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Protein

Aldehyde dehydrogenase family 1 member A3

Gene

Aldh1a3

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 5 out of 5-Experimental evidence at transcript leveli

Functioni

Recognizes as substrates free retinal and cellular retinol-binding protein-bound retinal. Seems to be the key enzyme in the formation of an RA gradient along the dorso-ventral axis during the early eye development and also in the development of the olfactory system (By similarity).By similarity

Catalytic activityi

An aldehyde + NAD(P)+ + H2O = a carboxylate + NAD(P)H.

Pathway:iretinol metabolism

This protein is involved in the pathway retinol metabolism, which is part of Cofactor metabolism.
View all proteins of this organism that are known to be involved in the pathway retinol metabolism and in Cofactor metabolism.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sitei181 – 1811Transition state stabilizerBy similarity
Active sitei280 – 2801Proton acceptorPROSITE-ProRule annotation
Active sitei314 – 3141NucleophilePROSITE-ProRule annotation

Regions

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Nucleotide bindingi257 – 2626NADBy similarity

GO - Molecular functioni

  • aldehyde dehydrogenase (NAD) activity Source: GO_Central
  • aldehyde dehydrogenase [NAD(P)+] activity Source: RGD
  • retinal dehydrogenase activity Source: RGD

GO - Biological processi

  • kidney development Source: RGD
  • pituitary gland development Source: RGD
  • response to drug Source: RGD
  • retinoic acid biosynthetic process Source: RGD
  • retinol metabolic process Source: UniProtKB-UniPathway
Complete GO annotation...

Keywords - Molecular functioni

Oxidoreductase

Keywords - Ligandi

NAD

Enzyme and pathway databases

BRENDAi1.2.1.36. 5301.
UniPathwayiUPA00912.

Names & Taxonomyi

Protein namesi
Recommended name:
Aldehyde dehydrogenase family 1 member A3 (EC:1.2.1.5)
Alternative name(s):
Aldehyde dehydrogenase 6
Retinaldehyde dehydrogenase 3
Short name:
RALDH-3
Short name:
RalDH3
Gene namesi
Name:Aldh1a3
Synonyms:Aldh6, Raldh3
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Unplaced

Organism-specific databases

RGDi628662. Aldh1a3.

Subcellular locationi

GO - Cellular componenti

  • cytosol Source: RGD
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Initiator methioninei1 – 11RemovedBy similarity
Chaini2 – 512511Aldehyde dehydrogenase family 1 member A3PRO_0000056480Add
BLAST

Amino acid modifications

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Modified residuei2 – 21N-acetylalanineBy similarity
Modified residuei378 – 3781N6-acetyllysine; alternateBy similarity
Modified residuei378 – 3781N6-succinyllysine; alternateBy similarity
Modified residuei394 – 3941N6-acetyllysine; alternateBy similarity
Modified residuei394 – 3941N6-succinyllysine; alternateBy similarity
Modified residuei409 – 4091N6-acetyllysine; alternateBy similarity
Modified residuei409 – 4091N6-succinyllysine; alternateBy similarity
Modified residuei421 – 4211N6-acetyllysine; alternateBy similarity
Modified residuei421 – 4211N6-succinyllysine; alternateBy similarity

Keywords - PTMi

Acetylation

Proteomic databases

PaxDbiQ8K4D8.
PRIDEiQ8K4D8.

Expressioni

Gene expression databases

GenevisibleiQ8K4D8. RN.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045261.

Structurei

3D structure databases

ProteinModelPortaliQ8K4D8.
SMRiQ8K4D8. Positions 20-511.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the aldehyde dehydrogenase family.Curated

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ8K4D8.
KOiK00129.
PhylomeDBiQ8K4D8.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Sequence processingi: The displayed sequence is further processed into a mature form.

