAAGG GGAQDPGAGC GSRALSALCL LLSVGSAAAC LLLGAQAAAL    50
    HGRVAALEQE RELLRHAGPS GALAAWAETH LERLLREKLD GVAKLRTVRE 100
    APSECICPPG PPGRRGKPGR RGDPGPPGQS GRDGYPGPLG LDGKPGLPGP 150
    KGEKGTPGDF GPRGAQGQDG VAGPPGPPGP PGARGPPGDT GKDGPRGAQG 200
    PAGPRGEPGQ DGEMGPKGPP GPKGEPGIPG KKGDDGMANQ PGLPGPPGPK 250
    GEPGDVGPRG ENGVDGIPGL KGEPGHPGVD GATGPRGAPG LKGEQGDTVV 300
    IDYDGRILDA LKGPPGPQGA PGPPGIPGAK GELGLPGAPG IDGEKGPKGP 350
    KGDPGEPGPA GPKGETGEMG LSGLPGADGP KGEKGESASD HLQESLAQII 400
    VEPGPPGPPG PPGPMGLQGI QGPKGLDGAK GEKGTSGERG PHGLPGPVGP 450
    PGLIGLPGTK GEKGRPGEPG LDGFPGPRGE KGDRSERGEK GERGVPGRKG 500
    VKGQKGEPGP PGLDQPCPVG PDGLPVPGCW HK 532
    Length:532
    Mass (Da):51,476
    Last modified:July 11, 2006 - v2
    Checksum:i035E8538D5642486
    GO

    Experimental Info

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sequence conflicti288 – 2881A → P in AAN03649. 1 PublicationCurated

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF410792 mRNA. Translation: AAN03649.1.
    AL645907, AL662843 Genomic DNA. Translation: CAI26117.1.
    AL662843, AL645907 Genomic DNA. Translation: CAI35929.1.
    CCDSiCCDS24652.1.
    RefSeqiNP_700442.2. NM_153393.2.
    UniGeneiMm.154093.

    Genome annotation databases

    EnsembliENSMUST00000102765; ENSMUSP00000099826; ENSMUSG00000063564.
    GeneIDi237759.
    KEGGimmu:237759.
    UCSCiuc007itv.2. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF410792 mRNA. Translation: AAN03649.1 .
    AL645907 , AL662843 Genomic DNA. Translation: CAI26117.1 .
    AL662843 , AL645907 Genomic DNA. Translation: CAI35929.1 .
    CCDSi CCDS24652.1.
    RefSeqi NP_700442.2. NM_153393.2.
    UniGenei Mm.154093.

    3D structure databases

    ProteinModelPortali Q8K4G2.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K4G2.

    Proteomic databases

    PRIDEi Q8K4G2.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000102765 ; ENSMUSP00000099826 ; ENSMUSG00000063564 .
    GeneIDi 237759.
    KEGGi mmu:237759.
    UCSCi uc007itv.2. mouse.

    Organism-specific databases

    CTDi 91522.
    MGIi MGI:2653243. Col23a1.

    Phylogenomic databases

    eggNOGi NOG320189.
    GeneTreei ENSGT00750000117303.
    HOGENOMi HOG000085653.
    HOVERGENi HBG004933.
    InParanoidi Q8K4G2.
    OMAi IPGRKGV.
    OrthoDBi EOG7D59P1.
    PhylomeDBi Q8K4G2.
    TreeFami TF338175.

    Enzyme and pathway databases

    Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
    REACT_199055. Collagen degradation.
    REACT_216309. Integrin cell surface interactions.

    Miscellaneous databases

    NextBioi 383470.
    PROi Q8K4G2.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K4G2.
    Bgeei Q8K4G2.
    CleanExi MM_COL23A1.
    Genevestigatori Q8K4G2.

    Family and domain databases

    InterProi IPR008160. Collagen.
    [Graphical view ]
    Pfami PF01391. Collagen. 7 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Alpha 1(XXIII), a new member of the transmembrane collagens."
      Koch M., Jin W., Burgeson R.E.
      Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Tissue: Cartilage.
    2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
      Strain: C57BL/6J.

    Entry informationi

    Entry nameiCONA1_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4G2
    Secondary accession number(s): Q5SUQ0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: July 11, 2006
    Last sequence update: July 11, 2006
    Last modified: October 1, 2014
    This is version 85 of the entry and version 2 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3