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Protein

Collagen alpha-1(XXIII) chain

Gene

Col23a1

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 2 out of 5-Experimental evidence at transcript leveli

Functioni

Enzyme and pathway databases

ReactomeiREACT_285754. Collagen biosynthesis and modifying enzymes.
REACT_313067. Collagen degradation.
REACT_319261. Integrin cell surface interactions.

Names & Taxonomyi

Protein namesi
Recommended name:
Collagen alpha-1(XXIII) chain
Gene namesi
Name:Col23a1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589 Componenti: Chromosome 11

Organism-specific databases

MGIiMGI:2653243. Col23a1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini1 – 2323CytoplasmicSequence AnalysisAdd
BLAST
Transmembranei24 – 4522Helical; Signal-anchor for type II membrane proteinSequence AnalysisAdd
BLAST
Topological domaini46 – 532487ExtracellularSequence AnalysisAdd
BLAST

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 532532Collagen alpha-1(XXIII) chainPRO_0000245227Add
BLAST

Post-translational modificationi

Undergoes proteolytic cleavage by furin protease to yield a 60 kDa soluble form that forms a homotrimer and exhibits a low affinity interaction with heparin.By similarity

Proteomic databases

PRIDEiQ8K4G2.

PTM databases

PhosphoSiteiQ8K4G2.

Expressioni

Gene expression databases

BgeeiQ8K4G2.
CleanExiMM_COL23A1.
ExpressionAtlasiQ8K4G2. baseline and differential.
GenevisibleiQ8K4G2. MM.

Interactioni

Subunit structurei

Homotrimer.By similarity

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099826.

Structurei

3D structure databases

ProteinModelPortaliQ8K4G2.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini108 – 16659Collagen-like 1Add
BLAST
Domaini173 – 23260Collagen-like 2Add
BLAST
Domaini240 – 29859Collagen-like 3Add
BLAST
Domaini313 – 37260Collagen-like 4Add
BLAST
Domaini404 – 45249Collagen-like 5Add
BLAST
Domaini455 – 51460Collagen-like 6Add
BLAST

Sequence similaritiesi

Contains 6 collagen-like domains.Curated

Keywords - Domaini

Collagen, Repeat, Signal-anchor, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG320189.
GeneTreeiENSGT00780000121854.
HOGENOMiHOG000085653.
HOVERGENiHBG004933.
InParanoidiQ8K4G2.
OMAiIPGRKGV.
OrthoDBiEOG7D59P1.
PhylomeDBiQ8K4G2.
TreeFamiTF338175.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 7 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4G2-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MGAGERAAGG GGAQDPGAGC GSRALSALCL LLSVGSAAAC LLLGAQAAAL
60 70 80 90 100
HGRVAALEQE RELLRHAGPS GALAAWAETH LERLLREKLD GVAKLRTVRE
110 120 130 140 150
APSECICPPG PPGRRGKPGR RGDPGPPGQS GRDGYPGPLG LDGKPGLPGP
160 170 180 190 200
KGEKGTPGDF GPRGAQGQDG VAGPPGPPGP PGARGPPGDT GKDGPRGAQG
210 220 230 240 250
PAGPRGEPGQ DGEMGPKGPP GPKGEPGIPG KKGDDGMANQ PGLPGPPGPK
260 270 280 290 300
GEPGDVGPRG ENGVDGIPGL KGEPGHPGVD GATGPRGAPG LKGEQGDTVV
310 320 330 340 350
IDYDGRILDA LKGPPGPQGA PGPPGIPGAK GELGLPGAPG IDGEKGPKGP
360 370 380 390 400
KGDPGEPGPA GPKGETGEMG LSGLPGADGP KGEKGESASD HLQESLAQII
410 420 430 440 450
VEPGPPGPPG PPGPMGLQGI QGPKGLDGAK GEKGTSGERG PHGLPGPVGP
460 470 480 490 500
PGLIGLPGTK GEKGRPGEPG LDGFPGPRGE KGDRSERGEK GERGVPGRKG
510 520 530
VKGQKGEPGP PGLDQPCPVG PDGLPVPGCW HK
Length:532
Mass (Da):51,476
Last modified:July 11, 2006 - v2
Checksum:i035E8538D5642486
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti288 – 2881A → P in AAN03649 (Ref. 1) Curated

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410792 mRNA. Translation: AAN03649.1.
AL645907, AL662843 Genomic DNA. Translation: CAI26117.1.
AL662843, AL645907 Genomic DNA. Translation: CAI35929.1.
CCDSiCCDS24652.1.
RefSeqiNP_700442.2. NM_153393.2.
UniGeneiMm.154093.

Genome annotation databases

EnsembliENSMUST00000102765; ENSMUSP00000099826; ENSMUSG00000063564.
GeneIDi237759.
KEGGimmu:237759.
UCSCiuc007itv.2. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF410792 mRNA. Translation: AAN03649.1.
AL645907, AL662843 Genomic DNA. Translation: CAI26117.1.
AL662843, AL645907 Genomic DNA. Translation: CAI35929.1.
CCDSiCCDS24652.1.
RefSeqiNP_700442.2. NM_153393.2.
UniGeneiMm.154093.

3D structure databases

ProteinModelPortaliQ8K4G2.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000099826.

PTM databases

PhosphoSiteiQ8K4G2.

Proteomic databases

PRIDEiQ8K4G2.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000102765; ENSMUSP00000099826; ENSMUSG00000063564.
GeneIDi237759.
KEGGimmu:237759.
UCSCiuc007itv.2. mouse.

Organism-specific databases

CTDi91522.
MGIiMGI:2653243. Col23a1.

Phylogenomic databases

eggNOGiNOG320189.
GeneTreeiENSGT00780000121854.
HOGENOMiHOG000085653.
HOVERGENiHBG004933.
InParanoidiQ8K4G2.
OMAiIPGRKGV.
OrthoDBiEOG7D59P1.
PhylomeDBiQ8K4G2.
TreeFamiTF338175.

Enzyme and pathway databases

ReactomeiREACT_285754. Collagen biosynthesis and modifying enzymes.
REACT_313067. Collagen degradation.
REACT_319261. Integrin cell surface interactions.

Miscellaneous databases

NextBioi383470.
PROiQ8K4G2.
SOURCEiSearch...

Gene expression databases

BgeeiQ8K4G2.
CleanExiMM_COL23A1.
ExpressionAtlasiQ8K4G2. baseline and differential.
GenevisibleiQ8K4G2. MM.

Family and domain databases

InterProiIPR008160. Collagen.
[Graphical view]
PfamiPF01391. Collagen. 7 hits.
[Graphical view]
ProtoNetiSearch...

Publicationsi

« Hide 'large scale' publications
  1. "Alpha 1(XXIII), a new member of the transmembrane collagens."
    Koch M., Jin W., Burgeson R.E.
    Submitted (AUG-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Tissue: Cartilage.
  2. Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE GENOMIC DNA].
    Strain: C57BL/6J.

Entry informationi

Entry nameiCONA1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4G2
Secondary accession number(s): Q5SUQ0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: July 11, 2006
Last sequence update: July 11, 2006
Last modified: June 24, 2015
This is version 91 of the entry and version 2 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.