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Protein

CD226 antigen

Gene

Cd226

Organism
Mus musculus (Mouse)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Involved in intercellular adhesion, lymphocyte signaling, cytotoxicity and lymphokine secretion mediated by cytotoxic T-lymphocyte (CTL) and NK cell. Cell surface receptor for NECTIN2. Upon ligand binding, stimulates T-cell proliferation and cytokine production, including that of IL2, IL5, IL10, IL13, and IFNG. Competes with PVRIG for NECTIN2-binding.By similarity

GO - Molecular functioni

GO - Biological processi

Complete GO annotation...

Keywords - Molecular functioni

Receptor

Keywords - Biological processi

Cell adhesion

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Names & Taxonomyi

Protein namesi
Recommended name:
CD226 antigen
Alternative name(s):
Platelet and T-cell activation antigen 1
CD_antigen: CD226
Gene namesi
Name:Cd226
Synonyms:Pta1
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
Proteomesi
  • UP000000589 Componenti: Chromosome 18

Organism-specific databases

MGIiMGI:3039602. Cd226.

Subcellular locationi

Topology

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Topological domaini19 – 254ExtracellularSequence analysisAdd BLAST236
Transmembranei255 – 275HelicalSequence analysisAdd BLAST21
Topological domaini276 – 333CytoplasmicSequence analysisAdd BLAST58

GO - Cellular componenti

Complete GO annotation...

Keywords - Cellular componenti

Cell membrane, Membrane

PTM / Processingi

Molecule processing

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Signal peptidei1 – 18Sequence analysisAdd BLAST18
ChainiPRO_000001466719 – 333CD226 antigenAdd BLAST315

Amino acid modifications

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Disulfide bondi37 ↔ 109PROSITE-ProRule annotation
Glycosylationi44N-linked (GlcNAc...)Sequence analysis1
Glycosylationi84N-linked (GlcNAc...)Sequence analysis1
Glycosylationi91N-linked (GlcNAc...)Sequence analysis1
Glycosylationi98N-linked (GlcNAc...)Sequence analysis1
Disulfide bondi153 ↔ 224PROSITE-ProRule annotation
Glycosylationi181N-linked (GlcNAc...)Sequence analysis1
Glycosylationi199N-linked (GlcNAc...)Sequence analysis1
Glycosylationi233N-linked (GlcNAc...)Sequence analysis1
Modified residuei319PhosphotyrosineBy similarity1

Post-translational modificationi

Phosphorylated.By similarity

Keywords - PTMi

Disulfide bond, Glycoprotein, Phosphoprotein

Proteomic databases

EPDiQ8K4F0.
MaxQBiQ8K4F0.
PaxDbiQ8K4F0.
PRIDEiQ8K4F0.

PTM databases

iPTMnetiQ8K4F0.
PhosphoSitePlusiQ8K4F0.

Expressioni

Gene expression databases

BgeeiENSMUSG00000034028.
CleanExiMM_CD226.
ExpressionAtlasiQ8K4F0. baseline and differential.
GenevisibleiQ8K4F0. MM.

Interactioni

Subunit structurei

Interacts with PVR and NECTIN2. Competes with PVRIG for NECTIN2-binding.By similarity

GO - Molecular functioni

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043551.

Structurei

3D structure databases

ProteinModelPortaliQ8K4F0.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)DescriptionActionsGraphical viewLength
Domaini19 – 127Ig-like C2-type 1Add BLAST109
Domaini136 – 237Ig-like C2-type 2Add BLAST102

