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Q8K4F0 (CD226_MOUSE) Reviewed, UniProtKB/Swiss-Prot

Last modified April 16, 2014. Version 86. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (2) | Third-party data text xml rdf/xml gff fasta
to top of pageNames·Attributes·General annotation·Ontologies·Sequence annotation·Sequences·References·Cross-refs·Entry info·DocumentsCustomize order

Names and origin

Protein namesRecommended name:
CD226 antigen
Alternative name(s):
Platelet and T-cell activation antigen 1
CD_antigen=CD226
Gene names
Name:Cd226
Synonyms:Pta1
OrganismMus musculus (Mouse) [Reference proteome]
Taxonomic identifier10090 [NCBI]
Taxonomic lineageEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus

Protein attributes

Sequence length333 AA.
Sequence statusComplete.
Sequence processingThe displayed sequence is further processed into a mature form.
Protein existenceEvidence at transcript level

General annotation (Comments)

Function

Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell By similarity.

Subunit structure

Interacts with PVR and PVRL2 By similarity.

Subcellular location

Membrane; Single-pass type I membrane protein Potential.

Post-translational modification

Phosphorylated By similarity.

Sequence similarities

Contains 2 Ig-like C2-type (immunoglobulin-like) domains.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Signal peptide1 – 1818 Potential
Chain19 – 333315CD226 antigen
PRO_0000014667

Regions

Topological domain19 – 254236Extracellular Potential
Transmembrane255 – 27521Helical; Potential
Topological domain276 – 33358Cytoplasmic Potential
Domain19 – 127109Ig-like C2-type 1
Domain136 – 237102Ig-like C2-type 2

Amino acid modifications

Modified residue3191Phosphotyrosine By similarity
Glycosylation441N-linked (GlcNAc...) Potential
Glycosylation841N-linked (GlcNAc...) Potential
Glycosylation911N-linked (GlcNAc...) Potential
Glycosylation981N-linked (GlcNAc...) Potential
Glycosylation1811N-linked (GlcNAc...) Potential
Glycosylation1991N-linked (GlcNAc...) Potential
Glycosylation2331N-linked (GlcNAc...) Potential
Disulfide bond37 ↔ 109 Potential
Disulfide bond153 ↔ 224 Potential

Sequences

Sequence LengthMass (Da)Tools
Q8K4F0 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: ACDE524D0F475C97

FASTA33338,063
        10         20         30         40         50         60 
MAYVTWLLAI LHVHKALCEE TLWDTTVRLS ETMTLECVYP LTHNLTQVEW TKNTGTKTVS 

        70         80         90        100        110        120 
IAVYNPNHNM HIESNYLHRV HFLNSTVGFR NMSLSFYNAS EADIGIYSCL FHAFPNGPWE 

       130        140        150        160        170        180 
KKIKVVWSDS FEIAAPSDSY LSAEPGQDVT LTCQLPRTWP VQQVIWEKVQ PHQVDILASC 

       190        200        210        220        230        240 
NLSQETRYTS KYLRQTRSNC SQGSMKSILI IPNAMAADSG LYRCRSEAIT GKNKSFVIRL 

       250        260        270        280        290        300 
IITDGGTNKH FILPIVGGLV SLLLVILIII IFILYNRKRR RQVRIPLKEP RDKQSKVATN 

       310        320        330 
CRSPTSPIQS TDDEKEDIYV NYPTFSRRPK PRL 

« Hide

References

[1]"Gene cloning and characterization of mouse platelet and T cell activation antigen 1 (PTA1/CD226)."
Jin B., Zhang X., Li D., Ouyang W., Jia W., Chen L., Xie X., Ning S., Zhang Y.
Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
Cited for: NUCLEOTIDE SEQUENCE [MRNA].
Strain: BALB/c.
Tissue: Thymus.
+Additional computationally mapped references.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ
AF416980 mRNA. Translation: AAN04295.1.
RefSeqNP_848802.2. NM_178687.2.
XP_006526525.1. XM_006526462.1.
UniGeneMm.139293.

3D structure databases

ProteinModelPortalQ8K4F0.
SMRQ8K4F0. Positions 45-167, 208-233.
ModBaseSearch...
MobiDBSearch...

PTM databases

PhosphoSiteQ8K4F0.

Proteomic databases

PaxDbQ8K4F0.
PRIDEQ8K4F0.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSMUST00000037142; ENSMUSP00000043551; ENSMUSG00000034028.
GeneID225825.
KEGGmmu:225825.
UCSCuc008fvo.1. mouse.

Organism-specific databases

CTD10666.
MGIMGI:3039602. Cd226.

Phylogenomic databases

eggNOGNOG41580.
GeneTreeENSGT00500000044993.
HOGENOMHOG000059567.
HOVERGENHBG050849.
InParanoidQ8K4F0.
KOK06567.
OMAEDIYVNY.
OrthoDBEOG79CZ0G.
PhylomeDBQ8K4F0.
TreeFamTF336260.

Gene expression databases

ArrayExpressQ8K4F0.
BgeeQ8K4F0.
CleanExMM_CD226.
GenevestigatorQ8K4F0.

Family and domain databases

Gene3D2.60.40.10. 2 hits.
InterProIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamPF07686. V-set. 2 hits.
[Graphical view]
SMARTSM00409. IG. 2 hits.
[Graphical view]
PROSITEPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetSearch...

Other

NextBio377801.
PROQ8K4F0.
SOURCESearch...

Entry information

Entry nameCD226_MOUSE
AccessionPrimary (citable) accession number: Q8K4F0
Entry history
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: April 16, 2014
This is version 86 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

MGD cross-references

Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot