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Q8K4D7

- PLCZ1_MOUSE

UniProt

Q8K4D7 - PLCZ1_MOUSE

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Protein

1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1

Gene

Plcz1

Organism
Mus musculus (Mouse)
Status
Reviewed - Annotation score: 5 out of 5- Experimental evidence at protein leveli

Functioni

The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca2+-dependent manner. Triggers intracellular Ca2+ oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.By similarity9 PublicationsCurated

Catalytic activityi

1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate + H2O = 1D-myo-inositol 1,4,5-trisphosphate + diacylglycerol.By similarity

Cofactori

Calcium.1 Publication

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Active sitei178 – 1781By similarityPROSITE-ProRule annotation
Active sitei223 – 2231By similarityPROSITE-ProRule annotation

GO - Molecular functioni

  1. calcium ion binding Source: InterPro
  2. phosphatidylinositol phospholipase C activity Source: UniProtKB-EC
  3. phospholipase C activity Source: MGI
  4. signal transducer activity Source: UniProtKB-KW

GO - Biological processi

  1. calcium ion transport Source: MGI
  2. egg activation Source: MGI
  3. intracellular signal transduction Source: InterPro
  4. lipid catabolic process Source: UniProtKB-KW
  5. multicellular organismal development Source: UniProtKB-KW
Complete GO annotation...

Keywords - Molecular functioni

Developmental protein, Hydrolase, Transducer

Keywords - Biological processi

Fertilization, Lipid degradation, Lipid metabolism

Keywords - Ligandi

Calcium

Enzyme and pathway databases

BRENDAi3.1.4.11. 3474.
ReactomeiREACT_196473. Synthesis of IP3 and IP4 in the cytosol.

Names & Taxonomyi

Protein namesi
Recommended name:
1-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1 (EC:3.1.4.11)
Alternative name(s):
Phosphoinositide phospholipase C-zeta-1
Phospholipase C-zeta-1By similarity
Short name:
PLC-zeta-1By similarity
Gene namesi
Name:Plcz1Imported
OrganismiMus musculus (Mouse)
Taxonomic identifieri10090 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeMusMus
ProteomesiUP000000589: Chromosome 6

Organism-specific databases

MGIiMGI:2150308. Plcz1.

Subcellular locationi

Nucleus 5 Publications. Cytoplasmperinuclear region 5 Publications
Note: Exhibits alternative cytoplasmic/nuclear localization during development. Translocates from the pronucleus into cytoplasm upon nuclear envelope breakdown for mitosis and localizes again to the pronuclei at interphase following meiosis and mitosis.5 Publications

GO - Cellular componenti

  1. cytosol Source: InterPro
  2. nucleus Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Cytoplasm, Nucleus

Pathology & Biotechi

Mutagenesis

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Mutagenesisi210 – 2101D → R: Defective in Ca(2+) oscillation activity and shows slower nuclear translocation. 1 Publication
Mutagenesisi299 – 2991K → E: Defective in Ca(2+) oscillation activity and loss of nuclear translocation. 1 Publication
Mutagenesisi301 – 3011K → E: Defective in Ca(2+) oscillation activity and loss of nuclear translocation. 1 Publication
Mutagenesisi376 – 3761R → E: Abolishes nuclear translocation. 1 Publication
Mutagenesisi377 – 3771K → E: Abolishes nuclear translocation. Prolongs Ca(2+) oscillations allowing them to occur during interphase. 2 Publications
Mutagenesisi378 – 3781R → E: Abolishes nuclear translocation. 1 Publication
Mutagenesisi379 – 3791K → E: Abolishes nuclear translocation. 1 Publication
Mutagenesisi381 – 3811K → E: Abolishes nuclear translocation. 1 Publication

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 6476471-phosphatidylinositol 4,5-bisphosphate phosphodiesterase zeta-1PRO_0000347246Add
BLAST

Proteomic databases

PRIDEiQ8K4D7.

PTM databases

PhosphoSiteiQ8K4D7.

Expressioni

Tissue specificityi

Highly expressed in postpuberal testis, where expression is sperm cell-specific. Also expressed in brain of both sexes.1 Publication

Gene expression databases

BgeeiQ8K4D7.
ExpressionAtlasiQ8K4D7. baseline.
GenevestigatoriQ8K4D7.