Q8K4D8-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MATANGAVEN GQPDGKPPAL PRPIRNLEVK FTKIFINNDW HEPKSGRKFA
60 70 80 90 100
TYNPSTLEKI CEVEEGDKPD VDKAVEAAQA AFQRGSPWRR LDALSRGQLL
110 120 130 140 150
HQLADLIERD RAILATLETM DTGKPFLHAF FVDLEGCIKT FRYFAGWADK
160 170 180 190 200
IQGRTIPTDD NVMCFTRHEP IGVCGAITPW NFPLLMLAWK LAPALCCGNT
210 220 230 240 250
VVLKPAEQTP LTALYLASLI KEVGFPPGVV NIVPGFGPTV GAAISSHPQI
260 270 280 290 300
NKIAFTGSTE VGKLVKEAAS RSNLKRVTLE LGGRNPCIVC ADADLDLAVE
310 320 330 340 350
CAHQGVFFNQ GQCCTAASRV FVEEQVYGEF VRRSVEFAKK RPVGDPFDAK
360 370 380 390 400
TEQGPQIDQK QFDKILELIE SGKKEGAKLE CGGSAMEDRG LFIKPTVFSD
410 420 430 440 450
VTDNMRIAKE EIFGPVQPIL KFKNLEEVIK RANSTDYGLT AAVFTKNLDK
460 470 480 490 500
ALKLASALES GTVWVNCYNA FYAQAPFGGF KMSGNGRELG EYALAEYTEV
510
KTVTIKLDEK NP
Length:512
Mass (Da):56,171
Last modified:October 1, 2002 - v1
Checksum:i2A818D7472F67A5E
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434845 mRNA. Translation: AAN03711.1.
RefSeqiNP_695212.1. NM_153300.1.
UniGeneiRn.8297.

Genome annotation databases

GeneIDi266603.
KEGGirno:266603.
UCSCiRGD:628662. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF434845 mRNA. Translation: AAN03711.1.
RefSeqiNP_695212.1. NM_153300.1.
UniGeneiRn.8297.

3D structure databases

ProteinModelPortaliQ8K4D8.
SMRiQ8K4D8. Positions 20-511.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000045261.

Proteomic databases

PaxDbiQ8K4D8.
PRIDEiQ8K4D8.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

GeneIDi266603.
KEGGirno:266603.
UCSCiRGD:628662. rat.

Organism-specific databases

CTDi220.
RGDi628662. Aldh1a3.

Phylogenomic databases

eggNOGiCOG1012.
HOGENOMiHOG000271505.
HOVERGENiHBG000097.
InParanoidiQ8K4D8.
KOiK00129.
PhylomeDBiQ8K4D8.

Enzyme and pathway databases

UniPathwayiUPA00912.
BRENDAi1.2.1.36. 5301.

Miscellaneous databases

NextBioi624416.
PROiQ8K4D8.

Gene expression databases

GenevisibleiQ8K4D8. RN.

Family and domain databases

Gene3Di3.40.309.10. 1 hit.
3.40.605.10. 1 hit.
InterProiIPR016161. Ald_DH/histidinol_DH.
IPR016163. Ald_DH_C.
IPR016160. Ald_DH_CS_CYS.
IPR016162. Ald_DH_N.
IPR015590. Aldehyde_DH_dom.
[Graphical view]
PfamiPF00171. Aldedh. 1 hit.
[Graphical view]
SUPFAMiSSF53720. SSF53720. 1 hit.
PROSITEiPS00070. ALDEHYDE_DEHYDR_CYS. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "A novel short-chain alcohol dehydrogenase from rats with retinol dehydrogenase activity, cyclically expressed in uterine epithelium."
    Rexer B.N., Ong D.E.
    Biol. Reprod. 67:1555-1564(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA].
    Strain: Sprague-Dawley.

Entry informationi

Entry nameiAL1A3_RAT
AccessioniPrimary (citable) accession number: Q8K4D8
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 27, 2004
Last sequence update: October 1, 2002
Last modified: June 24, 2015
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. PATHWAY comments
    Index of metabolic and biosynthesis pathways
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.