Skip Header

You are using a version of browser that may not display all the features of this website. Please consider upgrading your browser.

Q8K4F0

- CD226_MOUSE

UniProt

Q8K4F0 - CD226_MOUSE

(max 400 entries)x

Your basket is currently empty.

Select item(s) and click on "Add to basket" to create your own collection here
(400 entries max)

Protein

CD226 antigen

Gene

Cd226

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli

Functioni

Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell.By similarity

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cytokine production Source: MGI
  3. positive regulation of Fc receptor mediated stimulatory signaling pathway Source: Ensembl
  4. positive regulation of immunoglobulin mediated immune response Source: Ensembl
  5. positive regulation of mast cell activation Source: Ensembl
  6. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD226 antigen
Alternative name(s):
Platelet and T-cell activation antigen 1
CD_antigen: CD226
Gene namesi
Name:Cd226
Synonyms:Pta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:3039602. Cd226.

Subcellular locationi

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818Sequence AnalysisAdd
BLAST
Chaini19 – 333315CD226 antigenPRO_0000014667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 109PROSITE-ProRule annotation
Glycosylationi44 – 441N-linked (GlcNAc...)Sequence Analysis
Glycosylationi84 – 841N-linked (GlcNAc...)Sequence Analysis
Glycosylationi91 – 911N-linked (GlcNAc...)Sequence Analysis
Glycosylationi98 – 981N-linked (GlcNAc...)Sequence Analysis
Disulfide bondi153 ↔ 224PROSITE-ProRule annotation
Glycosylationi181 – 1811N-linked (GlcNAc...)Sequence Analysis
Glycosylationi199 – 1991N-linked (GlcNAc...)Sequence Analysis
Glycosylationi233 – 2331N-linked (GlcNAc...)Sequence Analysis
Modified residuei319 – 3191PhosphotyrosineBy similarity

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8K4F0.
PRIDEiQ8K4F0.

PTM databases

PhosphoSiteiQ8K4F0.

Expressioni

Gene expression databases

BgeeiQ8K4F0.
CleanExiMM_CD226.
ExpressionAtlasiQ8K4F0. baseline and differential.
GenevestigatoriQ8K4F0.

Interactioni

Subunit structurei

Interacts with PVR and PVRL2.By similarity

Structurei

3D structure databases

ProteinModelPortaliQ8K4F0.
SMRiQ8K4F0. Positions 33-244.
ModBaseiSearch...
MobiDBiSearch...

Topological domain

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 254236ExtracellularSequence AnalysisAdd
BLAST
Topological domaini276 – 33358CytoplasmicSequence AnalysisAdd
BLAST

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei255 – 27521HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 127109Ig-like C2-type 1Add
BLAST
Domaini136 – 237102Ig-like C2-type 2Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41580.
GeneTreeiENSGT00500000044993.
HOGENOMiHOG000059567.
HOVERGENiHBG050849.
InParanoidiQ8K4F0.
KOiK06567.
OMAiEDIYVNY.
OrthoDBiEOG79CZ0G.
PhylomeDBiQ8K4F0.
TreeFamiTF336260.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4F0-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MAYVTWLLAI LHVHKALCEE TLWDTTVRLS ETMTLECVYP LTHNLTQVEW
60 70 80 90 100
TKNTGTKTVS IAVYNPNHNM HIESNYLHRV HFLNSTVGFR NMSLSFYNAS
110 120 130 140 150
EADIGIYSCL FHAFPNGPWE KKIKVVWSDS FEIAAPSDSY LSAEPGQDVT
160 170 180 190 200
LTCQLPRTWP VQQVIWEKVQ PHQVDILASC NLSQETRYTS KYLRQTRSNC
210 220 230 240 250
SQGSMKSILI IPNAMAADSG LYRCRSEAIT GKNKSFVIRL IITDGGTNKH
260 270 280 290 300
FILPIVGGLV SLLLVILIII IFILYNRKRR RQVRIPLKEP RDKQSKVATN
310 320 330
CRSPTSPIQS TDDEKEDIYV NYPTFSRRPK PRL
Length:333
Mass (Da):38,063
Last modified:October 1, 2002 - v1
Checksum:iACDE524D0F475C97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416980 mRNA. Translation: AAN04295.1.
CCDSiCCDS29392.1.
RefSeqiNP_848802.2. NM_178687.2.
XP_006526525.1. XM_006526462.1.
UniGeneiMm.139293.

Genome annotation databases

EnsembliENSMUST00000037142; ENSMUSP00000043551; ENSMUSG00000034028.
GeneIDi225825.
KEGGimmu:225825.
UCSCiuc008fvo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416980 mRNA. Translation: AAN04295.1 .
CCDSi CCDS29392.1.
RefSeqi NP_848802.2. NM_178687.2.
XP_006526525.1. XM_006526462.1.
UniGenei Mm.139293.

3D structure databases

ProteinModelPortali Q8K4F0.
SMRi Q8K4F0. Positions 33-244.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K4F0.

Proteomic databases

PaxDbi Q8K4F0.
PRIDEi Q8K4F0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037142 ; ENSMUSP00000043551 ; ENSMUSG00000034028 .
GeneIDi 225825.
KEGGi mmu:225825.
UCSCi uc008fvo.1. mouse.

Organism-specific databases

CTDi 10666.
MGIi MGI:3039602. Cd226.

Phylogenomic databases

eggNOGi NOG41580.
GeneTreei ENSGT00500000044993.
HOGENOMi HOG000059567.
HOVERGENi HBG050849.
InParanoidi Q8K4F0.
KOi K06567.
OMAi EDIYVNY.
OrthoDBi EOG79CZ0G.
PhylomeDBi Q8K4F0.
TreeFami TF336260.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

NextBioi 377801.
PROi Q8K4F0.
SOURCEi Search...

Gene expression databases

Bgeei Q8K4F0.
CleanExi MM_CD226.
ExpressionAtlasi Q8K4F0. baseline and differential.
Genevestigatori Q8K4F0.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 2 hits.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene cloning and characterization of mouse platelet and T cell activation antigen 1 (PTA1/CD226)."
    Jin B., Zhang X., Li D., Ouyang W., Jia W., Chen L., Xie X., Ning S., Zhang Y.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Thymus.

Entry informationi

Entry nameiCD226_MOUSE
AccessioniPrimary (citable) accession number: Q8K4F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 91 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3