Interactioni

Subunit structurei

Interacts via its C2 domain with PtdIns3P and, to a lesser extent, PtdIns5P in vitro.1 Publication

Structurei

3D structure databases

ProteinModelPortaliQ8K4D7.
SMRiQ8K4D7. Positions 26-642.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Domains and Repeats

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Domaini43 – 7836EF-handPROSITE-ProRule annotationAdd
BLAST
Domaini163 – 307145PI-PLC X-boxPROSITE-ProRule annotationAdd
BLAST
Domaini386 – 502117PI-PLC Y-boxPROSITE-ProRule annotationAdd
BLAST
Domaini507 – 610104C2PROSITE-ProRule annotationAdd
BLAST

Domaini

The EF-hand and C2 domains are essential for triggering Ca2+ oscillating activity and the regulation of PLCZ1 enzyme activity.4 Publications
The X-Y linker region between PI-PLC X-box and Y-box domains may be a target for proteolysis and may play an important regulatory role during fertilization.4 Publications

Sequence similaritiesi

Contains 1 C2 domain.PROSITE-ProRule annotation
Contains 1 EF-hand domain.PROSITE-ProRule annotation
Contains 1 PI-PLC X-box domain.PROSITE-ProRule annotation
Contains 1 PI-PLC Y-box domain.PROSITE-ProRule annotation

Phylogenomic databases

eggNOGiNOG149692.
GeneTreeiENSGT00760000118936.
HOGENOMiHOG000006871.
HOVERGENiHBG053610.
InParanoidiQ8K4D7.
KOiK05861.
OMAiMPEKDDF.
OrthoDBiEOG7V49XT.
PhylomeDBiQ8K4D7.
TreeFamiTF313216.

Family and domain databases

Gene3Di1.10.238.10. 2 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProiIPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR028395. PLC-zeta1.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view]
PANTHERiPTHR10336. PTHR10336. 1 hit.
PTHR10336:SF29. PTHR10336:SF29. 1 hit.
PfamiPF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view]
PRINTSiPR00390. PHPHLIPASEC.
SMARTiSM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view]
SUPFAMiSSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEiPS50004. C2. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view]

Sequences (2)i

Sequence statusi: Complete.

This entry describes 2 isoformsi produced by alternative splicing. Align

Isoform 14 Publications (identifier: Q8K4D7-1) [UniParc]FASTAAdd to Basket

This isoform has been chosen as the 'canonical' sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

« Hide

        10         20         30         40         50
MESQLHELAE ARWFLSKVQD DFRGGKINVE ITHKLLEKLD FPCHFAHVKH
60 70 80 90 100
IFKENDRQNQ GRITIEEFRA IYRCIVHREE ITEIFNTYTE NRKILSENSL
110 120 130 140 150
IEFLTQEQYE MEIDHSDSVE IINKYEPIEE VKGERQMSIE GFARYMFSSE
160 170 180 190 200
CLLFKENCKT VYQDMNHPLS DYFISSSHNT YLISDQILGP SDIWGYVSAL
210 220 230 240 250
VKGCRCLEID CWDGSQNEPI VYHGYTFTSK LLFKTVVQAI NKYAFVTSDY
260 270 280 290 300
PVVLSLENHC SPGQQEVMAS ILQSTFGDFL LSDMLEEFPD TLPSPEALKF
310 320 330 340 350
KILVKNRKVG TLSETHERIG TDKSGQVLEW KEVIYEDGDE DSGMDPETWD
360 370 380 390 400
VFLSRIKEER EADPSTLSGI AGVKKRKRKM KIAMALSDLV IYTKAEKFRN
410 420 430 440 450
FQYSRVYQQF NETNSIGESR ARKLSKLRVH EFIFHTAAFI TRVYPKMMRA
460 470 480 490 500
DSSNFNPQEF WNVGCQMVAL NFQTPGLPMD LQNGKFLDNG GSGYILKPDI
510 520 530 540 550
LRDTTLGFNP NEPEYDDHPV TLTIRIISGI QLPVSSSSNT PDIVVIIEVY
560 570 580 590 600
GVPNDHVKQQ TRVVKNNAFS PKWNETFTFL IQVPELALIR FVVETQQGLL
610 620 630 640
SGNELLGQYT LPVLCMNKGY RRVPLFSKSG ANLEPSSLFI YVWYFRE
Length:647
Mass (Da):74,614
Last modified:October 1, 2002 - v1
Checksum:iABE24E5CCCC63CA2
GO
Isoform 21 Publication (identifier: Q8K4D7-2) [UniParc]FASTAAdd to Basket

The sequence of this isoform differs from the canonical sequence as follows:
     1-110: Missing.

