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Protein

Cytochrome P450 4X1

Gene

Cyp4x1

Organism
Rattus norvegicus (Rat)
Status
Reviewed-Annotation score: Annotation score: 3 out of 5-Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

hemeBy similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi452 – 4521Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4X1 (EC:1.14.14.1)
Alternative name(s):
CYPIVX1
Gene namesi
Name:Cyp4x1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494 Componenti: Chromosome 5

Organism-specific databases

RGDi628719. Cyp4x1.

Subcellular locationi

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Cytochrome P450 4X1PRO_0000051863Add
BLAST

Proteomic databases

PaxDbiQ8K4D6.
PRIDEiQ8K4D6.

Expressioni

Tissue specificityi

Expressed at high levels in brain, mainly in neurons in different regions, including brain stem, hippocampus, cortex and cerebellum. Also expressed in cerebral vasculature. Not detected in kidney, nor liver.1 Publication

Gene expression databases

GenevestigatoriQ8K4D6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011985.

Structurei

3D structure databases

ProteinModelPortaliQ8K4D6.
ModBaseiSearch...
MobiDBiSearch...

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ8K4D6.
KOiK07428.
OMAiMTESIAM.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ8K4D6.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4D6-1 [UniParc]FASTAAdd to basket

« Hide

        10         20         30         40         50
MEASWLENRW ARPLHLALVF CLALVLMQAV KLYLRRQRLL RDLRPFPGPT
60 70 80 90 100
AHWLLGHQKF LQEDNMEKLD EIVKEYPCAF PCWVGPFQAF FYIYDPDYAK
110 120 130 140 150
IFLSRTDPKT QYLHQLMTPF LGRGLLNLDG PRWFQHRCLL TPAFHQDILK
160 170 180 190 200
PCVDMMAHSV NMMLDKWEKT WTTQETTIEV FEHINLMTLD IIMKCAFGQE
210 220 230 240 250
TNCQINGTYE SYVKATFELG EIISSRLYNF WHHHDIIFKL SPKGHCFQEL
260 270 280 290 300
GKVIHQCTEK IIQDRKKTLK DQVNQDDTQT SQNFLDIVLS AQAGDEKAFS
310 320 330 340 350
DADLRSEVNT FMWAGHDASA ASISWLLYCL ALNPEHQDRC RTEIRSILGD
360 370 380 390 400
GSSITWEQLD EIPYTTMCIK ETLRLIPPIP SISRELSKPL TLPDGHSLPA
410 420 430 440 450
GMTVVLSIWG LHHNPAVWKD PKVFDPLRFT KENSEQRHPC AFLPFSSGPR
460 470 480 490 500
NCIGQQFAML ELKVAIALTL LRFRVAADLT RPPAFSSHTV LRPKHGIYLH

LKKLPEC
Length:507
Mass (Da):58,574
Last modified:September 30, 2002 - v1
Checksum:iE19D76B9811B8223
GO

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439343 mRNA. Translation: AAM73782.1.
PIRiJC7883.
RefSeqiNP_663708.1. NM_145675.1.
UniGeneiRn.85477.

Genome annotation databases

EnsembliENSRNOT00000011985; ENSRNOP00000011985; ENSRNOG00000043513.
GeneIDi246767.
KEGGirno:246767.
UCSCiRGD:628719. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBLi
GenBanki
DDBJi
Links Updated
AF439343 mRNA. Translation: AAM73782.1.
PIRiJC7883.
RefSeqiNP_663708.1. NM_145675.1.
UniGeneiRn.85477.

3D structure databases

ProteinModelPortaliQ8K4D6.
ModBaseiSearch...
MobiDBiSearch...

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011985.

Proteomic databases

PaxDbiQ8K4D6.
PRIDEiQ8K4D6.

Protocols and materials databases

Structural Biology KnowledgebaseSearch...

Genome annotation databases

EnsembliENSRNOT00000011985; ENSRNOP00000011985; ENSRNOG00000043513.
GeneIDi246767.
KEGGirno:246767.
UCSCiRGD:628719. rat.

Organism-specific databases

CTDi260293.
RGDi628719. Cyp4x1.

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ8K4D6.
KOiK07428.
OMAiMTESIAM.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ8K4D6.
TreeFamiTF105088.

Miscellaneous databases

NextBioi623832.
PROiQ8K4D6.

Gene expression databases

GenevestigatoriQ8K4D6.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]
ProtoNetiSearch...

Publicationsi

  1. "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain."
    Bylund J., Zhang C., Harder D.R.
    Biochem. Biophys. Res. Commun. 296:677-684(2001) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCP4X1_RAT
AccessioniPrimary (citable) accession number: Q8K4D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 6, 2004
Last sequence update: September 30, 2002
Last modified: January 6, 2015
This is version 92 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

Similar proteinsi

Links to similar proteins from the UniProt Reference Clusters (UniRef) at 100%, 90% and 50% sequence identity:
100%UniRef100 combines identical sequences and sub-fragments with 11 or more residues from any organism into Uniref entry.
90%UniRef90 is built by clustering UniRef100 sequences that have at least 90% sequence identity to, and 80% overlap with, the longest sequence (a.k.a seed sequence).
50%UniRef50 is built by clustering UniRef90 seed sequences that have at least 50% sequence identity to, and 80% overlap with, the longest sequence in the cluster.