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Q8K4D6 (CP4X1_RAT) Reviewed, UniProtKB/Swiss-Prot

Last modified May 1, 2013. Version 79. Feed History...

Clusters with 100%, 90%, 50% identity | Documents (1) | Third-party data text xml rdf/xml gff fasta
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Names and origin

Protein namesRecommended name:
Cytochrome P450 4X1
EC=1.14.14.1
Alternative name(s):
CYPIVX1
Gene names
Name:Cyp4x1
OrganismRattus norvegicus (Rat) [Reference proteome]
Taxonomic identifier10116 [NCBI]
Taxonomic lineageEukaryota › Metazoa › Chordata › Craniata › Vertebrata › Euteleostomi › Mammalia › Eutheria › Euarchontoglires › Glires › Rodentia › Sciurognathi › Muroidea › Muridae › Murinae › Rattus

Protein attributes

Sequence length507 AA.
Sequence statusComplete.
Protein existenceEvidence at transcript level

General annotation (Comments)

Catalytic activity

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactor

Heme group By similarity.

Subcellular location

Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Potential. Microsome membrane By similarity.

Tissue specificity

Expressed at high levels in brain, mainly in neurons in different regions, including brain stem, hippocampus, cortex and cerebellum. Also expressed in cerebral vasculature. Not detected in kidney, nor liver. Ref.1

Sequence similarities

Belongs to the cytochrome P450 family.

Sequence annotation (Features)

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifier

Molecule processing

Chain1 – 507507Cytochrome P450 4X1
PRO_0000051863

Regions

Transmembrane14 – 3421Helical; Potential

Sites

Metal binding4521Iron (heme axial ligand) By similarity

Sequences

Sequence LengthMass (Da)Tools
Q8K4D6 [UniParc].

Last modified October 1, 2002. Version 1.
Checksum: E19D76B9811B8223

FASTA50758,574
        10         20         30         40         50         60 
MEASWLENRW ARPLHLALVF CLALVLMQAV KLYLRRQRLL RDLRPFPGPT AHWLLGHQKF 

        70         80         90        100        110        120 
LQEDNMEKLD EIVKEYPCAF PCWVGPFQAF FYIYDPDYAK IFLSRTDPKT QYLHQLMTPF 

       130        140        150        160        170        180 
LGRGLLNLDG PRWFQHRCLL TPAFHQDILK PCVDMMAHSV NMMLDKWEKT WTTQETTIEV 

       190        200        210        220        230        240 
FEHINLMTLD IIMKCAFGQE TNCQINGTYE SYVKATFELG EIISSRLYNF WHHHDIIFKL 

       250        260        270        280        290        300 
SPKGHCFQEL GKVIHQCTEK IIQDRKKTLK DQVNQDDTQT SQNFLDIVLS AQAGDEKAFS 

       310        320        330        340        350        360 
DADLRSEVNT FMWAGHDASA ASISWLLYCL ALNPEHQDRC RTEIRSILGD GSSITWEQLD 

       370        380        390        400        410        420 
EIPYTTMCIK ETLRLIPPIP SISRELSKPL TLPDGHSLPA GMTVVLSIWG LHHNPAVWKD 

       430        440        450        460        470        480 
PKVFDPLRFT KENSEQRHPC AFLPFSSGPR NCIGQQFAML ELKVAIALTL LRFRVAADLT 

       490        500 
RPPAFSSHTV LRPKHGIYLH LKKLPEC

« Hide

References

[1]"Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain."
Bylund J., Zhang C., Harder D.R.
Biochem. Biophys. Res. Commun. 296:677-684(2002) [PubMed] [Europe PMC] [Abstract]
Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
Strain: Sprague-Dawley.
Tissue: Brain.

Cross-references

Sequence databases

EMBL
GenBank
DDBJ		AF439343 mRNA. Translation: AAM73782.1.
IPIIPI00203135.
PIRJC7883.
RefSeqNP_663708.1. NM_145675.1.
UniGeneRn.85477.

3D structure databases

ProteinModelPortalQ8K4D6.
ModBaseSearch...

Protein-protein interaction databases

STRING10116.ENSRNOP00000011985.

Proteomic databases

PaxDbQ8K4D6.
PRIDEQ8K4D6.

Protocols and materials databases

StructuralBiologyKnowledgebaseSearch...

Genome annotation databases

EnsemblENSRNOT00000011985; ENSRNOP00000011985; ENSRNOG00000043513.
GeneID246767.
KEGGrno:246767.
UCSCRGD:628719. rat.

Organism-specific databases

CTD260293.
RGD628719. Cyp4x1.

Phylogenomic databases

eggNOGCOG2124.
GeneTreeENSGT00660000095395.
HOGENOMHOG000233833.
HOVERGENHBG000182.
KOK07428.
OMAFQENEME.
OrthoDBEOG4V170S.

Gene expression databases

GenevestigatorQ8K4D6.
GermOnlineENSRNOG00000008842. Rattus norvegicus.

Family and domain databases

Gene3D1.10.630.10. 1 hit.
InterProIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamPF00067. p450. 1 hit.
[Graphical view]
PRINTSPR00463. EP450I.
PR00385. P450.
SUPFAMSSF48264. Cytochrome_P450. 1 hit.
PROSITEPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetSearch...

Other

NextBio623832.

Entry information

Entry nameCP4X1_RAT
AccessionPrimary (citable) accession number: Q8K4D6
Entry history
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: May 1, 2013
This is version 79 of the entry and version 1 of the sequence. [Complete history]
Entry statusReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Relevant documents

SIMILARITY comments

Index of protein domains and families

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