Show »
Length:537
Mass (Da):61,307
Checksum:i4B6832D35A65F75F
GO

Experimental Info

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Sequence conflicti58 – 581Q → H in AAI06768. (PubMed:15489334)Curated
Sequence conflicti360 – 3601R → K in AAI06768. (PubMed:15489334)Curated

Alternative sequence

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Alternative sequencei1 – 110110Missing in isoform 2. 2 PublicationsVSP_052863Add
BLAST

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF435950 mRNA. Translation: AAM95914.1.
AK006672 mRNA. No translation available.
BC106767 mRNA. Translation: AAI06768.1.
CCDSiCCDS20671.1. [Q8K4D7-1]
RefSeqiNP_473407.2. NM_054066.4. [Q8K4D7-1]
XP_006506966.1. XM_006506903.1. [Q8K4D7-2]
UniGeneiMm.50808.

Genome annotation databases

EnsembliENSMUST00000032356; ENSMUSP00000032356; ENSMUSG00000030230. [Q8K4D7-1]
GeneIDi114875.
KEGGimmu:114875.
UCSCiuc009eny.1. mouse. [Q8K4D7-1]

Keywords - Coding sequence diversityi

Alternative splicing

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF435950 mRNA. Translation: AAM95914.1 .
AK006672 mRNA. No translation available.
BC106767 mRNA. Translation: AAI06768.1 .
CCDSi CCDS20671.1. [Q8K4D7-1 ]
RefSeqi NP_473407.2. NM_054066.4. [Q8K4D7-1 ]
XP_006506966.1. XM_006506903.1. [Q8K4D7-2 ]
UniGenei Mm.50808.

3D structure databases

ProteinModelPortali Q8K4D7.
SMRi Q8K4D7. Positions 26-642.
ModBasei Search...
MobiDBi Search...

PTM databases

PhosphoSitei Q8K4D7.

Proteomic databases

PRIDEi Q8K4D7.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSMUST00000032356 ; ENSMUSP00000032356 ; ENSMUSG00000030230 . [Q8K4D7-1 ]
GeneIDi 114875.
KEGGi mmu:114875.
UCSCi uc009eny.1. mouse. [Q8K4D7-1 ]

Organism-specific databases

CTDi 89869.
MGIi MGI:2150308. Plcz1.

Phylogenomic databases

eggNOGi NOG149692.
GeneTreei ENSGT00760000118936.
HOGENOMi HOG000006871.
HOVERGENi HBG053610.
InParanoidi Q8K4D7.
KOi K05861.
OMAi MPEKDDF.
OrthoDBi EOG7V49XT.
PhylomeDBi Q8K4D7.
TreeFami TF313216.

Enzyme and pathway databases

BRENDAi 3.1.4.11. 3474.
Reactomei REACT_196473. Synthesis of IP3 and IP4 in the cytosol.

Miscellaneous databases

NextBioi 368899.
PROi Q8K4D7.
SOURCEi Search...

Gene expression databases

Bgeei Q8K4D7.
ExpressionAtlasi Q8K4D7. baseline.
Genevestigatori Q8K4D7.

Family and domain databases

Gene3Di 1.10.238.10. 2 hits.
2.60.40.150. 1 hit.
3.20.20.190. 2 hits.
InterProi IPR000008. C2_dom.
IPR011992. EF-hand-dom_pair.
IPR002048. EF_hand_dom.
IPR001192. PI-PLC_fam.
IPR017946. PLC-like_Pdiesterase_TIM-brl.
IPR028395. PLC-zeta1.
IPR015359. PLipase_C_EF-hand-like.
IPR000909. PLipase_C_PInositol-sp_X_dom.
IPR001711. PLipase_C_Pinositol-sp_Y.
[Graphical view ]
PANTHERi PTHR10336. PTHR10336. 1 hit.
PTHR10336:SF29. PTHR10336:SF29. 1 hit.
Pfami PF00168. C2. 1 hit.
PF09279. EF-hand_like. 1 hit.
PF00388. PI-PLC-X. 1 hit.
PF00387. PI-PLC-Y. 1 hit.
[Graphical view ]
PRINTSi PR00390. PHPHLIPASEC.
SMARTi SM00239. C2. 1 hit.
SM00148. PLCXc. 1 hit.
SM00149. PLCYc. 1 hit.
[Graphical view ]
SUPFAMi SSF49562. SSF49562. 1 hit.
SSF51695. SSF51695. 1 hit.
PROSITEi PS50004. C2. 1 hit.
PS50222. EF_HAND_2. 1 hit.
PS50007. PIPLC_X_DOMAIN. 1 hit.
PS50008. PIPLC_Y_DOMAIN. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

