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Q8K4D6

- CP4X1_RAT

UniProt

Q8K4D6 - CP4X1_RAT

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Protein

Cytochrome P450 4X1

Gene

Cyp4x1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group.By similarity

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi452 – 4521Iron (heme axial ligand)By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4X1 (EC:1.14.14.1)
Alternative name(s):
CYPIVX1
Gene namesi
Name:Cyp4x1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi628719. Cyp4x1.

Subcellular locationi

GO - Cellular componenti

  1. endoplasmic reticulum Source: UniProtKB-KW
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Cytochrome P450 4X1PRO_0000051863Add
BLAST

Proteomic databases

PaxDbiQ8K4D6.
PRIDEiQ8K4D6.

Expressioni

Tissue specificityi

Expressed at high levels in brain, mainly in neurons in different regions, including brain stem, hippocampus, cortex and cerebellum. Also expressed in cerebral vasculature. Not detected in kidney, nor liver.1 Publication

Gene expression databases

GenevestigatoriQ8K4D6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011985.

Structurei

3D structure databases

ProteinModelPortaliQ8K4D6.
ModBaseiSearch...
MobiDBiSearch...

Transmembrane

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421HelicalSequence AnalysisAdd
BLAST

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.Curated

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00760000118816.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
InParanoidiQ8K4D6.
KOiK07428.
OMAiTTIEVFE.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ8K4D6.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4D6-1 [UniParc]FASTAAdd to Basket

« Hide

        10         20         30         40         50
MEASWLENRW ARPLHLALVF CLALVLMQAV KLYLRRQRLL RDLRPFPGPT
60 70 80 90 100
AHWLLGHQKF LQEDNMEKLD EIVKEYPCAF PCWVGPFQAF FYIYDPDYAK
110 120 130 140 150
IFLSRTDPKT QYLHQLMTPF LGRGLLNLDG PRWFQHRCLL TPAFHQDILK
160 170 180 190 200
PCVDMMAHSV NMMLDKWEKT WTTQETTIEV FEHINLMTLD IIMKCAFGQE
210 220 230 240 250
TNCQINGTYE SYVKATFELG EIISSRLYNF WHHHDIIFKL SPKGHCFQEL
260 270 280 290 300
GKVIHQCTEK IIQDRKKTLK DQVNQDDTQT SQNFLDIVLS AQAGDEKAFS
310 320 330 340 350
DADLRSEVNT FMWAGHDASA ASISWLLYCL ALNPEHQDRC RTEIRSILGD
360 370 380 390 400
GSSITWEQLD EIPYTTMCIK ETLRLIPPIP SISRELSKPL TLPDGHSLPA
410 420 430 440 450
GMTVVLSIWG LHHNPAVWKD PKVFDPLRFT KENSEQRHPC AFLPFSSGPR
460 470 480 490 500
NCIGQQFAML ELKVAIALTL LRFRVAADLT RPPAFSSHTV LRPKHGIYLH

LKKLPEC
Length:507
Mass (Da):58,574
Last modified:October 1, 2002 - v1
Checksum:iE19D76B9811B8223
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF439343 mRNA. Translation: AAM73782.1.
PIRiJC7883.
RefSeqiNP_663708.1. NM_145675.1.
UniGeneiRn.85477.

Genome annotation databases

EnsembliENSRNOT00000011985; ENSRNOP00000011985; ENSRNOG00000043513.
GeneIDi246767.
KEGGirno:246767.
UCSCiRGD:628719. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF439343 mRNA. Translation: AAM73782.1 .
PIRi JC7883.
RefSeqi NP_663708.1. NM_145675.1.
UniGenei Rn.85477.

3D structure databases

ProteinModelPortali Q8K4D6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011985.

Proteomic databases

PaxDbi Q8K4D6.
PRIDEi Q8K4D6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011985 ; ENSRNOP00000011985 ; ENSRNOG00000043513 .
GeneIDi 246767.
KEGGi rno:246767.
UCSCi RGD:628719. rat.

Organism-specific databases

CTDi 260293.
RGDi 628719. Cyp4x1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00760000118816.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
InParanoidi Q8K4D6.
KOi K07428.
OMAi TTIEVFE.
OrthoDBi EOG7CNZFK.
PhylomeDBi Q8K4D6.
TreeFami TF105088.

Miscellaneous databases

NextBioi 623832.
PROi Q8K4D6.

Gene expression databases

Genevestigatori Q8K4D6.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain."
    Bylund J., Zhang C., Harder D.R.
    Biochem. Biophys. Res. Commun. 296:677-684(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCP4X1_RAT
AccessioniPrimary (citable) accession number: Q8K4D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: October 29, 2014
This is version 90 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3