Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8K4G2

- CONA1_MOUSE

UniProt

Q8K4G2 - CONA1_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

Collagen alpha-1(XXIII) chain

Gene

Col23a1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 2 out of 5- Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiREACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXIII) chain
Gene namesi
Name:Col23a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 11

Organism-specific databases

MGIiMGI:2653243. Col23a1.

Subcellular locationi

Cell membrane By similarity; Single-pass type II membrane protein By similarity; Extracellular side By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4522Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini46 – 532487ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. collagen trimer Source: UniProtKB-KW
  2. extracellular region Source: Reactome
  3. integral component of membrane Source: UniProtKB-KW
  4. plasma membrane Source: Reactome
Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Collagen alpha-1(XXIII) chainPRO_0000245227Add
BLAST

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.By similarity

Proteomic databases

PRIDEiQ8K4G2.

PTM databases

PhosphoSiteiQ8K4G2.

Expressioni

Gene expression databases

BgeeiQ8K4G2.
CleanExiMM_COL23A1.
ExpressionAtlasiQ8K4G2. baseline and differential.
GenevestigatoriQ8K4G2.

Interactioni

Subunit structurei

Homotrimer.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8K4G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 16659Collagen-like 1Add
BLAST
Domaini173 – 23260Collagen-like 2Add
BLAST
Domaini240 – 29859Collagen-like 3Add
BLAST
Domaini313 – 37260Collagen-like 4Add
BLAST
Domaini404 – 45249Collagen-like 5Add
BLAST
Domaini455 – 51460Collagen-like 6Add
BLAST

Sequence similaritiesi

Contains 6 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320189.
GeneTreeiENSGT00770000120541.
HOGENOMiHOG000085653.
HOVERGENiHBG004933.
InParanoidiQ8K4G2.
OMAiIPGRKGV.
OrthoDBiEOG7D59P1.
PhylomeDBiQ8K4G2.
TreeFamiTF338175.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4G2-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MGAGERAAGG GGAQDPGAGC GSRALSALCL LLSVGSAAAC LLLGAQAAAL
60 70 80 90 100
HGRVAALEQE RELLRHAGPS GALAAWAETH LERLLREKLD GVAKLRTVRE
110 120 130 140 150
APSECICPPG PPGRRGKPGR RGDPGPPGQS GRDGYPGPLG LDGKPGLPGP
160 170 180 190 200
KGEKGTPGDF GPRGAQGQDG VAGPPGPPGP PGARGPPGDT GKDGPRGAQG
210 220 230 240 250
PAGPRGEPGQ DGEMGPKGPP GPKGEPGIPG KKGDDGMANQ PGLPGPPGPK
260 270 280 290 300
GEPGDVGPRG ENGVDGIPGL KGEPGHPGVD GATGPRGAPG LKGEQGDTVV
310 320 330 340 350
IDYDGRILDA LKGPPGPQGA PGPPGIPGAK GELGLPGAPG IDGEKGPKGP
360 370 380 390 400
KGDPGEPGPA GPKGETGEMG LSGLPGADGP KGEKGESASD HLQESLAQII
410 420 430 440 450
VEPGPPGPPG PPGPMGLQGI QGPKGLDGAK GEKGTSGERG PHGLPGPVGP
460 470 480 490 500
PGLIGLPGTK GEKGRPGEPG LDGFPGPRGE KGDRSERGEK GERGVPGRKG
510 520 530
VKGQKGEPGP PGLDQPCPVG PDGLPVPGCW HK
Length:532
Mass (Da):51,476
Last modified:July 11, 2006 - v2
Checksum:i035E8538D5642486
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881A → P in AAN03649. 1 PublicationCurated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410792 mRNA. Translation: AAN03649.1.
AL645907, AL662843 Genomic DNA. Translation: CAI26117.1.
AL662843, AL645907 Genomic DNA. Translation: CAI35929.1.
CCDSiCCDS24652.1.
RefSeqiNP_700442.2. NM_153393.2.
UniGeneiMm.154093.

Genome annotation databases

EnsembliENSMUST00000102765; ENSMUSP00000099826; ENSMUSG00000063564.
GeneIDi237759.
KEGGimmu:237759.
UCSCiuc007itv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410792 mRNA. Translation: AAN03649.1 .
AL645907 , AL662843 Genomic DNA. Translation: CAI26117.1 .
AL662843 , AL645907 Genomic DNA. Translation: CAI35929.1 .
CCDSi CCDS24652.1.
RefSeqi NP_700442.2. NM_153393.2.
UniGenei Mm.154093.

3D structure databases

ProteinModelPortali Q8K4G2.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K4G2.

Proteomic databases

PRIDEi Q8K4G2.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000102765 ; ENSMUSP00000099826 ; ENSMUSG00000063564 .
GeneIDi 237759.
KEGGi mmu:237759.
UCSCi uc007itv.2. mouse.

Organism-specific databases

CTDi 91522.
MGIi MGI:2653243. Col23a1.

Phylogenomic databases

eggNOGi NOG320189.
GeneTreei ENSGT00770000120541.
HOGENOMi HOG000085653.
HOVERGENi HBG004933.
InParanoidi Q8K4G2.
OMAi IPGRKGV.
OrthoDBi EOG7D59P1.
PhylomeDBi Q8K4G2.
TreeFami TF338175.

Enzyme and pathway databases

Reactomei REACT_198984. Collagen biosynthesis and modifying enzymes.
REACT_199055. Collagen degradation.
REACT_216309. Integrin cell surface interactions.

Miscellaneous databases

NextBioi 383470.
PROi Q8K4G2.
SOURCEi Search...

Gene expression databases

Bgeei Q8K4G2.
CleanExi MM_COL23A1.
ExpressionAtlasi Q8K4G2. baseline and differential.
Genevestigatori Q8K4G2.

Family and domain databases

InterProi IPR008160. Collagen.
[Graphical view ]
Pfami PF01391. Collagen. 7 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "Alpha 1(XXIII), a new member of the transmembrane collagens."
    Koch M., Jin W., Burgeson R.E.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cartilage.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCONA1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4G2
Secondary accession number(s): Q5SUQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: November 26, 2014
This is version 87 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3