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Q8K4G2 (CONA1_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified July 9, 2014. Version 83. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
Collagen alpha-1(XXIII) chain
Gene names
Name:Col23a1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length532 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Subunit structure

Homotrimer By similarity.

Subcellular location

Cell membrane; Single-pass type II membrane protein; Extracellular side By similarity.

Post-translational modification

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin By similarity.

Sequence similarities

Contains 6 collagen-like domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 532532Collagen alpha-1(XXIII) chain
PRO_0000245227

Regions

Topological domain1 – 2323Cytoplasmic Potential
Transmembrane24 – 4522Helical; Signal-anchor for type II membrane protein; Potential
Topological domain46 – 532487Extracellular Potential
Domain108 – 16659Collagen-like 1
Domain173 – 23260Collagen-like 2
Domain240 – 29859Collagen-like 3
Domain313 – 37260Collagen-like 4
Domain404 – 45249Collagen-like 5
Domain455 – 51460Collagen-like 6

Experimental info

Sequence conflict2881A → P in AAN03649. Ref.1

Sequences

Sequence LengthMass (Da)Tools
Q8K4G2 [UniParc].

Last modified July 11, 2006. Version 2.
Checksum: 035E8538D5642486

FASTA53251,476
        10         20         30         40         50         60 
MGAGERAAGG GGAQDPGAGC GSRALSALCL LLSVGSAAAC LLLGAQAAAL HGRVAALEQE 

        70         80         90        100        110        120 
RELLRHAGPS GALAAWAETH LERLLREKLD GVAKLRTVRE APSECICPPG PPGRRGKPGR 

       130        140        150        160        170        180 
RGDPGPPGQS GRDGYPGPLG LDGKPGLPGP KGEKGTPGDF GPRGAQGQDG VAGPPGPPGP 

       190        200        210        220        230        240 
PGARGPPGDT GKDGPRGAQG PAGPRGEPGQ DGEMGPKGPP GPKGEPGIPG KKGDDGMANQ 

       250        260        270        280        290        300 
PGLPGPPGPK GEPGDVGPRG ENGVDGIPGL KGEPGHPGVD GATGPRGAPG LKGEQGDTVV 

       310        320        330        340        350        360 
IDYDGRILDA LKGPPGPQGA PGPPGIPGAK GELGLPGAPG IDGEKGPKGP KGDPGEPGPA 

       370        380        390        400        410        420 
GPKGETGEMG LSGLPGADGP KGEKGESASD HLQESLAQII VEPGPPGPPG PPGPMGLQGI 

       430        440        450        460        470        480 
QGPKGLDGAK GEKGTSGERG PHGLPGPVGP PGLIGLPGTK GEKGRPGEPG LDGFPGPRGE 

       490        500        510        520        530 
KGDRSERGEK GERGVPGRKG VKGQKGEPGP PGLDQPCPVG PDGLPVPGCW HK 

« Hide

References

« Hide 'large scale' references
[1]"Alpha 1(XXIII), a new member of the transmembrane collagens."
Koch M., Jin W., Burgeson R.E.
Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Tissue: Cartilage.
[2]"Lineage-specific biology revealed by a finished genome assembly of the mouse."
Church D.M., Goodstadt L., Hillier L.W., Zody M.C., Goldstein S., She X., Bult C.J., Agarwala R., Cherry J.L., DiCuccio M., Hlavina W., Kapustin Y., Meric P., Maglott D., Birtle Z., Marques A.C., Graves T., Zhou S. expand/collapse author list , Teague B., Potamousis K., Churas C., Place M., Herschleb J., Runnheim R., Forrest D., Amos-Landgraf J., Schwartz D.C., Cheng Z., Lindblad-Toh K., Eichler E.E., Ponting C.P.
PLoS Biol. 7:E1000112-E1000112(2009) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
Strain: C57BL/6J.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF410792 mRNA. Translation: AAN03649.1.
AL645907, AL662843 Genomic DNA. Translation: CAI26117.1.
AL662843, AL645907 Genomic DNA. Translation: CAI35929.1.
CCDSCCDS24652.1.
RefSeqNP_700442.2. NM_153393.2.
UniGeneMm.154093.

3D structure databases

ProteinModelPortalQ8K4G2.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K4G2.

Proteomic databases

PRIDEQ8K4G2.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000102765; ENSMUSP00000099826; ENSMUSG00000063564.
GeneID237759.
KEGGmmu:237759.
UCSCuc007itv.2. mouse.

Organism-specific databases

CTD91522.
MGIMGI:2653243. Col23a1.

Phylogenomic databases

eggNOGNOG320189.
GeneTreeENSGT00750000117303.
HOGENOMHOG000085653.
HOVERGENHBG004933.
InParanoidQ8K4G2.
OMAIPGRKGV.
OrthoDBEOG7D59P1.
PhylomeDBQ8K4G2.
TreeFamTF338175.

Enzyme and pathway databases

ReactomeREACT_206066. Extracellular matrix organization.

Gene expression databases

ArrayExpressQ8K4G2.
BgeeQ8K4G2.
CleanExMM_COL23A1.
GenevestigatorQ8K4G2.

Family and domain databases

InterProIPR008160. Collagen.
[Graphical view]
PfamPF01391. Collagen. 7 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio383470.
PROQ8K4G2.
SOURCESearch...

Entry information

Entry nameCONA1_MOUSE
AccessionPrimary (citable) accession number: Q8K4G2
Secondary accession number(s): Q5SUQ0
Entry history
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: July 9, 2014
This is version 83 of the entry and version 2 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot