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Q8K4D8

- AL1A3_RAT

UniProt

Q8K4D8 - AL1A3_RAT

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Protein

Aldehyde dehydrogenase family 1 member A3

Gene
Aldh1a3, Aldh6, Raldh3
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 4 out of 5 - Experimental evidence at transcript leveli

Functioni

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system By similarity.

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathwayi

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei181 – 1811Transition state stabilizer By similarity
Active sitei280 – 2801Proton acceptor By similarity
Active sitei314 – 3141Nucleophile By similarity

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi257 – 2626NAD By similarity

GO - Molecular functioni

  1. aldehyde dehydrogenase [NAD(P)+] activity Source: RGD
  2. retinal dehydrogenase activity Source: RGD

GO - Biological processi

  1. kidney development Source: RGD
  2. pituitary gland development Source: RGD
  3. response to drug Source: RGD
  4. retinoic acid biosynthetic process Source: RGD
  5. retinol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.36. 5301.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 1 member A3 (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 6
Retinaldehyde dehydrogenase 3
Short name:
RALDH-3
Short name:
RalDH3
Gene namesi
Name:Aldh1a3
Synonyms:Aldh6, Raldh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Unplaced

Organism-specific databases

RGDi628662. Aldh1a3.

Subcellular locationi

Cytoplasm By similarity

GO - Cellular componenti

  1. cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11Removed By similarity
Chaini2 – 512511Aldehyde dehydrogenase family 1 member A3PRO_0000056480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanine By similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8K4D8.
PRIDEiQ8K4D8.

Expressioni

Gene expression databases

GenevestigatoriQ8K4D8.

Structurei

3D structure databases

ProteinModelPortaliQ8K4D8.
SMRiQ8K4D8. Positions 20-511.

Family & Domainsi

Sequence similaritiesi

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ8K4D8.
KOiK00129.
PhylomeDBiQ8K4D8.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4D8-1 [UniParc]FASTAAdd to Basket

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MATANGAVEN GQPDGKPPAL PRPIRNLEVK FTKIFINNDW HEPKSGRKFA    50
TYNPSTLEKI CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDALSRGQLL 100
HQLADLIERD RAILATLETM DTGKPFLHAF FVDLEGCIKT FRYFAGWADK 150
IQGRTIPTDD NVMCFTRHEP IGVCGAITPW NFPLLMLAWK LAPALCCGNT 200
VVLKPAEQTP LTALYLASLI KEVGFPPGVV NIVPGFGPTV GAAISSHPQI 250
NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGRNPCIVC ADADLDLAVE 300
CAHQGVFFNQ GQCCTAASRV FVEEQVYGEF VRRSVEFAKK RPVGDPFDAK 350
TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSD 400
VTDNMRIAKE EIFGPVQPIL KFKNLEEVIK RANSTDYGLT AAVFTKNLDK 450
ALKLASALES GTVWVNCYNA FYAQAPFGGF KMSGNGRELG EYALAEYTEV 500
KTVTIKLDEK NP 512
Length:512
Mass (Da):56,171
Last modified:October 1, 2002 - v1
Checksum:i2A818D7472F67A5E
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF434845 mRNA. Translation: AAN03711.1.
RefSeqiNP_695212.1. NM_153300.1.
UniGeneiRn.8297.

Genome annotation databases

GeneIDi266603.
KEGGirno:266603.
UCSCiRGD:628662. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF434845 mRNA. Translation: AAN03711.1 .
RefSeqi NP_695212.1. NM_153300.1.
UniGenei Rn.8297.

3D structure databases

ProteinModelPortali Q8K4D8.
SMRi Q8K4D8. Positions 20-511.
ModBasei Search...
MobiDBi Search...

Proteomic databases

PaxDbi Q8K4D8.
PRIDEi Q8K4D8.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

GeneIDi 266603.
KEGGi rno:266603.
UCSCi RGD:628662. rat.

Organism-specific databases

CTDi 220.
RGDi 628662. Aldh1a3.

Phylogenomic databases

eggNOGi COG1012.
HOGENOMi HOG000271505.
HOVERGENi HBG000097.
InParanoidi Q8K4D8.
KOi K00129.
PhylomeDBi Q8K4D8.

Enzyme and pathway databases

UniPathwayi UPA00912 .
BRENDAi 1.2.1.36. 5301.

Miscellaneous databases

NextBioi 624416.

Gene expression databases

Genevestigatori Q8K4D8.

Family and domain databases

Gene3Di 3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProi IPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view ]
Pfami PF00171. Aldedh. 1 hit.
[Graphical view ]
SUPFAMi SSF53720. SSF53720. 1 hit.
PROSITEi PS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium."
    Rexer B.N., Ong D.E.
    Biol. Reprod. 67:1555-1564(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiAL1A3_RAT
AccessioniPrimary (citable) accession number: Q8K4D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2002
Last modified: June 11, 2014
This is version 84 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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