« Hide 'large scale' publications
  1. "PLC zeta: a sperm-specific trigger of Ca(2+) oscillations in eggs and embryo development."
    Saunders C.M., Larman M.G., Parrington J., Cox L.J., Royse J., Blayney L.M., Swann K., Lai F.A.
    Development 129:3533-3544(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORM 1), FUNCTION, TISSUE SPECIFICITY.
    Strain: C57BL/6JImported.
    Tissue: Spermatid1 Publication.
  2. "Recombinant phospholipase Czeta has high Ca2+ sensitivity and induces Ca2+ oscillations in mouse eggs."
    Kouchi Z., Fukami K., Shikano T., Oda S., Nakamura Y., Takenawa T., Miyazaki S.
    J. Biol. Chem. 279:10408-10412(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA] (ISOFORMS 1 AND 2), FUNCTION, SUBCELLULAR LOCATION.
    Tissue: Testis1 Publication.
  3. "The transcriptional landscape of the mammalian genome."
    Carninci P., Kasukawa T., Katayama S., Gough J., Frith M.C., Maeda N., Oyama R., Ravasi T., Lenhard B., Wells C., Kodzius R., Shimokawa K., Bajic V.B., Brenner S.E., Batalov S., Forrest A.R., Zavolan M., Davis M.J.
    , Wilming L.G., Aidinis V., Allen J.E., Ambesi-Impiombato A., Apweiler R., Aturaliya R.N., Bailey T.L., Bansal M., Baxter L., Beisel K.W., Bersano T., Bono H., Chalk A.M., Chiu K.P., Choudhary V., Christoffels A., Clutterbuck D.R., Crowe M.L., Dalla E., Dalrymple B.P., de Bono B., Della Gatta G., di Bernardo D., Down T., Engstrom P., Fagiolini M., Faulkner G., Fletcher C.F., Fukushima T., Furuno M., Futaki S., Gariboldi M., Georgii-Hemming P., Gingeras T.R., Gojobori T., Green R.E., Gustincich S., Harbers M., Hayashi Y., Hensch T.K., Hirokawa N., Hill D., Huminiecki L., Iacono M., Ikeo K., Iwama A., Ishikawa T., Jakt M., Kanapin A., Katoh M., Kawasawa Y., Kelso J., Kitamura H., Kitano H., Kollias G., Krishnan S.P., Kruger A., Kummerfeld S.K., Kurochkin I.V., Lareau L.F., Lazarevic D., Lipovich L., Liu J., Liuni S., McWilliam S., Madan Babu M., Madera M., Marchionni L., Matsuda H., Matsuzawa S., Miki H., Mignone F., Miyake S., Morris K., Mottagui-Tabar S., Mulder N., Nakano N., Nakauchi H., Ng P., Nilsson R., Nishiguchi S., Nishikawa S., Nori F., Ohara O., Okazaki Y., Orlando V., Pang K.C., Pavan W.J., Pavesi G., Pesole G., Petrovsky N., Piazza S., Reed J., Reid J.F., Ring B.Z., Ringwald M., Rost B., Ruan Y., Salzberg S.L., Sandelin A., Schneider C., Schoenbach C., Sekiguchi K., Semple C.A., Seno S., Sessa L., Sheng Y., Shibata Y., Shimada H., Shimada K., Silva D., Sinclair B., Sperling S., Stupka E., Sugiura K., Sultana R., Takenaka Y., Taki K., Tammoja K., Tan S.L., Tang S., Taylor M.S., Tegner J., Teichmann S.A., Ueda H.R., van Nimwegen E., Verardo R., Wei C.L., Yagi K., Yamanishi H., Zabarovsky E., Zhu S., Zimmer A., Hide W., Bult C., Grimmond S.M., Teasdale R.D., Liu E.T., Brusic V., Quackenbush J., Wahlestedt C., Mattick J.S., Hume D.A., Kai C., Sasaki D., Tomaru Y., Fukuda S., Kanamori-Katayama M., Suzuki M., Aoki J., Arakawa T., Iida J., Imamura K., Itoh M., Kato T., Kawaji H., Kawagashira N., Kawashima T., Kojima M., Kondo S., Konno H., Nakano K., Ninomiya N., Nishio T., Okada M., Plessy C., Shibata K., Shiraki T., Suzuki S., Tagami M., Waki K., Watahiki A., Okamura-Oho Y., Suzuki H., Kawai J., Hayashizaki Y.
    Science 309:1559-1563(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 2).
    Tissue: Testis1 Publication.
  4. "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."
    The MGC Project Team
    Genome Res. 14:2121-2127(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [LARGE SCALE MRNA] (ISOFORM 1).
  5. "Mammalian phospholipase Czeta induces oocyte activation from the sperm perinuclear matrix."
    Fujimoto S., Yoshida N., Fukui T., Amanai M., Isobe T., Itagaki C., Izumi T., Perry A.C.F.
    Dev. Biol. 274:370-383(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.
