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Q8K4F0

- CD226_MOUSE

UniProt

Q8K4F0 - CD226_MOUSE

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Protein
CD226 antigen
Gene
Cd226, Pta1
Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Receptor involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell By similarity.

GO - Molecular functioni

  1. protein binding Source: MGI
Complete GO annotation...

GO - Biological processi

  1. cell adhesion Source: UniProtKB-KW
  2. cytokine production Source: MGI
  3. positive regulation of Fc receptor mediated stimulatory signaling pathway Source: Ensembl
  4. positive regulation of immunoglobulin mediated immune response Source: Ensembl
  5. positive regulation of mast cell activation Source: Ensembl
  6. positive regulation of natural killer cell mediated cytotoxicity directed against tumor cell target Source: Ensembl
Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiREACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD226 antigen
Alternative name(s):
Platelet and T-cell activation antigen 1
CD_antigen: CD226
Gene namesi
Name:Cd226
Synonyms:Pta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 18

Organism-specific databases

MGIiMGI:3039602. Cd226.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Topological domaini19 – 254236Extracellular Reviewed prediction
Add
BLAST
Transmembranei255 – 27521Helical; Reviewed prediction
Add
BLAST
Topological domaini276 – 33358Cytoplasmic Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. external side of plasma membrane Source: MGI
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Signal peptidei1 – 1818 Reviewed prediction
Add
BLAST
Chaini19 – 333315CD226 antigen
PRO_0000014667Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Disulfide bondi37 ↔ 109 Reviewed prediction
Glycosylationi44 – 441N-linked (GlcNAc...) Reviewed prediction
Glycosylationi84 – 841N-linked (GlcNAc...) Reviewed prediction
Glycosylationi91 – 911N-linked (GlcNAc...) Reviewed prediction
Glycosylationi98 – 981N-linked (GlcNAc...) Reviewed prediction
Disulfide bondi153 ↔ 224 Reviewed prediction
Glycosylationi181 – 1811N-linked (GlcNAc...) Reviewed prediction
Glycosylationi199 – 1991N-linked (GlcNAc...) Reviewed prediction
Glycosylationi233 – 2331N-linked (GlcNAc...) Reviewed prediction
Modified residuei319 – 3191Phosphotyrosine By similarity

Post-translational modificationi

Phosphorylated By similarity.

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

PaxDbiQ8K4F0.
PRIDEiQ8K4F0.

PTM databases

PhosphoSiteiQ8K4F0.

Expressioni

Gene expression databases

ArrayExpressiQ8K4F0.
BgeeiQ8K4F0.
CleanExiMM_CD226.
GenevestigatoriQ8K4F0.

Interactioni

Subunit structurei

Interacts with PVR and PVRL2 By similarity.

Structurei

3D structure databases

ProteinModelPortaliQ8K4F0.
SMRiQ8K4F0. Positions 45-167.

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini19 – 127109Ig-like C2-type 1
Add
BLAST
Domaini136 – 237102Ig-like C2-type 2
Add
BLAST

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiNOG41580.
GeneTreeiENSGT00500000044993.
HOGENOMiHOG000059567.
HOVERGENiHBG050849.
InParanoidiQ8K4F0.
KOiK06567.
OMAiEDIYVNY.
OrthoDBiEOG79CZ0G.
PhylomeDBiQ8K4F0.
TreeFamiTF336260.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4F0-1 [UniParc]FASTAAdd to Basket

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MAYVTWLLAI LHVHKALCEE TLWDTTVRLS ETMTLECVYP LTHNLTQVEW    50
TKNTGTKTVS IAVYNPNHNM HIESNYLHRV HFLNSTVGFR NMSLSFYNAS 100
EADIGIYSCL FHAFPNGPWE KKIKVVWSDS FEIAAPSDSY LSAEPGQDVT 150
LTCQLPRTWP VQQVIWEKVQ PHQVDILASC NLSQETRYTS KYLRQTRSNC 200
SQGSMKSILI IPNAMAADSG LYRCRSEAIT GKNKSFVIRL IITDGGTNKH 250
FILPIVGGLV SLLLVILIII IFILYNRKRR RQVRIPLKEP RDKQSKVATN 300
CRSPTSPIQS TDDEKEDIYV NYPTFSRRPK PRL 333
Length:333
Mass (Da):38,063
Last modified:October 1, 2002 - v1
Checksum:iACDE524D0F475C97
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416980 mRNA. Translation: AAN04295.1.
CCDSiCCDS29392.1.
RefSeqiNP_848802.2. NM_178687.2.
XP_006526525.1. XM_006526462.1.
UniGeneiMm.139293.

Genome annotation databases

EnsembliENSMUST00000037142; ENSMUSP00000043551; ENSMUSG00000034028.
GeneIDi225825.
KEGGimmu:225825.
UCSCiuc008fvo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF416980 mRNA. Translation: AAN04295.1 .
CCDSi CCDS29392.1.
RefSeqi NP_848802.2. NM_178687.2.
XP_006526525.1. XM_006526462.1.
UniGenei Mm.139293.

3D structure databases

ProteinModelPortali Q8K4F0.
SMRi Q8K4F0. Positions 45-167.
ModBasei Search...

PTM databases

PhosphoSitei Q8K4F0.

Proteomic databases

PaxDbi Q8K4F0.
PRIDEi Q8K4F0.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000037142 ; ENSMUSP00000043551 ; ENSMUSG00000034028 .
GeneIDi 225825.
KEGGi mmu:225825.
UCSCi uc008fvo.1. mouse.

Organism-specific databases

CTDi 10666.
MGIi MGI:3039602. Cd226.

Phylogenomic databases

eggNOGi NOG41580.
GeneTreei ENSGT00500000044993.
HOGENOMi HOG000059567.
HOVERGENi HBG050849.
InParanoidi Q8K4F0.
KOi K06567.
OMAi EDIYVNY.
OrthoDBi EOG79CZ0G.
PhylomeDBi Q8K4F0.
TreeFami TF336260.

Enzyme and pathway databases

Reactomei REACT_202937. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

NextBioi 377801.
PROi Q8K4F0.
SOURCEi Search...

Gene expression databases

ArrayExpressi Q8K4F0.
Bgeei Q8K4F0.
CleanExi MM_CD226.
Genevestigatori Q8K4F0.

Family and domain databases

Gene3Di 2.60.40.10. 2 hits.
InterProi IPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view ]
Pfami PF07686. V-set. 2 hits.
[Graphical view ]
SMARTi SM00409. IG. 2 hits.
[Graphical view ]
PROSITEi PS50835. IG_LIKE. 2 hits.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Gene cloning and characterization of mouse platelet and T cell activation antigen 1 (PTA1/CD226)."
    Jin B., Zhang X., Li D., Ouyang W., Jia W., Chen L., Xie X., Ning S., Zhang Y.
    Submitted (SEP-2001) to the EMBL/GenBank/DDBJ databases
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: BALB/c.
    Tissue: Thymus.

Entry informationi

Entry nameiCD226_MOUSE
AccessioniPrimary (citable) accession number: Q8K4F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: September 3, 2014
This is version 89 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi