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Q8K4D6

- CP4X1_RAT

UniProt

Q8K4D6 - CP4X1_RAT

Protein

Cytochrome P450 4X1

Gene

Cyp4x1

Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5- Experimental evidence at transcript leveli
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    • History
      Entry version 89 (01 Oct 2014)
      Sequence version 1 (01 Oct 2002)
      Previous versions | rss
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    Functioni

    Catalytic activityi

    RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

    Cofactori

    Heme group.By similarity

    Sites

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Metal bindingi452 – 4521Iron (heme axial ligand)By similarity

    GO - Molecular functioni

    1. aromatase activity Source: UniProtKB-EC
    2. heme binding Source: InterPro
    3. iron ion binding Source: InterPro

    Keywords - Molecular functioni

    Monooxygenase, Oxidoreductase

    Keywords - Ligandi

    Heme, Iron, Metal-binding

    Names & Taxonomyi

    Protein namesi
    Recommended name:
    Cytochrome P450 4X1 (EC:1.14.14.1)
    Alternative name(s):
    CYPIVX1
    Gene namesi
    Name:Cyp4x1
    OrganismiRattus norvegicus (Rat)
    Taxonomic identifieri10116 [NCBI]
    Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
    ProteomesiUP000002494: Chromosome 5

    Organism-specific databases

    RGDi628719. Cyp4x1.

    Subcellular locationi

    GO - Cellular componenti

    1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
    2. integral component of membrane Source: UniProtKB-KW

    Keywords - Cellular componenti

    Endoplasmic reticulum, Membrane, Microsome

    PTM / Processingi

    Molecule processing

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Chaini1 – 507507Cytochrome P450 4X1PRO_0000051863Add
    BLAST

    Proteomic databases

    PaxDbiQ8K4D6.
    PRIDEiQ8K4D6.

    Expressioni

    Tissue specificityi

    Expressed at high levels in brain, mainly in neurons in different regions, including brain stem, hippocampus, cortex and cerebellum. Also expressed in cerebral vasculature. Not detected in kidney, nor liver.1 Publication

    Gene expression databases

    GenevestigatoriQ8K4D6.

    Interactioni

    Protein-protein interaction databases

    STRINGi10116.ENSRNOP00000011985.

    Structurei

    3D structure databases

    ProteinModelPortaliQ8K4D6.
    ModBaseiSearch...
    MobiDBiSearch...

    Transmembrane

    Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
    Transmembranei14 – 3421HelicalSequence AnalysisAdd
    BLAST

    Family & Domainsi

    Sequence similaritiesi

    Belongs to the cytochrome P450 family.Curated

    Keywords - Domaini

    Transmembrane, Transmembrane helix

    Phylogenomic databases

    eggNOGiCOG2124.
    GeneTreeiENSGT00740000115505.
    HOGENOMiHOG000233833.
    HOVERGENiHBG000182.
    KOiK07428.
    OMAiTTIEVFE.
    OrthoDBiEOG7CNZFK.
    PhylomeDBiQ8K4D6.
    TreeFamiTF105088.

    Family and domain databases

    Gene3Di1.10.630.10. 1 hit.
    InterProiIPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view]
    PfamiPF00067. p450. 1 hit.
    [Graphical view]
    PRINTSiPR00463. EP450I.
    PR00385. P450.
    SUPFAMiSSF48264. SSF48264. 1 hit.
    PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view]

    Sequencei

    Sequence statusi: Complete.

    Q8K4D6-1 [UniParc]FASTAAdd to Basket

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    MEASWLENRW ARPLHLALVF CLALVLMQAV KLYLRRQRLL RDLRPFPGPT    50
    AHWLLGHQKF LQEDNMEKLD EIVKEYPCAF PCWVGPFQAF FYIYDPDYAK 100
    IFLSRTDPKT QYLHQLMTPF LGRGLLNLDG PRWFQHRCLL TPAFHQDILK 150
    PCVDMMAHSV NMMLDKWEKT WTTQETTIEV FEHINLMTLD IIMKCAFGQE 200
    TNCQINGTYE SYVKATFELG EIISSRLYNF WHHHDIIFKL SPKGHCFQEL 250
    GKVIHQCTEK IIQDRKKTLK DQVNQDDTQT SQNFLDIVLS AQAGDEKAFS 300
    DADLRSEVNT FMWAGHDASA ASISWLLYCL ALNPEHQDRC RTEIRSILGD 350
    GSSITWEQLD EIPYTTMCIK ETLRLIPPIP SISRELSKPL TLPDGHSLPA 400
    GMTVVLSIWG LHHNPAVWKD PKVFDPLRFT KENSEQRHPC AFLPFSSGPR 450
    NCIGQQFAML ELKVAIALTL LRFRVAADLT RPPAFSSHTV LRPKHGIYLH 500
    LKKLPEC 507
    Length:507
    Mass (Da):58,574
    Last modified:October 1, 2002 - v1
    Checksum:iE19D76B9811B8223
    GO

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF439343 mRNA. Translation: AAM73782.1.
    PIRiJC7883.
    RefSeqiNP_663708.1. NM_145675.1.
    XP_006238674.1. XM_006238612.1.
    UniGeneiRn.85477.

    Genome annotation databases

    EnsembliENSRNOT00000011985; ENSRNOP00000011985; ENSRNOG00000043513.
    GeneIDi246767.
    KEGGirno:246767.
    UCSCiRGD:628719. rat.

    Cross-referencesi

    Sequence databases

    Select the link destinations:
    EMBL
    GenBank
    DDBJ
    Links Updated
    AF439343 mRNA. Translation: AAM73782.1 .
    PIRi JC7883.
    RefSeqi NP_663708.1. NM_145675.1.
    XP_006238674.1. XM_006238612.1.
    UniGenei Rn.85477.

    3D structure databases

    ProteinModelPortali Q8K4D6.
    ModBasei Search...
    MobiDBi Search...

    Protein-protein interaction databases

    STRINGi 10116.ENSRNOP00000011985.

    Proteomic databases

    PaxDbi Q8K4D6.
    PRIDEi Q8K4D6.

    Protocols and materials databases

    Structural Biology Knowledgebase Search...

    Genome annotation databases

    Ensembli ENSRNOT00000011985 ; ENSRNOP00000011985 ; ENSRNOG00000043513 .
    GeneIDi 246767.
    KEGGi rno:246767.
    UCSCi RGD:628719. rat.

    Organism-specific databases

    CTDi 260293.
    RGDi 628719. Cyp4x1.

    Phylogenomic databases

    eggNOGi COG2124.
    GeneTreei ENSGT00740000115505.
    HOGENOMi HOG000233833.
    HOVERGENi HBG000182.
    KOi K07428.
    OMAi TTIEVFE.
    OrthoDBi EOG7CNZFK.
    PhylomeDBi Q8K4D6.
    TreeFami TF105088.

    Miscellaneous databases

    NextBioi 623832.
    PROi Q8K4D6.

    Gene expression databases

    Genevestigatori Q8K4D6.

    Family and domain databases

    Gene3Di 1.10.630.10. 1 hit.
    InterProi IPR001128. Cyt_P450.
    IPR017972. Cyt_P450_CS.
    IPR002401. Cyt_P450_E_grp-I.
    [Graphical view ]
    Pfami PF00067. p450. 1 hit.
    [Graphical view ]
    PRINTSi PR00463. EP450I.
    PR00385. P450.
    SUPFAMi SSF48264. SSF48264. 1 hit.
    PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
    [Graphical view ]
    ProtoNeti Search...

    Publicationsi

    1. "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain."
      Bylund J., Zhang C., Harder D.R.
      Biochem. Biophys. Res. Commun. 296:677-684(2002) [PubMed] [Europe PMC] [Abstract]
      Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
      Strain: Sprague-Dawley.
      Tissue: Brain.

    Entry informationi

    Entry nameiCP4X1_RAT
    AccessioniPrimary (citable) accession number: Q8K4D6
    Entry historyi
    Integrated into UniProtKB/Swiss-Prot: June 7, 2004
    Last sequence update: October 1, 2002
    Last modified: October 1, 2014
    This is version 89 of the entry and version 1 of the sequence. [Complete history]
    Entry statusiReviewed (UniProtKB/Swiss-Prot)
    Annotation programChordata Protein Annotation Program

    Miscellaneousi

    Keywords - Technical termi

    Complete proteome, Reference proteome

    Documents

    1. SIMILARITY comments
      Index of protein domains and families

    External Data

    Dasty 3