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Q8K4F0

- CD226_MOUSE

UniProt

Q8K4F0 - CD226_MOUSE

Protein

CD226 antigen

Gene

Cd226

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 90 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.By similarity

    GO - Molecular functioni

    1. protein binding Source: MGI

    GO - Biological processi

    1. cell adhesion Source: UniProtKB-KW
    2. cytokine production Source: MGI
    3. positive regulation of Fc receptor mediated stimulatory signaling pathway Source: Ensembl
    4. positive regulation of immunoglobulin mediated immune response Source: Ensembl
    5. positive regulation of mast cell activation Source: Ensembl
    6. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: Ensembl

    Keywords - Molecular functioni

    Receptor

    Keywords - Biological processi

    Cell adhesion

    Enzyme and pathway databases

    ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    CD226 antigen
    Alternative name(s):
    Platelet and T-cell activation antigen 1
    CD_antigen: CD226
    Gene namesi
    Name:Cd226
    Synonyms:Pta1
    OrganismiMus musculus (Mouse)
    Taxonomic identifieri10090 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
    ProteomesiUP000000589: Chromosome 18

    Organism-specific databases

    MGIiMGI:3039602. Cd226.

    Subcellular locationi

    GO - Cellular componenti

    1. external side of plasma membrane Source: MGI
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Membrane

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Signal peptidei1 – 1818Sequence AnalysisAdd
    BLAST
    Chaini19 – 333315CD226 antigenPRO_0000014667Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Disulfide bondi37 ↔ 109PROSITE-ProRule annotation
    Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
    Disulfide bondi153 ↔ 224PROSITE-ProRule annotation
    Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
    Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
    Modified residuei319 – 3191PhosphotyrosineBy similarity

    Post-translational modificationi

    Phosphorylated.By similarity

    Keywords - PTMi

    Disulfide bond, Glycoprotein, Phosphoprotein

    Proteomic databases

    PaxDbiQ8K4F0.
    PRIDEiQ8K4F0.

    PTM databases

    PhosphoSiteiQ8K4F0.

    Expressioni

    Gene expression databases

    ArrayExpressiQ8K4F0.
    BgeeiQ8K4F0.
    CleanExiMM_CD226.
    GenevestigatoriQ8K4F0.

    Interactioni

    Subunit structurei

    Interacts with PVR and PVRL2.By similarity

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4F0.
    SMRiQ8K4F0. Positions 45-167.
    ModBaseiSearch...
    MobiDBiSearch...

    Topological domain

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Topological domaini19 – 254236ExtracellularSequence AnalysisAdd
    BLAST
    Topological domaini276 – 33358CytoplasmicSequence AnalysisAdd
    BLAST

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei255 – 27521HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Domains and Repeats

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Domaini19 – 127109Ig-like C2-type 1Add
    BLAST
    Domaini136 – 237102Ig-like C2-type 2Add
    BLAST

    Sequence similaritiesi

    Keywords - Domaini

    Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiNOG41580.
    GeneTreeiENSGT00500000044993.
    HOGENOMiHOG000059567.
    HOVERGENiHBG050849.
    InParanoidiQ8K4F0.
    KOiK06567.
    OMAiEDIYVNY.
    OrthoDBiEOG79CZ0G.
    PhylomeDBiQ8K4F0.
    TreeFamiTF336260.

    Family and domain databases

    Gene3Di2.60.40.10. 2 hits.
    InterProiIPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view]
    PfamiPF07686. V-set. 2 hits.
    [Graphical view]
    SMARTiSM00409. IG. 2 hits.
    [Graphical view]
    PROSITEiPS50835. IG_LIKE. 2 hits.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K4F0-1 [UniParc]FASTAAdd to Basket

