ID   AL1A3_RAT               Reviewed;         512 AA.
AC   Q8K4D8;
DT   27-SEP-2004, integrated into UniProtKB/Swiss-Prot.
DT   01-OCT-2002, sequence version 1.
DT   16-JUN-2009, entry version 48.
DE   RecName: Full=Aldehyde dehydrogenase family 1 member A3;
DE            EC=1.2.1.5;
DE   AltName: Full=Aldehyde dehydrogenase 6;
DE   AltName: Full=Retinaldehyde dehydrogenase 3;
DE            Short=RALDH-3;
GN   Name=Aldh1a3; Synonyms=Aldh6, Raldh3;
OS   Rattus norvegicus (Rat).
OC   Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi;
OC   Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Sciurognathi;
OC   Muroidea; Muridae; Murinae; Rattus.
OX   NCBI_TaxID=10116;
RN   [1]
RP   NUCLEOTIDE SEQUENCE [MRNA].
RC   STRAIN=Sprague-Dawley;
RX   MEDLINE=22277966; PubMed=12390888; DOI=10.1095/biolreprod.102.007021;
RA   Rexer B.N., Ong D.E.;
RT   "A novel short-chain alcohol dehydrogenase from rats with retinol
RT   dehydrogenase activity, cyclically expressed in uterine epithelium.";
RL   Biol. Reprod. 67:1555-1564(2002).
CC   -!- FUNCTION: Recognizes as substrates free retinal and cellular
CC       retinol-binding protein-bound retinal. Seems to be the key enzyme
CC       in the formation of an RA gradient along the dorso-ventral axis
CC       during the early eye development and also in the development of
CC       the olfactory system (By similarity).
CC   -!- CATALYTIC ACTIVITY: An aldehyde + NAD(P)(+) + H(2)O = an acid +
CC       NAD(P)H.
CC   -!- PATHWAY: Cofactor metabolism; retinol metabolism.
CC   -!- SUBCELLULAR LOCATION: Cytoplasm (By similarity).
CC   -!- SIMILARITY: Belongs to the aldehyde dehydrogenase family.
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DR   EMBL; AF434845; AAN03711.1; -; mRNA.
DR   IPI; IPI00203138; -.
DR   RefSeq; NP_695212.1; -.
DR   UniGene; Rn.8297; -.
DR   HSSP; P51977; 1BXS.
DR   Ensembl; ENSRNOG00000013028; Rattus norvegicus.
DR   GeneID; 266603; -.
DR   KEGG; rno:266603; -.
DR   RGD; 628662; Aldh1a3.
DR   HOVERGEN; Q8K4D8; -.
DR   BRENDA; 1.2.1.36; 248.
DR   BRENDA; 1.2.1.5; 248.
DR   NextBio; 624416; -.
DR   ArrayExpress; Q8K4D8; -.
DR   GermOnline; ENSRNOG00000013028; Rattus norvegicus.
DR   GO; GO:0005829; C:cytosol; NAS:RGD.
DR   GO; GO:0004030; F:aldehyde dehydrogenase [NAD(P)+] activity; IDA:RGD.
DR   GO; GO:0001822; P:kidney development; IEP:RGD.
DR   GO; GO:0055114; P:oxidation reduction; IEA:UniProtKB-KW.
DR   GO; GO:0021983; P:pituitary gland development; IEP:RGD.
DR   GO; GO:0042493; P:response to drug; IEP:RGD.
DR   InterPro; IPR016160; Ald_DH_CS.
DR   InterPro; IPR016162; Ald_DH_N.
DR   InterPro; IPR015590; Aldehyde_DH.
DR   Gene3D; G3DSA:3.40.605.10; Aldehyde_dehydrogenase_N; 1.
DR   PANTHER; PTHR11699; Aldehyde_dehyd; 1.
DR   Pfam; PF00171; Aldedh; 1.
DR   PROSITE; PS00070; ALDEHYDE_DEHYDR_CYS; 1.
DR   PROSITE; PS00687; ALDEHYDE_DEHYDR_GLU; FALSE_NEG.
PE   2: Evidence at transcript level;
KW   Acetylation; Cytoplasm; NAD; Oxidoreductase.
FT   INIT_MET      1      1       Removed (By similarity).
FT   CHAIN         2    512       Aldehyde dehydrogenase family 1 member
FT                                A3.
FT                                /FTId=PRO_0000056480.
FT   NP_BIND     257    262       NAD (By similarity).
FT   ACT_SITE    280    280       Proton acceptor (By similarity).
FT   ACT_SITE    314    314       Nucleophile (By similarity).
FT   SITE        181    181       Transition state stabilizer (By
FT                                similarity).
FT   MOD_RES       2      2       N-acetylalanine (By similarity).
SQ   SEQUENCE   512 AA;  56171 MW;  2A818D7472F67A5E CRC64;
     MATANGAVEN GQPDGKPPAL PRPIRNLEVK FTKIFINNDW HEPKSGRKFA TYNPSTLEKI
     CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDALSRGQLL HQLADLIERD RAILATLETM
     DTGKPFLHAF FVDLEGCIKT FRYFAGWADK IQGRTIPTDD NVMCFTRHEP IGVCGAITPW
     NFPLLMLAWK LAPALCCGNT VVLKPAEQTP LTALYLASLI KEVGFPPGVV NIVPGFGPTV
     GAAISSHPQI NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGRNPCIVC ADADLDLAVE
     CAHQGVFFNQ GQCCTAASRV FVEEQVYGEF VRRSVEFAKK RPVGDPFDAK TEQGPQIDQK
     QFDKILELIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSD VTDNMRIAKE EIFGPVQPIL
     KFKNLEEVIK RANSTDYGLT AAVFTKNLDK ALKLASALES GTVWVNCYNA FYAQAPFGGF
     KMSGNGRELG EYALAEYTEV KTVTIKLDEK NP
//