  6. "Cell cycle-dependent Ca2+ oscillations in mouse embryos are regulated by nuclear targeting of PLCzeta."
    Larman M.G., Saunders C.M., Carroll J., Lai F.A., Swann K.
    J. Cell Sci. 117:2513-2521(2004) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION, MUTAGENESIS OF LYS-377.
  7. "Nuclear translocation of phospholipase C-zeta, an egg-activating factor, during early embryonic development."
    Sone Y., Ito M., Shirakawa H., Shikano T., Takeuchi H., Kinoshita K., Miyazaki S.
    Biochem. Biophys. Res. Commun. 330:690-694(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: SUBCELLULAR LOCATION.
  8. "The role of EF-hand domains and C2 domain in regulation of enzymatic activity of phospholipase Czeta."
    Kouchi Z., Shikano T., Nakamura Y., Shirakawa H., Fukami K., Miyazaki S.
    J. Biol. Chem. 280:21015-21021(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, COFACTOR, INTERACTION WITH PTDINS(3)P AND PTDINS(5)P, DOMAIN.
  9. "Role of phospholipase C-zeta domains in Ca2+-dependent phosphatidylinositol 4,5-bisphosphate hydrolysis and cytoplasmic Ca2+ oscillations."
    Nomikos M., Blayney L.M., Larman M.G., Campbell K., Rossbach A., Saunders C.M., Swann K., Lai F.A.
    J. Biol. Chem. 280:31011-31018(2005) [PubMed] [Europe PMC] [Abstract]
    Cited for: DOMAIN.
  10. "The role of X/Y linker region and N-terminal EF-hand domain in nuclear translocation and Ca2+ oscillation-inducing activities of phospholipase Czeta, a mammalian egg-activating factor."
    Kuroda K., Ito M., Shikano T., Awaji T., Yoda A., Takeuchi H., Kinoshita K., Miyazaki S.
    J. Biol. Chem. 281:27794-27805(2006) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN, MUTAGENESIS OF ASP-210; LYS-299; LYS-301; ARG-376; LYS-377; ARG-378; LYS-379 AND LYS-381.
  11. "Broad, ectopic expression of the sperm protein PLCZ1 induces parthenogenesis and ovarian tumours in mice."
    Yoshida N., Amanai M., Fukui T., Kajikawa E., Brahmajosyula M., Iwahori A., Nakano Y., Shoji S., Diebold J., Hessel H., Huss R., Perry A.C.
    Development 134:3941-3952(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, OVEREXPRESSION.
  12. "Proteolytic processing of phospholipase Czeta and [Ca2+]i oscillations during mammalian fertilization."
    Kurokawa M., Yoon S.Y., Alfandari D., Fukami K., Sato K., Fissore R.A.
    Dev. Biol. 312:407-418(2007) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, DOMAIN.
  13. "Difference in Ca2+ oscillation-inducing activity and nuclear translocation ability of PLCZ1, an egg-activating sperm factor candidate, between mouse, rat, human, and medaka fish."
    Ito M., Shikano T., Oda S., Horiguchi T., Tanimoto S., Awaji T., Mitani H., Miyazaki S.
    Biol. Reprod. 78:1081-1090(2008) [PubMed] [Europe PMC] [Abstract]
    Cited for: FUNCTION, SUBCELLULAR LOCATION.

Entry informationi

Entry nameiPLCZ1_MOUSE
AccessioniPrimary (citable) accession number: Q8K4D7
Secondary accession number(s): Q3KPE5
Entry historyi
Integrated into UniProtKB/Swiss-Prot: September 2, 2008
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 99 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Miscellaneous

Transgenic mice, where broad ectopic expression is forced, initially appear healthy and their oocytes undergo unperturbed meiotic maturation to metaphase II but subsequently exhibit autonomous intracellular free calcium oscillations, second polar body extrusion, pronucleus formation and parthenogenetic development. Transgenic males remained largely asymptomatic, whereas transgenic females develop abdominal swellings caused by benign ovarian teratomas.

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. MGD cross-references
    Mouse Genome Database (MGD) cross-references in UniProtKB/Swiss-Prot
  2. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3