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Q8K4D6

- CP4X1_RAT

UniProt

Q8K4D6 - CP4X1_RAT

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Protein
Cytochrome P450 4X1
Gene
Cyp4x1
Organism
Rattus norvegicus (Rat)
Status
Reviewed - Annotation score: 3 out of 5 - Experimental evidence at transcript leveli

Functioni

Catalytic activityi

RH + reduced flavoprotein + O2 = ROH + oxidized flavoprotein + H2O.

Cofactori

Heme group By similarity.

Sites

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Metal bindingi452 – 4521Iron (heme axial ligand) By similarity

GO - Molecular functioni

  1. aromatase activity Source: UniProtKB-EC
  2. heme binding Source: InterPro
  3. iron ion binding Source: InterPro
Complete GO annotation...

Keywords - Molecular functioni

Monooxygenase, Oxidoreductase

Keywords - Ligandi

Heme, Iron, Metal-binding

Names & Taxonomyi

Protein namesi
Recommended name:
Cytochrome P450 4X1 (EC:1.14.14.1)
Alternative name(s):
CYPIVX1
Gene namesi
Name:Cyp4x1
OrganismiRattus norvegicus (Rat)
Taxonomic identifieri10116 [NCBI]
Taxonomic lineageiEukaryotaMetazoaChordataCraniataVertebrataEuteleostomiMammaliaEutheriaEuarchontogliresGliresRodentiaSciurognathiMuroideaMuridaeMurinaeRattus
ProteomesiUP000002494: Chromosome 5

Organism-specific databases

RGDi628719. Cyp4x1.

Subcellular locationi

Endoplasmic reticulum membrane By similarity; Single-pass membrane protein Reviewed prediction. Microsome membrane By similarity

Topology

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Transmembranei14 – 3421Helical; Reviewed prediction
Add
BLAST

GO - Cellular componenti

  1. endoplasmic reticulum membrane Source: UniProtKB-SubCell
  2. integral component of membrane Source: UniProtKB-KW
Complete GO annotation...

Keywords - Cellular componenti

Endoplasmic reticulum, Membrane, Microsome

PTM / Processingi

Molecule processing

Feature keyPosition(s)LengthDescriptionGraphical viewFeature identifierActions
Chaini1 – 507507Cytochrome P450 4X1
PRO_0000051863Add
BLAST

Proteomic databases

PaxDbiQ8K4D6.
PRIDEiQ8K4D6.

Expressioni

Tissue specificityi

Expressed at high levels in brain, mainly in neurons in different regions, including brain stem, hippocampus, cortex and cerebellum. Also expressed in cerebral vasculature. Not detected in kidney, nor liver.1 Publication

Gene expression databases

GenevestigatoriQ8K4D6.

Interactioni

Protein-protein interaction databases

STRINGi10116.ENSRNOP00000011985.

Structurei

3D structure databases

ProteinModelPortaliQ8K4D6.

Family & Domainsi

Sequence similaritiesi

Belongs to the cytochrome P450 family.

Keywords - Domaini

Transmembrane, Transmembrane helix

Phylogenomic databases

eggNOGiCOG2124.
GeneTreeiENSGT00740000115505.
HOGENOMiHOG000233833.
HOVERGENiHBG000182.
KOiK07428.
OMAiTTIEVFE.
OrthoDBiEOG7CNZFK.
PhylomeDBiQ8K4D6.
TreeFamiTF105088.

Family and domain databases

Gene3Di1.10.630.10. 1 hit.
InterProiIPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view]
PfamiPF00067. p450. 1 hit.
[Graphical view]
PRINTSiPR00463. EP450I.
PR00385. P450.
SUPFAMiSSF48264. SSF48264. 1 hit.
PROSITEiPS00086. CYTOCHROME_P450. 1 hit.
[Graphical view]

Sequencei

Sequence statusi: Complete.

