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Q8K4D8

- AL1A3_RAT

UniProt

Q8K4D8 - AL1A3_RAT

Protein

Aldehyde dehydrogenase family 1 member A3

Gene

Aldh1a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 85 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system By similarity.By similarity

    Catalytic activityi

    An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

    Pathwayi

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Sitei181 – 1811Transition state stabilizerBy similarity
    Active sitei280 – 2801Proton acceptorPROSITE-ProRule annotation
    Active sitei314 – 3141NucleophilePROSITE-ProRule annotation

    Regions

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Nucleotide bindingi257 – 2626NADBy similarity

    GO - Molecular functioni

    1. aldehyde dehydrogenase [NAD(P)+] activity Source: RGD
    2. retinal dehydrogenase activity Source: RGD

    GO - Biological processi

    1. kidney development Source: RGD
    2. pituitary gland development Source: RGD
    3. response to drug Source: RGD
    4. retinoic acid biosynthetic process Source: RGD
    5. retinol metabolic process Source: UniProtKB-UniPathway

    Keywords - Molecular functioni

    Oxidoreductase

    Keywords - Ligandi

    NAD

    Enzyme and pathway databases

    BRENDAi1.2.1.36. 5301.
    UniPathwayiUPA00912.

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Aldehyde dehydrogenase family 1 member A3 (EC:1.2.1.5)
    Alternative name(s):
    Aldehyde dehydrogenase 6
    Retinaldehyde dehydrogenase 3
    Short name:
    RALDH-3
    Short name:
    RalDH3
    Gene namesi
    Name:Aldh1a3
    Synonyms:Aldh6, Raldh3
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Unplaced

    Organism-specific databases

    RGDi628662. Aldh1a3.

    Subcellular locationi

    Cytoplasm By similarity

    GO - Cellular componenti

    1. cytosol Source: RGD

    Keywords - Cellular componenti

    Cytoplasm

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Initiator methioninei1 – 11RemovedBy similarity
    Chaini2 – 512511Aldehyde dehydrogenase family 1 member A3PRO_0000056480Add
    BLAST

    Amino acid modifications

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Modified residuei2 – 21N-acetylalanineBy similarity

    Keywords - PTMi

    Acetylation

    Proteomic databases

    PaxDbiQ8K4D8.
    PRIDEiQ8K4D8.

    Expressioni

    Gene expression databases

    GenevestigatoriQ8K4D8.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4D8.
    SMRiQ8K4D8. Positions 20-511.
    ModBaseiSearch...
    MobiDBiSearch...

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the aldehyde dehydrogenase family.Curated

    Phylogenomic databases

    eggNOGiCOG1012.
    HOGENOMiHOG000271505.
    HOVERGENiHBG000097.
    InParanoidiQ8K4D8.
    KOiK00129.
    PhylomeDBiQ8K4D8.

    Family and domain databases

    Gene3Di3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProiIPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view]
    PfamiPF00171. Aldedh. 1 hit.
    [Graphical view]
    SUPFAMiSSF53720. SSF53720. 1 hit.
    PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Sequence processingi: The displayed sequence is further processed into a mature form.

    Q8K4D8-1 [UniParc]FASTAAdd to Basket

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    MATANGAVEN GQPDGKPPAL PRPIRNLEVK FTKIFINNDW HEPKSGRKFA    50
    TYNPSTLEKI CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDALSRGQLL 100
    HQLADLIERD RAILATLETM DTGKPFLHAF FVDLEGCIKT FRYFAGWADK 150
    IQGRTIPTDD NVMCFTRHEP IGVCGAITPW NFPLLMLAWK LAPALCCGNT 200
    VVLKPAEQTP LTALYLASLI KEVGFPPGVV NIVPGFGPTV GAAISSHPQI 250
    NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGRNPCIVC ADADLDLAVE 300
    CAHQGVFFNQ GQCCTAASRV FVEEQVYGEF VRRSVEFAKK RPVGDPFDAK 350
    TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSD 400
    VTDNMRIAKE EIFGPVQPIL KFKNLEEVIK RANSTDYGLT AAVFTKNLDK 450
    ALKLASALES GTVWVNCYNA FYAQAPFGGF KMSGNGRELG EYALAEYTEV 500
    KTVTIKLDEK NP 512
    Length:512
    Mass (Da):56,171
    Last modified:October 1, 2002 - v1
    Checksum:i2A818D7472F67A5E
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF434845 mRNA. Translation: AAN03711.1.
    RefSeqiNP_695212.1. NM_153300.1.
    UniGeneiRn.8297.

    Genome annotation databases

    GeneIDi266603.
    KEGGirno:266603.
    UCSCiRGD:628662. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF434845 mRNA. Translation: AAN03711.1 .
    RefSeqi NP_695212.1. NM_153300.1.
    UniGenei Rn.8297.

    3D structure databases

    ProteinModelPortali Q8K4D8.
    SMRi Q8K4D8. Positions 20-511.
    ModBasei Search...
    MobiDBi Search...

    Proteomic databases

    PaxDbi Q8K4D8.
    PRIDEi Q8K4D8.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    GeneIDi 266603.
    KEGGi rno:266603.
    UCSCi RGD:628662. rat.

    Organism-specific databases

    CTDi 220.
    RGDi 628662. Aldh1a3.

    Phylogenomic databases

    eggNOGi COG1012.
    HOGENOMi HOG000271505.
    HOVERGENi HBG000097.
    InParanoidi Q8K4D8.
    KOi K00129.
    PhylomeDBi Q8K4D8.

    Enzyme and pathway databases

    UniPathwayi UPA00912 .
    BRENDAi 1.2.1.36. 5301.

    Miscellaneous databases

    NextBioi 624416.

    Gene expression databases

    Genevestigatori Q8K4D8.

    Family and domain databases

    Gene3Di 3.40.309.10. 1 hit.
    3.40.605.10. 1 hit.
    InterProi IPR016161. Ald_DH/histidinol_DH.
    IPR016163. Ald_DH_C.
    IPR016160. Ald_DH_CS_CYS.
    IPR016162. Ald_DH_N.
    IPR015590. Aldehyde_DH_dom.
    [Graphical view ]
    Pfami PF00171. Aldedh. 1 hit.
    [Graphical view ]
    SUPFAMi SSF53720. SSF53720. 1 hit.
    PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium."
      Rexer B.N., Ong D.E.
      Biol. Reprod. 67:1555-1564(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA].
      Strain: Sprague-Dawley.

    Entry informationi

    Entry nameiAL1A3_RAT
    AccessioniPrimary (citable) accession number: Q8K4D8
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: September 27, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 85 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. PATHWAY comments
      Index of metabolic and biosynthesis pathways
    2. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3