Sequence similaritiesi

Keywords - Domaini

Immunoglobulin domain, Repeat, Signal, Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiENOG410IDXC. Eukaryota.
ENOG41129MS. LUCA.
GeneTreeiENSGT00500000044993.
HOGENOMiHOG000059567.
HOVERGENiHBG050849.
InParanoidiQ8K4F0.
KOiK06567.
OMAiYVNYPTF.
OrthoDBiEOG091G0823.
PhylomeDBiQ8K4F0.
TreeFamiTF336260.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4F0-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MAYVTWLLAI LHVHKALCEE TLWDTTVRLS ETMTLECVYP LTHNLTQVEW
60 70 80 90 100
TKNTGTKTVS IAVYNPNHNM HIESNYLHRV HFLNSTVGFR NMSLSFYNAS
110 120 130 140 150
EADIGIYSCL FHAFPNGPWE KKIKVVWSDS FEIAAPSDSY LSAEPGQDVT
160 170 180 190 200
LTCQLPRTWP VQQVIWEKVQ PHQVDILASC NLSQETRYTS KYLRQTRSNC
210 220 230 240 250
SQGSMKSILI IPNAMAADSG LYRCRSEAIT GKNKSFVIRL IITDGGTNKH
260 270 280 290 300
FILPIVGGLV SLLLVILIII IFILYNRKRR RQVRIPLKEP RDKQSKVATN
310 320 330
CRSPTSPIQS TDDEKEDIYV NYPTFSRRPK PRL
Length:333
Mass (Da):38,063
Last modified:October 1, 2002 - v1
Checksum:iACDE524D0F475C97
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416980 mRNA. Translation: AAN04295.1.
CCDSiCCDS29392.1.
RefSeqiNP_848802.2. NM_178687.2.
XP_006526525.1. XM_006526462.3.
UniGeneiMm.139293.

Genome annotation databases

EnsembliENSMUST00000037142; ENSMUSP00000043551; ENSMUSG00000034028.
GeneIDi225825.
KEGGimmu:225825.
UCSCiuc008fvo.1. mouse.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF416980 mRNA. Translation: AAN04295.1.
CCDSiCCDS29392.1.
RefSeqiNP_848802.2. NM_178687.2.
XP_006526525.1. XM_006526462.3.
UniGeneiMm.139293.

3D structure databases

ProteinModelPortaliQ8K4F0.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10090.ENSMUSP00000043551.

PTM databases

iPTMnetiQ8K4F0.
PhosphoSitePlusiQ8K4F0.

Proteomic databases

EPDiQ8K4F0.
MaxQBiQ8K4F0.
PaxDbiQ8K4F0.
PRIDEiQ8K4F0.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSMUST00000037142; ENSMUSP00000043551; ENSMUSG00000034028.
GeneIDi225825.
KEGGimmu:225825.
UCSCiuc008fvo.1. mouse.

Organism-specific databases

CTDi10666.
MGIiMGI:3039602. Cd226.

Phylogenomic databases

eggNOGiENOG410IDXC. Eukaryota.
ENOG41129MS. LUCA.
GeneTreeiENSGT00500000044993.
HOGENOMiHOG000059567.
HOVERGENiHBG050849.
InParanoidiQ8K4F0.
KOiK06567.
OMAiYVNYPTF.
OrthoDBiEOG091G0823.
PhylomeDBiQ8K4F0.
TreeFamiTF336260.

Enzyme and pathway databases

ReactomeiR-MMU-198933. Immunoregulatory interactions between a Lymphoid and a non-Lymphoid cell.

Miscellaneous databases

PROiQ8K4F0.
SOURCEiSearch...

Gene expression databases

BgeeiENSMUSG00000034028.
CleanExiMM_CD226.
ExpressionAtlasiQ8K4F0. baseline and differential.
GenevisibleiQ8K4F0. MM.

Family and domain databases

Gene3Di2.60.40.10. 2 hits.
InterProiIPR007110. Ig-like_dom.
IPR013783. Ig-like_fold.
IPR003599. Ig_sub.
IPR013106. Ig_V-set.
[Graphical view]
PfamiPF07686. V-set. 2 hits.
[Graphical view]
SMARTiSM00409. IG. 2 hits.
[Graphical view]
SUPFAMiSSF48726. SSF48726. 2 hits.
PROSITEiPS50835. IG_LIKE. 2 hits.
[Graphical view]
ProtoNetiSearch...

Entry informationi

Entry nameiCD226_MOUSE
AccessioniPrimary (citable) accession number: Q8K4F0
Entry historyi
Integrated into UniProtKB/Swiss-Prot: May 24, 2004
Last sequence update: October 1, 2002
Last modified: November 2, 2016
This is version 110 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into one UniRef entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.