Q8K4D6-1 [UniParc]FASTAAdd to Basket

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MEASWLENRW ARPLHLALVF CLALVLMQAV KLYLRRQRLL RDLRPFPGPT    50
AHWLLGHQKF LQEDNMEKLD EIVKEYPCAF PCWVGPFQAF FYIYDPDYAK 100
IFLSRTDPKT QYLHQLMTPF LGRGLLNLDG PRWFQHRCLL TPAFHQDILK 150
PCVDMMAHSV NMMLDKWEKT WTTQETTIEV FEHINLMTLD IIMKCAFGQE 200
TNCQINGTYE SYVKATFELG EIISSRLYNF WHHHDIIFKL SPKGHCFQEL 250
GKVIHQCTEK IIQDRKKTLK DQVNQDDTQT SQNFLDIVLS AQAGDEKAFS 300
DADLRSEVNT FMWAGHDASA ASISWLLYCL ALNPEHQDRC RTEIRSILGD 350
GSSITWEQLD EIPYTTMCIK ETLRLIPPIP SISRELSKPL TLPDGHSLPA 400
GMTVVLSIWG LHHNPAVWKD PKVFDPLRFT KENSEQRHPC AFLPFSSGPR 450
NCIGQQFAML ELKVAIALTL LRFRVAADLT RPPAFSSHTV LRPKHGIYLH 500
LKKLPEC 507
Length:507
Mass (Da):58,574
Last modified:October 1, 2002 - v1
Checksum:iE19D76B9811B8223
GO

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF439343 mRNA. Translation: AAM73782.1.
PIRiJC7883.
RefSeqiNP_663708.1. NM_145675.1.
XP_006238674.1. XM_006238612.1.
UniGeneiRn.85477.

Genome annotation databases

EnsembliENSRNOT00000011985; ENSRNOP00000011985; ENSRNOG00000043513.
GeneIDi246767.
KEGGirno:246767.
UCSCiRGD:628719. rat.

Cross-referencesi

Sequence databases

Select the link destinations:
EMBL
GenBank
DDBJ
Links Updated
AF439343 mRNA. Translation: AAM73782.1 .
PIRi JC7883.
RefSeqi NP_663708.1. NM_145675.1.
XP_006238674.1. XM_006238612.1.
UniGenei Rn.85477.

3D structure databases

ProteinModelPortali Q8K4D6.
ModBasei Search...
MobiDBi Search...

Protein-protein interaction databases

STRINGi 10116.ENSRNOP00000011985.

Proteomic databases

PaxDbi Q8K4D6.
PRIDEi Q8K4D6.

Protocols and materials databases

Structural Biology Knowledgebase Search...

Genome annotation databases

Ensembli ENSRNOT00000011985 ; ENSRNOP00000011985 ; ENSRNOG00000043513 .
GeneIDi 246767.
KEGGi rno:246767.
UCSCi RGD:628719. rat.

Organism-specific databases

CTDi 260293.
RGDi 628719. Cyp4x1.

Phylogenomic databases

eggNOGi COG2124.
GeneTreei ENSGT00740000115505.
HOGENOMi HOG000233833.
HOVERGENi HBG000182.
KOi K07428.
OMAi TTIEVFE.
OrthoDBi EOG7CNZFK.
PhylomeDBi Q8K4D6.
TreeFami TF105088.

Miscellaneous databases

NextBioi 623832.
PROi Q8K4D6.

Gene expression databases

Genevestigatori Q8K4D6.

Family and domain databases

Gene3Di 1.10.630.10. 1 hit.
InterProi IPR001128. Cyt_P450.
IPR017972. Cyt_P450_CS.
IPR002401. Cyt_P450_E_grp-I.
[Graphical view ]
Pfami PF00067. p450. 1 hit.
[Graphical view ]
PRINTSi PR00463. EP450I.
PR00385. P450.
SUPFAMi SSF48264. SSF48264. 1 hit.
PROSITEi PS00086. CYTOCHROME_P450. 1 hit.
[Graphical view ]
ProtoNeti Search...

Publicationsi

  1. "Identification of a novel cytochrome P450, CYP4X1, with unique localization specific to the brain."
    Bylund J., Zhang C., Harder D.R.
    Biochem. Biophys. Res. Commun. 296:677-684(2002) [PubMed] [Europe PMC] [Abstract]
    Cited for: NUCLEOTIDE SEQUENCE [MRNA], TISSUE SPECIFICITY.
    Strain: Sprague-Dawley.
    Tissue: Brain.

Entry informationi

Entry nameiCP4X1_RAT
AccessioniPrimary (citable) accession number: Q8K4D6
Entry historyi
Integrated into UniProtKB/Swiss-Prot: June 7, 2004
Last sequence update: October 1, 2002
Last modified: May 14, 2014
This is version 88 of the entry and version 1 of the sequence. [Complete history]
Entry statusiReviewed (UniProtKB/Swiss-Prot)
Annotation programChordata Protein Annotation Program

Miscellaneousi

Keywords - Technical termi

Complete proteome, Reference proteome

Documents

  1. SIMILARITY comments
    Index of protein domains and families

External Data

Dasty 3

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