Reviewed,
UniProtKB/Swiss-Prot Q8K4D8 (AL1A3_RAT)
Last modified
January 19, 2010.
Version 54.
History...
Clusters with 100%,
90%,
50% identity |
Documents (2) |
Third-party data |
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Names and origin
| Protein names | Recommended name: Aldehyde dehydrogenase family 1 member A3 EC=1.2.1.5 Alternative name(s): Aldehyde dehydrogenase 6 Retinaldehyde dehydrogenase 3 Short name=RALDH-3 Short name=RalDH3 | ||||
| Gene names |
| ||||
| Organism | Rattus norvegicus (Rat) | ||||
| Taxonomic identifier | 10116 [NCBI] | ||||
| Taxonomic lineage | Eukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus |
Protein attributes
| Sequence length | 512 AA. |
| Sequence status | Complete. |
| Sequence processing | The displayed sequence is further processed into a mature form. |
| Protein existence | Evidence at transcript level. |
General annotation (Comments)
| Function | Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system By similarity. |
| Catalytic activity | An aldehyde + NAD(P)+ + H2O = an acid + NAD(P)H. |
| Pathway | |
| Subcellular location | Cytoplasm By similarity. |
| Sequence similarities | Belongs to the aldehyde dehydrogenase family. |
Ontologies
| Keywords | |
|---|---|
| Cellular component | Cytoplasm |
| Ligand | NAD |
| Molecular function | Oxidoreductase |
| PTM | Acetylation |
| Gene Ontology (GO) | |
| Biological process | kidney development Inferred from expression pattern. Source: RGD oxidation reductionInferred from electronic annotation. Source: UniProtKB-KW pituitary gland developmentInferred from expression pattern. Source: RGD response to drugInferred from expression pattern. Source: RGD |
| Cellular component | cytosol Non-traceable author statement. Source: RGD |
| Molecular function | aldehyde dehydrogenase [NAD(P)+] activity Inferred from direct assay. Source: RGD |
| Complete GO annotation... | |
Sequence annotation (Features)
| Feature key | Position(s) | Length | Description | Graphical view | Feature identifier | ||||
Molecule processing | |||||||||
|---|---|---|---|---|---|---|---|---|---|
| Initiator methionine | 1 | 1 | Removed By similarity | ||||||
| Chain | 2 – 512 | 511 | Aldehyde dehydrogenase family 1 member A3 | PRO_0000056480 | |||||
Regions | |||||||||
| Nucleotide binding | 257 – 262 | 6 | NAD By similarity | ||||||
Sites | |||||||||
| Active site | 280 | 1 | Proton acceptor By similarity | ||||||
| Active site | 314 | 1 | Nucleophile By similarity | ||||||
| Site | 181 | 1 | Transition state stabilizer By similarity | ||||||
Amino acid modifications | |||||||||
| Modified residue | 2 | 1 | N-acetylalanine By similarity | ||||||
Sequences
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References
| [1] | "A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium." Rexer B.N., Ong D.E. Biol. Reprod. 67:1555-1564(2002) [PubMed: 12390888] [Abstract] Cited for: NUCLEOTIDE SEQUENCE [MRNA]. Strain: Sprague-Dawley. |
| + | Additional computationally mapped references. |
Cross-references
Sequence databases | |
|---|---|
| EMBL GenBank DDBJ | AF434845 mRNA. Translation: AAN03711.1. |
| IPI | IPI00203138. |
| RefSeq | NP_695212.1. |
| UniGene | Rn.8297 |
3D structure databases | |
| SMR | Q8K4D8. Positions 20-511. |
| ModBase | Search... |
Protein-protein interaction databases | |
| STRING | Q8K4D8. |
Genome annotation databases | |
| Ensembl | ENSRNOT00000043019; ENSRNOP00000045261; ENSRNOG00000013028; Rattus norvegicus. [Genome view] |
| GeneID | 266603. |
| KEGG | rno:266603. |
Organism-specific databases | |
| CTD | 266603. |
| RGD | 628662. Aldh1a3. |
Phylogenomic databases | |
| eggNOG | maNOG06232. |
| HOVERGEN | Q8K4D8. |
| InParanoid | Q8K4D8. |
| PhylomeDB | Q8K4D8. |
Enzyme and pathway databases | |
| BRENDA | 1.2.1.36. 248. 1.2.1.5. 248. |
Gene expression databases | |
| Genevestigator | Q8K4D8. |
| GermOnline | ENSRNOG00000013028. Rattus norvegicus. |
Family and domain databases | |
| InterPro | IPR016161. Ald_DH/histidinol_DH. IPR016160. Ald_DH_CS. IPR016162. Ald_DH_N. IPR015590. Aldehyde_DH. [Graphical view] |
| Gene3D | G3DSA:3.40.605.10. Aldehyde_dehydrogenase_N. 1 hit. |
| PANTHER | PTHR11699. Aldehyde_dehyd. 1 hit. |
| Pfam | PF00171. Aldedh. 1 hit. [Graphical view] |
| PROSITE | PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit. PS00687. ALDEHYDE_DEHYDR_GLU. False negative. [Graphical view] |
| ProtoNet | Search... |
Other Resources | |
| NextBio | 624416. |
Entry information
| Entry name | AL1A3_RAT | ||||||||
| Accession | Primary (citable) accession number: Q8K4D8 | ||||||||
| Entry history |
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| Entry status | Reviewed (UniProtKB/Swiss-Prot) | ||||||||
| Annotation project | HPI (Human Proteome Initiative) | ||||||||
Relevant documents
| PATHWAY comments Index of metabolic and biosynthesis pathways |
| SIMILARITY comments Index of protein domains and families |

Clusters with