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    MAYVTWLLAI LHVHKALCEE TLWDTTVRLS ETMTLECVYP LTHNLTQVEW    50
    TKNTGTKTVS IAVYNPNHNM HIESNYLHRV HFLNSTVGFR NMSLSFYNAS 100
    EADIGIYSCL FHAFPNGPWE KKIKVVWSDS FEIAAPSDSY LSAEPGQDVT 150
    LTCQLPRTWP VQQVIWEKVQ PHQVDILASC NLSQETRYTS KYLRQTRSNC 200
    SQGSMKSILI IPNAMAADSG LYRCRSEAIT GKNKSFVIRL IITDGGTNKH 250
    FILPIVGGLV SLLLVILIII IFILYNRKRR RQVRIPLKEP RDKQSKVATN 300
    CRSPTSPIQS TDDEKEDIYV NYPTFSRRPK PRL 333
    Length:333
    Mass (Da):38,063
    Last modified:October 1, 2002 - v1
    Checksum:iACDE524D0F475C97
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF416980 mRNA. Translation: AAN04295.1.
    CCDSiCCDS29392.1.
    RefSeqiNP_848802.2. NM_178687.2.
    XP_006526525.1. XM_006526462.1.
    UniGeneiMm.139293.

    Genome annotation databases

    EnsembliENSMUST00000037142; ENSMUSP00000043551; ENSMUSG00000034028.
    GeneIDi225825.
    KEGGimmu:225825.
    UCSCiuc008fvo.1. mouse.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF416980 mRNA. Translation: AAN04295.1 .
    CCDSi CCDS29392.1.
    RefSeqi NP_848802.2. NM_178687.2.
    XP_006526525.1. XM_006526462.1.
    UniGenei Mm.139293.

    3D structure databases

    ProteinModelPortali Q8K4F0.
    SMRi Q8K4F0. Positions 45-167.
    ModBasei Search...
    MobiDBi Search...

    PTM databases

    PhosphoSitei Q8K4F0.

    Proteomic databases

    PaxDbi Q8K4F0.
    PRIDEi Q8K4F0.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSMUST00000037142 ; ENSMUSP00000043551 ; ENSMUSG00000034028 .
    GeneIDi 225825.
    KEGGi mmu:225825.
    UCSCi uc008fvo.1. mouse.

    Organism-specific databases

    CTDi 10666.
    MGIi MGI:3039602. Cd226.

    Phylogenomic databases

    eggNOGi NOG41580.
    GeneTreei ENSGT00500000044993.
    HOGENOMi HOG000059567.
    HOVERGENi HBG050849.
    InParanoidi Q8K4F0.
    KOi K06567.
    OMAi EDIYVNY.
    OrthoDBi EOG79CZ0G.
    PhylomeDBi Q8K4F0.
    TreeFami TF336260.

    Enzyme and pathway databases

    Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

    Miscellaneous databases

    NextBioi 377801.
    PROi Q8K4F0.
    SOURCEi Search...

    Gene expression databases

    ArrayExpressi Q8K4F0.
    Bgeei Q8K4F0.
    CleanExi MM_CD226.
    Genevestigatori Q8K4F0.

    Family and domain databases

    Gene3Di 2.60.40.10. 2 hits.
    InterProi IPR007110. Ig-like_dom.
    IPR013783. Ig-like_fold.
    IPR003599. Ig_sub.
    IPR013106. Ig_V-set.
    [Graphical view ]
    Pfami PF07686. V-set. 2 hits.
    [Graphical view ]
    SMARTi SM00409. IG. 2 hits.
    [Graphical view ]
    PROSITEi PS50835. IG_LIKE. 2 hits.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Gene cloning and characterization of mouse platelet and T cell activation antigen 1 (PTA1/CD226)."
      Jin B., Zhang X., Li D., Ouyang W., Jia W., Chen L., Xie X., Ning S., Zhang Y.
      Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: BALB/c.
      Tissue: Thymus.

    Entry informationi

    Entry nameiCD226_MOUSE
    AccessioniPrimary (citable) accession number: Q8K4F0
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: May 24, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 90 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. MGD cross-references
      Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3